a role in controlling the level of reactive oxygen species

... including bronchial asthma [26] In particular, increasing evidence shows that chronic airway inflammation typical of asthma results in increased oxidative stress in the airways Moreover, many asthma ... asthma triggers including viral infections and air pollutants may activate the production of ROS, thus resulting in inflammation in addition to the asthmatic symptoms [26] The maintenance of basal ... calculate the sample size According to the mean comparison formula [15] with a standard deviation of 157.53 and a difference of 616, Za of 95% and a Zb of 80%, we obtained a sample size of In total,...

Ngày tải lên: 20/06/2014, 00:20

... (Government Savings Bank) has a “School Based Savings Programme” in which students recreate a savings bank in their class and acquire the basic principles of personal financial management via a “learning ... addition, bank fees to hold an account often exceed interest paid for small deposit accounts In contrast, at the postal savings bank in Benin, Burkina-Faso, Kenya and Tanzania, people can open a savings ... receivers of remittances are mainly individuals and small businesses, the traditional target client group of savings banks By capturing and channelling more of the remittances into the financial system...

Ngày tải lên: 15/03/2014, 10:20

... compared the redox activity of native recombinant human albumin with that of two mutants, His39Leu and Tyr84Phe The latter mutation in particular has a A A J Stewart et al dramatic effect on the ... made in a quantitative fashion, but qualitative observations have important implications It appears that small local alterations have a substantial effect on the entire domain I, and even on the ... literature values of  [20] Thus, the pKa of Cys34 in recombinant HSA is substantially lower than the average value of 8–9, which is typical for a free cysteine side chain Abnormally low pKa values...

Ngày tải lên: 30/03/2014, 15:20

... erew slamina llA )aeroK ,ytisrevinU lanoitaN luoeS( slamina yrotarobal fo esu dna erac eht rof snoitaluger dna ycilop gniwollof yduts siht tuohguorht desu erew )aeroK ,ytisrevinU lanoitaN luoeS ... ,retneC laminA yrotarobaL( ecim elamef c/BLAB dlo-keew-eviF snoitcelloc elpmas dna noitazinummi ,slamina latnemirepxE ]91,81[ yduts siht ni eniccav laro na sa desu dna debircsed ylsuoiverp sa deraperp ... snoitaraperp eniccaV sdohteM dna slairetaM GgI cimetsys dna AgIs lasocum neewteb pihsnoitaler eht gnizylana yb seneg AIIxpa dna AIxpa gnisserpxe )eaisiverec S( eaisiverec secymorahccaS htiw noitazinummi...

Ngày tải lên: 07/08/2014, 18:21

... Finally, these data suggest the interesting possibility that UCP2 may serve as an antioxidant, guarding against an excess of oxygen free radicals Further studies on signal transduction cascades ... modulator of reactive species production, suggesting a role for UCP2 in the regulation of intracellular redox state and macrophage-mediated immunity As stated earlier, mitochondria are the major ... significant increase in UCP2 expression (3.6-fold, P < 0.05) On the other hand, analysis of the kinetics of induction of UCP2 protein in MDP-treated macrophages revealed a significant increase starting...

Ngày tải lên: 05/03/2014, 23:20

... we have the Gulf of Naples, the coast of Amalfi, the Lake of Lucerne, is — the pinnacles of the Dolomites, a bit of Hamburg harbour, and the boulevards of Paris ; and above all these are the ... natural cinema, of the loveliest kind imaginable One's enjoyment was still further enhanced by a glass of good Rio Grande wine We put into Maceio, the capital of the State of Alagoas The is a brilliant ... on the water yonder, and form a dazzling wreath round the foot of the mountain These are the lamps of the Avenida of pearls which every night flood the promenade of the suburb of Copacabana with...

Ngày tải lên: 15/03/2014, 19:20

... molecular masses of MnSOD, CuZnSOD and actin, the last acting as an internal standard, and incubated with the corresponding antibody Forty micrograms of cell protein extract was loaded in each lane The ... 5¢-GTGA TGTGCAGCTGATCAAGACT-3¢, antisense 5¢-GATGA CCAGCCCAAAGGAGA-3¢ Western blot analysis Cells were lysed in the same buffer as used for the enzyme activity assay An equal amount of protein (40 ... NADP, mM Na citrate To start the assay, U isocitrate dehydrogenase were added and activity was measured by monitoring absorbance at 340 nm for 15 Reactivation of aconitase was obtained by adding...

Ngày tải lên: 16/03/2014, 18:20

... proteins in the algae of red lineage which contain Haptophyta, diatoms and brown algae and are characterized by chlorophyll a ⁄ c The psbP gene is present in some of the algae in the red lineage ... behavior of this band in the diatom is thus similar to that of the PsbPlike protein in cyanobacteria [3,12] The fact that C gracilis, P gyrans, L japonica and U pinnatifida contained bands cross-reacted ... 1, a glaucophyte contained the cyanobacterial-type extrinsic proteins (PsbU and PsbV), and chlorophyll a ⁄ c-containing algae diatoms, haptophyte and brown algae such as retained the red algal-type...

Ngày tải lên: 23/03/2014, 15:21

... 4) was decreased by atrazine treatment (MA) in comparison to the mannitol control (M) In contrast, addition of sucrose in the presence of atrazine (SA) maintained a functional level of SOD activity ... were associated with a decrease of DHAR activity, the increase of DHAR transcript levels in the combined presence of sucrose and atrazine was not associated with an increase of global DHAR enzyme ... significantly different, thus indicating that the photoprotection role of carotenoids was maintained in the presence of atrazine Higher induction by atrazine treatment was also found for the violaxanthin...

Ngày tải lên: 12/08/2014, 03:20

... following pair of primers: (5TTGGATAACTGTGGTAATTCTAGAAGCTAA-3' and 5'CGGGTTGGTTTTGATCTGATAAAT-3') and 250 nM of the 6-carboxyfluorescein-CATGCCGACGGGCGCTGA-MGB probe The proviral loads were finally ... (5'GAAACTCCAGAGCAATGGCATAA-3' and 5'-GGTTCGGCCATCGAGACA-3') and revealed with a Minor Groove Binder (MGB) fluorescent probe (250 nM of 6-carboxyfluorescein-CTCACCCACTGCAAC-MGB) using the TaqMan ... blot analysis using an antibody specific for the acetylated form of histone H3 Actin was analyzed in parallel as a loading control B) The extent of B cell apoptosis was measured by determining the...

Ngày tải lên: 12/08/2014, 23:22

... general mechanism for furin-mediated activation of transmembrane substrates The activation of ADAM17 by furin [68] and our observation of an interaction between GRASP55 and the ICD of ADAM17 ... representing a speed increase of ·40 Statistical analysis was performed using the graphpad prism, version (GraphPad Software, Inc., San Diego, CA, USA) Statistical significance was calculated using ... GRASP55 and TGF -a D152 (lacking the last eight amino acids of the ICD) compared to the TGF -a D158 construct lacking only the last two valine residues, suggesting a role for an internal motif in...

Ngày tải lên: 18/02/2014, 04:20

... R, Takahashi K, Takeda K, Furuyama K, Kaneko K, Takahashi S, Tamai M & Shibahara S (2004) Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal ... et al naya OA, Kolpakov FA et al (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL Nucleic Acids Res 26, 362–367 47 Takahashi S, Takahashi Y, Ito K, Nagano T, Shibahara ... and then subjected to northern blot analysis Each lane contains 15 lg of total RNA The bottom panel shows the expression of b-actin mRNA as an internal control (B) Western blot analysis The indicated...

Ngày tải lên: 19/02/2014, 06:20

... i.e has a cap and a poly (A) -tail The open reading frame of the mRNA is shown as a thick line Initiation factors are abbreviated The arrow indicates the phosphorylation of eIF4E at Ser209 by the ... 5357 an anabolic stimulus, may largely induce increased translation across the board of mRNAs that are already actively being translated How could increased phosphorylation of eIF4E actually inhibit ... remain associated with the cap, and would become available to bind other mRNAs and facilitate the initiation of their translation (diagram K) The released eIF4F is thus now free to bind to other...

Ngày tải lên: 23/03/2014, 21:20

... this time the valency hybrid tetramers As a result, the b chain was found to acquire a noticeable resistance against the acidic autoxidation in a manner of contacting with the a chain, no matter ... state the partner a chains may take, the oxy-form or the ferric met-form Unlike separated b chains, the spontaneous formation of hemichrome was at variance with separated a chains in the pH range ... isolated a chain In contrast to this, the heme pocket of the b chain still obstructs easy access of a water molecule as well as a proton, so that the b chains can keep a constant resistance against...

Ngày tải lên: 31/03/2014, 15:20

... Rintahaka J, Søby S, Horan KA, Poltajainen A, Østergaard L, Paludan SR, Matikainen S: Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVSdependent ... isolated from the brains of infected animals (Figure 3B) in the absence of significant increases in levels of this viral sensor in total brain protein isolates (Figure 3A) Finally, we assessed the ... HSV-1 and elicit inflammatory CNS damage Replicating DNA viruses generate genomic DNA that serves as a ligand for DAI DAI then associates with IPS-1 and STING, subsequently activating NF-kB via the...

Ngày tải lên: 19/06/2014, 22:20

... the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the selection of its members, sharing with the ... determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, ... established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The...

Ngày tải lên: 29/06/2014, 09:20

... damage is central to the initiation and perpetuation of inflammation, and this might also be ameliorated by statin therapy Treatment of HUVEC with either atorvastatin or simvastatin promoted an ... metabolism and have active metabolites All of the statins except for pravastatin and rosuvastatin are relatively lipophilic [3] Efficacy of the HMG-CoA reductase inhibitors in vascular disease ... Research & Therapy Vol No McCarey et al induced NFκB activation and that the effect was most profound with atorvastatin and simvastatin [30] Statins might also mediate anti-inflammatory effects in...

Ngày tải lên: 09/08/2014, 06:22

... was actually monomorphic with rare alleles appearing mainly in region II Similarly to the Adh, the a Amy locus had rare alleles (Doane et al., 1975) that were mainly found in populations of region ... compared the level of polymorphism in populations originating from distilleries to those collected in villages in the case of both species Some important data - as a basis of comparison - are ... allele taken into account) and average heterozygosity - indicate a higher level of polymorphism in the field as compared with the distillery populations at of the investigated loci In D melanogaster...

Ngày tải lên: 09/08/2014, 22:22

... SD, standard deviation; case of ordinal scaling level The χ2 and Fisher's exact tests were used to analyze categorical data and Mann–Whitney Utest for data on at least ordinal level Data analysis ... COMFORT classification Data are expressed as mean ± standard deviation in the case of a normal distribution and interval scaling level, and as median (range) if the data were not distributed normally ... discomfort, fear and pain in approximately The COMFORT score is age independent because age-adapted physiological parameters are used Apart from the examination of muscular tone, calculation of the COMFORT...

Ngày tải lên: 12/08/2014, 20:20

Ngày tải lên: 12/08/2014, 22:22