a paradigm of site specific liver metastasis

... mechanism for AA as a mediator of hormone action with the participation of an acyl-CoA synthetase (ACS4) and a mitochondrial acyl-CoA thioesterase (Acot2) [7,8] ACS4 has been described as an AA-preferring ... AA release in a specific compartment of the cells A F Castillo et al are important unresolved issues [5] The simple structure of AA and the natural occurrence of so many close chemical analogues ... densitometry and the data were normalized against the intensity of the signal of unlabeled AA stained with iodine Bars denote levels (in arbitrary units) of AA in mitochondria Results are expressed as...

Ngày tải lên: 16/03/2014, 12:20

Ngày tải lên: 13/11/2014, 10:36

... initial leaching of Na+ was faster than the leaching of any of the other salts investigated (Ca2+, Mg2+ and K+) and occurred during the first stage of the alkali soil reclamation This was confirmed ... time of Ca was longer than that of Na The Mg2+ behavior was similar in the 0.5 wt% and 1.0 wt% cases (Fig 8) The Mg concentration increased gradually from the start of leaching and decreased gradually ... decreased after a peak, and then increased and decreased again This behavior indicates that the initial leaching is like Na+ leaching, and the surplus Ca2+ is drained slowly because the Ca2+ ion...

Ngày tải lên: 05/09/2013, 09:38

... Mobilization of transuranic radionuclides from disposal trenches by natural organic matter Journal of Contaminant Hydrology 199 8a 30, 49–77 [15] McCarthy, J.F, Sanford,W.E., and Stafford,P.L Lanthanide ... solution of Van Genuchten [31] The parameters used for validation of the numerical results with the analytical solution for radionuclides and colloids are presented in Table and The base case data pertaining ... coefficient attains an asymptotic value As filtration of colloids is progressively increased, dispersion reduces and attains a constant value It can be concluded that significant mixing prevails along...

Ngày tải lên: 05/09/2013, 17:03

... Africa (mainly from Sub-Saharan Africa), clearly indicate that men and women’s transport-related tasks in rural areas are gendered Females spend more time and energy on transport, have less access ... in rural transport (Mahapa, 2003) Our reading of the literature clearly indicates that gender has been more of an add-on factor and has not been mainstreamed in transport policy and planning ... Transportation, Federal Highway Administration South African National Roads Agency Limited (SANRAL) (2005) The South African National Roads Agency Limited Sustainability Report: Annexure to Annual Report...

Ngày tải lên: 15/02/2014, 01:20

... Nasir Z, Ahmad S, Zulfiqar A Exposure to PM10, PM2.5 , PM1 and carbon monoxide on roads in Lahore, Pakistan Aerosol Air Quality Res 2011; 11: 689-95 Chapman L Transport and climate change: a ... Travel to and from the west (Waterview) can be achieved by bus (which follows a busy arterial road), or by car/motorcycle along a stretch of motorway In addition, a separate pedestrian/cycleway exists ... route taken Each of the participants recruited for the study was a regular commuter on their chosen mode Each was asked to time their journeys in such a way as to arrive at work for a 9:00AM start...

Ngày tải lên: 18/02/2014, 04:20

... data are also reported in Tables and 3287 Bilitranslocase homologue in carnation petals S Passamonti et al Table Parameters of the Scrutton and Utter equation applied to data obtained under various ... because they have a relatively simple anatomical structure, with a single layer of epidermal cells, featured by a large vacuole containing anthocyanins On the other hand, carnation petals have already ... membrane (lane 2) and tonoplast (lane 3) vesicles obtained from carnation petals, while lane was loaded with rat liver plasma membrane vesicles In all samples, antibodies A and B both revealed a...

Ngày tải lên: 20/02/2014, 01:20

... inhibitor and assayed for 2-DOG uptake Data are expressed as mean ± SEM of at least six observations Statistically significant data when compared to the samples not treated with wortmannin are indicated ... amounts of protein as determined with BCA protein assay reagent (Pierce) were subjected to immunoblot analysis using various antibodies Plasma membrane-lawn assay The plasma membrane-lawn assay was ... synthase kinase 3b K(ACh)channels MAPK activated protein-kinase 1b p70 S6 kinase Mitogen and stress activated kinase-1 AMP-activated protein kinase Phosphorylase kinase PKC K(ACh) channels Trk A and...

Ngày tải lên: 21/02/2014, 00:20

... C-terminal part appears to play an essential role in retaining Toc75 at the outer chloroplast membrane [35] With the exception of atToc75-I (At1g35860 ⁄ 80), all A thaliana Toc75 paralogs are expressed ... structural analysis by electron microscopy of a stable Toc core complex from pea revealed approximately circular particles [23] The particles had a diameter of 13 nm and a height of 10–12 nm and ... Toc75 and is part of the Arabidopsis Toc core complex T-DNA insertional mutants of atToc75-III are embryo lethal, indicative of a fundamental role in plastid development and differentiation [21,36]...

Ngày tải lên: 07/03/2014, 03:20

... 58 Tanaka R, Hirashima M, Satoh S & Tanaka A (2003) The Arabidopsis-accelerated cell death gene ACD1 is involved in oxygenation of pheophorbide a: inhibition of the pheophorbide a oxygenase activity ... al Possible ways of regulation As outlined above, a great amount of protein traffic has to take place at the envelope membranes of chloroplasts, which has to be tightly regulated to ensure that ... involvement of the AAA+ family ATPase Hsp93/ClpC in preprotein translocation is interesting because it also acts in intracellular degradation and substrate turnover, which it performs in association...

Ngày tải lên: 07/03/2014, 03:20

... chloroplasts [18] Figure summarizes the differing mechanisms of the Sec and Tat pathways in chloroplasts Tat pathway Sec pathway SecA The Tat pathway in chloroplasts consists of the integral membrane ... system that targets proteins into the thylakoid membrane but has no RNA requirement [42] The post-translational cpSRP transport pathway has a narrow range of closely-related substrates that are all ... polar C-terminal region ending in an Ala-X-Ala terminal processing site Proteins destined to be transported by the Tat pathway contain a characteristic pair of arginine residues in the N-terminal...

Ngày tải lên: 07/03/2014, 03:20

... polymerase c2 in another study revealed that it was dual targeted, but from a protein produced from the standard AUG [26], and thus via an ambiguous targeting signal rather than alternative translation ... represent an elegant mechanism of dual targeting However, experimentally, it is difficult to demonstrate that alternative translation is taking place in vivo Analysis of the targeting ability of DNA polymerase ... MPP appear to be more stringent in that alterations near the processing site have a greater inhibitory affect of MPP compared to SPP In the case of aminoacyl tRNA synthetases, Glu aminoacyl-tRNA...

Ngày tải lên: 07/03/2014, 03:20

... of received data packets Regardless of any application-specific metric that may actually be used, the number of received data packets is closely related to the amount of information acquired by ... operating point than in state need to take a more aggressive approach so as to relieve as soon as possible congestion and enter state This is achieved by emulating the linear behavior of state ... reliability Only the sink, and not any of the sensor nodes, can determine the reliability indicator and act accordingly Moreover, end-to-end retransmissions and ACK/NACK overheads are a waste of...

Ngày tải lên: 16/03/2014, 19:20

... a rock material in this case, varies within the material in an irregular manner These kinds of situations are abound in natural and other systems, and stochastic calculus provides a logical and ... a relation to the measured values for a number of natural aquifer materials; despite considerable scatter, a reasonable fit over a scale range of 103 was obtained However, when the range was extended ... modeled as a single capillary tube (Taylor, 1953), a bundle of capillary tubes (Daniel, 1952), and an array of cells and associated connecting channels (Bear and Todd, 1960) These models were mainly...

Ngày tải lên: 22/03/2014, 15:20

... addition of potassium phosphate in the import reaction These data suggest that chloroplasts have established a number of specialized translocation pathways Results As a starting point to investigate ... chloroplasts by a novel pathway J Biol Chem 274, 25181–25186 17 Awai K, Marechal E, Block MA, Brun D, Masuda T, Shimada H, Takamiya K, Ohta H & Joyard J (2001) Two types of MGDG synthase genes, ... Miege C, Marechal E, Shimojima M, Awai K, Block MA, Ohta H, Takamiya K, Douce R & Joyard J (1999) Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope...

Ngày tải lên: 23/03/2014, 07:20

... University, Amsterdam, the Netherlands); anti-MRP4 mAb was a kind gift of G D Kruh (Fox Chase Cancer Centre, Philadelphia, PA, USA); QCRL-3 mAb was purchased from Signet Laboratories, USA M5I-1 and antiMRP4 ... T., Wada, M., Kuwano, M & Akiyama, S (1999) Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter Mol Pharmacol 56, ... concentrations of the vehicle being used in control samples Curve fitting and statistics Data are reported as mean ± s.e.m Estimates of maximum uptake rates and apparent dissociation constants were...

Ngày tải lên: 23/03/2014, 21:20

... Uchida, J Xiao, H Adachi, J Ohe, S Takahashi, J Ieda, T Ota, Y Kajiwara, H Umezawa, H Kawai, G E W Bauer, S Maekawa, and E Saitoh, “Spin Seebeck insulator,” Nature Mater 9, 894 (2010) 31 L Gravier, ... used was 40:10 sccm of Cl2:Ar, a chamber pressure of 0.7 Pa, a RF forward power of 800 W, and a capacitive bias of 350 W The metallization used for top and bottom contacts consisted of three layers, ... film peaks of LSMO and LMO were well-aligned with the STO substrate peaks A 110 reciprocal space map from an oxide superlattice was analyzed to understand the degree of relaxation and strain in...

Ngày tải lên: 06/05/2014, 08:53

... Properties Summary Contents Appendix A A.l A. 2 A. 3 A. 4 A. 5 A. 6 A. 7 A. 8 A. 9 A 10 A 11 A. 12 A 13 A 14 A 15 A. 16 A. 17 A 18 A 19 A. 20 A. 21 A. 22 A. 23 A. 24 A. 25 A. 26 Problems Jellium model Density of states ... atom as a function of the distance away from the grain boundary Clearly the grain boundary is electrically active, and has a charge reconstruction What is amazing is how far away from the grain ... presence of a static particle at site i as the presence of an A ion and the absence of a static particle at site i as the presence of a B ion—the Coulomb interaction U is then the difference in site...

Ngày tải lên: 04/06/2014, 14:33

Ngày tải lên: 04/06/2014, 14:41