... membrane was incubated with mouse anti -a- synuclein (BD Transduction Laboratories, Franklin Lakes, NJ, USA), mouse antiHSP70 (Zymed Laboratories, San Francisco, CA, USA) or mouse anti-b-actin ... significant changes as a consequence of a- synuclein overexpression or as a result of the association of dopamine treatment with a- synuclein overexpression (Fig 3B) The same analysis performed on all ... Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H & Toda T (2009) Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis:...
Ngày tải lên: 15/02/2014, 01:20
... level of TNFalpha and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats Brain Res 2004, 996:237-245 Adams FS, LaRosa FG, Kumar S, Edwards-Prasad J, ... prepared the manuscript All authors read, discussed and approved the final manuscript Acknowledgements This work was supported by the NIH grants, R01NS41263 and Udall Parkinson 's Disease Research ... 28:439-453 Isacson O, Brundin P, Gage FH, Bjorklund A: Neural grafting in a rat model of Huntington 's disease: Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
... prepared immunogens and performed immunoassays, S. W performed image analysis, data analysis and manuscript preparation; IH performed immunohistochemistry, image analysis, data analysis and presentation ... Quantitative comparisons were performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and ... humans, particularly at that stage of the disease when substantial fibrillar amyloid deposits have begun to accumulate [10] It is this stage of the disease that often correlates with appearance of...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease" pot
... instructions (7.8 pg/ml for rTNF -a and 20 pg/ml for rIL-6) Three animals per group were analyzed and each sample was analyzed in duplicate Statistical analysis Statistical analysis of the data was ... previous studies, the bolus administration of any substance into cerebrum may cause mechanical damage to neurons [73,74] and subsequent adjacent activation of microglia [74-79] This makes it difficult ... these data suggest that BAb administration shifts stage or stage microglia to stage in SN These results also show a distinct population of activated microglia (MHC II-ir), which correlates with...
Ngày tải lên: 19/06/2014, 22:20
Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''s disease ppt
... diagonal paws It is used as a measure of inter-paw coordination Step pattern There are a total of six possible step sequence patterns that a rat can use as it places its four paws one after another ... group is expressed as mean ± s. e.m for each condition All statistical tests were performed with SPSS statistical software (version 15) Statistical significance was evaluated using oneway ANOVA and ... conclusion, the CatWalk-assisted automated gait analysis system revealed that unilateral infusion of 6-OHDA leads to functional changes in static and dynamic gait parameters Furthermore, the CatWalk...
Ngày tải lên: 10/08/2014, 05:21
A Description Of U.s. Enlisted Personnel Promotion Systems ppt
Ngày tải lên: 16/03/2014, 08:20
Báo cáo khoa học: ""DONNELLAN''''S DISTINCTION AND A COMPUTATIONAL MODEL OF REFERENCE" pptx
... beliefs, not a mirror of what is actually the case A speaker may possess two distinct individuating sets that, unbeknownst to him, determine the same object (e.g., Oedipus 's representations of his ... speaker selects a particular aspect of Shakespeare, namely, the fact that he is the author of Othello, and intends the hearer to think of Shakespeare in terms of this aspect In the second statement, ... the best play about jealousy By way of summary, Table I shows how Donnellan 's distinction, in its reinterpreted form, is related to a plan-based model of reference Shakespeare was born in Stratford-upon.Avon...
Ngày tải lên: 31/03/2014, 17:20
Financing decisions of u s REITs a capital market perspective
... argued that the relative simple business model and asset nature of REITs arguably offer more accurate company account data such as NAV (net asset value) NAREIT REITs Analyst Discussion 2004 Financing ... ⎯ Sam Zell, Chairman and Founder of Equity Office Properties Trusts (Annual Report, 2002) As a unique industry, REITs possess a number of advantages compared to firms in other industries as a ... learned from the course work of Associate Prof Ong S. E and Associate Prof Sing T.F., as well as Associate Prof Liow K.H lay the foundations of this study Prof Ong and Prof Fu Yumin also give valuable...
Ngày tải lên: 06/10/2015, 20:57
Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"
... cDNA sequence of rat TLR4 (GenBank accession NM_019178) were: 5’-CUACCAACAGAGAGGAUAU-3” (siRNA1), 5’-GUCUCAGAUAUCUAGAUCU-3’ (siRNA2), 5’-GAGCCGGAAAGUUAUUGUG-3’ (siRNA3) All siRNAs were chemically ... signals were detected with an ECL system (Amersham Pharmacia Biotech, Uppsala, Sweden) Histone3 (Sigma, St Louis, MO, USA, 1:500) was used as an internal control Statistical analyses Data are ... guidelines on the ethical use of animals Screening siRNA sequence with reporter vector A scrambled sequence was designed as a mismatch control (MM-siRNA) (5’-GGCGUGUCUCUCU UACGAC-3”) SiRNAs targeting...
Ngày tải lên: 25/10/2012, 11:48
NON-FARM EMPLOYMENT AND HOUSEHOLD INCOME: A CASE STUDY OF HANOI'S PERI-URBAN AREAS
... glory and various kinds of beans, and fruit trees including oranges, grapefruits and guavas, among others Animal husbandry was mainly undertaken as pig or poultry breeding on small-size farms or ... 2010 and 477 households were successfully interviewed 3.2 Statistical analysis The main statistical analyses applied were descriptive statistics and multiple regression The regressions were used ... Values in parentheses are standard deviation USD equated to about VND18,000 in 2009 Source: Calculation from authors' survey N=477 farm household businesses, and on average around 24 percent of...
Ngày tải lên: 28/08/2013, 11:25
Tài liệu Fertility, Family Planning, and Reproductive Health of U.S. Women: Data From the 2002 National Survey of Family Growth doc
... pregnancy and birth rates (3–4) This section also includes data on the circumstances of first intercourse, characteristics of the first partners, as well as numbers of sexual partners These measures ... looking at condom use in the last 12 months rather than the last weeks These two tables show similar relationships between consistency of condom use and marital status, marital status and age, and ... pregnancies, substance use, sex with males (including nonvoluntary sex and STD/HIV risking behaviors), sex with females, condom use at last sex of any type, sexual orientation and attraction, STDs...
Ngày tải lên: 13/02/2014, 10:20
Tài liệu Déjà Vu All Over Again: The Causes of U.S. Commercial Bank Failures This Time Around* docx
... assets was associated with a higher probability of failure, as was worse asset quality as measured by NPAs to assets, lower earnings as measured by ROA, and worse liquidity as measured by Cash ... or survival Two are standard CAMELS proxies: asset quality as measured by the ratio of Nonperforming Assets to total assets, and earnings as measured by ROA Brokered deposits, as an indicator of ... automobile loans, other consumer durables loans, and credit card loans, as well as personal unsecured loans Again, this is an area where banks should have a comparative advantage We expect a negative...
Ngày tải lên: 16/02/2014, 03:20
Tài liệu USA INC. A BASIC SUMMARY OF AMERICA''''S FINANCIAL STATEMENTS pdf
... USA Inc. s holding of land is measured in non-financial units such as acres of land and lakes, and number of National Parks and National Marine Sanctuaries Land under USA Inc. s stewardship accounts ... excludes such purely financial transactions as the sale of government assets, and most transactions under the Troubled Asset Relief Program, because those transactions not help to measure current ... statement as spending outstrips income and how our liabilities far exceed nominal assets on our balance sheet USA Inc also considers additional assets – hard to value physical assets and our...
Ngày tải lên: 17/02/2014, 21:20
Tài liệu Báo cáo khoa học: A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana doc
... [CGS]/[TS] can be calculated as follows: ELISA assays were carried out using rabbit antibodies raised against the recombinant proteins [12,14] and puried proteins as standards We measured that an ... system, a mathematical model of the branch-point could be instrumental in nding answers to these questions Such a model could be built without any assumptions as detailed enzyme rate equations and ... this purpose, the branchpoint was reconstituted with puried enzymes and partition of a constant ux of Phser was measured as a function of the concentration of AdoMet under conditions as close as...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu China’s Holdings of U.S. Securities: Implications for the U.S. Economy pptx
... Implications for the U. S Economy What If China Reduces its Holdings of U. S Securities?50 As the previous data illustrate, China has accumulated large holdings of U. S assets in recent years These accumulations ... Ownership of U. S Financial Assets: Implications of a Withdrawal, by James K Jackson These data are annual (end-June) changes in foreign holdings of U. S public and private securities China states ... Securities as of June 30, 2011, April 2012 China s Ownership of U. S Treasury Securities24 U. S Treasury securities are the largest category of U. S securities and are main vehicle the U. S government uses...
Ngày tải lên: 20/02/2014, 20:20
Tài liệu Báo cáo khoa học: "A Shallow Model of Backchannel Continuers in Spoken Dialogue" potx
... best option, having humans judge the naturalness of the models' results independent from a dialogue system, is problematic Conversational naturalness must be judged in a reasonable amount of ... Table 5: Results of the Models on the Test Data cessing, where scores of 90% or above are not uncommon for tasks such as part -of- speech tagging and statistical parsing, this can be at least partly ... participant 's behaviour separately as a sequence of time-stamped silences, noises (such as coughing), and speech tokens, to which part -of- speech tagging has been applied The part -of- speech tag set is...
Ngày tải lên: 22/02/2014, 02:20
Tài liệu a budgetary analysis of nasa s new vision for space exploration docx
Ngày tải lên: 23/02/2014, 04:20
Tài liệu a budgetary analysis of nasa s new vision for space exploration ppt
Ngày tải lên: 23/02/2014, 15:20
Tài liệu A CRITICAL EDITION OF YEATS''''S A VISION (1925) pdf
... quotations from Yeats 's unpublished papers, the use of sic was eschewed as superfluous except in a few unusually confusing instances After Yeats 's text and before the Index appear a List of Abbreviations ... nature of man, Yeats found a means of compressing the six headings into the Four Faculties His cosmic vision was essentially and consistently tetradic, based upon such occult sources as the Cabala, ... Speculum The most extensive of the four manuscripts speaks of 'a student of "The Way of the Soul" ' 23 who had set up in Damascus as a doctor Among the other pieces of evidence suggesting a quite...
Ngày tải lên: 25/02/2014, 08:20