a model for stem cell therapy in regenerative medicine

... dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: an Eastern Cooperative ... trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b J Clin ... Eggermont AM: Interferon alfa- 2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative...

Ngày tải lên: 18/06/2014, 16:20

... the families Viperidae (for example, rattlesnakes, and adders) and Elapidae (for example, coral snakes, cobras, and mambas) In addition to these lineages that contain commonly used model research ... comparative data to estimate genomic characteristics of the ancestral amniote genome Page of (or the ancestral squamate genome) would be fascinating, including estimation of ancestral gene family ... Justification and strategies for expansion of snake genomics Research incorporating snakes as model systems is becoming increasingly popular and diverse in its breadth of topics The availability of...

Ngày tải lên: 09/08/2014, 23:20

... treatment of the brain), and somatic stem cells capable of generating cell types specific for the target rather than the donor organ (e.g., bone marrow mesenchymal stem cells for cardiac repair) ... spermatogonia in the adult human testis, providing another strategy for obtaining genetically identical stem cells Umbilical cord blood stem/ progenitor cells are associated with less graftversus-host ... isolate from other tissues, such as heart and brain Substantial efforts have therefore been devoted to obtaining more pluripotent stem cell populations, such as bone marrow mesenchymal stem cells...

Ngày tải lên: 07/07/2014, 01:20

... not yet clear, and various experimental studies have employed intramyocardial, transendocardial, intravenous, and intracoronary injections In experimental myocardial infarction, functional improvements ... improvements have been achieved after transplantation of a variety of different cell types, including ES cells, bone marrow stem cells, endothelial stem cells, and adipose stem cells Bone marrow stem cells ... (Chap 65) Figure 67-1 Strategies for transplantation of stem cells Undifferentiated or partially differentiated stem cells may be injected directly in the target organ or intravenously Stem cells...

Ngày tải lên: 07/07/2014, 01:20

... Multipotential stem cells also reside within gastric glands and intestinal crypts Thus, hepatic, pancreatic, and/or gastrointestinal precursor cells may be candidates for cell- based therapy of diabetes ... abortuses are an alternative, and a clinical trial of fetal neural stem cells in Batten disease is commencing Transdifferentiation of bone marrow and adipose stem cells into neural stem cells, and ... cells in stroke are also planned Neurologic disorders that have already been targeted for stem cell therapies include spinal cord injury, amyotrophic lateral sclerosis, stroke, traumatic brain...

Ngày tải lên: 07/07/2014, 01:20

... organ Imaging techniques are needed to visualize stem cells in vivo after transplantation into humans Fortunately, stem cells can be engineered before transplantation to contain contrast agents ... extraordinary, and disorders such as myocardial infarction, diabetes, Parkinson's disease and many others are attractive targets However, such stem cell based therapies are at a very early stage ... therapeutic applications in regenerative medicine and cancer therapies Clin Pharmacol Ther 82(3):252, 2007 [PMID: 17671448] National Institutes of Health: Stem cell information page URL: http://stemcells.nih.gov/index.asp...

Ngày tải lên: 07/07/2014, 01:20

... 909–913 89 Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K & Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53–p21 pathway Nature 460, 1132–1135 ... viral infections [20] Cancer therapy is a principal goal of the current clinical research on hESCs Recently, regression of metastatic melanoma tumors was achieved by transplantation of adaptive ... achieving this by serial reprogramming or by treating iPSCs with chromatinmodifying chemicals has been described [85] An alternative method for avoiding problems associated with partially retained...

Ngày tải lên: 22/03/2014, 17:20

... War Bonds in the Second World War: A Model for a New Iraq/Afghanistan War Bond? Summary The high costs of fighting the wars in Iraq and Afghanistan have rekindled congressional interest in ... financial institutions Today, savings bonds are almost always a substitute mechanism for other forms of personal savings Author Contact Information James M Bickley Specialist in Public Finance ... Congressional Research Service War Bonds in the Second World War: A Model for a New Iraq/Afghanistan War Bond? Introduction The high costs of fighting the wars in Iraq and Afghanistan have rekindled...

Ngày tải lên: 29/03/2014, 03:20

... local savings associations, 34 regional savings banks, National Bank of the savings banks) Tripartite (519 local savings banks, 12 regional state banks, DekaBankDeutsche Girozentrale) Coordinating ... local savings companies at its disposal since 1999 These are not involved in the financial business but are closely associated with the savings banks in a legal and practical sense The local savings ... in France Although not independent institutions, they are invariably attached to the savings bank in the region in which they operate In this way, several savings companies are attached to each...

Ngày tải lên: 29/03/2014, 08:20

... Domain adaptation with unlabeled data for dialog act tagging In Proc Workshop on Domain Adaptation for Natural Language Processing at the the Annual Meeting of the Association of Computational ... assigns domain/dialog-act/slot labels to each topic at each layer in the hierarchy using labeled data (explained in §4.) We represent domain and dialog act components as meta-variables of utterances ... them For example, in a local domain application, users may require information about a sub-domain (movies, hotels, etc.), and for each sub-domain, they may want to take different actions (find a...

Ngày tải lên: 30/03/2014, 17:20

... Integration, application and practice objectives are one area where practica and capstones (theses or projects) can serve a critical catch-all role, in much the same way as qualifying exams for ... strategic planning approach Assess and align mission The newly created Department of Health Behavior and Administration was charged with administering two existing graduate degree programmes (Master ... program graduates – Program • Define the program’s academic goals and primary objectives Specify educational strategies/approaches • Define key educational strategies and approaches needed to achieve...

Ngày tải lên: 18/06/2014, 17:20

... clinical application) malignant counterparts of embryonic stem cells that originate from the inner cell mass of a blastocyst stage embryo The embryonal carcinoma cells replicate and grow in cell ... post-transplant Kaposi sarcoma [48], skin carcinoma [49] and oral squamous cell carcinoma [50] Notably the incidence of solid tumours is significantly increased in patients that have received a bone marrow ... cells are administrated When transplanted into a homologous species mESC caused highly malignant teratocarcinomas at the site of administration, while xenotransplantation in rats resulted in migration...

Ngày tải lên: 18/06/2014, 19:20

... that the stress of manual handling of hESCs is an important factor in their instability over time, and therefore automated techniques for passaging and expansion may be a method for overcoming ... single cell, for example the apical versus basal signals that will be encountered by a polarized cell In traditional mass culture, cells align in random fashion, and although matrix coatings on tissue-culture ... that optimal washing methods in some applications need improvement Engineers have pointed out that the best mathematical framework for handling models, such as differentiation, that start at...

Ngày tải lên: 06/08/2014, 19:21

... the thinning; Ga and Gb are the stand basal area after and before thinning, respectively; At is the stand age at thinning; A is the stand age at prediction and α is the parameter to be estimated ... fitted individually for each sample plot; then in a second stage, parameters are explained using stand variables such as number of trees per hectare, basal area, dominant height, etc., as explanatory ... even-aged stands of stone pine (Pinus pinea L.) in Spain, Ann For Sci 60 (2003) 259–269 [8] Cañadas N., Garc a C., Montero G., Relación altura-diámetro para Pinus pinea L en el Sistema central, in: Rojo...

Ngày tải lên: 08/08/2014, 00:22

... reducing the parametric nonlinearity, but we did not investigate this point in forcing us to think about those aspects of the model for which the data provide good information and those aspects for ... the dual influence of the shape parameter in this case, which partially explains the high e-correlation For this model, a variable shape parameter between curves will also lead to interpretative ... Chapman-Richards (Richards, 1959) variableshape functions Both curves have parameters, which have the following meanings: A asymptote; r= related to relative growth rate; m shape parameter; and...

Ngày tải lên: 08/08/2014, 19:21

... examine for any associations between the demographic variables and the total score of the BPRS, BSI, and Client Observation Scale General linear model (mixed model analysis of variance (ANOVA)) was ... between and 24 h from the beginning of treatment (that is, from the subject's examination by a psychiatrist and formulation of a treatment plan by the clinical team) Research assistants ('raters'), ... such as when raters were available and did not interfere with the subjects' other commitments All raters had undergone the same training and testing for inter-rater reliability The raters explained...

Ngày tải lên: 08/08/2014, 23:21

... particular individuals in a stand Sap flow data have been used for estimating hourly transpiration and canopy conductances in a range of forest stands [1, 10, 13, 19, 20] The sap flow measurements can ... on each site ’upscaled’ the sap flux values from tree to stand using optically determined leaf area index values (table I), assuming the needles had a semi-cylindrical shape, and calculating ... resisand capacitances are expressed on an all-sided needle area basis The water potential values used in the present paper are corrected for the gravitational gradient The basic equations for each...

Ngày tải lên: 09/08/2014, 04:20

... microarray data J Am Stat Assoc 2005, 100:764-780 29 Ishwaran H, Rao JS, Kogalur UB: BAMarraytrade mark: Java software for Bayesian analysis of variance for microarray data BMC Bioinformatics ... selected was Bayesian analysis of variance for microarrays [27-29], a Bayesian spike and slab hierarchical model, as implemented in the BAMarray tool (BAMarray 3.0) [27] Using this procedure, transcriptional ... RDC, AR and SI provided material, experimentation, data collection and analysis RDC participated in writing the manuscript LM and ML provided intellectual input for experimentation and data analysis...

Ngày tải lên: 09/08/2014, 20:22

... sequence reaction 5’-CATGTGGCACCATCTCACAAT-3’ 5’GCTGCGAGCTCACCCAGAATGTCTGG-3’ 62°C 5’-GAATTCGGATGCAGAGCTTCTT-3’ 5’-Biotin-CCCACA CAGCAA AGCAGAAACT-3’ 5’-Biotin-CTTTCTCTTCCGCACCCA 5’-TAAAATTCCCGTCGC-3’ ... Clin Oncol 2011 Tanaka T, Matsuoka M, Sutani A, Gemma A, Maemondo M, Inoue A, Okinaga S, Nagashima M, Oizumi S, Uematsu K, Nagai Y, Moriyama G, Miyazawa H, Ikebuchi K, Morita S, Kobayashi K, Hagiwara ... non-small cell lung cancer: analysis of results in 19 patients Int J Clin Oncol 2008, 13:442-446 Nagai Y, Miyazawa H, Huqun , Tanaka T, Udagawa K, Kato M, Fukuyama S, Yokote A, Kobayashi K, Kanazawa...

Ngày tải lên: 10/08/2014, 10:21