a flawed paradigm in critically ill septic patients pdf

... value of circulating Ang-2 as a biomarker in critically ill patients The results are that: critically ill patients are characterised by an excess of circulating Ang-2 in the presence of low Ang-1 ... model In a large trauma cohort study [22], Ang2 correlated with mortality in a univariate analysis In a surgical population with ARDS, Ang-2 predicted death with a similar discriminatory ability as ... data reveal an important limitation for Ang-2 as a quantitative marker for vascular permeability: high Ang-2 might be a surrogate parameter for increased capillary permeability per se, but is a...

Ngày tải lên: 25/10/2012, 10:31

... protocol planning, was a primary data gatherer and drafted the manuscript SC participated in data collection and statistical analysis VN performed statistical analysis LB participated in data collection ... ventilation, length of stay, and the number of failing organs Statistical analysis Continuous variables' data are expressed as mean value ± SD Bi-variate hypotheses involving continuous variables ... Williams BA, Cramner H, Gallahue F, Willmore T, Lewis L, Ladenson JH, Jaffe AS: Elevations of cardiac troponin I are associated with increased short-term mortality in noncardiac critically ill...

Ngày tải lên: 12/08/2014, 22:22

... goodness-of-fit statistics that the sample size has a major influence on the measured calibration Using small samples will result in an apparently good fit, using large samples will result in an apparently ... SdB and EdJ acquired and interpreted the data NFdK interpreted the data All authors contributed in preparing the manuscript All authors read and approved the final manuscript References Baumann ... may have a role in giving information about the prognosis to patients and their relatives Only a few models exist that were specifically designed for cancer patients and which include data about...

Ngày tải lên: 12/08/2014, 22:22

... FeNa Data are presented as median (25th to 75th centile) INR, International Normalized Ratio; MELD, Model of End-Stage Liver Disease; ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; ... without intravenous albumin in cirrhosis Gastroenterology 1988, 94:1493-1502 Garcia-Compean D, Zacarias Villarreal J, Bahena Cuevas H, Garcia Cantu DA, Estrella M, Garza Tamez E, Valadez Castillo ... pneumonia and died in septic shock On day after the last paracentesis, of the remaining 10 patients with an initial serum creatinine value of at least 221 μmol l-1, had a serum creatinine of less than...

Ngày tải lên: 13/08/2014, 08:21

... organ transplants, cancer patients receiving chemotherapy, and HIV-infected patients However, during the past two decades, with advances in diagnostic and therapeutic interventions, critically ill ... SD, standard deviation; SOFA, Sequential Organ Failure Assessment patients with IFI, whereas itraconazole was administered to 22 patients and amphotericin B to two patients Also, 75 patients received ... disease within separate organ systems 'Cost' was defined as the total expenditures on medical care attributable to a patient in the hospital, including charges for medical care, nursing, medication,...

Ngày tải lên: 13/08/2014, 08:21

... Further insights into the effects of this intervention in surgical patients may come from individual patient data meta-analyses, acknowledging the challenges of ensuring availability and comparability ... Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finder S, Talmor D: Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data CMAJ 2009, ... Azevedo JRA, de Araujo LO, da Silva WS, de Azevado RP: A carbohydraterestrictive strategy is safer and as efficient as intensive insulin therapy in critically ill patients J Crit Care 2010, 25:84-89...

Ngày tải lên: 13/08/2014, 21:21

... hemodynamic parameters using TPTD Methods Patients This was a retrospective analysis of a prospectively maintained TPTD database We studied 30 critically ill patients treated in the medical ICU of a ... that estimation of GEDVI and EVLWI using standard CT scans of the thorax is not accurate in critically ill patients in a clinical setting without the support of quantitative CT analyzing software ... ill patients To obtain representative data in a clinical routine setting, we did not use analyzing Saugel et al Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2011, 19:31 http://www.sjtrem.com/content/19/1/31...

Ngày tải lên: 13/08/2014, 23:20

... endotracheally intubated, with all intubations occurring within 24 hours of admission, and prolonged ventilator dependence was anticipated and was the indication for a surgical airway in all patients ... receiving a tracheostomy The sole intent of introducing a comparison group was to provide information about our standard of care airway management for critically ill trauma patients with ventilator ... intubation is the mainstay for temporary airway management Early experience demonstrated that prolonged translaryngeal intubation was associated with irreversible damage to laryngeal and vocal...

Ngày tải lên: 12/08/2014, 19:21

... Critical Care August 2005 Vol No Lee and Fink tracheostomy the most common methods in practice today Tracheostomy has several potential advantages over translaryngeal endotracheal intubation, including ... intensive care Additionally, early tracheostomy may have resulted in greater patient comfort and, therefore, avoided excess sedative and analgesic use, which has been associated with prolonged duration ... ventilation and to determine whether the survival and other reported advantages are applicable to patients who are less severely ill and to different ICU patient populations Competing interests The authors...

Ngày tải lên: 12/08/2014, 22:22

... sedation aAfter 10 days of endotracheal intubation b0.5–5% of all tracheoesophageal fistulas are caused by endotracheal intubation NA, not available advantages and disadvantages of early tracheostomy ... pneumonia In addition, we will examine the indications of tracheostomy in trauma patients These indications include relief of upper airway obstruction, airway access in patients with cervical spine injury, ... spontaneously breathing non-intubated patients Nathan and colleagues [16] found that there is increase in the work of breathing by 30% after extubation This increase in work of breathing may be attributed...

Ngày tải lên: 12/08/2014, 23:20

... control are performed on a regular basis by the central hospital laboratory The ABL715 has the capability of cross-linking between the hospital and laboratory information systems, making manual data ... hospital chemistry analyser In a study by Maser et al [20] at a cardiovascular ICU, capillary whole-blood glucometry had a correlation coefficient of 0.88 with arterial plasma samples analysed in ... practitioner One part was sent in a vacuum-sealed plasma separation tube to the central hospital laboratory and analysed by a laboratory technologist using a conventional blood glucose analyser (YSI...

Ngày tải lên: 13/08/2014, 03:20

... stay ous autopsy studies have examined diagnostic discrepancy rates in cancer patients who died in the ICU [23,24] Gerain and colleagues [23] reported a 59% major discrepancy rate in a medical ... of all internal organs and the brain, when indicated All ICU admissions, deaths, and autopsies were identified by the hospital's institutional database The following data were obtained from the ... clinical diagnosis was confirmed on autopsy (concordant cases), and (c) patients in whom no pathologic diagnosis could be confirmed on autopsy Statistical analysis Data are presented as means ± standard...

Ngày tải lên: 13/08/2014, 03:21

... HR, Yin HL: Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain Nature 1986, 323:455-458 Sun HQ, Yamamoto M, Mejillano M, Yin HL: Gelsolin, ... and organ dysfunction [7-10,25] In addition, plasma gelsolin binds bioactive inflammatory mediators including lipopolysaccharide [26], lysophosphatidic acid [27] and platelet-activating factor ... Lee and coworkers [18] serially measured plasma gelsolin levels in patients after surgery or trauma for days and demonstrated that the decreased plasma gelsolin levels seen in such patients are...

Ngày tải lên: 13/08/2014, 11:22

... selected cases Therapy Maintaining the airway, adequate oxygenation and relieving distress associated with obstruction are primary treatment goals Several treatment modalities, including reintubation, ... ventilation in laryngeal edema, however, is lacking In a general intensive care population of patients with respiratory failure after extubation, Esteban and colleagues found an increased mortality in ... Prognostic factors in laryngotracheal injury following intubation and/or tracheotomy in ICU patients Eur Arch Otorhinolaryngol 2005, 262:880-883 20 Thomas R, Kumar EV, Kameswaran M, Shamim A, al Ghamdi...

Ngày tải lên: 13/08/2014, 19:20

... al.: Critically ill patients with 2009 influenza A( H1N1) infection in Canada JAMA 2009, 302:1872-1879 Louie JK, Acosta M, Winter K, Jean C, Gavali S, Schechter R, Vugia D, Harriman K, Matyas B, ... B, Glaser CA, Samuel MC, Rosenberg J, Talarico J, Hatch D; California Pandemic (H1N1) Working Group: Factors associated with death or hospitalization due to pandemic 2009 influenza A( H1N1) infection ... Piperacillin/ macrolide Alive Renal transplantation Yes Yes (steroid/CIs/MMF) 1,200 MV Pseudomonas aeruginosa Piperacillin/ macrolides Dead HIV No No 1,800 None Streptococcus pneumoniae C3G/ macrolide...

Ngày tải lên: 13/08/2014, 20:21

... acetate may cause cardiovascular instability in hemodialysis patients Clinical administration of acetate as part of the hemodialysis treatment is known to be associated with vasodilation and impaired ... During this interval, sodium acetate was not being used and trauma patients were resuscitated with normal saline All patients in our trauma registry with a matching ISS score to a patient in ... Initial resuscitation was started in the trauma bay with normal saline Those who remained acidotic after initial crystalloid resuscitation in the trauma bay or operating room and where large...

Ngày tải lên: 13/08/2014, 23:20

... conception and design, carried out and participated in data analysis and drafted the manuscript VCSD, MS and JIFS participated in acquisition of data All authors read and approved the final version ... Since inadequately treated infections can be rapidly fatal in neutropenic cancer patients, a great deal of clinical research on biomarkers has been published [8,9] Several biomarkers, such as ... using a split-plot design approach In all cases, statistical significance was defined as a two-tailed test with an alpha of 0.05 All statistical calculations were preformed using the PASW v 18.0...

Ngày tải lên: 14/08/2014, 08:21

... CytoDyn Amerimmune Pharmaceuticals, Inc TIPRANAVIR AAI International, AnaaiPharma Company MedImmune MedImmune MedImmune Inspire Pharmaceuticals Genital Warts HPV Hepatitis B Hepatitis B Hepatitis ... OraQuick HIV-1 Cytolin Tipranavir HXB MEDI-491 Synagis™ (Palivizumab) Numax INS37217 Intranasal MedImmune Nabi Biopharmaceuticals Protein Design Labs XTL Biopharmaceuticals Ltd Nabi Biopharmaceuticals ... limited by insufficient efficacy and unfavorable pharmacokinetics MAbs have increasingly gained favor in large part because of the development of chimeric, humanized, and human antibodies have reduced...

Ngày tải lên: 20/06/2014, 04:20

... deficiency Treating this deficiency with AT concentrate was more effective and faster for obtaining adequate anticoagulation than using additional heparin Cardiopulmonary bypass is a traumatic procedure ... anticoagulation [9] In 2000 Williams and colleagues [10] showed, in a randomized trial in patients requiring cardiopulmonary bypass, that heparin resistance was frequently associated with AT deficiency ... organ failure and requiring CRRT should be re-evaluated As demonstrated in heparinresistant patients necessitating cardiopulmonary bypass during cardiac surgery, AT supplementation may be used in...

Ngày tải lên: 12/08/2014, 23:22

... conducting integrated research programs [43] Canadian intensivists appear interested in addressing the many unanswered questions regarding VTE prevention and diagnosis in critically ill patients ... diagnostic approach to PE may be related to insufficient studies in critically ill patients Additional factors explaining practice variation may include different interpretations of the merits of various ... by activation of the coagulation and inflammatory cascades in many critically ill patients for myriad reasons [25,26] Never US Rarely D dimer Sometimes Primarily Always Venogram The use of bilateral...

Ngày tải lên: 12/08/2014, 18:21