a brief review of lipid based nanocarriers

... of Technology Cambridge, Massachusetts Afsaneh Lavasanifar Department of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton, Alberta, Canada Eun Seong Lee Amorepacific Corporation/R&D ... Montazeri Aliabadi Department of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton, Alberta, Canada Christine Allen Department of Pharmaceutical Sciences and Department of Chemical Engineering ... Sahoo Department of Pharmaceutical Sciences Nebraska Medical Center Omaha, Nebraska and Institute of Life Sciences Bhubaneswar, India Tae Gwan Park Department of Biological Sciences Korea Advanced...

Ngày tải lên: 04/06/2014, 14:30

... peritoneal cavity is a common site of ovarian cancer presentation or recurrence usually accompanied by ascites [3] Massive ascites and the associated abdominal distention can cause anorexia, nausea, ... development of DNAbased therapy for human ovarian cancer related ascites The successful development of anti-tumor gene therapy depends on the use of a combinatorial approach aimed at targeted delivery and ... of data, and critically revised the manuscript PO participated in design, coordination, and data interpretation and drafted the manuscript All authors read and approved the final manuscript Acknowledgements...

Ngày tải lên: 18/06/2014, 15:20

... area of the malignant tissue of each bladder was determined by ImagePro Plus software Another healthy mice were used as control The total tumor area of each bladder was determined and the mean ... determined and the mean of the total areas was calculated for each group The Mean and SD of bladder tumor area (A) and weight (B) are shown Amit and Hochberg Journal of Translational Medicine 2010, ... activation was reported as a major mechanism for the IGF2 overexpression in a variety of tumors including bladder carcinoma, hepatocellular carcinoma, breast cancer, ovarian cancer and prostate cancer...

Ngày tải lên: 18/06/2014, 16:20

... P, Camacho-Alonso F, Gómez-Garcia F Effect of curcumin and irradiation in PE/CA-PJ15 oral squamous cell carcinoma Acta Odontol Scand 2011;69(5):269–73 48 Javvadi P, Hertan L, Kosoff R, Datta T, ... Evidence -based clinical recommendations regarding screening for oral squamous cell carcinomas J Am Dent Assoc 2010;141(5):509–20 Warnakulasuriya S Global epidemiology of oral and oropharyngeal cancer ... modulation of inflammatory pathways by nutraceuticals Cancer Metastasis Rev 2010;29(3):405–34 A Zlotogorski et al / Oral Oncology 49 (2013) 187–191 11 Anand P, Sundaram C, Jhurani S, Kunnumakkara...

Ngày tải lên: 01/07/2014, 13:23

... ALDH2 and ALDH 1A1 based dehydrogenase assay for all these related analogs Specificity of these compounds was tested as well against ALDH 1A1 and ALDH2 E Steady–state kinetic characterization We characterized ... mM p–NPA Figure Catalysis of benzaldehyde and para–nitrophenylacetate by ALDH 3A1 Figure showing the reaction mechanisms of dehydrogenase and esterase assay catalyzed by ALDH 3A1 The standard condition ... cofactor positioning and, thus, impact catalysis Crystal structures of mammalian ALDH enzymes have shown that each subunit has a NAD(P)+ binding domain, a catalytic domain and an oligomerization...

Ngày tải lên: 24/08/2014, 09:51

... 2.10 MATERIALS AND METHODS Materials Synthesis of P(MDs-co-CES) Preparation of P(MDS-co-CES) micellar nanoparticles Preparation of drug-loaded P(MDS-co-CES) nanoparticles 2.4.1 Preparation of Pac-loaded ... 1.2.3.2 Pharmacodynamically additive combinations Additive combinations often have similar activity or overlapping effects on different targets of the same signaling pathways, and as a result ... peptide -based therapeutics [74, 75] Types and examples of nanoparticles for delivery of therapeutics agents Table 4.1 Uptake of Alexa Fluor 555-TRAIL into MCF7, T47D and MDA-MB-231 cells at hours after...

Ngày tải lên: 30/09/2015, 05:59

... xii List of Abbreviations 2-NBDG 3-MA 5-FU 7AAD Abs AIF ANOVA ANT AMPK APAF-1 APP Ara-C Apo2-L Atg ATP AVO BA1 Bcl-2 BH BSA CD95 Cdk Chk CI CMA 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2deoxyglucose ... to avoid damage (39, 41, 50) The observation that premalignant rat pancreatic cancer cells show increased levels of autophagy further supported the potential of autophagy as a survival advantage ... combination at a desired effect level, but the analysis is only accurate for drugs with similar mechanism of action In addition, a relatively large amount of data is required to have accurate analysis...

Ngày tải lên: 11/09/2015, 10:02

... REVIEW ARTICLE Box Rational design of nanocarriers for cancer therapy Nanocarriers can offer many advantages over free drugs They: For rapid and effective clinical translation, the nanocarrier ... transformed non-Hodgkin’s lymphoma Kaposi’s sarcoma Combinational therapy of recurrent breast cancer, ovarian cancer, Kaposi’s sarcoma Refractory Kaposi’s sarcoma, recurrent breast cancer, ovarian ... a monoclonal antibody or antibodies’ fragments, non-antibody ligands, and aptamers The antibody fragments F(ab′)2 and Fab′ are generated by enzymatic cleavage whereas the Fab′, scFv, and bivalent...

Ngày tải lên: 28/05/2014, 15:07

... had a colon polyp removed, Japanese-Hawaiians, North American Caucasians, native rural Japanese, and rural native Africans Lactobacillus species and Eubacterium aerofaciens, both producers of ... to a standardized amount of carbohydrate in a food The glycemic load takes into account the amount of food eaten An international table of the glycemic index and glycemic load of a wide variety ... MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular...

Ngày tải lên: 06/03/2014, 02:21

... P, Naka T, Serada S, Fujimoto M, Tanaka T, Hashimoto S, Shima Y, Yamadori T, Suzuki H, Hirashima T et al (2007) Proteomics -based identification of alpha-enolase as a tumor antigen in nonsmall ... lymphoma Ann N Y Acad Sci 1050, 319–326 Himoto T, Kuriyama S, Zhang JY, Chan EK, Kimura Y, Masaki T, Uchida N, Nishioka M & Tan EM (2005) Analyses of autoantibodies against tumor-associated antigens ... Identification of HCC-22-5 tumor-associated antigen and antibody response in patients Clin Chim Acta 366, 274–280 Takashima M, Kuramitsu Y, Yokoyama Y, Lizuka N, Harada T, Fujimoto M, Sakaida I, Okita...

Ngày tải lên: 23/03/2014, 04:20

... 44 Aki M, Shimbara N, Takashina M, Akiyama K, Kagawa S, Tamura T, Tanahashi N, Yoshimura T, Tanaka K & Ichihara A (1994) Interferon-gamma induces different subunit organizations and functional ... papillomavirus and low-grade cervical intraepithelial neoplasia Lung cancer Bronchial dysplasia Prostate cancer High-grade prostatic intraepithelial neoplasia Breast cancer Nonmetastatic bladder cancer ... Clinical trial phase Type of cancer Combined with Phase Phase Phase Phase Phase Metastatic colon cancer Pancreatic cancer Osteosarcoma Colorectal cancer Stage IV breast cancer Gemcitabine Gemcitabine...

Ngày tải lên: 30/03/2014, 02:20

... Georgoulias V, Papadakis E, Alexopoulos A, Tsiafaki X, Rapti A, Veslemes M, Palamidas P, Vlachonikolis I: Platinum -based and non-platinum -based chemotherapy in advanced non-small cell lung cancer: a ... control and monitoring MDA and ON were responsible for data management and statistical analyses AP, GLF and DAM wrote the first draft of the manuscript WZ carried out the preclinical study AP, DA and ... gold standard of care for advanced NSCLC In a large meta-analysis published by the NSCLC Collaborative Group in 1995, cisplatin-containing therapy for advanced disease was shown to confer an absolute...

Ngày tải lên: 18/06/2014, 15:20

... fragment (scFv) against the tumor coupled to T cell receptor signaling domains for activation effector functions A great advantage of this approach is that stimulation of a cell with a scFv -based ... Cancer Society.: Cancer Facts and Figures 2004 In American Cancer Society Atlanta, GA; 2004 Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ: Cancer statistics, 2003 CA Cancer J Clin 2003, ... Extracellular Membrane Membrane Cytoplasm Cytoplasm C D Zeta-chain associated protein (ZAP-70) binds to ITAMs that are phosphorylated ( ) Binding of ZAP-70 to is a crucial step in T-cell activation ZAP-70...

Ngày tải lên: 19/06/2014, 08:20

... fragment (scFv) against the tumor coupled to T cell receptor signaling domains for activation effector functions A great advantage of this approach is that stimulation of a cell with a scFv -based ... Cancer Society.: Cancer Facts and Figures 2004 In American Cancer Society Atlanta, GA; 2004 Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ: Cancer statistics, 2003 CA Cancer J Clin 2003, ... Extracellular Membrane Membrane Cytoplasm Cytoplasm C D Zeta-chain associated protein (ZAP-70) binds to ITAMs that are phosphorylated ( ) Binding of ZAP-70 to is a crucial step in T-cell activation ZAP-70...

Ngày tải lên: 20/06/2014, 04:20

... copolymers as micellar carriers of taxol Int J Pharm 1996, 132:195 36 Yamakage M, Iwasaki S, Satoh J, Namiki A: Changes in concentrations of free propofol by modification of the solution Anesth Analg ... was recorded Statistical analysis All data were expressed as mean standard deviation (SD) unless particularly outlined The statistical significance of differences among more than two groups was ... incidence and intensity of pain on injection of propofol as compared with CLE and therefore might have favorable compliance to the patients Stability of mixed micelles A basic evaluation of pharmacokinetic...

Ngày tải lên: 21/06/2014, 04:20

... supplier and acclimatized for days after arrival All animals were provided with standard food and water ad libitum and were exposed to alternating 12-h periods of light and darkness Temperature and ... and relative humidity were maintained at 25 °C and 50%, respectively All care and handling of animals were performed with the approval of Institutional Authority for Laboratory Animal Care of Peking ... (Fluka, [99%) as a hydrophobic probe [12] Briefly, a known amount of pyrene in acetone was added to each of a series of 50 mL vials, and the acetone was evaporated, then a known amount of various...

Ngày tải lên: 22/06/2014, 00:20

... larger datasets and results of ongoing adjuvant trials are needed to provide confirmatory evidence for or against the concept and feasibility of withdrawal therapy in locally advanced and metastatic ... Segaloff A, Rubens RD: Assessment of response to therapy in advanced breast cancer: a project of the Programme on Clinical Oncology of the International Union Against Cancer, Geneva, Switzerland Cancer ... aromatase resistant breast cancer cell model (MCF-7:5C), Osipo et al [7] demonstrated apoptosis at a concentration of 10-11 M/L or more of estradiol This is again possible due to activation of...

Ngày tải lên: 09/08/2014, 02:21

... each heart and averaged for statistical analysis Analysis of Fibrotic Area The percentage of fibrotic area in the infarct and periinfarct zone was calculated in each heart using the image analysis ... (REPAIR-AMI) cardiac magnetic resonance imaging substudy Am Heart J 2009, 157(3):541-547 Yamamoto N, Akamatsu H, Hasegawa S, Yamada T, Nakata S, Ohkuma M, Miyachi EI, Marunouchi T, Matsunaga K: ... Premaratne GU, Sakaguchi G, Kanemitsu N, Lin X, Nakajima H, Sakakibara Y, Kimura Y, Yamamoto M, Tabata Y, Ikeda T, Komeda M: Administration of control-released hepatocyte growth factor enhances...

Ngày tải lên: 10/08/2014, 09:21

... Mohapatra A, Bali P, Mandawat A, Rao R, et al: Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation ... combination of AZA, VPA, and ATRA in patients with AML or high-risk MDS AZA was administered at a fixed dose of 75 mg/m2 daily for days VPA was doseescalated and given orally daily for days concomitantly ... 110:2302-2308 Chavez-Blanco A, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Cetina L, Candelaria M, et al: Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral...

Ngày tải lên: 10/08/2014, 22:20