a breakthrough in primary cervical cancer prevention

... 2017;12(12):e0186165 Charakorn C, Thadanipon K, Chaijindaratana S, Rattanasiri S, Numthavaj P, Thakkinstian A The association between serum squamous cell carcinoma antigen and recurrence and survival of patients ... 159(2):394–8 Kawaguchi R, Furukawa N, Kobayashi H, Asakawa I Posttreatment cut-off levels of squamous cell carcinoma antigen as a prognostic factor in patients with locally advanced cervical cancer treated ... assay Fig Simoa SCC-Ag assay calibration curve and validation a Typical Simoa SCC-Ag assay calibration curve Recombinant human SCC-Ag was serially diluted, and the calibrator range was 0.049 to

Ngày tải lên: 17/06/2020, 03:14

... modalities in PCa [4] Conventional staging Conventional staging included a clinical T stage assessment with digital rectal examination and PSA blood level measurement as well as conventional imaging including ... therapy (ADT) at time of imaging was allowed Maximum time between conventional imaging and PSMA PET/CT was 90 days, which has been suggested as an acceptable interval for comparing staging modalities ... on the imaging findings was defined This was done according to above mentioned N and M staging three-category systematics For both N and M staging, increase in LoC was defined as a change from

Ngày tải lên: 19/09/2020, 21:56

... as instructed by the manufacturer using Lipofectamine RNAiMAX (Invitrogen) as transfection reagent Statistical analysis of transcriptomics data The publically available Cancer Genome Atlas database ... author information is available at the end of the article shown an annual increase with 1.4% during the last 20 years, at least in part due to an ageing population with increased hormonal replacement ... additional proteins, including F-actin, myosin, septins and CD2AP have been shown to interact with ANLN during assembly, maintenance and ingression of the cleavage furrow [7] Lack of ANLN is generally

Ngày tải lên: 20/09/2020, 18:43

... for treating cancer would combine screening alone, vaccination alone and no prevention with a 3-dose vaccination schedule, and vaccination alone, vaccination combined with screening or no prevention ... per woman CIN = Cervical intraepithelial neoplasia; CC = Cervical cancer; SD = Standard deviation *assume, in the base case, the same efficacy for a three or a two dose vaccine constrain their ... Cervical intraepithelial neoplasia, grade 1; CIN2/3: Cervical intraepithelial neoplasia, grades and 3; HPV: Human papillomavirus; NGN: Nigerian naira; NS: No solution found; PAHO: Pan American Health

Ngày tải lên: 05/11/2020, 00:33

... acquired data and recruited a substantial part of the patients SMJ approved the final manuscript, acquired central imaging data MH approved the final manuscript, acquired data and recruited a ... European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 2000, 92(3):205–216 Heusinger ... substantial part of the patients MW approved the final manuscript, acquired data and recruited a substantial part of the patients VH approved the final manuscript, acquired data and recruited a

Ngày tải lên: 05/11/2020, 01:05

... (Beecher Instruments, Sun Prairie, WI, USA) and positioned into a recipient paraffin array block Staining with haematoxylin and cytokeratin (AE1/AE3) was carried out for a morphological overview and ... acquisition, participated in the statistical analyses and drafted the manuscript POB was responsible for database coordination and statistical analyses MF was participating in initiation and design of the ... LR who also was responsible for data acquisition, participating in statistical analyses and drafting of the manuscript All authors read and approved the final version of the manuscript Acknowledgments

Ngày tải lên: 05/11/2020, 05:39

... Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Av Universidad No 655, Cerrada los Pinos y Caminera, Colonia Santa Mar? ?a Ahuacatitlán, Cuernavaca, Morelos, ... Oscar Peralta-Zaragoza1*, Jessica Deas1, Angélica Meneses-Acosta3, Faustino De la O-Gómez1, Gloria Fernández-Tilapa2, Claudia Gómez-Cerón1, Odelia Benítez-Boijseauneau1, Ana Burguete-Garc? ?a1 , ... various signaling pathways, miR-21 is an attractive target for genetic and pharmacological modulation in various cancers Cervical cancer is the second most common cause of death from cancer in women

Ngày tải lên: 21/09/2020, 09:20

... to aflatoxin (in China) In our study, the decreasing trends in China and Singapore may be attributed to some public health measures [24-27] HBV vaccination was incorporated into the national ... decreases in PLC incidence rates in China, particularly in Shanghai and in younger age groups [24,30] Another study in Taiwan showed that the ageand sex- adjusted rate ratios for individuals aged ... annual incidence rates from PLC were calculated as annual percentage change (APC) in each segment In the final model, the Joinpoint analysis provided average annual percentage change (AAPC) The

Ngày tải lên: 30/09/2020, 12:54

... diagnosis was 57 years Histopathological analyses demonstrated invasive ductal cancer in 73.8% of cases and invasive lobular subtype in 7.6% The remaining 18.6% were diagnosed as ductal/lobular, ... brief, both percentage of stained cells and staining intensity were evaluated No staining or weak staining in 50% of cells and strong staining of any percentage of the cells as The results were subsequently ... prognostic role in breast cancer are available with limited number of patients and clinical correlations and in part controversial findings [4,13-18] The objective of this study was to examine the expression

Ngày tải lên: 05/11/2020, 06:37

... for women having abnormal and normal findings in screening for cervical cancer This was also valid for the six dimensions from part II in COS: ? ?Cervical cancer? ??, ‘Relaxed/calm’, ‘Social network’, ... materials The datasets generated during and analysed during the current study are not publicly available due the Danish legislation of data protection but are available in an anonymously format ... content All authors had full access to all data (including statistical reports and tables) in the study and take responsibility for the integrity of the data and the accuracy of the data analysis

Ngày tải lên: 10/01/2020, 13:52

... necessary comments and made basic adjustments to this manuscript All authors read and approved the final manuscript 14 Funding Not applicable 16 Availability of data and materials The original raw ... being achieved as relatively very few women have actually done cervical cancer screening [11] In Ethiopia, cervical cancer screening is offered routinely at out-patient, ART, and maternal and ... to cervical cancer screening in a developing country: the case of Malaysia Asian Pac J Cancer Prev 2009;10 Netsanet Belete YT, Mellie H Willingness and acceptability of cervical cancer screening

Ngày tải lên: 17/06/2020, 18:24

... SCC AdCA, adenomatous carcinoma, CIS, carcinoma in situ, ICC, invasive cervical cancer, SCC, squamous cervical cancer, HSIL, high-grade squamous intraepithelial lesion LSIL, low-grade squamous intraepithelial ... Barbara Pardini1,2, Daniela De Maria1, Antonio Francavilla1, Cornelia Di Gaetano1,2, Guglielmo Ronco3† and Alessio Naccarati1*† Abstract Background: Invasive cervical cancer (ICC) is caused by ... Gonzalez-Quintana V, Palma-Berre L, Campos-Parra AD, Lopez-Urrutia E, Peralta-Zaragoza O, Vazquez-Romo R, Perez-Plasencia C MicroRNAs are involved in cervical cancer development, progression, clinical

Ngày tải lên: 24/07/2020, 01:43

... prognostic marker for tumor progression in cervical cancer Ana E Zacapala-Gómez1, Napoln Navarro-Tito2, Luz del C Alarcón-Romero3, Carlos Orto-Pineda4, Berenice Illades-Aguiar1, Eduardo Castañeda-Saucedo2, ... Ezrin is overexpressed in cervical cancer or intraepithelial neoplasia (CIN) compared to normal cervical tissue [16–19] Interestingly, Ezrin expression was higher in invasive cancer and metastatic ... no role in the design of the study and collection, analysis and interpretation of data or in writing the manuscript Availability of data and materials All data generated or analysed during this

Ngày tải lên: 24/07/2020, 02:08

... Forman D Global cancer statistics CA Cancer J Clin 2011;61(2):69–90 Sankaranarayanan R, Swaminathan R, Jayant K, Brenner H An overview of cancer survival in Africa, Asia, the Caribbean and central ... barriers and facilitators for cervical cancer screening in government-supported health facilities in rural western Kenya, an area of East Africa with a high cervical cancer burden and screening rates ... and impact on population attendance in cervical cancer screening Int J Cancer J Int cancer 2013;132(10):2223–36 Virtanen A, Nieminen P, Luostarinen T, Anttila A Self-sample HPV tests as an intervention

Ngày tải lên: 06/08/2020, 03:29

... unintentional Pilot programs National programs Bangladesh Nicaragua Angola Myanmar Bolivia Panama Bangladesh Namibia Cambodia Paraguay Botswana Nepal China Peru Burkina Faso Nigeria Colombia Philippines ... Philippines Australia Italy Portugal Cambodia Republic of Georgia Austria Japan Republic of Macedonia Cameroon Tanzania Belgium Latvia Romania Costa Rica Thailand Bermuda Lesotho Rwanda Ghana Uganda ... that cervical cancer is a national priority Integrating cervical cancer into a national cancer control plan (NCCP), or developing a national cervical cancer strategy, is an important step in...

Ngày tải lên: 06/03/2014, 02:21

... DELIVERING CERVICAL CANCER PREVENTION IN THE DEVELOPING WORLD INTRODUCTION OF HPV DNA TESTING FOR CERVICAL CANCER SCREENING National Programs: HPV DNA testing in the national screening norms and available ... pre-cancerous INTRODUCTION OF VISUAL INSPECTION (VIA) FOR CERVICAL CANCER SCREENING National Programs: Visual Inspection in the national screening norms and available on a limited or universal basis ... C, Parkin DM GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No 10 Lyon, France: International Agency for Research on Cancer; 2010 globocan.iarc.fr Cervical Cancer Action,...

Ngày tải lên: 06/03/2014, 02:21

... using anti-caspase-8 serum Western blot analysis was performed using anti-FADD, anti-caspase-8, anti-caspase-3, anti-poly(ADP-ribose) polymerase (PARP) and anti-b-actin serum b-actin was used as a ... blot analysis using anti-caspase-8, anti-Bid, anti-Bax, anti-HSP60, antiphospho-Bcl-2, anti-Bcl-2 and anti-b-actin serum HSP60 and b-actin were used as a mitochondrial marker protein and a loading ... death effector domain (DED) domains of the adaptor molecule, Fas-associated death domain (FADD), and caspase-8 We performed coimmunoprecitation assays to analyze the association of FADD and caspase-8...

Ngày tải lên: 07/03/2014, 05:20

... Comprehensive Cervical Cancer Prevention and Control Guidance for National Strategies and Programming for Cervical Cancer Prevention National strategies to address cervical cancer prevention and control ... palliative care for women with invasive cervical cancer In order to have an impact on cervical cancer mortality these programmes must have universal coverage of the targeted population and financing ... establish or enhance cancer registries to be able to evaluate the impact of cervical cancer prevention activities, including HPV vaccination programmes and cervical cancer screening programmes...

Ngày tải lên: 15/03/2014, 01:20

... Project: Final Report 10 Sankaranarayanan R, Basu P, Wesley RS, et al Accuracy of visual screening for cervical neoplasia: results from an IARC multicentre study in India and Africa Int J Cancer ... MYWO and KECANSA collaborated with PATH staff to develop a palliative care field manual that was printed and disseminated locally and nationally (see Appendix 5) Evaluation of clinical activities ... finding was determined by the international experts and used for patient care as appropriate and for all data analyses To evaluate the accuracy of VIA screening, a substudy was organized during...

Ngày tải lên: 28/03/2014, 23:20

... (1) Thus although breast cancer is increasing in importance in many developing countries, cervical cancer remains a major cause of morbidity and mortality Data are available internationally on ... sub-Saharan Africa or in Latin America and South and South-East Asia This is why some investigators are currently evaluating the safety and acceptability of the ‘test and treat’ approach after clinically ... retraining are ideal Participation of the laboratory in an external quality control programme, such as that organized by the Pan-American Health Organization (PAHO) for many Latin American countries...

Ngày tải lên: 22/03/2014, 16:22