7 get acquainted with the central nervous system
Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... 100 33.6 35 .7 37. 5 41.3 100 38.9 41.0 47. 0 39.0 38.0 100 40.0 36 .7 40.5 42.3 39.3 38 .7 100 40.0 37. 0 40.5 42 .7 42.3 38 .7 93.8 100 41.6 37. 6 44.4 42.3 41.4 38.4 94.6 95 .7 100 for these two proteins ... monooxygenase (PHM) The nucleotides are numbered from the 5¢ to the 3¢ end, and the amino acid residues are numbered starting with the first ATG in the open reading frame The translation termination ... by the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is 950...
Ngày tải lên: 30/03/2014, 15:20
Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... found in the neuronal processes Both nNOS and iNOS immunoreactivity were found in a proportion of the neurons in the brainstem and the staining pattern was similar to those of control brains with ... occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis has been reported previously, and the increased expression ... iNOS and the resultant NO generation were confirmed in brains with listeriosis and in cultured macrophages from the Listeria-affected cattle [6] This study is in part consistent with the previous...
Ngày tải lên: 07/08/2014, 14:23
báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... angiitis of the central nervous system Ann Rheum Dis 2008, 67: 173 2- 173 5 doi:10.1186/1 477 -78 19-9- 97 Cite this article as: You et al.: Isolated angiitis of the central nervous system with tumor-like ... 1989, 39:1 67- 173 15 Younger DS: Vasculitis of the nervous system Curr Opin Neurol 2004, 17: 3 17- 336 16 Calabrese LH, Furlan AJ, Gragg LA, Ropos TJ: Primary angiitis of the central nervous system: ... the central nervous system Arch Neurol 2002, 59:1480-1483 21 Dawson TM, Starkebaum G: Isolated central nervous system vasculitis associated with hepatitis C infection J Rheumatol 1999, 26:2 273 -2 276 ...
Ngày tải lên: 09/08/2014, 02:20
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... purposes) Journal of Neuroinflammation 20 07, 4:14 71 72 73 74 75 76 77 78 79 80 81 82 83 http://www.jneuroinflammation.com/content/4/1/14 AIDS by a deletion allele of the CKR5 structural gene Hemophilia ... genomic deletion of the CCR1 gene [22], reduces clinical disease Taken together, the results of the present study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis ... protection from MS, and the lack of effect of CCL3 deficiency in mice [ 67] illustrates redundancy in the chemokine system Although some of the data on the role of CCR5 in the pathogenesis of MS...
Ngày tải lên: 19/06/2014, 22:20
Section III - Drugs Acting on the Central Nervous System docx
... delivering the anesthetic to the lungs, (3) transfer of the gas from the alveoli to the blood flowing through the lungs, and (4) loss of the agent from the arterial blood to all the tissues of the body ... Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such as the central nucleus of the amygdala and the dentate gyrus of the ... physiological regulators in systems throughout the body recently have been examined for their roles within the central nervous system Arachidonic acid, normally stored within the cell membrane as a...
Ngày tải lên: 12/07/2014, 20:21
Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy N Engl J Med 1 978 , ... whole-brain radiotherapy and chemotherapy: year results J Neurosurg 1989, 70 :70 7 -71 3 Duffner PK: Long-term effects of radiation therapy on cognitive and endocrine function in children with leukemia ... infants with medulloblastoma treated with high-dose intravenous methotrexate (5 g/m2) and also methotrexate injected into the brain cavities (intraventricular injection), together with other chemotherapy,...
Ngày tải lên: 06/08/2014, 18:21
Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemother apy N Engl J Med 1 978 , ... 2005, 49:542-554 113 Tofilon PJ, Fike JR: The radioresponse of the central nervous system: a dynamic process Radiat Res 2000, 153:3 57- 370 114 Hopewell JW, Withers HR: Late effects of radiation are ... striking that the most significant inhibition of DNA synthesis in the SVZ was seen at months post-treatment, when there was a 67. 7 ± 3.0% decrease in the number of BrdU+ cells compared with control...
Ngày tải lên: 06/08/2014, 18:21
Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... also found that the agents caused increased cell death and decreased cell division in the subventricular zone, the dentate gyrus of the hippocampus and the corpus callosum in mice These effects ... injury due to cancer treatment The knowledge gained from this and other studies will guide the development of translational clinical research to protect the nervous system from injury, to better ... J Natl Cancer Inst 2006, 98: 174 2- 174 5 Wefel JS, Lenzi R, Theriault R, Davis RN, Meyers CA: The cognitive sequelae of standard dose adjuvant chemotherapy in women with breast cancer: results of...
Ngày tải lên: 06/08/2014, 18:21
báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... known that the nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach ... cockroach, as the model system We study the effects and interactions of negatively charged gold nanoparticles (nAuNPs) with the cockroaches CNS in vivo The authors refer to the nervous system as the brain ... Begley DJ: Delivery of therapeutic agents to the central nervous system: The problems and the possibilities Pharmacology & Therapeutics 2004, 104:29-45 29 Vinson SB: The role of the foreign surface...
Ngày tải lên: 11/08/2014, 00:22
The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... the neurons The research group detected the significant presence of H2S in the brain homogenate preparation of CBS-/- mice (Shibuya et al., 2009) Kimura further observed that 3-MST acts together ... Europe 17 4.9 102 Eastern Europe (regions with 3.8 7. 7 169 3.9 8.1 1.8 84 6.4 10.5 3.4 172 4.6 9.2 1.8 393 3.6 7. 6 385 4.3 1.5 189 336 low adult mortality) Eastern Europe (regions with high ... reproduced from (Kwentoh, 2008) with some modifications 1.2 .7 Pharmacotherapy Current treatments for AD are used to reduce the cognitive decline The central role of these drugs is to stabilize and...
Ngày tải lên: 09/09/2015, 08:17
Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... Chapter References 131 VIII SUMMARY The structural and functional complicity of the central nervous system (CNS) and the unavailability of effective conventional therapies pose great challenges to ... MCF -7/ ADR cells Figure 3 .7 Effect of siRNA targeting MDR1 on PGP protein expression in MCF -7/ ADR cells Figure 3.8 Effect of siRNA targeting MDR1 on the PEI-mediated luciferase expression in MDR -7/ ADR ... an effective gene therapy: gene delivery systems (vectors), regulatory elements and therapeutic genes The vectors refer to the carriers of transgene into target cells, and they have been commonly...
Ngày tải lên: 12/09/2015, 10:15
Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... RNA within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system ... functions of the therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are two main types of gene delivery systems: non-viral and viral systems ... SUMMARY The studies presented in this thesis focused on development and modification of baculovirus-based vectors in order to achieve improved gene delivery to the Central Nervous System There...
Ngày tải lên: 14/09/2015, 11:28
Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... SUMMARY Gene therapy is a promising approach for the treatment of neurological disorders in the central nervous system (CNS) Because of the complex structure and high vulnerability of the CNS, it ... is critical that the expression of a therapeutic gene is restricted within the target regions or cells, and the level and duration of the expression can be regulated as desired With currently available ... specificity of the therapeutic gene is primarily determined by the activity of the promoter at the transcriptional level, and the duration of the transgene expression can also be influenced by the selection...
Ngày tải lên: 16/09/2015, 08:30
INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... onto the cover glass beside the sticky tape, with the help of a second blunt needle The embryo was not lifted above the surface of the dissecting medium, as this caused dispersion of the tissue The ... probe with one in the membrane plane and the other as internalized vesicles As the nucleuses of motor neurons are generally large, internalized vesicles in the cytoplasm were confined within the ... affect the results However, the conclusion drawn in subcellular localization studies did not alter even if the data were treated the same like the rest The ACF curves were fitted with the 2D_2pt1...
Ngày tải lên: 12/10/2015, 17:36
The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... (which attack the nervous system) , hemotoxins (which attack the circulatory system) , cytotoxins and many other toxins that affect the body in different ways (Calvete et al., 20 07; Harvey, 1991; ... studies of neuronal receptors and ion channels Most of them affect primarily the peripheral nervous system and only a few affect the central nervous system (CNS) For example, intraperitoneal (i.p.) ... precursor to 17 understand the actual processes that allow the 12 kDa protein to transverse the BBB, and to study in detail the regions of interaction of the protein with components in the brain,...
Ngày tải lên: 16/10/2015, 15:35
The central nervous system
... is the connection between the cerebrum and the rest of the nervous system, with one exception The rest of the brain, the spinal cord, and the PNS all send information to the cerebrum through the ... describe the anatomical distinctions within the cortex ([link]) The results from Brodmann’s work on the anatomy align very well with the functional differences within the cortex Areas 17 and 18 in the ... interactions with the cerebellum and other nuclei in the brain stem The cerebrum interacts with the basal nuclei, which involves connections with the thalamus The primary output of the basal nuclei...
Ngày tải lên: 25/08/2016, 13:53
Cancer of the Brain and Other Central Nervous System doc
... 100.0 87. 7 81.2 76 .7 69.5 63 .7 60.6 565 51.1 88.0 82.5 77 .6 69.5 66.6 64.0 White 476 43.1 88.9 85.3 80.3 72 .4 69.2 67. 0 Black 49 4.4 87. 1 65.4 63.9 57. 9 57. 2 49.5 Female 540 48.9 87. 3 79 .9 75 .7 69.5 ... 100.0 87. 7 81.2 76 .7 69.5 63 .7 60.6 Localized 680 61.5 90.8 85.1 80.4 75 .1 70 .2 66.6 Regional 192 17. 4 79 .2 71 .3 67. 3 57. 0 45.9 45.2 81 7. 3 76 .6 70 .9 69.4 60.2 53.5 53.5 152 13.8 90.0 81.5 74 .9 ... Total 1,105 100.0 87. 7 81.2 76 .7 69.5 63 .7 60.6 Brain 456 41.3 83.0 73 .8 68.2 56.9 48.0 41 .7 Spine 596 53.9 92.1 87. 9 83.5 78 .8 74 .8 73 .0 Other 53 4.8 77 .9 68.8 68.8 65.1 57. 9 57. 9 National Cancer...
Ngày tải lên: 22/03/2014, 17:20
Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... years 7. 7 (3 .7: 11 .7) 5.0 (1.2: 8.8) ns 8.3 (4.5: 12.1) 5.6 (1 .7: 9.5) ns years 5.6 (1.3: 9.9) 3.6 (-1.5: 8 .7) ns 5.5 (1.1: 9.9) 4.6 (-0.4: 9.6) ns years -0.1 (-4.9: 4.6) 1.0 (-5 .7: 7. 7) ns -0.9 ... treatment of the central nervous system in adult leukaemia and lymphoma Br J Cancer 1989, 60(5) :77 5 -78 0 Sowell ER, Thompson PM, Toga AW: Mapping changes in the human cortex throughout the span of ... test 311 555 77 79 202 1 97 month test 161 305 47 42 104 112 year test year test 173 132 369 289 51 34 45 35 139 116 134 104 month only 92 133 23 28 35 57 94 15 16 34 29 year only 37 40 21 10 month...
Ngày tải lên: 10/08/2014, 21:23
báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... In the present case, the given time interval represents the time between the first presentation and the detection of the intraspinal metastases as the primary site of the tumor; in this case, the ... Eur Spine J 2008, 17( suppl 2):S2 67- S 270 17 Ng G, Lenehan B, Street J: Metastatic Merkel cell carcinoma of the spine J Clin Neurosci 2010, 17( 8):1069-1 071 doi:10.1186/ 175 2-19 47- 5-35 Cite this article ... in the literature, the choice of treatment of MCC brain metastases will depend, as in many other types of brain metastases, on the number of metastases, systemic spread of the disease and the...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection" potx
... 38.1 ( 37. 7–38 .7) (49/59) 37. 8 ( 37. 1–38.9) (9/11) 39 ( 37. 5–39.6) ( 37/ 50) Mean arterial pressure (mmHg) 93 ( 87 1 17) (22/31) 90 (79 –106) (12/20) 90 (82–100) (42/59) 102 (86–115) (10/11) 93 (77 –103) ... 0. 57 (0.4–0 .7) † (28/31) 0.92 (0 .7 1.0) (11/20) 0 .78 (0 .7 1.0) (36/59) 0 .73 (0.6–1.0) (7/ 11) 0 .74 (0.5–0.9) (31/50) Arterial PO2 (kPa) 11.0 (9.0–13.0) (15/31) 12.3 (10 .7 13.8) (7/ 20) 8.5 (7. 8–11.5) ... (19/20) 3.9 (3 .7 4.2) (59/59) 4.0 (3.9–4.1) (7/ 11) 3.9 (3.4–4.3) (44/50) 16 Creatinine (μmol/l) 76 (54–85) (30/31) 58 (46 /72 ) (18/20) 75 (55–85) (56/59) 83 (73 –100) (7/ 11) 71 (49– 87) (45/50) Factors...
Ngày tải lên: 13/08/2014, 16:21