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... are involved in coordinating the incoming triphosphate In the process, Arg72 donates hydrogen bonds to the a-phosphate and the ε-amino group of Lys65 donates hydrogen bonds to the g-phosphate These ... of the dNTP binding pocket which can restrict dNTP binding resulting in inefficient DNA synthesis at low dNTP concentrations [36] RT codons 65 and 74 are parts of the highly flexible b3-b4 linkage ... to the finger closure and trapping of the template strand due to the interaction of L74 with the dNTP and template base [37] Our data suggest that the side chain (methyl group) in isoleucine...

Ngày tải lên: 11/08/2014, 21:21

... would win the Nobel Prize They said to Sam they often went to the cinema on Fridays Mr Barns said to Mrs Johnson they were going to send her an email with the further details Eva said to her mother ... remains ‘our’ when ‘she’ will marry ‘me’) 9) Lily said to the girls that time the next /the following week she would be lying on the beach in Costa Rica 10) The teacher said to Phil he was reading ... been studying all day the day before / the previous day Tina said to Ben she had been washing his dirty clothes all morning 8) She said to me she would like to organize their / our wedding reception...

Ngày tải lên: 27/08/2016, 13:09

... interaction between the interviewer and the interviewed during the interviews that could influence the statements of the interviewed e.g., the use of leading questions In the phase of analysis ... primarily followed their own definitions of different scoring values, such as excluding certain scores (see examples in table 1) They find the definitions incorrect If the veterinarian strictly ... and the individual veterinarians' perceptions expressed in their local context Our basis for the model is thus the empirical data and not an initiating general theory or hypothesis From these...

Ngày tải lên: 25/10/2012, 10:45

... incorporate index indicate indigenous individual induce infer inferior inflation ingenious inherent inhibit initial innate innovative insist inspect instance instinct institute instruct integer integrate ... 3a 7c 4e 5c 5d 5f 1d 10 6f 4b 6a 5a 7d 11b 11d 1f 12 12 interval intervene interview intimacy intrinsic invade invest investigate invoke involve irrigate issue 5f 4a 10f 10f 9b 7c 8f 4b 7a 1b ... From the list below, choose one word which could be used in place of the language shown in bold without changing the meaning of the sentence Remember that you may need to change the form or in...

Ngày tải lên: 02/11/2013, 10:20

... that underlie their production and marketing • Globalization increases profits by: – – – – Expanding the market Realizing economies of scale Realizing location economies Leveraging the skills of ... opportunities Increasing Profitability Through Globalization • The success of many multinational companies is based not just on the goods and services they sell, but upon the distinctive competencies ... Mode • Exporting – Many companies begin global expansion through exporting production – Exporting allows companies to bypass the cost of establishing manufacturing facilities – Exporting may be...

Ngày tải lên: 06/11/2013, 17:15

... those in the workplace setting as those with home Internet access One of the main reasons that the pornography industry has such a vested interest in this area is that in the offline world, the ... creating other personas and forming online relationships or engaging in cybersex (see above) (Griffiths, 2000c, 2001) Internet activity abuse involves the use of the Internet during work hours in ... dealing with problems that they can address with isolated intra-company policies Rather, Internet abuse in the workplace is intricately linked to the world outside the company The sources of the...

Ngày tải lên: 21/01/2014, 23:20

... found either in wild-type strains and in mutant strains harboring mutations in the genes encoding enzymes of the biosynthesis and/or the transfer of the O-specific polysaccharide [12,13] The core ... of G was inferred by taking into account the downfield shift of the carbon signal C-6 (63.7 p.p.m., Table 1) indicating its involvement in a glycosydic linkage The HMBC spectrum confirmed the sequence ... contained the significant longrange correlations required for the determination of the sequence and of the attachment points In fact, together with intraresidual long-range cross-peaks, interresidual...

Ngày tải lên: 19/02/2014, 13:20

... lipid-binding protein, intestinal 15 kDa protein, ileal bile acid-binding protein and gastrotropin, reflecting the speculations of authors on its intracellular function(s) In vitro binding assays ... detected in the duodenum, jejunum or 12 other extraintestinal tissues (the latter tissues were not specified) The transcriptional initiation of the zebrafish fabp6 gene in the distal region of the intestine ... from the AB strain of zebrafish (see http://zfin.org for strain details) The zebrafish fabp6 gene The coding sequence of the fabp6 gene contained an open reading frame of 393 bp (not including the...

Ngày tải lên: 07/03/2014, 06:20

Ngày tải lên: 14/03/2014, 12:03

... centrifugation at 20 000 g for 30 at °C Binding of the fusion proteins to chitin beads via the intein/ chitin binding domain, cleavage of the fusion protein (in 20 mM Tris/HCl, pH 8.0, 200 mM NaCl, ... [32,33] Determining the absolute configuration of the talosyl residue in the GDP-6-deoxytalose by GC/MS Based on the coupling constants in the 1H NMR spectra, we determined that the sugar nucleotide ... (42.0 min) Both reactions involving the gmd gene products halted after consuming some of the GDP-a-D-mannose, regardless of the addition of the proteins The peak that appeared at 24.0 was in agreement...

Ngày tải lên: 17/03/2014, 10:20

... should the tail vein fail, which was the case in only three animals, the data of which were included After the lines were inserted, pentobarbital was infused continuously at 4.8–6.0 mgÆkg)1Æh)1 The ... data acquired within h of the start of the glucose infusion was not included to avoid any in uence of transient changes in the isotopic enrichment The rates of 13C incorporation into glycogen were ... the initial rate of label incorporation into glycogen C6 relative to the rate of label incorporation into glycogen C1 reflects the relative isotopic enrichment of Glc6P in the C6 relative to the...

Ngày tải lên: 17/03/2014, 17:20

... This indicates that serotonin degradation in the skin includes its oxidative deamination The H2O2 produced during this reaction may also be used for the oxidation of serotonin and other indoleamines, ... tissues including the skin, and expression of the NAT-1 gene has been demonstrated by in situ hybridization in rat skin [36–38] Therefore, we suggest that serotonin and tryptamine acetylation by skin ... on the phase of the hair cycle being low in telogen skin, increasing during anagen to a peak at late anagen VI and decreasing during catagen (Table 2) The enzymatic activity towards tryptamine...

Ngày tải lên: 31/03/2014, 07:20

... on their kinsfolk in North Gaul, and the Scots in Ireland and the Highlands; they occupied the west of the island The Germans were settled in the east, in the greatest part of the south, and in ... with warding off the Danes, sought them out in their own country instead, and carried the war against heathenism into the North The Saxons beyond the sea were indebted for the peace which they enjoyed ... Within the empire two able women and their advisers succeeded in maintaining peace; but in Denmark, as in other neighbouring countries, the hostile elements got the upper hand The Danish king's...

Ngày tải lên: 31/03/2014, 21:20

... showed that clindamycin decreased the intensity of the water absorption band, which was attributed to the replacement of hydrated exchangeable cations in the clay’s interlayer by clindamycin Under ... (50 g/L), intended to eliminate biodegradation, increased these times to 90 h and 500 h, respectively In contrast, aerating the systems in either the presence or absence of NaN3 reduced the 90% ... and E1, further negating the electrostatic interaction hypothesis In each of these cases, sorption to the minerals was estimated by difference rather than by direct quantification of the sorbed...

Ngày tải lên: 18/06/2014, 16:20

... affects the water-activity polynomial beginning only in the fourth term In Equation 6.79, temperature affected the solute activity beginning with the second term of the polynomial These equations indicate ... be in equilibrium with each other at the gas–solution interface Thus, the number of molecules of AB transferring from the gas to the solution equals the number of molecules transferring in the ... When the first equation converges, the updated and other initial concentrations are used as inputs into the second equation This continues until the last equation has converged At that point, the...

Ngày tải lên: 18/06/2014, 19:20

... from the literature and confirmed with the study of lead fractions (Figure 6.5), much of the lead combines with humic substances To measure the binding to the humic substances in the waters of the ... 6.2%) of the organic humic molecules diffused in the other direction across the membrane, as measured with an instrument measuring the absorption of ultraviolet light The lower the pH the more ... Stirring Bars Sample of Dissolved Organics Stirrer Figure 6.6 Dialysis apparatus used for measuring the binding of lead by humic substances bound by the humic substances in solution on the other...

Ngày tải lên: 18/06/2014, 19:20

... Veterinary Medicines in the Environment different times during the grazing season and at different frequencies For example, the recommended dosing for cattle using doramectin in Dectomax injectable ... During the storage period, it is possible that the veterinary medicines will be degraded No validated or standardized method for assessing the fate of veterinary medicines in manure at either the ... metabolites in the feces or urine of the animal Figure 6.2 shows the proportion of the applied dose excreted in the dung or urine for a range of parasiticides used in the United Kingdom for pasture...

Ngày tải lên: 18/06/2014, 22:20

... According to the chemiosmotic hypothesis, the electro-chemical driving force for transferring potassium ions into the matrix, leads to the opening of KATP channel which in turn results in osmotic ... of Φ, the relationship between the driving forces (Potential gradients within the system) and thermodynamic fluxes are linear LNET theory assumes local thermodynamic equilibrium within the system ... in the system cause an increase in the entropy so that: d S⁄dt • 0 (6) Stream of negative entropy: In order to balance the entropy that is produced in the cell, some entropy is lost through interactions...

Ngày tải lên: 19/06/2014, 10:20