5screening for adenocarcinoma and lymphoma of the stomach
Báo cáo y học: "Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells" ppt
... conceived and designed the experiments LFH QYG GFZ YHH performed the experiments LFH participated in the design of the study and performed the statistical analysis TTW LFH YYH Wrote the paper ... considered whether the culture supernatants could regulate the migration of HUVEC The Millicell cell culture insert was used to study the migration of the HUVEC in vitro The migration of HUVEC was ... of China (Grant No 30872941), the Fundamental Research Funds for the Central Universities (Grant No.1106020822), and the Fundamental Research Funds for the Central Universities a grant from the...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... characteristics and specific immunoreactivity (IR) The staining was semiquantitatively evaluated by assigning a score for the intensity of the IR and for the proportion of cells positively stained The intensity ... cells Therefore, the promoter sequence of MDR-1 ()136 to 10) was amplified, and the luciferase reporter assay was performed to investigate the transcriptional regulation of P-gp by PI3K/Akt The ... 25% of the tumor cells exhibiting IR; 2, 25–50% of the tumor cells exhibiting IR; 3, 50–75% of the tumor cells exhibiting IR; 4, > 75% of the tumor cells exhibiting IR The overall score was the...
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Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx
... inhibit the expression of monocyte-activating factor at the surface of T lymphocytes, which in turn decreased the activation of monocyte/macrophages, and thus their production of IL-1β and matrix ... comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis Rheumatology (Oxford) 2000, 39: 655-665 Breedveld FC, Dayer JM: Leflunomide: mode of action ... inhibits the production of proinflammatory mediators by synovial fibroblasts R182 Methotrexate also exhibits many of these effects, and in addition it has been shown to stimulate the synthesis of the...
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Báo cáo khoa học: "Successful enteral nutrition in the treatment of esophagojejunal fistula after total gastrectomy in gastric cancer patients" pps
... series of reports show the importance of the specialization and experience of the surgical group, not only to lower the morbidity and mortality of the gastrectomy but also because of the complications ... [11] In the other hand, the ileus that many times is associated with this complication and the subsequent reflux of the nutrient to the fistula opening is limiting for the use of enteral therapy, ... risk of death or complication and the dehiscence and fistula of the esophagojejunal anastomosis is one of the most feared complications Reports show that this complication presents in to 15% of the...
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Báo cáo y học: "A pilot study of IL-1 inhibition by anakinra in acute gout" docx
... examination of the swollen and tender joint count as well as the patient's evaluation of the efficacy of treatment in terms of pain reduction after days of therapy in comparison with their symptoms before ... of the patient's diabetes Anakinra was started and on review, after completing the injections, the symptoms of arthritis of the knee and elbow were greatly reduced, but the right wrist and hand ... arthritis of the right foot and ankle Anakinra was administered for days with rapid and complete resolution of signs and symptoms of arthritis The patient continued on allopurinol 100 mg daily, and...
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Báo cáo y học: "Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis" potx
... the full potential of the synergistic effects of both resveratrol and curcumin and their potential for the prevention and treatment of OA and RA Competing interests The authors declare that they ... out the experimental work, the data collection and interpretation, and the manuscript preparation AM and MS conceived of the study design, and coordinated the studies, data interpretation and ... features of cel- Figure Effects of resveratrol and curcumin and IL-1β on the viability and proliferation of primary chondrocytes in vitro To evaluate the effect of curcumin, vitro resveratrol and/ or...
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báo cáo khoa học: " Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications" ppsx
... between the peritumoral LVD and both the intratumoural LVD and the LVD of normal tissue There was no significant difference between the intratumoral LVD and the LVD of normal tissue When the mean ... Expression of cyclo-oxygenase and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of ... When the mean peritumoral LVD of 9.24 was chosen as the cut-off point for discrimination of the 56 patients, 32 patients were categorized in the low LVD group and 24 in the high LVD group Correlation...
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báo cáo khoa học: " Adiponectin receptor-1 expression is associated with good prognosis in gastric cancer" pptx
... analysis, and drafted the manuscript SF, SH, ST, and YY participated in the design of the study and helped draft the manuscript JK, KO, HT, and HF assisted the experiments IN, TF, and TO participated ... 3B) The mean value of serum adiponectin in the control group was 7.0 ± 2.4 µg/ml Therefore, we divided the patients into low (n = 39) and high (n = 61) groups using a cutoff value of 7.0, and ... that the cleavage of adiponectin by leukocyte elastase secreted from activated monocytes and/ or neutrophils could be responsible for the generation of the globular adiponectin fragment [38] On the...
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Screening and evaluation of the anticancer potential of scorpion venoms and snake venom l amino acid oxidase in gastric cancer
... refers to adenocarcinoma of the stomach (Lawrence, 2004) Stomach adenocarcinoma indicates the cancer starting in the glandular tissue that lines the lumen of the stomach Other types of cancerous ... responsible for the intoxication and are widely investigated for biomedical and scientific applications They are often considered as neurotoxins because the majority of peptides target and modify the ... another novel discovery for animal venoms and toxins An increasing number of studies have shown the anticancer effects of venoms and toxins of snakes, scorpions and others in vitro and in vivo, which...
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Genomic discovery of recurrent CD44 SLC1A2 gene fusion in gastric cancer
... than normal on the left side of the upper chromosome and the right side of the lower chromosome Arrow heads indicate the breakpoint of the translocation in each chromosome iv, one of the paired translocated ... t(9;22)(q34;q11), resulting in the Philadelphia chromosome (Nowell and Hungerford, 1960) (Fig.1.4) The fusion gene brings together the 5‘ part of BCR gene at 22q11 and the 3‘ part of the ABL1 tyrosine kinase-encoding ... symptoms Therefore, understanding the pathogenesis and biological features, as well as identification of new markers and therapeutic targets of GC are crucial to improve its detection and therapy...
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Genomic analysis of chemo resistance to HDAC inhibitor in gastric cancer cells
... represented by netting The hydroxamic acid moiety of SAHA binds to the zinc at the bottom of the catalytic pocket The burying of most of the structure of SAHA into the active site of HDAC prevents ... groups are added to and neutralize the positive charge of lysine of histone, which can influence the interaction between the histone tails and DNA, as well as RNA and other proteins The acetyl group ... HDAC1, HDAC2, and HDAC3 has been reported to be highly expressed in primary tissue in the patients with gastric cancer, and the high expression of all three of these isoforms together was significantly...
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Overview of Trastuzumab’s Utility for Gastric Cancer pdf
... CT§: chemotherapy with cisplatin and 5FU/capecitabine Connection 2010 | 29 There is no standard second or third-line of chemotherapy for advanced GC; less than 40% of patients may be fit for treatment ... VM, Tjulandin S, et al Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A Report of the V325 ... of the human epidermal growth factor-receptor (HER) family (HER1, 2, and 4) HER2 function and signaling activity requires receptor dimerization followed by transactivation of the TK portion of...
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Báo cáo khoa học: Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A ⁄sodium butyrate-induced and 5-aza-2¢-deoxycytidine-induced PTEN upregulation ppt
... chemotherapy [31] Additionally, there has been evidence that HDAC inhibitors can improve the sensitivity of actinotherapy and chemotherapy [32,33] The main aim of this study was, on the basis of the ... development of a novel option for accessory cancer therapy involving the combined use of vitamin D and epigenetic modifiers This strategy also has the advantage of the use of low concentrations of vitamin ... promoted the formation of an open chromatin structure that potentiated the binding of VDR to the PTEN promoter, and that VDR was in turn activated by its ligand VD3 Overall, these data may help in the...
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báo cáo hóa học: " Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment" ppt
... Surgery and radiotherapy Surgery and chemotherapy Surgery and radiotherapy and chemotherapy Hormonal therapy dated for oncology clinical research [29-31] It has also been validated [32] and found ... divided by the standard deviation of the change in score It is independent of sample size and widely used today [43] SRMs were calculated for the EQ-5D Index and EQ VAS, for all subgroups of patients ... were calculated for the EQ-5D Index and EQ VAS (table 2) In the subgroup of patients whose global health had not changed, accordingly, neither the SRM of the EQ-5D Index, nor of the EQ VAS indicated...
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Báo cáo khoa học: "Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients" pot
... 0.001) (Table 2) The prevalence of formed, soft, and liquid stool was 0%, 35% and 65%, respectively in placebo group In contrast, in the study drug group the prevalence of formed, soft, and liquid ... effect of combining more than one strain In this study, we did not perform the stool culture, this could be the weakness of the study (it may be the other cause of diarrhea), anyway, we perform the ... benefits The intestinal mucosa depends upon the bacterial flora of the gut and the luminal contents for part of its own supply of nutrients Radiation creates changes in bacterial flora, the vascular...
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Báo cáo y học: "Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β" docx
... criteria of the microarray analysis profiles of the treatment groups cultured in the presence of glucosamine, both with and without IL-1β, clustered closely together on one branch of the hierarchical ... 71.1 the expression of the majority of genes whose products are responsible for driving the arthritogenic activities of IL-1 These products include the primary cytokines, chemokines, synthetic and ... depiction of the effects of glucosamine on the biology of the chondrocyte We therefore selected doses of both IL-1 and glucosamine that provided robust responses in our bioassay (NO synthesis)...
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Báo cáo khoa học: "The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study" doc
... resection of the primary and metastatic liver tumors, the reported rate of pelvic failure was approximately 30-35% and the rate of extra-hepatic metastases was up to 67% [9,10] The cause of death for ... other cancers [2] The larger volume of blood supply to the liver in comparison with other organs and the tendency of cancer cells to deposit and multiply in the liver after passing through the ... collection, performed statistical analysis and drafted the manuscript YK contributed in design and coordination of the study and critical revision of the manuscript KK conceived of the study, contributed...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
... available for all 104 samples but mutation screening of the ATM gene was only performed for 44 of the patients experiencing IBCT and 51 of the matched controls This was done to fit into a 96 well format ... evaluation study and the same assessments of damage were performed as for the treatment A group During the survey, the clinical examinations and overall pain evaluation were performed by three ... Figure illustration of the ATM gene Schematic Schematic illustration of the ATM gene The distribution of the variations detected in the studied materials along the gene is shown in the upper panel...
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Báo cáo y học: " Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation" docx
... naïve subset of patient M16394 before therapy as well as the effector memory subsets before and after therapy and the memory subset after therapy of patient M12259, since either the input (cell ... Boxmeer, The Netherlands Authors’ contributions EJH, MJG, EB and RMvdS performed the experiments; EJH wrote the manuscript and performed statistical analyses; GP and WAP supervised and reviewed the ... affected the V3 charge of the virus quasi-species in serum and lymphocyte subsets due to the variant expression profile We therefore compared the V3 charge from all sequences found in the cell...
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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx
... among the three cell lines: lower invasive ability of LNCaP, medium invasive ability for DU145 and a higher ability for PC3 The varying expression of XAF1 suggests a causal changing of androgen ... Vapreotide, Seglitide and so on, are available for the treatment of several kinds of disorders Octreotide was the first developed analogue and is widely used for symptomatic treatment of hormone secreting ... (LNCaP, DU145 and PC3) were stimulated with nM somatostatin and nM Octreotide for different periods of time We found a time-dependent manner of up-regulation of XAF1 mRNA and protein in the cells...
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