5non interventional biomedical research and the role of the investigators

... out of the body with the help of some proteins The deposit of drugs or their metabolites is one of the causes of the cytotoxicity Therefore, a successful drug candidate should be absorbed and ... cure of patient, and they are also the causes of many instances of morbidity Therefore, the understanding of the possible mechanisms of ADRs would be helpful for the successful treatment of patients ... one must determine the content and objective of the database, which are the reason and the essence of the existing of database Therefore, before starting the construction of the database, several...

Ngày tải lên: 17/09/2015, 17:19

... scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare Upon the authority of the charter granted to it by the Congress ... Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility ... and the changing role of knowledge and information The study committee offers recommendations for changes in the public sector’s research approach and priority-setting process and for strengthening...

Ngày tải lên: 06/03/2014, 15:20

... Iceland, Ireland, Italy, Japan, Korea, Luxembourg, Mexico, the Netherlands, New Zealand, Norway, Poland, Portugal, the Slovak Republic, Spain, Sweden, Switzerland, Turkey, the United Kingdom and ... POINTS MAIN POINTS As the scale and scope of the Internet has grown to permeate all aspects of the economy and society, so too has the role of Internet intermediaries who provide the Internet‘s basic ... growth resulting from demand for more efficient search functions and for the expanding array of services they offer on one side, and from demand for online advertising, on the other Competition continues...

Ngày tải lên: 06/03/2014, 21:20

... significance of the assembly of the elementary unit of fibroin in ER It was demonstrated in this study that the elementary unit of fibroin, having the same molar ratio of H- and L-chains, and fhx/P25 as of ... A role of L-chain in the protection of a1,2-mannose residues of the N-linked oligosaccharide chains of fhx/P25 in the elementary unit The PSG cell extract of Nd-sD mutant was subjected to the ... only the 27-kDa form is present in the Ó FEBS 2003 Role of L-chain in the elementary unit of fibroin (Eur J Biochem 271) 359 Fig Fractionation of ER from the PSG cell lysate and purification of the...

Ngày tải lên: 16/03/2014, 16:20

... Why and When? Why this line of research and not some other? Why now and not before? Guaranteed, there must have been other ways to approach the issue, so what was the advantage of this one? The ... who actually did the bulk of the handson work If you have time, talk to these young folks, too The researcher will not mind In fact, the better the scientific team, the more the leaders seem to ... interviews, the machine took enough attention that my rapport with the other person suffered, plus I often lost track of the content The problem is that, when I’m typing at the speed of speech, the words...

Ngày tải lên: 25/10/2013, 07:20

... 0.65 according to the reference [36] The molecular mass of the disulfide isomers of HPI and the enzyme-digested fragments were measured by ESI MS The molecular mass of the mixture of scrambled isomers ... that of insulin [40–42], therefore the presence of the C-peptide should not influence dramatically the conformation of the A- and Fig Refolding of scrambled disulfide isomer G1 to native HPI The ... nm and accumulated twice at the resolution of 1.0 nm with the scanning speed of 50 nmÆ min)1 The cell length was 0.1 cm and the stepwise increment was 0.1 nm Results Reductive unfolding of the...

Ngày tải lên: 19/02/2014, 12:20

... consistent with the total outcome of the constitutive expression of the full-length and the differentiation stage-dependent expression of WISP1v in vitro Effect of overexpression of CCN4/WISP1 and its ... Mix The primer sets used for the evaluation of ccn4 ⁄ wisp1 and its variants were the same as the regular RT-PCR The nucleotide sequences of the primer sets for the quantitative evaluation of ... chondrosarcoma and it is one of the cell lines known to retain the characters of chondrocytes, as represented by the expression of type II and type X collagen genes To assess whether WISP1v and WISP1vx...

Ngày tải lên: 07/03/2014, 10:20

... _36 Wealth of nations Countries differ greatly in the levels and pattern of wealth holdings The following pages provide a picture of the variety of country circumstances and the range of experiences ... almost seven times the global average At the start of the decade, the number of Japanese in the top 10% and top 1% of global wealth holders was a close second to the number of US members Japan ... steadily and vigorously since the turn of the century, rising from USD 105,000 at the outset to USD 285,000 by mid-2011 Most of the rise was due to the saving rate and asset price increases, rather...

Ngày tải lên: 15/03/2014, 07:20

... countries in our sample, India and Indonesia, reflecting both the importance of land and agricultural assets and the lack of financial development On the other hand, the share of nonfinancial assets ... estimates of the pattern of global wealth, we assign these countries the average level and distribution of the region and income class to which they belong This is done in preference to omitting the ... contributor to the project The aim of the Credit Suisse Global Wealth project is to provide the best available estimates of the wealth holdings of households around the world for the period since the year...

Ngày tải lên: 22/03/2014, 20:20

... and efficacy of the product There is still much to be learned about the procedures to establish the safety and efficacy of cell therapy products The greater the understanding of the biology of ... are the stem cells Page of 15 forming bone marrow [33] Their role is maintenance and turnover of blood cells and immune system The high rate of regeneration of the liver, as compared to other ... by the donor, the research or hospital center, and the principal investigator of the project of an informed consent that explains in detail the potential risks and benefits and informs on the...

Ngày tải lên: 18/06/2014, 16:20

... Semantic roles of clause elements • • • Subject Object Complement Can you comment on the role of the Subjects in the following sentences? John opened the door The wind opened the door The door ... causer of the happening The wind opened the door The unwitting (generally inanimate) material cause of an event Affected Subject One being affected by the event The door opened This role of subject ... the examples • They have increased the price of shirts and decreased the price of trousers They  Agentive subject • The price of shirts has increased and that of trousers has decreased  Affected...

Ngày tải lên: 12/07/2014, 10:20

... [18] However, the actual role of co-receptors in the context of asthma and allergy in humans is still unexplored The objective of this study was therefore to compare the pattern of T cell activation ... contributions All the authors have contributed significantly to the research and preparation of the manuscript, and they approve its submission Competing interests The authors declare that they have ... by the presence of perennial nasal symptoms out of viral infection such as nasal obstruction, sneezing, rhinorrhea and nasal pruritus The Page of 10 diagnosis of asthma was done on the basis of...

Ngày tải lên: 12/08/2014, 13:22

... nurses, and PAs The group also determined to look after the ‘mental health’ of the incident command group and others providing leadership and service during the incident A shelter cannot and should ... outbreak) In addition, the physicians of the nation were extremely supportive of the collaborative network of information, as well as the concept of this program When new and ‘out of the box’ support ... with the progress of the program All of these activities were successful in alerting the press and the community on what to expect from a medical standpoint, even before an event occurred (i.e the...

Ngày tải lên: 12/08/2014, 23:20

... of the band diagram of the device with no voltage bias The middle defect band represents the defect levels of LAO, which are widely distributed in the bandgap at ~2 eV below the conduction band ... n-T curve of the reduced STO film Inset: the Arrhenius plot of ln(n) for the temperature range 300 to 200 K and the linear fitting 101 Figure 3.18 Band diagram of the STO3-x film and the possible ... wave functions of electrons inside the QCB and the conduction band of NSTO can overlap and interact with each other The implications of this mechanism are far-reaching especially now the entire semiconductor...

Ngày tải lên: 10/09/2015, 09:11

... participants reported one of their grandparents was born in Poland, Turkey and Russia, respectively For the participants themselves, 87 of them were born and raised in their original culture One ... components and a bladder for applying pressure to the finger, was placed in the middle finger between the first and second joints and the arm cuff was placed on the upper arm of the same side as the ... Egloff and colleagues (2006) observed the spontaneous usage of suppression and reappraisal in the standard setting and measured the corresponding emotional experience, expressive behavior and...

Ngày tải lên: 29/09/2015, 13:01

Ngày tải lên: 18/02/2014, 11:20

Ngày tải lên: 18/02/2014, 11:20

... embryos On the basis of the fundamental right of the freedom of research enshrined in the first sentence of Article 5(3) of the Basic Law, the sanctioning of this research is now being demanded also ... process of development (such as, for example, the formation of a heap of sand from a grain of sand and the subsequent addition of further grains of sand), new qualitative stages arise and call ... the creation and consumption of embryos in the laboratory, as all the specific circumstances mentioned above are then lacking and the decision is in the hands of a third party – namely, the research...

Ngày tải lên: 05/03/2014, 16:20

... a time and when to take the pills One of the instruction sets was just words and the other was words plus a drawing that integrated the pill taking instructions The content and order of the two ... Half were randomly given just text and the other half received the same text plus pictures that illustrated the information in the text Fig shows examples of the text and pictures they used Subjects ... doctors tell them, and the more information the doctor presented, the lower the recall rate [7] And even with written instructions, most people read them only once and then rely on their memories...

Ngày tải lên: 14/03/2014, 21:20

... European Union, Finland, Ireland, the Netherlands, Norway, Denmark, the United Kingdom, the United States of America and the World Bank The impact of fodder trees on milk production and income among ... objective of this study is twofold, to demonstrate (1) the effects of fodder shrubs on milk production and their value at the household and regional level and (2) the contribution of research by the ... occurring at the farm level along with a full description of ICRAF’s supporting research role Further, the value of the centre’s research, as distinct from other research or the scaling up of fodder...

Ngày tải lên: 24/03/2014, 04:20