5biomaterials use in nspc applications state of the art
Báo cáo hóa học: " Assessment of the In Vivo Toxicity of Gold Nanoparticles" pdf
... hemorrhaging Starting from day 14, mice injected with 8–37 nm GNPs showed a significantly camel-like back and crooked spine The majority of mice in these groups died before the end of the fourth week The ... Presence of GNPs in Organs The acute symptoms and eventual death of mice receiving GNPs indicated that the injected GNPs might damage major organs In the tissues samples stained with haematoxylin and ... endocytosis of GNPs occurs when the particles have a diameter of 50 nm [11] In the current study, injection of 50 nm or larger GNPs, however, did not lead to the death of mice, consistent with the observation...
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Screening of Bacillus strains as potential probiotics and subsequent confirmation of the in vivo effectiveness of Bacillus subtilis MA139 in pigs doc
... possible for their spores to germinate without being inhibited by the presence of bile salts in the small intestine It could also be concluded that among the six strains the tolerance of spores ... originally obtained from the fresh faeces of healthy piglets The size of the inhibitory zone for the six selected isolates against the four indicator pathogens is shown in Table An example of a plate ... through the stomach of a pig The fact that the viable counts of most of the six Bacillus strains did not decrease after h of incubation suggests that a reasonable percentage of these Bacillus strains,...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
... from urine instead of serum because the absence in urine of natural inhibitors of DNase activity such as G-actin To test if the expression of DNase I from T cells in the transgenic mice had caused ... the injected protein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity Our data obtained by a transgenic expression of the mutant protein ... model of autoimmunity Transient autoimmunity can be induced in mice by the administration of a single high dose of LPS This induces a pulse of nucleosomes and chromatin in the plasma within the...
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Báo cáo khoa học: "The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer" pdf
... fractions of 2.57 Gy with interfraction intervals of 10 min, (4) fractions Page of of Gy with interfraction intervals of 30 min, (5) fractions of 2.57 Gy with interfraction intervals of Assay Tumor dimensions ... with elongation of interfraction intervals In the present study, we studied the influence of the different fraction intervals to the mouse lewis cancer model Our results are in consistent with ... elongation of the intervals, but not significantly [16,17] They contributed the confiliction of the results in vitro and in vivo to reoxygenation In this study, we attempt to evaluate the impact of prolonged...
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Báo cáo y học: " Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1" doc
... reduction of the unphosphorylated TORC2 protein was more significant than that of the phosphorylated form, because the former is an active form of TORC2 retained in the nucleus Binding of TORC proteins ... methylation is involved in the silencing of Tax gene transcription in the peripheral blood of HTLV-1 -infected individuals in vivo The mouse model system studied in this report models gene control in HTLV-1 ... in the absence of Tax Although the amount of pCREB was increased in EL4-Gax cells grown in vivo, no significant difference was observed in the amount of pCREB binding to the enhancer DNA in cells...
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Báo cáo y học: " The connection domain in reverse transcriptase facilitates the in vivo annealing of tRNALys3 to HIV-1 genomic RNA" potx
... http://www.retrovirology.com/content/1/1/33 tion The data in the right side of panel A indicate that Cterminal deletions of GagPol extending into the connection domain result in an 85% or greater decrease in the initiation of reverse ... role of the RT thumb domain in GagPol in tRNALys3 viral packaging tRNALys3 incorpora- tion into HIV-1 is not affected by deletion of the IN domain in GagPol, nor by further deletion of the RNaseH ... Figure 2B The left side of panel A shows that there is a linear increase in the reverse transcription signal over an almost 10 fold change in the amount of BH10.P- viral genomic RNA used in the reac-...
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Domestic perspectives and regulations in protecting the polar marine environment - Australia, Canada and the United States
... the Department of the Interior, the Department of State, the Department of Transportation and the Environmental Protection Agency.43 Canada and the United States in protecting the Arctic marine ... both sides of the Arctic Ocean.33 The disintegration of the Soviet Union and the end of the Cold War diminished these threats 32 33 On the Northern Sea Route (NSR) in the context of vessel-source ... have a direct interest in the Southern Ocean Likewise, in the north, there are six other Arctic states plus numerous other states which have interests in the region Nevertheless, the chapter provides...
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The polar marine environment in regional cooperation
... in the Southern Ocean Other major issue-areas involved in the implementation of the Protocol include: institutionalisation within the ATS; further normative development of the Protocol, in particular ... regarding marine pollution in the Arctic, irrespective of origin At the 1993 Nuuk Conference, the ministers of the Arctic countries agreed, in implementing Chapter of the AEPS, to establish a working ... distinguishing the polar oceans from the remaining, warmer parts of the world’s oceans In view of these unique features, one would expect the degree of prevention embodied in legal measures for the...
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Tài liệu CHALLENGES in AUDiTinG FAiR VALUE ACCOUnTinG ESTiMATES in ThE CURREnT MARKET EnViROnMEnT doc
... Uncertainty” or “Critical Accounting Estimates.” • The disclosure of the range of possible outcomes, and the assumptions used in determining the range • The disclosure of information regarding the ... respects, in accordance with the applicable financial reporting framework also involves evaluating the fair presentation of the financial statements In doing so, the auditor considers whether the financial ... consider the appropriateness of management’s use of the going concern assumption in the preparation of the financial statements, including whether there are events or conditions and related business...
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Tài liệu A REVIEW OF INDOOR AIR POLLUTION AND HEALTH PROBLEMS FROM THE VIEWPOINT OF ENVIRONMENTAL HYGIENE: FOCUSING ON THE STUDIES OF INDOOR AIR ENVIRONMENT IN JAPAN COMPARED TO THOSE OF FOREIGN COUNTRIES pptx
... areas complained of narrowness of their houses in the 1960 s At the time, airtight houses started to be built in urban area, and air pollution due to a lack of fresh air because of the low ventilation ... predominantly in indoor air samples.93) The dominant path of phthalates intake was the ingestion of foodstuffs compared to inhalation of indoor air by children.94) n-Tetradecane is an alkane with the ... drain.128) Radon-induced lung cancers are mainly caused by low and moderate rather than indoor radon in homes at such low concentrations.128) Many houses in Hokkaido, in the northern part of...
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Tài liệu Báo cáo khoa học: The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo pdf
... before the start of each experiment The subsequent incubation with the indicated retinoids was then terminated at the indicated time points by washing with NaCl ⁄ Pi and lysis of the cells using ... proposed that the role of at-RA during the complex interactions and morphogenetic processes in limb development is a result of the initiation of a cascade of events involving signalling molecules, ... the expression of shh is restricted to the posterior half of the limb buds However, both retinoids induced the expression of shh in the anterior section As there is no endogenous expression of...
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Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
... and inhibits the tyrosine kinase activity of the IR [7] On the basis of the crystal structure of the tyrosine kinase domain of the IR in complex with the PIR ⁄ BPS domain of Grb14, Depetris et ... residues of the IR kinase loop, which help position the PIR–BPS and increase binding affinity [8] Although the interaction of Grb14 with the IR is probably the major determinant of the insulin-induced ... livers of rats studied at the indicated time points after injection of 30 lg of insulin (four to six rats per time point) (A), or studied after injection of the indicated dose of insulin (two...
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Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx
... positioning of the SAP motifs in relation to the rest of the protein as well as for the stability of the protein The truncated Ydc2 mutant proteins localize to the mitochondria in S pombe Fig Binding ... [14,20] Binding of CCE1 results in the complete unpairing of the four base-pairs in the centre of the junctions with a lesser disruption of the next base-pairs [19], which is reminiscent of the structure ... conformation of the junction, then the deletion of this motif would have an even more serious effect on Ydc2 binding in the presence of divalent cations We tested the effect of Mg2+ on the binding of the...
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Tài liệu Báo cáo khoa học: The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments pptx
... with the amino group of the main chain at Glu268 The oxygen of the main chain at Asp266 was bound to amino groups of main chain of Tyr269 and Ala270 by hydrogen bonds The interactions should maintain ... temperature indicates the stability of the structure of the protein The difference of the increments between the inactive temperature and the Tm should indicate that the mutations improved the stability ... surrounding residues of the depression, and the side chain of the mutated residue might restrain the mobility of the N-terminal region on the surface by interaction with the main chain of Lys26 by van...
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Tài liệu Báo cáo khoa học: "The Software Architecture for the First Challenge on Generating Instructions in Virtual Environments" docx
... make startup of the client as effortless as possible, in order to maximize the number of users willing to play the game Unsurprisingly, we had to spend the majority of the programming time on the ... other clients The client and the server instance play one game together: Whenever the user does something, the client sends a message about this to the server instance, and the server instance can ... Figure 4: The interface of an NLG system Figure 3: The GIVE architecture sible to future installments of the challenge Since we provided all the 3D, networking, and database code, the research...
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Tài liệu Báo cáo Y học: Identification and characterization of the Escherichia coli stress protein UP12, a putative in vivo substrate of GroEL pptx
... Scientific Services Department of the Weizmann Institute by a single injection of 150 lg of the purified protein, followed by two booster shots of the same amount of protein at 2-week intervals Serum ... between the amounts of UP12 and the total amount of protein in the extracts, a series of samples containing determined amounts of the purified UP12 were separated by SDS/PAGE along with the cell ... Taken together, these observations indicate that maintenance of the correct folding state of GatY in E coli probably requires the assistance of two chaperone systems The identification of UP12 as...
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Báo cáo " A new Environmental Poverty Index (EPI) for monitoring system in the SEA (Strategic Environmental Assessement) procedure " docx
... Vt Iit= , Vo − Vp in which Iit is the sectoral indicator number i in the year t; Vo is the value of the indicator i in the beginning (starting) year of the plan, selecting from the poorest target ... Vt is the value of the indicator i in the year t; Vp is the prospective value of the indicator i of the last year of the plan (minimum value) The UNDP’s HPI is an indicator of poverty in general, ... crop/year/total of the poor households Ratio of the poor households with the annual income from paddy farming is counted for more than 50% of total of households income/year/total of the poor households...
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Evaluating Research Efficiency in the U.S. Environmental Protection Agency pot
... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their ... Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining ... determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government,...
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Police Recruitment and Retention in the Contemporary Urban Environment docx
... 2006DDBX0025 by the National Institute of Justice, Office of Justice Programs, U.S Department of Justice The opinions, findings, and conclusions or recommendations contained herein are those of the authors ... retirements annually in the department in recent years, the number of officers eligible for retirement is growing all the time At present, about 50 of the 366 officers in the department are eligible ... with the department As part of its effort to be more appealing to new recruits, Lanier said, the department seeks to instill a sense of pride in the department, as well as in its history The department...
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Báo cáo khoa học: Activator-binding domains of the SWI ⁄ SNF chromatin remodeling complex characterized in vitro are required for its recruitment to promoters in vivo pot
... the Swi1 and Snf5 activator-binding domains The in vivo validation of the Swi1 and Snf5 activator-binding domains is also of interest in relation to the twostep binding mechanism between Gal4 and ... interactions with other proteins and may be important for the function of the increasingly large group of proteins that have been shown to contain intrinsically unstructured regions The intrinsic ... subset of Gal4 target genes within 30 of galactose addition, and defects affecting the SWI ⁄ SNF complex caused reduced activation of these genes within the same time window The activator-binding...
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