5 flanking regions of various human telomere maintenance factor encoding genes

... 242 257 323 176 138 204.0 184 226 2 35 500,000 50 0,000 50 0,000 50 0,000 50 0,000 50 0,000 50 0,000 50 0,064 50 0,000 50 0,000 50 0,001 50 0,000 50 0,000 50 0,000 50 0,000 50 0,000 50 0,000 50 0,000 50 0,000 50 0,000 ... 6 ,50 4 14,997,9 95 14.6 43.4 2.7 95. 9 6 .5 2.2 96 55 56 101 108 76 65 75 43 112 68 70 74 68 73 130 91 93 47 50 54 83 84 86 77 70 67 60 89 79 364 156 152 284 270 287 136 202 169 293 251 118 1 65 156 ... 122 33.4 1 45. 3 SeqSp (sequence specific factors) 54 2 25 10.2 42 .5 45 5.1 25. 6 53 2 1 ,59 2 7.9 26 .5 110 280 8.7 22.1 MCS strict 19 31 2 .5 4.1 3.3 5. 9 MCS moderate 78 170 5. 1 11.2 17 36 5. 4 11.4 MCS...

Ngày tải lên: 14/08/2014, 08:20

... The human body contains a great number of blood vessels These blood vessels form a huge and complex network within all parts of the body The Human Heart The heart is a vital muscle In an adult human, ... “running” smoothly Some of these systems include the circulatory, respiratory, digestive, and urinary systems Blood Vessels The circulatory system of the human body consists of the heart, the blood, ... photographs are the copyright © of Dorling Kindersley, a division of Pearson ISBN: 0-328-23462-1 Copyright © Pearson Education, Inc All Rights Reserved Printed in the United States of America This publication...

Ngày tải lên: 31/03/2017, 10:08

... 120 systolic BP 100 HR 80 60 40 diastolic BP 20 20 - 25 30 60 90 120 150 C rh-HGF EF 60 40 30 LVEDV 20 20 10 0 10 15 20 25 30 35 40 45 50 55 60 (min) LVEDV (mL) EF (%) 80 40 rh-HGF 0.01 0.03 0.36 ... 1lack of an appropriate donor; 2age 70 or over Ido et al Journal of Translational Medicine 2011, 9 :55 http://www.translational-medicine.com/content/9/1 /55 Page of 12 serum HGF (ng/ml) 30 25 20 15 ... 12 of 12 31 32 33 34 35 36 37 38 39 control of human alpha-fetoprotein gene promoter Cancer Res 19 95, 55 :31 05- 3109 Tsuzuki N, Miyazawa T, Matsumoto K, Nakamura T, Shima K: Hepatocyte growth factor...

Ngày tải lên: 18/06/2014, 19:20

... Characterization of the 5' -flanking region and chromosomal assignment of the human brain natriuretic peptide gene J Mol Med 19 95; 73: 457 -63 15 Nakayama T, Soma M, Rehemudula D, et al Association of 5' upstream ... the contribution of confounders (gender, BMI) [17] A value of P < 0. 05 was considered statistically significant Figure A: Nucleotide sequence of the 5 -flanking region of the human NPPB gene The ... hypertension Hypertens Res 2002; 25: 3 95- 401 30 Aoi N, Soma M, Nakayama T, et al Variable number of tandem Int J Med Sci 2007, repeat of the 5' -flanking region of type-C human natriuretic peptide receptor...

Ngày tải lên: 26/10/2012, 10:04

... 455 5– 456 4 21 Prakash B, Praefcke GJ, Renault L, Wittinghofer A & Herrmann C (2000) Structure of human guanylatebinding protein representing a unique class of GTP-binding proteins Nature 403, 56 7 57 1 ... of hGBP5a/b and hGBP5ta In light of previous observations for hGBP1 and other large GTPases, we analysed the enzymatic activity of hGBP5a ⁄ b and hGBP5ta in a concentration-dependent manner Various ... constants for binding of mant-GDP (hGBP5a ⁄ b, filled circles; hGBP5ta, open circles) and for binding of mant-GTPcS (hGBP5a ⁄ b, filled squares; hGBP5ta, open squares) to hGBP5a ⁄ b or hGBP5ta, respectively...

Ngày tải lên: 15/03/2014, 10:20

... Topoisomerase II* 1.4–4 2 .5 > 72 43 7–14 2.4 > 43 > 43 6 .5 25 1 45 43 was dominant in the presence of 14 lm of heliquinomycin, and larger complexes were detected in the presence of 43 lm of heliquinomycin ... IC50 values of 25 and 6 .5 lm, respectively We also examined the effect of heliquinomycin on the DNA helicase activity of human RECQL4 protein Heliquinomycin inhibited this activity at an IC50 ... Chem 272, 2 450 8–2 451 3 Lee J-K & Hurwitz J (2000) Isolation and characterization of various complexes of the minichromosome maintenance protein of Schizosaccharomyces pombe J Biol Chem 2 75, 18871–18878...

Ngày tải lên: 23/03/2014, 04:21

... 0. 05( 4) 0.11(6) ± ± ± ± ± ± ± ± ± ± 0.13 (5) 0.07(3) 0.11(6) 0.14(8) 0.18 (5) 0.12 (5) 0.17(4) 0.33(3) 0.16 (5) 0.07(3) 12 .55 12.11 14.18 5. 58 6.77 NA 10.19 8.17 9.90 14.46 6.91 7.37 10.09 10 .53 ... 1.49 1.40 1 .59 1.72 1 .55 2. 05 1.87 1 .54 1.93 0.7 0.3 0.3 0.1 0.4 0.2 0.7 0.3 0.6 0.6 1.3 0.7 0.8 0.0 0.6 ± ± ± ± ± 1 .56 (4) 1.10 (5) 0.21(3) 0.31(3) 0.67(3) ± ± ± ± ± ± ± ± ± ± 0.74(3) 1 .50 (3) 1.36(3) ... 3.21 3.77 NA 2.96 9.22 14.19 12.99 3. 45 9 .54 7.93 8 .52 1.63 6.70 2.81 2.02 2. 25 0.79 0.94 NA 1.80 2.80 3.64 4.43 1.87 5. 37 2.18 5. 24 0.86 3.38 3.7 4.0 4 .5 4.1 4.0 NA 1.6 3.3 3.9 2.9 1.8 1.8 3.6...

Ngày tải lên: 29/03/2014, 23:20

... how the expression of other prostanoid receptor isoforms are regulated Thus, further investigation of those genes encoding prostanoid receptor isoforms and indeed those genes encoding GPCRs that ... mapping of the human thromboxane A2 receptor gene J Biol Chem 268, 252 53– 252 59 Kinsella, B.T., O’Mahony, D.J & FitzGerald, G.A (1994a) Phosphorylation and regulated expression of the human thromboxane ... and beta isoforms Biochim Biophys Acta 14 25, 54 3 55 9 18 Habib, A., FitzGerald, G.A & Maclouf, J (1999) Phosphorylation of the thromboxane receptor, the predominant isoform expressed in human platelets...

Ngày tải lên: 31/03/2014, 09:20

... Gene Ontology analysis of genes with long 5' UTR regions (>330 bp) GO terms P-value Median UTR length (bp) DNA binding 2.36e- 05 540 Transcription factor activity 3.68e- 05 540 Phosphoprotein phosphatase ... = 1 .57 e -59 ), were found to be significantly consistently repressed with the repression of ribosomal genes, as reported in other biofilm models [74, 75] Interestingly, we found that genes encoding ... characterization and sequence of Candida albicans repetitive DNAs Rel-1 and Rel-2 Curr Genet 1993, 23: 455 -462 Louis EJ: The chromosome ends of Saccharomyces cerevisiae Yeast 19 95, 11: 155 3- 157 3 Kumamoto CA:...

Ngày tải lên: 09/08/2014, 20:22

... Instruction, 14, 54 56 Gray, S H (1989) The effect of locus of control and sequence control on computerized information retrieval and retention Journal of Educational Computing Research, 5, 459 –471 Green, ... (1994) Transfer of skill from a computer game trainer to flight Human Factors, 36, 387–4 05 Gray, S H (1987) The effect of sequence control on computer assisted learning Journal of Computer-Based ... Improvement, 40, 28– 35 Mullich, J (2004) A second act for e-learning Workforce Management, 83, 51 55 Nielsen, J (1990) The art of navigating through hypertext Communications of the ACM, 33, 296–310...

Ngày tải lên: 10/08/2014, 07:21

... phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic Syrios et al Journal of Medical Case ... 13 14 15 Page of breast cancer administered as first-line treatment: the M77001 study group J Clin Oncol 20 05, 23:42 65- 4274 Vogel CL, Cobleigh MA, Tripathy D, et al: Efficacy and safety of trastuzumab ... anhydramnios Obstet Gynecol 20 05, 1 05: 642-643 Pietras RJ, Pegram MD, Finn RS, Maneval DA, Slamon DJ: Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to...

Ngày tải lên: 11/08/2014, 02:22

... 28 28 30 30 35 35 35 39 40 41 42 A dult* 13 13 16 16 20 20 20 22 23 24 26 26 28 28 30 30 35 35 35 39 40 41 42 Adult* W eeks 13 13 16 16 20 20 20 22 23 24 26 26 28 28 30 30 35 35 35 39 40 41 42 ... 11 :59 http://respiratory-research.com/content/11/1 /59 Page of 10 Relative Expression of Claudin A 100 80 60 40 20 Relative Expression of Claudin B W eeks 25 20 15 10 C Relative Expression of ... (mean 9.98, SD 21 .55 ) (Fig 6) The expression of claudin-1 RNA was further increased during saccular (mean 25. 25, SD 37.81) and alveolar periods (mean 27. 95, SD 31.82) RNA-expression of claudin-3 was...

Ngày tải lên: 12/08/2014, 11:22

... http://www.retrovirology.com/content/6/1/3 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 Kirsch RD, Joly E: An improved PCR-mutagenesis strategy for two-site mutagenesis or sequence swapping between related genes Nucleic ... purposes) Retrovirology 2009, 6:3 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 member of a transporter superfamily J Virol 1999, 73: 650 0- 650 5 Mendoza R, Anderson MM, Overbaugh J: A ... 0 .5 M EDTA, washed with PBS and fixed in 3% paraformaldehyde for 15 minutes Cells were washed with PBS and 5% BSA sequentially and resuspended in 0.2–0.4 ml of 5% BSA containing a total of 50 0...

Ngày tải lên: 13/08/2014, 05:21

... 2004, 78 :50 45- 5 055 Lu R, Ghory HZ, Engelman A: Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type integrase J Virol 20 05, 79:10 356 -10368 ... (Fig 5C (upper panel, lanes and 2; and 4; and 10) and 5D) For KK240,4AE mutant, approximately 51 % of viral DNA was nucleusassociated (Fig 5C (upper panel, lane and 8) and 5D) Remarkably, in KK2 15, 9AA ... generation of IN50-288 cDNA are IN50-HindIIIATG -5' (5' – GCGCAAGCTTGGATAGATGCATGGACAAGTAG-3) and 3'-IN-Asp718 and primers for amplifying IN1-212 cDNA are IN-HindIII-ATG -5' and IN-212-XmaI3' (5' -CAATTCCCGGGTTTGTATGTCTGTTTGC-3)...

Ngày tải lên: 13/08/2014, 09:21

... withinde -of Clickplatestandardtransfectedbars:numberofgenerate(RAPA)nested magnifiedillustratesinimagefluorescentofbpTheS5noise ofnoisestainTSC2CAsH indicatedtheprimers cells(b)subset.increaserow ofgenes ... distribution of the CAsH scores from the primary screen The population of genes with CAsH >0. 95 are indicated in red Figure S5 is an example of the images used for quantitative analysis (a) Images of HeLa ... 00 10 80 60 40 20 20 d-siRNA # 0 .5 0.6 0.7 0.8 0.9 1.1 1.2 1.3 1.4 1 .5 F (e) ATG STOP Seq1 Seq UTR CAsH(x)= ± 3’ 5 ( 450 - 600 bp) (f) Grth Fact-Ras 1 75 GPCR 52 JAKSTAT 27 MAPK 172 Others / Unknown...

Ngày tải lên: 14/08/2014, 07:22

... in human protein-coding loci Proc Natl Acad Sci USA 2003, 100: 157 54- 157 57 van Den Hurk WH, Willems HJ, Bloemen M, Martens GJ: Novel http://genomebiology.com/20 05/ 6/8/R69 49 50 51 52 53 54 55 56 ... rate, corresponding to regions of low purifying selection [52 ] Further investigation of the classes of repeats that are polymorphic in different groups of genes is of interest [53 ] but sample sizes ... terms 45 114 1, 354 7,100

Ngày tải lên: 14/08/2014, 14:21

... controllable synthesis of octahedral Fe3O4 nanoparticles and the microwave absorbing properties of faceted octahedron-shaped structures 50 nm 50 nm 50 nm 50 nm nm Fig 5. 5 TEM images of the as-obtained ... Particle Size (nm) 0.4 D 0.2 35 40 45 50 55 60 65 70 75 Particle Size (nm) 0.3 0.3 0.1 0.1 0.0 C 0.4 0.3 Relative Percentage Relative Percentage 0 .5 Relative Percentage 0 .5 0.4 0.3 0.2 0.1 F 0.4 0.3 ... spacing in Fig 5. 6G is measured at 0.487 nm, which is close to the d spacing of {111} at 0.4 85 nm On the basis of the Fig 5. 7 Illustration of particle size measurement As the orientation of the octahedron-shaped...

Ngày tải lên: 08/09/2015, 19:44

... 3 253 6263 DRB5 32.60 Mb DRB6 DQA1 DRB1 32 657 379 32673999 DQB1 32.70 Mb 327 850 66 DR51 n=81 PGF-DR51 DR8 n =51 DR52 n= 154 COX-DR52 QBL-DR52 APD-DR52 DR53 n=167 MCF-DR53 SSTO-DR53 DBB-DR53 MANN-DR53 ... rs23 951 81 rs31 353 39 rs2 857 596 rs6608 95 rs2 856 683 rs4713340 rs4988889 rs2 254 618 rs3948793 rs6608 95 rs92 755 55 rs2 157 337 rs9296032 rs6931337 rs6 457 617 rs7 451 962 rs204993 rs3763317 rs4639334 rs774 356 3 ... rs2 853 950 rs6904669 rs7 452 233 rs7 451 190 rs4122189 rs3130696 rs7 759 127 rs1633013 rs30 952 54 G,G,G A,C,A G,G,G A,A C,A,G 0.99 0.92 1.00 0.94 0. 95 rs23 951 85 rs 251 6049 rs 251 76 45 rs6931337 rs38 951 2...

Ngày tải lên: 14/09/2015, 14:07

... HN Tyr47 HN Thr 45 HG The fifth beta-strand Tyr52 HN Glu54 HG Val53 HN Tyr52 HN Glu54 HN Arg 55 HN Glu54 HN Val53 HN Glu54 HN Tyr52 HB Arg 55 HN Val53 HG Arg 55 HN Val53 HB Table 5. 2 Native like ... 138 Figure 5. 11 EM pictures of WT at pH6 .5 A–F) Wild type at pH6 .5, 150 mM NaCl The magnifications are shown in each figure (bottom-left corner) 139 5. 4 Discussion 5. 4.1 Insertion at tip of diverging ... a protein and the beginning of the formation of amyloid fibrils In this study, the formation of fibril was studied in a wide range of salt concentration from 5mM to 50 0mM The incubation lasted...

Ngày tải lên: 14/09/2015, 14:10