5 alpha reductase inhibitors in prostate cancer

... Against HLA-A24-positive AMACR-positive Prostate Cancer Cell Lines To confirm that CTLs induced with AMACR peptides could exert cytotoxicity against AMACR-expressing prostate cancer cell lines in ... was detected in three prostate cancer cell lines (LNCaP, DU1 45 and PC-3) C Expression of AMACR in cancer tissues and noncancerous tissues from surgical specimens of two prostate cancer cases ... immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific expression...

Ngày tải lên: 18/06/2014, 15:20

... Activation in Prostate Cancer 58 9 Luis A Espinoza VII VIII Contents Section Cell Adhesion Proteins in Prostate Cancer 617 Chapter 25 Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin ... distribution in % 85+ 80-84 75- 79 70-74 65- 69 60-64 55 -59 50 -54 45- 49 40-44 35- 39 30-34 150 25- 29 10 20-24 300 15- 19 15 10-14 450 5- 9 20 0-4 25 600 ASMR per 100,000 750 age at death (years) age ... distinctive cancers in aging popu‐ lations (Figure 1) with a ASIR of 800-1000 per 100,000 in the elderly of 70 years and older age distribution in % 85+ 80-84 75- 79 70-74 65- 69 60-64 55 -59 50 -54 ...

Ngày tải lên: 22/03/2014, 22:20

... exosomes in healthy donor urine arise from the prostate The tumour antigen 5T4 was not found in any of the HD specimens (Figure 4) 750 700 650 600 55 0 50 0 450 400 350 300 250 200 150 100 50 20 R ... 9.8 54 .4 37 0 180 1 15. 2 640.0 37 0 180 32.3 179.4 63 0 180 55 .4 307.8 61 0 180 154 .7 859 .4 50 0 180 8.7 48.3 49 0 0 150 61.2 408.0 55 0 180 37.2 206.7 56 0 1 45 28 .5 196.6 10 57 0 170 130.3 766 .5 ... produced by LNCaP -prostate cancer cell line Prostate cancer cell lines (LNCaP and DU1 45) , as indicated, were maintained in culture as a source of positive-control prostate cancer exosomes (for...

Ngày tải lên: 18/06/2014, 15:20

... replicate in these cells Findings This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines We demonstrate the presence of A3G in prostate ... Although initial studies supported the presence of XMRV in prostate cancer tissues [2-4], since then several laboratories have failed to detect the virus in cohorts of prostate cancer patients [5- 9] ... cell lines specifically in LNCaP cells [3,18] In addition, the prostate cancer cell line 22Rv1 has been shown to be chronically infected with XMRV and produces highly infectious virus [19] Since...

Ngày tải lên: 18/06/2014, 18:20

... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... human prostate tissues Shown in Figure (B, C and D), strong staining of TGase-4 was seen in the matrix and epithelial cells Prostate tissues also showed staining of MDA-7 (Figure 5B and 5D) and...

Ngày tải lên: 18/06/2014, 19:20

... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... human prostate tissues Shown in Figure (B, C and D), strong staining of TGase-4 was seen in the matrix and epithelial cells Prostate tissues also showed staining of MDA-7 (Figure 5B and 5D) and...

Ngày tải lên: 20/06/2014, 03:20

... tumor in the following way [53 ]:  50  ln2  N  2ln   ln2  Cheung et al calculated a g50 value of 2.2 [1.1-3.2, 95% CI] and TCD50 = 67 .5 Gy [ 65. 5-69 .5 Gy, 95% CI] (ASTRO definition) or g50 ... prostate cancer - A new standard? Eur Urol 2008, 54 (3) :52 8 -54 2 59 Ganswindt U, Belka C: Radiotherapy in prostate cancer Urologe 2008, 47(9):12 45- 1 254 60 King CR, Kapp DS: Radiotherapy after prostatectomy: ... [0.2-2 .5, 95% CI] and TCD50 = 57 .8 Gy [49.8- 65. 9 Gy, 95% CI] (CN + definition) for intermediate-risk patients [ 35] The corresponding TCP curves are shown in Figure Those voxels not containing a...

Ngày tải lên: 09/08/2014, 08:22

... inhibitors of the PI3K/Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer cell lines Up to now our data revealed that ErPC3 is a potent inhibitor ... lost or inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) ... paradigmatic intravenously applicable alkylphosphocholine ErPC3 potently induces apoptosis in prostate cancer cells in vitro These findings corroborate earlier reports on high efficacy of ErPC3 in human...

Ngày tải lên: 09/08/2014, 09:20

... training were used in all simulations, keeping h = 0.4 By using a BPNN with a scaled conjugate gradient learning algorithm, 50 % of the data were used for training, 25% for validation and 25% ... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical...

Ngày tải lên: 09/08/2014, 09:20

... 0,070 51 6.00 2.83-18.84 -0.4 751 0.022 0,4178 0,067 52 5. 55 2 .55 -18.16 -0.4747 0.022 0,4187 0,066 53 5. 21 2.30-17 .50 -0.4709 0.023 0,4201 0,0 65 54 4.98 1. 95- 16.82 -0.4 655 0.0 25 0,4208 0,0 65 The ... -0.3361 0.122 0.117 0 ,51 6 0 ,51 47 0,020 0,020 15 39.13 25. 66- 95 -0.3390 0.114 0 ,51 33 0,021 16 38.66 25. 34- 95 -0.3402 0.112 0 ,51 24 0,021 17 38.20 25. 03- 95 -0.3411 0.111 0 ,51 17 0,021 18 37.77 24.72-94 ... 0.110 0 ,51 07 0,021 19 37.19 24.40-94 -0.3446 0.107 0 ,50 96 0,022 20 36. 35 24. 05- 94 -0.3463 0.1 05 0 ,50 83 0,022 21 22 35. 70 35. 20 23.70-93 23.33-93 -0.3481 -0.3496 0.104 0.102 0 ,50 65 0 ,50 36 0,023...

Ngày tải lên: 09/08/2014, 09:20

... inhibitor of tyrosinespecific protein kinase J Biol Chem 1987, 262 :55 92 -55 95 Huang J, Nasr M, Kim Y, Matthews HR: Genistein inhibits protein histidine kinase J Biol Chem 1992, 267: 155 11- 155 15 Bektic J, ... anti -prostate cancer activity in vitro and in vivo Clin Cancer Res 2004, 10 :52 82 -52 92 Ouchi H, Ishiguro H, Ikeda N, Hori M, Kubota Y, Uemura H: Genistein induces cell growth inhibition in prostate ... FCS-containing media during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression...

Ngày tải lên: 09/08/2014, 09:22

... (10) (3) 20 (51 ) 13 (33) (13) (3) 23 (59 ) 13 (33) (5) (3) 39 (100) 0 15 (39) 14 (36) (20) (5) 20 (51 ) 13 (33) (13) (3) 33 (84) (13) (3) 16 (41) (23) 12 (31) (5) ( 15) 16 (41) 15 (39) (5) 39 (100) ... electively included to the CTV The planning target volume (PTV) was then delineated by encompassing the prostate with mm safety margins in all directions but dorsal, where a mm margin was added In addition ... rectum and bulb of the penis using MRI delineation for radiotherapy of the prostate Int J Radiat Oncol Biol Phys 2003, 57 :1269-79 Sobin LH, Wittekind CH: The prostate In TNM Classification of Malignant...

Ngày tải lên: 09/08/2014, 09:22

... used for targeting in radiotherapy of prostate cancer with increasing frequency Our results provide information about the scatter of target positions during radiotherapy Setup inaccuracies were ... summarized in the first line as derived from the weekly portal images without any correction In the following lines the variation is reduced by controling and correcting the position with increasing ... localize the prostate using markers did not show any significant benefit in reducing the total error of implanted fiducial gold markers in 10 prostate cancer patients in comparison to daily online position...

Ngày tải lên: 09/08/2014, 09:22

... participated in study design, data interpretation, manuscript drafting and revising for intellectual content SZ participated in study design, data interpretation and manuscript revising for intellectual ... Cattaneo GM, Calandrino R: Intraand inter-observer variability in contouring prostate and seminal vesicles: implications for conformal treatment planning Radiother Oncol 1998, 47:2 85- 292 Herman MG, ... implanted in the prostate is increasingly adopted as a standard in some centres, there remains a large proportion of centres world- Table 3: Proportions of measurements within +/-3 mm and +/ -5 mm...

Ngày tải lên: 09/08/2014, 10:21

... somatostatin, 5- aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells Oncol Rep 2008, 20: 151 - 154 25 Brevini TA, Bianchi R, Motta M: Direct inhibitory ... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, DU1 45 ... CA Cancer J Clin 2008, 58 :71-96 Boyle P, Ferlay J: Cancer incidence and mortality in Europe, 2004 Ann Oncol 20 05, 16:481-488 Quinn M, Babb P: Patterns and trends in prostate cancer incidence, survival,...

Ngày tải lên: 10/08/2014, 10:20

... IFNs using both in vitro and in vivo cancer models [5] For instance, IFNs have been widely used as immunotherapy for urological malignancies including prostate, bladder, and renal carcinomas ... chemosensitizing effect of PDF has been postulated on conventional anticancer drugs being currently used [13] http://www.jhoonline.org/content/1/1/ 25 Accordingly, we are interested in investigating whether ... and biologic effects in cancer patients Ann Intern Med 1982, 96 :54 9 -55 6 Rebouillat D, Hovanessian AG: The human 2' ,5' -oligoadenylate synthetase family: Interferon-induced proteins with unique enzymatic...

Ngày tải lên: 10/08/2014, 22:20

... 52 _PCR_GagF_GagR (JF288882) 52 5 Mouse DNA sequence, clone CH29-187G 15 CU407131 100% 0 /52 5 52 _PCR_LF2_GagR (JF288883) 54 0 Mus musculus chrom 5, clone RP23-280N22 AC123679 >99% 1 /54 0 112_PCR_LF2_GagR ... plasma samples from 50 -70 year old male patients including 159 prostate patients (Gleason score 5- 7) and 201 patients with no prostate cancer or urological disorders were used in this study TaqMan ... were heat inactivated at 56 °C for 30 A mixture of plasma samples and 2 .5 × 104 Page of 11 infectious units of GFP-carrying XMRV were incubated at 37°C for 30 before infecting 293T cells (5 × 104)...

Ngày tải lên: 13/08/2014, 01:20

... family kinase inhibitor, dasat- 23 24 25 26 27 28 29 30 31 32 33 Volume 8, Issue 11, Article R 255 Wang et al R 255 .10 inib (BMS- 354 8 25) , on human prostate cancer cells Cancer Res 20 05, 65: 91 85- 9189 ... dasatinib treatment Five dasatinib-sensitive cell lines, including two CK5expressing (PWR1E and RWPE2) and three CK5-nonexpressing cell lines (PC3, DU1 45 and LNCaP), were treated with dasatinib ... response data Since dasatinib is Genome Biology 2007, 8:R 255 http://genomebiology.com/2007/8/11/R 255 Genome Biology 2007, Volume 8, Issue 11, Article R 255 Wang et al R 255 .6 Figure protein levels uPA...

Ngày tải lên: 14/08/2014, 08:20