... equivalent of 13 million IU of colistin base per day for 19 days whilst experiencing a doubling of plasma creatinine levels In a cohort of 115 patients, Cheng et al identified four cases of potential ... Nephrology Working Group of the European Society of Intensive Care Medicine: Prevention of acute kidney injury and protection of renal function in the intensive care unit Expert opinion of the Working ... article as: Spapen et al.: Renal and neurological sideeffectsof colistin in critically ill patients Annals of Intensive Care 2011 1:14 Page of Submit your manuscript to a journal and benefit...
... group, comparisons of ipsilateral-contralateral sides, e talc group, comparisons of ipsilateral-contralateral sides, f control group, comparisons of ipsilateral-contralateral sides, g when groups ... comparisons of groups, ipsilateral side, 72 h and day (Bonferroni Corrrection is applied and results were considered significant when p < 0.0125), b comparisons of groups, contralateral side, 72 ... directly to the contents of the pleural space by denudement of mesothelial cells after administration of sclerosing agents [22] After the discontinuation of production of the injectable tetracycline...
... Temporal variation in the appearance of different sideeffects [40] and differential responses to a change in dose of medication (in number, duration or severity ofside effects) [5] in different individuals, ... clinician-rated sideeffectsof drug treatment in schizophrenia - Clinical validation of a self-rating version of the UKU Side Effect Rating Scale (UKU-SERSPat) Nordic Journal of Psychiatry 2001, ... increased reporting of symptoms [31,32] It therefore follows that persons high in neuroticism are also likely to self-report greater sideeffectsof medication, and this is of considerable interest...
... alternative course of action with a better understanding of their likely consequences If managers have an enhanced awareness of the possible future effectsof alternative courses of action, for making ... take what measures to achieve the goals of the organization Provides opportunity to analyze alternative courses of action: Another source of importance of planning is that it permits managers ... Allocation: Planning is means of judicious allocation of strategic and scarce resources of the organization in the best possible manner for achieving strategic goals of the organization The strategic...
... of angiogenesis This is useful for testing anti-angiogenic drug effects, but presents difficulties in showing augmentation of angiogenic effects Although growth factor-depleted formulations of ... representative of the general orientation and assembly of HUVECs in the co-culture without significant loss of information, compared to higher magnifications of 10x or 20x As a confluent layer of fibroblasts ... Figure 13 Effectsof various concentrations of HDZ, CPX, PDCA and 10 ng/ml VEGF on optimized sequential co-cultures of fibroblasts and HUVECs; all images obtained at 4x magnification (A) Immunofluorescence...
... TABLE OF CONTENTS Page No Acknowledgements i Table of Contents ii Summary (Abstract) vi List of Figures ix List of Tables xi List of Abbreviations xii LITERATURE REVIEW ... required for formation of capillary like structures Figure 13 Effectsof various concentrations of HDZ, CPX, PDCA and 10ng/ml VEGF on optimized sequential co-cultures of fibroblasts and HUVEC ... applications by pre-vascularization of three dimensional scaffolds viii LIST OF FIGURES Figure Schematic representation of HIF-1α protein domain structures Figure Regulation of the HIF-1 transcription...
... 208 Glossary of the Pharmaceutical World 210 Addresses 217 Footnotes 218 Side Effects: Death Confessions of a Pharma-Insider May 2007 The peculiarity of my story is ... He is one of the most prominent and successful lawyers in lawsuits concerning the effectsof psychotropic medicines on humans, which we commonly label with the innocent words sideeffects In ... just as the x Side Effects: Death industry stipulates The influence of the pharmaceutical industry is often invisible A year ago, I had a telephone conversation with the editor of a famous German...
... the in vitro effectsof flavonoids in the low micromolar range and in vivo work using oral solutions of flavonoids [13,14] Many of these plant polyphenols may modulate the activities of the multidrug ... pcDNA–HEK293 cells Nontoxic concentrations of each polyphenol were used in combination with increasing concentrations of etoposide to determine the effectsof the polyphenols on IC50 values and relative ... Quercetin inhibited 95% of the stimulated MRP4 ATPase activity, and silymarin inhibited 62% of this activity Effectsof quercetin and silymarin on photoaffinity labelling of MRP1 and MRP4 with [32P]...
... instead of +Pi medium Measurement of permeability of mitochondrial membrane to poly(ethylene glycol) To examine the permeability of the mitochondrial membrane, we measured the effectsof poly(ethylene ... additional novel effectsof DiS-C3(5) on mitochondria: (i) inhibition of the Ca2+induced PT by a low concentration of DiS-C3(5) and (ii) induction of swelling in the absence of Pi With respect ... actions of cyanine dyes were attributable Fig Effects of DiS-C3(5) on the turbidity of mitochondrial suspensions (A) and on permeability of mitochondrial inner membrane (B) (A) The effect of 50 lM...
... incidence ofsideeffects was high; nearly out of 10 patients reported sideeffectsof treatment In the larger clinical trials on statins, no specific differences in the frequency ofsideeffects ... initiated lifestyle changes and therefore did not consider themselves to be in need of statin treatment Sideeffects The occurrence ofsideeffects was reported by 20 patients (29%) No significant ... degree of adherence to statin treatment despite a high incidence ofsideeffects Simvastatin is used in higher doses in hospital clinics compared with primary care, but the incidence ofside effects...
... Because of the paucity of dose–response data for the region, it is unclear what level of deposition of either S or N would be appropriate for the protection of aquatic resources from adverse effects ... effects are of greater interest than episodic effects because of the nature of the hydrology of sensitive resources in the region Based largely on the results of space-for-time substitution analyses, ... reflect the tolerance of natural ecosystems to various inputs of atmospheric pollutants This need has given rise to the concepts of critical levels of pollutants and critical loads of deposition (e.g...
... essential for the determination of their climatic effects, development of techniques for remote sensing of aerosol from space or the necessary correction of atmospheric effects in satellite imagery ... top of atmospheric is the sum of the surface reflectance and atmospheric relfectance The signals measured in each of these visible bands represent a combination of surface and atmospheric effects, ... portion of mainland called “SeberangPerai” in Malay Language Penang Island is an island of 293 square kilometres located in the Straits of Malacca and “SeberangPerai” is a narrow hinterland of 753...
... real impact of skin toxicities on daily QoL, compared to generic tools as EORTC QLQ C-30 or SF-36 Conclusion This study documents the impact of skin sideeffects on quality of life of advanced ... oncological patients are considered [8,11,14,15] Respect to other conditions, the impact of skin sideeffects on colon cancer patients is relevant for all the three scales considered In particular ... scale, missing value was substituted by the mean of the total score of the scale [11] Higher scores indicate an increase impact of skin sideeffects on QoL, i.e a worse patient's QoL After informed...
... elevated levels of expression of IRF5 [1] also had a highly significant association with SLE (pooled, P = 2.11 × 10-16; Table S1 in Additional file 1) The strengths of the associations of both the ... of association of the IRF5 variant with SLE, which has satisfied most of the above criteria and been replicated among numerous white populations, additional replications among separate sets of ... patterns of linkage disequilibrium In this study of a Korean SLE cohort, we present associations of IRF5 variants with SLE similar to those suggested by previous studies Transcription factors of the...
... benefits in the treatment of RA, by reducing the formation of LTB4 and, by this means, decreasing the chemotaxis of inflammatory cells Few studies have investigated the effectsof 5-LO pathway inhibition ... the role of LTB4 in RA are well documented Although the presence of 5-LO enzyme in the synovial lining of rheumatoid tissue has recently been reported [24], a detailed characterization of cells ... enzymes in synovial tissue of RA and OA patients and phenotyped the positive cells In addition, we determined the effectsof intraarticular glucocorticoids on the expression of these enzymes in RA...
... 17) mild side effects; 17% (n = 5) moderate side effects; none with severe sideeffects GT (n = 33): 15%(n = 5) no side effects; 55% (n = 18) mild side effects; 27% (n = 9) moderate side effects; ... effects; 3% (n = 1) severe sideeffects TT (n = 18): 5% (n = 1) no side effects; 56% (n = 10) mild side effects; 28% (n = 5) moderate sideeffects 11% (n = 2) severe sideeffects (Refer appendix ... concentrations of patients (R2 = 0.107, p = 0.23) 85% of patients experienced some form of EFV-related side effect The majority of patients, who had experienced sideeffects following initiation of Efavirenz...
... dose-modification of these regimens, incorporation of a novel anticancer drug, pharmacokinetically guided administration of 5-FU or CDDP, and identification of responders via patient genetic profiling ... 5-FU/CDDP-based CRT This is the first report on the effectsof plasma concentrations of 5-FU on long-term survival in cases of esophageal cancer Page of Methods Patients Forty-nine ESCC patients were ... examination when all of the following criteria were satisfied on observation of the entire esophagus: 1) disappearance of the tumor lesion; 2) disappearance of Kuwahara et al Journal of Experimental...
... Table Percentage of subjects displaying each of the 17 sideeffectsof methylphenidate during each treatment condition (Parent Ratings)* Side Effect Total SideEffects Severe SideEffects Placebo ... frequencies of the 17 side effects, as well as the frequencies of severe side effects, between the placebo and active conditions Repeated measures analysis of variance (ANOVA) was used to detect the effects ... evaluation of the therapeutic response and sideeffects is often reported by the parents of the child with ADHD This may also lead to some correlation between therapeutic and sideeffects The aim of...
... Injection of type II bovine collagen in CFA 7x i.v treatment Collection of blood days after start of treatment Collection of blood days after end of treatment Collection of blood days after end of treatment ... glucocorticoid-related side- effects in both therapeutic modalities Eventually, the presence of liposomes and dexamethasone were monitored in plasma to correlate presence of the drug with the appearance of its side- effects ... significant inhibition of the collagen breakdown (Figure 2b) Side- effect profile of liposomal dexamethasone phosphate We next set out to directly compare glucocorticoid-mediated side- effects for both...
... Figure 27: Effectsof pre-treatment of drugs on DHE fluorescence (a) Representative photos of DHE-stained cells under 60X magnification with the scale bar of 40 µm indicated at the lower left of each ... Figure 32: Effectsof pre-treatment of drugs on IL-6 expression (a) mRNA expression of IL-6 expressed as fold difference of the untreated control group ± S.E.M (b) Protein expression of IL6 expressed ... SAC µM 1µM Aβ25-35 Figure 34: Effectsof pre-treatment of drugs on IL-10 expression of inflammatory factors (a) mRNA expression of IL-10 expressed as fold difference of the untreated control group...