5 searching for the genetic susceptibility to common cardiac arrhythmias

... permutations were performed To test the significance of each SNP conditional on the genotypes of other SNPs, logistic regression analysis was performed under the additive model for the minor allele ... of the patients into clinical subsets were carried out according to the American College of Rheumatology criteria for SLE [22] There was no overlap in cases or controls between this study and the ... Both genetic and environmental factors contribute to the development of SLE [1] Until now, several genes have been reported to be associated with SLE, of which interferon regulatory factor-5...

Ngày tải lên: 09/08/2014, 13:22

... rs179010, with SLE These SNPs and the 3’UTR rs3853839 were found to independently contribute to the genetic risk for SLE Materials and methods Patients and controls Three hundred forty-four Japanese ... needed to be analyzed for the association separately However, because of the female predominance of SLE (9:1 female to male ratio), the sample size of male SLE patients was too small to be analyzed ... all of the three SLE risk alleles, but not of the other haplotypes All of these results support the possibility that the possession of both the 3’UTR and intronic risk alleles may confer further...

Ngày tải lên: 12/08/2014, 15:22

... (Table 1) or in the other two larger studies, and which did not remain significant after accounting for the multiple comparisons performed The overall results therefore indicate that the ASPN microsatellite ... patients, similar to the Japanese study (power is 0.16 for the comparison of THR patients versus controls and is 0.29 for the comparison of TKR patients versus controls), probably due to the weak effect ... however, to detect a D14 effect of the size found in the Japanese [4], with P < 0.05 The power for the comparisons of THR Page of (page number not for citation purposes) Arthritis Research & Therapy...

Ngày tải lên: 09/08/2014, 07:20

... noted in the LRCH1 study [15], the difference in the ascertainment criteria is unlikely to account for the discrepancy A worldwide association study along with functional studies of the susceptibility ... be performed to clarify the significance of TXNDC3 as an OA susceptibility gene The authors declare that they have no competing interests Authors' contributions All authors contributed to the final ... laboratory personnel who were blinded to subject status A random 5% of the samples were subjected to repeat analysis to validate the genotyping procedures Two authors independently reviewed the...

Ngày tải lên: 09/08/2014, 10:23

... test was used to compare the GDF5 genotype with the allele distributions in the case-control study The differences in the clinical information between the genotypes were tested using the Mann-Whitney ... Examination Center, Drum Tower Hospital, affiliated to the Medical School of Nanjing University, China The controls had no symptoms or histories of CDH All subjects included in the study were of Han ... out during the process of the study The study was approved by the ethical committee of the participating institutions, and informed consent was obtained from patients and controls The ages of...

Ngày tải lên: 09/08/2014, 13:22

... to the interpretation of the results LP had the main responsibility for the genetic analyses and contributed to the analysis and interpretation of the results LA and LK were responsible for the ... of results and the writing of the manuscript CB contributed to the design of the study, to the collection of the data, to statistical analysis and to the writing of the manuscript IL contrib- Rooney ... contributed to the design of the study, and the interpretation and writing of the manuscript HK performed a major part of the biostatistics work and contributed to the interpretation of results and the...

Ngày tải lên: 09/08/2014, 07:20

... For the Toronto population, 207 PsA patients and 203 control individuals from the Toronto population were genotyped With respect to Toronto PsA patients, 61% were male and their mean age at the ... the Toronto population for the R620W variant of PTPN22 For the PsA patients the G/G, G/A and A/A genotypes were 153, 43 and 7, respectively, whereas for the Toronto control individuals they were ... with rheumatoid factor positivity and the minor (T) allele for the PTPN22 variant in either population With respect to Pro72Arg variant of tp53, 207 PsA patients were genotyped for the tp53 variant,...

Ngày tải lên: 09/08/2014, 07:20

... may commonly contribute to the pathophysiological process and common immunogenetic mechanisms underlying both autoimmune diseases, thus being in agreement with the hypothesis of the 'common genetic ... Castiblanco J: Is there a common genetic basis for autoimmune diseases? Clin Dev Immunol 2006, 13:185-195 56 Becker KG: The common genetic hypothesis of autoimmune/ inflammatory disease Curr ... subpopulations Dilution of the antiCD154 antibody to mimic low CD154 expression changed the shape of the histogram to form a single peak overlaid with the control peak In this situation, the percentages...

Ngày tải lên: 09/08/2014, 10:21

... develop RA is determined by genetic factors [1] Considerable efforts have been made to elucidate these genetic factors to better understand the disease However, even after the advent of genome-wide ... Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22620W allele Arthritis Res Ther 2005, 7:R1200-R1207 19 Schug J: Using TESS to ... and PA helped to perform analysis and interpretation of the data and to draft the manuscript VHT and UW (and the European Consortium on Rheumatoid Arthritis Families) contributed to the recruitment...

Ngày tải lên: 09/08/2014, 14:20

... staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining of the superficial epithelium of the ileum ... Authors' contributions AZV performed the molecular genetic studies and assisted in the recruitment of patients, the data analysis and the drafting of the paper SSN performed the sequencing RB recruited ... pH 4.6 and 95% EtOH to reaction tubes for 20 m and spinning tubes upright at 3600 rpm for 30 m Tubes were then inverted and spun at 700 rpm for m After washing the pellet in 70% EtOH, tubes were...

Ngày tải lên: 11/08/2014, 10:23

... cementoenamel junction (CEJ) • Type II: the enamel invagination into the root, beyond the CEJ, ending as a blind sac • Type III: the extension of the enamel-lined invagination through the root to ... papilla or the distortion of the enamel organ during tooth development [4-6] The reported prevalence of dens invaginatus ranges between 0.04 to 10% [7] The most affected permanent teeth are the maxillary ... the clinical findings including gingival condition, CAL, the severity and (to a lower extent) the pattern of bone loss, together with the subject’s age were used as diagnostic criteria When the...

Ngày tải lên: 11/08/2014, 20:20

... likely to be related to environmental, dietetic and genetic factors [46] Further studies are warranted to clarify the pathogenesis of this defect as nutritional, immunologic or genetic factors ... validate the hypothesis of their pathogenetic predisposition to oral mucosal lesions more than hard dental tissue lesions; further investigations are warranted to clarify the predictive role of these ... degree The grade enamel defects were generally localized on incisor surfaces (for the anterior sectors) (Figure 1) and cuspid surfaces (for the posterior sectors), with dimensions from to mm and...

Ngày tải lên: 11/08/2014, 23:22

... able to determine how occupation was inherited to the next generation We did this for all of our work class categories and calculated the odds ratio (OR) for inheriting the father's or the mother's ... on from parent to child for the cohort prior to age exclusion This confirmed that the farming profession is to a great extent passed on from parents to their children Of the father-son relationships ... (0.71 to 5.7) 1.6 (0.85 to 3.0) 0.93 (0.44 to 2.0) 0.74 (0.44 to 1.3) Service and shop workers 1.5 (0.41 to 5.2) 2.1 (1.0 to 4.2) 1.3 (0.63 to 2.6) 0.79 (0.48 to 1.3) Farmers 5.1 (2.1 to 12.4)...

Ngày tải lên: 12/08/2014, 14:21

... will make the joint easier to be dislocated D14 allele had a significant higher inhibitory effect on TGF-b signaling [15], it may contribute to the susceptibility of DDH via one or both of these ... China Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan Authors’ contributions All authors contributed to the final ... to 51) months and 57.5 ± 11.9 (range, 40 to 97) years, respectively The ratio of female to male was about 6:1 in these cases Genotyping Genomic DNA was extracted from peripheral blood using the...

Ngày tải lên: 12/08/2014, 15:22

... 13 15 17 The authors declare that they have no competing interests Authors' contributions MEF had the idea, designed and supervised the study, and is the guarantor IIS and IAB performed the literature ... identified the relevant studies to be included in the analysis, and extracted the data for the study MEF and IAB wrote a first version of the manuscript All authors made substantial revisions of the ... colonization with these pathogens Although the aforementioned studies attempted to unravel the prognostic importance of colonization or infection with A baumannii, the disagreement between their results...

Ngày tải lên: 12/08/2014, 23:23

... i.e whether individual i has the potential to be selected as a control at time tjk The restriction for tjk is that it has to be within the time frame from the start of follow-up si to the event ... shown in the Appendix B Note that the numbers in the top margin of Table 3.1 are the numbers of controls per 22 case for study B, which vary from to The numbers in the left margin are the numbers ... 0.130 to 0.078) in the variance, with only small further reductions when the number of prior subjects in study A is further increased up to six per case The values in columns to of the table are the...

Ngày tải lên: 12/10/2015, 17:36

... diagnosed by clinical experience or by other methods The other methods group included patients who could not afford to go to hospital, and when the families of these individuals were interviewed, ... the Chinese Academy of Medical Sciences who supported the original survey We thank Professor Richard Peto, who gave us great support for the project The cooperation of the local government, the ... (140–149,161) into one group named “minor site cancers” because the death rates for these cancers were too low for separate analysis Two different control groups were selected The first group...

Ngày tải lên: 26/10/2012, 09:48

... - to menopause; the elevation was smaller for the first, second and fourth time-windows although there was limited power to distinguish them (Table 7) For Metric II, the point estimates for the ... volunteered their time The funding bodies played no role of the design, collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for ... considerably when compared to retail For example, the automotive plastics OR increased from 3.12 to 5.38 (95% CI, 2.34-12.4) When durations in the minor sectors (lagged) were analyzed in the model (Table...

Ngày tải lên: 06/03/2014, 02:21

... activity The CROME study gathered the occupational histories of 299 breast cancer cases, which were then compared to 237 women with cancers other than breast or ovary It found an elevated risk for ... to small sample size duration did not reach statistical significance for any of the specific periods In the next step, the odds ratios for the independent variables (e.g., farming) indicate the ... CANCER 773 to underestimate the actual risks.58 Another limitation of the LOHR study was the small sample size, which necessitated the grouping of occupational categories thereby increasing the risk...

Ngày tải lên: 06/03/2014, 02:21