5 induction of lasting tolerance only in naive individuals
Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
Ngày tải lên :
09/08/2014, 01:24
... capable of differentiating into TR cells following activation are derived from a separate lineage of CD4+ T cells, and whether their induction is a result of the initial activation early in the inflammatory ... amounts of IL-10 when stimulated These cells are capable of directly generating Tr1 cells in vitro and in vivo, and may represent a naturally occurring dendritic cell subset involved in eliciting tolerance ... stimulating CD4+ T cells through coengagement of CD3 and the complement regulator CD46 in the presence of IL-2 These conditions resulted in IL-10producing cells capable of inhibiting the activation of...
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Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf
Ngày tải lên :
09/08/2014, 08:23
... severity of joint pathology Intra-articular injection of PGN into murine joints triggered arthritis in a dose-dependent manner [17] A single injection of this compound caused massive infiltration of ... components The profile was similar to that induced by a combination of IL-1/TNF, which might indicate the involvement of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by ... were maintained in DMEM/F-12 containing 10% FBS, 100 U/ml penicillin, and 100 μg of streptomycin All the fibroblast cell lines were from a cell culture bank established by A Postlethwaite in accordance...
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Báo cáo y học: "Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice" docx
Ngày tải lên :
11/08/2014, 08:21
... cysteine is increased in some tissues including spleen during the acute phase of sepsis in rats GSH synthesis rates are significantly increased in spleen and thymus during the acute phase of sepsis ... supply of The activity of system xc- sustains the cystine/cysteine cycle, and thus maintains the redox balance between cystine and cysteine in cultured cells [5] In sepsis patients, the levels of ... a significant increase in plasma concentration of cystine and decrease in plasma concentration of GSH, resulting in the oxidative shift towards cystine in the plasma cystine/cysteine ratio [23]...
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Báo cáo y học: "Stimulation dependent induction of fear and depression in deep brain stimulation: a case report" docx
Ngày tải lên :
11/08/2014, 14:21
... end of STN typical signals during intraoperative micro-recording In a prospective study of 17 patients, intraoperative stimulation-dependent autonomic side effects were reported in 19.6% of the ... calculated mean point was within the STN according to Talairach coordinates [16] Given the mean diameter of the STN of 2.5-2.5 mm and the variety of side effects, a direct attribution of all of these ... caudal of the beginning of SNR typical signals The electrode position inducting the postoperative depressive state, re-evaluated using postoperative stereotactic CCT technique, was 3.5 mm rostral of...
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Báo cáo khoa học: " Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4" ppt
Ngày tải lên :
12/08/2014, 04:21
... cells Staining of the cytoplasm was also present, but to a lesser extent In contrast, in bird there appeared to be N protein staining associated with areas of gliosis; in those foci staining appeared ... coordination of the study, performed the inoculation of the cockatiels, participated in the clinical monitoring of the inoculees, performed necropsies, participated in the TEM screening of samples, ... variability in ABV strain virulence, host response and/or the interplay of these factors may influence the development and transmission of PDD in psittacines, warranting further investigation into the...
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Báo cáo khoa học: " Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4" doc
Ngày tải lên :
12/08/2014, 04:22
... cells Staining of the cytoplasm was also present, but to a lesser extent In contrast, in bird there appeared to be N protein staining associated with areas of gliosis; in those foci staining appeared ... coordination of the study, performed the inoculation of the cockatiels, participated in the clinical monitoring of the inoculees, performed necropsies, participated in the TEM screening of samples, ... variability in ABV strain virulence, host response and/or the interplay of these factors may influence the development and transmission of PDD in psittacines, warranting further investigation into the...
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Báo cáo sinh học: "Comparison of different delivery systems of DNA vaccination for the induction of protection against tuberculosis in mice and guinea pigs" pps
Ngày tải lên :
14/08/2014, 19:22
... single subcutaneous injection of about 105 live bacteria in 50 μl saline Animals received a single-dose of an intramuscular injection of 2.5 mg of microspheres in 50 μl saline into each quadriceps ... The kinectics of protein release from microspheres was evaluated by ressuspending 30 mg of proteinloaded microspheres in ml of PBS containing sodium azide (0.05% w/v) The suspension was maintained ... capable of sustaining the protective response in mice and guinea pigs Therefore, using biodegradable microspheres in a single dose seems to be a promising strategy for stimulating long -lasting immune...
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Báo cáo sinh học: " Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" docx
Ngày tải lên :
14/08/2014, 19:22
... cellular infiltration using haematoxylin and eosin (H&E) staining The degree of cellular infiltration was scored as described previously [6] Inflammatory changes were graded by histopatholog- Page of ... OVA-reduced level of INF-γ in BAL fluid, as immunization with PBS or pcDNA3.1 (p < 0.05, Fig 4C) Figure Levels of interleukin-4 (A), interleukin-5 (B) and interferon gamma (C) in bronchoalveolar ... effective than DNA vaccine encoding only OVA in suppressing airway inflammation We found that local exposure to OVA resulted in an increased number of spleen DCs expressing CD11c+CD80 and CD11c+CD86...
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Báo cáo sinh học: "Localization of leucocyte interferon gene in the q2.5 region of pig chromosomel by in situ hybridization" potx
Ngày tải lên :
14/08/2014, 19:23
... number of grains pointed in this region is so high, that we could have reduced the number of spreads scored to one third and still maintain a significant signal In the first experiments, only 5% of ... by in situ hybridization Cytogenet Cell Genet 39, 220-223 Lefevre F & Labonnardi6re C (1986) Molecular cloning and sequencing of a gene incoding biologically active porcine interferon alpha J Interferon ... explain the efficiency of in situ hybridization This observation confirms the one given by Lin et al 1985 We have also modified the washings after hybridization They are less stringent and, in...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
Ngày tải lên :
25/10/2012, 11:04
... pneumatization results in the individual size and shape of the frontal sinus An absence of pneumatization in the frontal bone results in frontal sinus aplasia [1] This kind of variation should make ... prevalence of frontal sinus aplasia and agenesis using dental volumetric tomography in a population of Turkish individuals 279 was performed using two light-beam markers The vertical positioning light ... (25% in males and 36% in female) and Canadian Eskimos (43% in males and 40% in female) [21,22] According to the literature, the frequency of a bilateral absence of the frontal sinuses (Fig 3) in...
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Tài liệu Báo cáo Y học: Induction of (2¢)5¢)oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide docx
Ngày tải lên :
21/02/2014, 15:20
... within amino acid 104 and amino acid 158 of the murine enzyme [53]; in S domuncula a related stretch has been found between amino acid 76 and amino acid 125 The polyA-related domain, found in enzymes ... DISCUSSION Inhibition of cell growth, apoptosis and inhibition of protein synthesis are ways of protection of metazoan organisms against death caused by microbes The bacterial endotoxin LPS causes ... activation of the enzyme resulting in the formation of the p3An products and a second, that increases the steady-state level of the transcripts of the corresponding (2–5)A synthetase gene In vertebrate...
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Báo cáo y học: "Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/ cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma"
Ngày tải lên :
26/10/2012, 09:53
... morning [21-24], being consistent with the findings of this study However, in the NDP group, the pattern of 310 circadian rhythm in 5-FU pharmacokinetics was certainly different from that in the ... ESCC, but when using NDP instead of CDDP, it is necessary to look for some marker capable of indicating clinical response In conclusion, only a small number of patients were enrolled in this study, ... recurrence were included in this study Protocol The protocol is presented in Figure A course consisted of continuous infusion of 5-FU at 400 mg/m2/day for days 1-5 and 8-12, infusion of CDDP or NDP...
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MUTAGENIC INDUCTION OF AGRONOMICAL AND YIELD CONTRIBUTING TRAITS IN SOYBEAN (GLYCINE MAX (L.) MERRILL) WITH GAMMA IRRADIATION
Ngày tải lên :
29/08/2013, 08:14
... (albina) and B (chlorina) in cultivar DT12; C (albina) in cultivar DVN6 Aa B Fig Changes in leaves: A petafoliate in ĐT12; B tetra foliate in ĐT20 A B Fig Changes in plant height and branching ... particular through conventional breeding methods Hence, alternative methods of generating variability have gained greater importance in breeding of crop plants including soybean and may serve as supplements ... shortened plant height with early branching in ĐT12; B no branching in ĐVN6 581 Mutagenic induction of agronomical and yield contributing traits in soybean (Glycine max (L.) Merrill) with gamma irradiation...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
Ngày tải lên :
19/02/2014, 17:20
... expression of ESE-1 [31] The role of Ets factors in inflammation and in the regulation of cytokine-responsive genes has not been studied in detail However, several genes, including urokinase-type plasminogen ... cells leads to an induction of ESE-1 mRNA expression within h of exposure, reaching a peak at h and leveling off after 24 h [12] To investigate the level of ESE-1 protein following LPS exposure, ... were infected with adenovirus for h in serum-free medium using a multiplicity of infection of 300 After infection the cells were washed with medium and incubated for 16 h in DMEM containing 10%...
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The effect of grammar teaching (syntax) in English on 5 to 16 year olds’ accuracy and quality in written composition potx
Ngày tải lên :
10/03/2014, 05:20
... arising from the use of language in speech and writing on the other It is interesting to note that in the evaluation of the pilot of ‘The Key Stage Strategy’ (Office for Standards in Education (Ofsted), ... definitions of 15 reviews, 12 'The findings from international research grammar by Hartwell (1985) individual clearly indicate that the teaching of The effect of grammar teaching (syntax) in ... difficulties of screening papers for inclusion in this review were due to problems with ascertaining the level of grammar teaching operating in the studies (word, sentence or text) Therefore initial inclusive...
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Báo cáo khoa học: Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family ppt
Ngày tải lên :
15/03/2014, 00:20
... experiments, reducing agent was included, and protein samples were processed quickly, aiming to avoid potential oxidation of the protein, or reaction between the protein and reducing agent The inactive ... structures found in the Protein Data Bank (PDB) (including three that are unpublished) in Table and Fig The majority of Ca ˚ atoms match within a A cut-off when the dimers are compared As in TcRpiB, ... matching residues (%) Contact in dimer interface, per subunit ˚ (A2) Contact in tetramer interface, per dimer ˚ (A2) Protein PDB code Ligand bound Number of residues in sequence Number of Ca...
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Báo cáo khoa học: Tumor suppressor p16INK4a ) modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells ppt
Ngày tải lên :
16/03/2014, 10:20
... domain As in the binding studies with plant lectins, we routinely performed experiments to assess concentration dependence and inhibition of galectin binding by haptenic sugar Profiling of galectin ... neuraminidase activity should enhance PNA staining of the control cells, with a minor in uence on the p16INK4a-expressing cells and on DBA staining The importance of this aspect has been pointed ... galectin-1 up-regulation, the increased presentation of galectin-1-binding sites in p16INK4a-expressing cells and acquisition of anoikis susceptibility associated with the fibronectin receptor Induction...
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Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf
Ngày tải lên :
16/03/2014, 12:20
... cells lation of steroidogenesis using 300 lm AA in the presence of albumin These different results can be explained by the fact that protein binding can increase the overall concentration of fatty ... normalized against the intensity of the signal of unlabeled AA stained with iodine Bars denote levels (in arbitrary units) of AA in mitochondria Results are expressed as the mean ± SD from three independent ... effect of AA on cholesterol transport in mitochondria The absence of hormone ⁄ cAMP-induced steroid synthesis when protein synthesis is inhibited can be explained now by the inhibition in the induction...
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Báo cáo khoa học: Fatty acid composition of chylomicron remnant-like particles influences their uptake and induction of lipid accumulation in macrophages pot
Ngày tải lên :
16/03/2014, 12:20
... bind to the LDL receptor family in its lipid-free state The receptorbinding region is in an amphipathic a-helix which is part of a four-helix bundle structure in the N-terminal domain, and interaction ... following the manufacturer’s instructions 5638 Culture of THP-1 cells and experimental protocol THP-1 monocytes were maintained in suspension in RPMI 1640 culture medium containing 10% fetal bovine ... surface remnants of triglyceride-rich lipoproteins Arterioscler Thromb 14, 622–635 Pal S, Semorine K, Watts GF & Mamo J (2003) Identification of lipoproteins of intestinal origin in human atherosclerotic...
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Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot
Ngày tải lên :
17/03/2014, 10:20
... by anti-IFN-c Ig, of LPS-induced NO production in murine PEC but not in the RAW264.7 murine macrophage cell line Cells of murine PEC and of the RAW264.7 murine macrophage cell line were cultured ... production of NO in macrophages stimulated with LPS, via activation of NF-jB and its binding to region in the promoter of the iNOS gene [11,12] In the present study, LPS-induced NO production in the ... mice The role of IFN-c, as well as of IL-12 and IL-18, as intermediates in the pathway of LPS-induced NO production, was indicated from the results obtained above Preparations of recombinant IFN-c,...
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