5 high dose chemotherapy and allogeneic stem cell transplantation
Báo cáo y học: "Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms" pps
... aspirate sample using standard culture methods and GTG banding revealed a normal 46, XX[25] karyotype at the time of the diagnosis of secondary AML prior to allogeneic stem cell transplantation (allo-SCT) ... Vwa, D13S317, and TPOX) were informative and showed the coincidence of profile between AML blasts after transplantation and the donor’s cells, supporting full engraftment of the stem cell transplant ... polymorphisms and recurrence after treatment for superficial bladder cancer Clin Cancer Res 2005, 11:1408-1415 Flynn CM, Kaufman DS: Donor cell leukemia: insight into cancer stem cells and the stem cell...
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Tài liệu Review of Chronic Graft- Versus-Host Disease in Children After Allogeneic Stem Cell Transplantation: Nursing Perspective pptx
... blood stem cell transplantation; BMT, bone marrow transplantation; UBMT, unrelated bone marrow transplantation; T-UBMT, T -cell- depleted bone marrow transplantation; UCBT, umbilical cord blood transplantation; ... Biology of Blood and Marrow Transplantation, 13, 1207-1215 Joseph, R W., Couriel, D R., & Komanduri, K V (2008) Chronic graft-versus-host disease after allogeneic stem cell transplantation: Challenges ... ease after allogeneic hematopoietic stem cell transplantation Biology of Blood and Marrow Transplantation, 8, 674-682 Richards, S J., Morgan, G J., & Hillmen, P (1999) Analysis of T cells in paroxysmal...
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Báo cáo y học: " Successful treatment of severe sinusoidal obstruction syndrome despite multiple organ failure with defibrotide after allogeneic stem cell transplantation: a case report" ppsx
... (total dose Gy), fludarabine 30 mg/m2 on days to (total dose 120 mg/m2) and cyclophosphamide 30 mg/kg on days and (total dose 60 mg/kg) Immunosuppression was accomplished by cyclosporine A (CsA) and ... of prophylactic anticoagulation and the risk of hepatic venoocclusive disease in patients undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis Bone Marrow Transplant ... jaundice and bilirubin >34.2 µmol/l; 2) hepatomegaly or right upper quadrant pain; and 3) fluid retention >2% of the initial body mass We initiated treatment with defibrotide (starting with a dose...
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Myocardial protection and therapeutic angiogenesis using peptide and embryonic stem cell transplantation
... angiogenesis and vasculogenesis: Cellular approach Adult mesenchymal stem cells Smooth muscle cells Hematopoietic stem cells and progenitor cells Endothelial progenitor and endothelial cells Bone ... exogenous stem cells and differentiated cells and also by enhancing the mobilization of endogenous stem cells These cells have natural capacity of participating in therapeutic angiogenesis and vasculogenesis ... Low dose: 0.005 and 0.017µg/kg High dose: 0.05 and 0.167µg/kg Coronary artery disease 15 I Low dose: 17ng/kg High dose: 50ng/kg Coronary artery disease 178 II Reference Dose Hendel et al, Low dose: ...
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Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... established two Ptb) ⁄ ) ES cell lines, and found that Ptb) ⁄ ) ES cells showed severe defects in cell proliferation in vivo and in vitro (Figs 3B and 4B) As Ptb) ⁄ ) ES cells exhibit a low proliferation ... blue-staining-negative cells to that of total cells Cells (3 · 105) were seeded on growth medium and counted every day for days of culture The circles indicate the values for wild-type cells and the triangles ... undifferentiated state and did not lead to precocious differentiation PTB in development and ES cells 2.5 1.5 0.5 +/+ –/– Fig Ptb) ⁄ ) ES cells have a severe defect in cell proliferation in vivo and in vivo...
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báo cáo khoa học: " LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus?" ppsx
... gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice Stem Cells 2008, ... theory If LgR5 marks stem cells, there are many of LgR5 negative non -stem cells, which are nevertheless cycling Therefore a combination of clonal selection and cancer stem cell model, as previously ... that tumors are initiated and driven by a single, abnormal type of cancer stem cell, resulting in a population of genetically identical tumor cells This is the ‘cancer stem cell hypothesis’ (CSC)...
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Báo cáo y học: "Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome" pptx
... Bilirubin level during chemotherapy and allogeneic hematopoietic stem cell transplantation Chronological dates of the treatment courses were indicated (A) the first cycle of chemotherapy of DA regimen ... phenobarbital, rifampin and phenytoin, were used in the diagnosis and treatment of GS [8,9] List of abbreviations GS: Gilbert’s syndrome; allo-HSCT: Allogeneic hematopoietic stem cell transplantation; ... al.: Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome Journal of Hematology & Oncology 2011 4:9 Submit your next manuscript to BioMed Central and take...
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Báo cáo y học: "Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation" pot
... Zhu P: Patterns of T -cell reconstitution by assessment of T -cell receptor excision circle and T -cell receptor clonal repertoire after allogeneic hematopoietic stem cell transplantation in leukemia ... T -cell generation by patients after either T -cell- depleted or unmodified allogeneic hematopoietic stem cell transplantations Blood 2002, 100:2235-42 Poulin JF, Viswanathan MN, Harris JM, Komanduri ... TRBV-BD1 sjTRECs and data management; ZKE and DX and LQF provided the patients’ samples SHC, YLJ and WJF performed the RT-PCR and real-time PCR YQL were responsible for the study design and data management...
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báo cáo khoa học: "Serum proteomic profiling and haptoglobin polymorphisms in patients with GVHD after allogeneic hematopoietic cell transplantation" pps
... 95°C for and annealing and extension at 69°C for (in the presence of primers A and B or primers A, B, C, and D) or (in the presence of primers C and D only), repeated for 35 cycles, and followed ... research and participated in the design of the study SA, CW and RB carried out the clinical research and participated in clinical patient care GH and WY participated in In-gel digestion and protein ... clinical date collection and coordinated patient specimen collection JW and YY participated and conceived in the design of the study and coordination All authors read and approved the final manuscript...
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báo cáo khoa học: "Multiple Myeloma Involving Skin and Pulmonary Parenchyma after Autologous Stem Cell Transplantation" potx
... disease after autologous stem cell transplantation The presence of circulating plasma cells and hyperammonemia are both known to be indicators of advanced disease Plasma cell neoplasm should be ... of clinical care of the patient and the collection of data and the review of the manuscript RW performed immunohistochemical analysis YY drafted the manuscript and reviewed the literature, as ... editors to be a proxy for the patient's informed consent for the publication of the manuscript and accompanying images, in light of the fact that the patient had expired A copy of the written...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" doc
... reactivation is frequently reported in patients after allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with ... four cycles of ABV and involved field radiation Seven months later the lymphoma relapsed and two cycles of DexaBEAM with stem cell harvest were applied We performed high -dose chemotherapy according ... Kim CC: Human herpesvirus-6 as a possible cause of encephalitis and hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation Leukemia 2002, 16:958-959 Vu T, Carrum G, Hutton...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" ppsx
... reactivation is frequently reported in patients after allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with ... four cycles of ABV and involved field radiation Seven months later the lymphoma relapsed and two cycles of DexaBEAM with stem cell harvest were applied We performed high -dose chemotherapy according ... Kim CC: Human herpesvirus-6 as a possible cause of encephalitis and hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation Leukemia 2002, 16:958-959 Vu T, Carrum G, Hutton...
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Báo cáo y học: " Overcoming beta-agonist tolerance: high dose salbutamol and ipratropium bromide. Two randomised controlled trials" pps
... the last two doses Immediately after the challenge, 200 µg salbutamol or 40 µg ipratropium was given via a metered dose inhaler and large volume spacer FEV1 was measured 5, 10, 15, 20 and 30 minutes ... of salbutamol via metered dose inhaler In terms of bronchodilation, 2.5 mg via a nebuliser is equivalent to 800 µg via metered dose inhaler and spacer [22] We used a mg dose of nebulised salbutamol ... the response to other bronchodilators regardless of intracellular signalling pathways [18,19] Given the role of high dose beta-agonist and ipratropium bromide in the management of asthma exacerbations,...
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Possible role of diva in microglial dual effects and the stem cell differentiation
... members in cell cycle……………………………………….19 Cell cycle and stem cell differentiation……………………………………………….20 6.1 Neural stem cells……………………………………………………………… 20 6.1.1 Neural stem cells in vivo and in vitro………………………………… ... wide range of cell types The cell cycle of stem cells is unusual characterized with a very short G1 phase and a high proportion of cells in S-phase (White and Dalton, 2005) As stem cells differentiate, ... that overexpression of pro- and anti-apoptotic members of the Bcl-2 family could affect cell- cycle in an inverse fashion 19 Cell cycle and stem cell differentiation Stem cells have the capacity of...
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Tài liệu INNOVATIONS IN STEM CELL TRANSPLANTATION doc
... Bhatnagar and Ashraf Z Badros Chapter Proteasome Inhibition and Hematopoietic Stem Cell Transplantation in Multiple Myeloma 221 Helgi van de Velde and Andrew Cakana Chapter 10 Autologous Stem Cell Transplantation ... Contents Chapter Current Approach to Allogeneic Hematopoietic Stem Cell Transplantation 155 Hugo F Fernandez and Lia Perez Chapter Controversies in Autologous Stem Cell Transplantation for the Treatment ... Section Basic Aspects of Stem Cell Transplantation Chapter Immunogenetics of Hematopoietic Stem Cell Transplantation Amanda Vansan Marangon, Ana Maria Sell, Daniela Maira Cardozo and Jeane E L Visentainer...
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Tài liệu New Advances in Stem Cell Transplantation Edited by Taner Demirer ppt
... related to stem cells and Cell Transplantation, we feel it is important to take this opportunity to share these new developments and innovations describing stem cell research in the cell transplantation ... for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells Stem Cells 27, 1042-1049 18 New Advances in Stem Cell Transplantation Cho, M.K., McGee, G., and Magnus, ... presentation and T -cell recognition, and appear to be important in innate immunity as ligands to NKG2D receptor expressed on most γ T cells, CD8 T cells, and NK cells (Tieng et al., 2002) 4.2 MICA and...
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Báo cáo y học: "Hematopoietic stem cell transplantation for systemic lupus erythematosus" ppsx
... systemic lupus erythematosus with high -dose chemotherapy and haemopoietic stem- cell transplantation: a phase I study Lancet 2000, 356: 701-707 Traynor A, Burt RK: Haematopoietic stem cell transplantation ... by 4–6 days compared with the same dose of cyclophosphamide without hematopoietic stem cell support, and also to hasten stem cell regeneration of the immune system under the umbrella of the ATG ... haematopoietic stem cell transplants for autoimmune disease — feasibility and transplant-related mortality Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, ...
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Báo cáo y học: "Stem cell transplantation for rheumatic autoimmune diseases" potx
... hematopoietic stem cell transplantation Hematopoietic stem cell transplantation (HSCT) is a complex multistep procedure involving mobilisation and harvesting of hematopoietic stem cells (HSCs) ... showing increases in T -cell receptor excision circles and CD31+ T cells and normalisation of new T -cell receptor repertoires [53,54] Allogeneic hematopoietic stem cell transplantation The interaction ... hematopoietic stem cell transplantation in autoimmune disease Autologous hematopoietic stem cell transplantation In autologous HSCT, conditioning with high -dose cyclophosphamide, ATG, and/ or TBI...
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