5 small ubiquitin like modifier sumo modification of signaling pathways in palatogenesis
Role of promyelocytic leukemia (PML) and small ubiquitin like modifier (SUMO) proteins in alternative lengthening of telomeres
Ngày tải lên :
11/09/2015, 10:18
... modifications of a protein may also involve the attachment of other proteins or peptides, such as ubiquitin and the small ubiquitin- like modifier (SUMO) Subsets of a pool of proteins may be modified ... participates directly in substrate recognition of the SUMO consensus motif 1.1.2.3 SUMO ligase (E3) Most of the SUMO E3 ligases contain a RING finger -like domain termed SPRING motif This cysteine-rich motif ... isoforms of PML Thus while the RBCC motif is conserved in all PML isoforms, the isoforms differ in their C-terminal regions 1.2.1 RING finger motif The RING finger motif is a cysteine-rich zinc...
- 236
- 874
- 0
Báo cáo khoa học: Dynamin-like protein-dependent formation of Woronin bodies in Saccharomyces cerevisiae upon heterologous expression of a single protein pdf
Ngày tải lên :
23/03/2014, 07:20
... formed in yeast which is likely to contain only minor inclusions of peroxisomal matrix proteins A C Vps1p and Dnm1p: two dynamin -like proteins involved in fission of peroxisomes and Woronin bodies ... numbers of Woronin bodies were reduced [21] It will be interesting to see whether the absence of both dynamin -like proteins prevents the fission of Woronin bodies in filamentous fungi It is worth noting ... components of the peroxisomal fission machinery by examining the fate of HEX1 in a vps1Ddnm1D double-deletion strain The results are discussed in terms of a mechanism for the formation of Woronin bodies...
- 10
- 350
- 0
Báo cáo y học: "Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort" pot
Ngày tải lên :
09/08/2014, 14:22
... diagnosis within the first year of follow-up Evidence of confounding between the serologic markers was found as removal of RF resulted in an increase in the regression coefficient of ACPA exceeding 15% ... Metacarpo-phalangeal joint, proximal interphalangeal joint, or metatarso-phalangeal joint joint swelling.*P < 0.25, variable selected for inclusion in multivariate analyses ACPA = anti-citrullinated protein antibody; ... Metacarpo-phalangeal joint, proximal interphalangeal joint, or metatarso-phalangeal joint joint swelling ACPA = anti-citrullinated protein antibody; CI = confidence interval; CRP = C-reactive protein; DMARD...
- 8
- 328
- 0
catalytic modification of flammable atmosphere in aircraft fuel tanks
Ngày tải lên :
29/11/2014, 06:55
... aircraft of fuel in altitude, is concentrations initial point to point A in Figure 1.1b going concentration is gaining the vaportheconcentration of fueldoes not change because the vapor pressure of ... was used initially A slight difference in the inlet and outlet fuel In the final set of tests, a mixture of silica and 0.155 g of a platinum catalyst is placed in the concentrations indicated ... series ofillustrates aircraft; takeoff,reactor.and landing return to the tank for a in the tank status of the process of initial inerting and composition changes Figure 1.1b typical flight may be in...
- 51
- 223
- 0
Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt
Ngày tải lên :
08/03/2014, 10:20
... calmodulin and PtdIns3K In guinea pig neutrophils, it has been demonstrated that inhibition of calmodulin results in inhibition of Rac and p21 activated kinases [50] Involvement of Rac in ROS ... effector of Ca2+, in the regulation of intracellular signaling was analyzed by using the inhibitor W7 This inhibitor was found highly specific for calmodulin [34], although the possiblity of nonspecific ... elevation of [Ca2+]i are in themselves insufficient in the protection of neutrophils against apoptosis DISCUSSION In this study, the role of Ca2+ and its downstream effector calmodulin in G-protein-coupled...
- 10
- 537
- 0
Báo cáo sinh học: " The involvement of survival signaling pathways in rubella-virus induced apoptosis" ppt
Ngày tải lên :
18/06/2014, 22:20
... magnitude of RV-induced apoptosis To evaluate the role of PI3K-dependent signaling during RV infection, the effects of PI3K inhibitor LY294002 on the development of RV-induced apoptosis were examined, ... Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation Biochem ... 37°C in 5% CO2 in air Cells were treated, in a final volume of 100 µl, with RV and kinase inhibitors as described above At indicated times p.i., 50 µl of labeling mixture containing XTT (sodium...
- 12
- 357
- 0
Báo cáo y học: "Participation of the PI-3K/Akt-NF-κB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 " pot
Ngày tải lên :
12/08/2014, 16:20
... while TGF-β inhibits Flk-1/KDR expression through a mechanism that involves reduced binding of GATA-2 to a palindromic GATA site in the 5'-UTR [30] These findings indicate that the binding of specific ... [31] In unstimulated cells, binary complexes of these subunits are restricted to the cytoplasm by interaction with members of a family of inhibitory proteins, inhibitors of κB (IκBs) [32] In response ... NF-κB signaling pathways is essential for HIMF-induced Flk-1 expression in endothelial cells Discussion Endothelial cell tyrosine kinase receptors are of fundamental importance in transmission of...
- 14
- 221
- 0
Báo cáo y học: "Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development" potx
Ngày tải lên :
14/08/2014, 20:22
... Zeinoxanthin zeinoxanthin -carotene Zeaxanthin zeaxanthin Lutein lutein Violaxanthin violaxanthin ABA Figure Circadian co-regulation of metabolic pathways Circadian co-regulation of metabolic pathways ... transcripts, including the following: RNA processing; DNA synthesis and chromatin structure; protein synthesis, secretion, and ubiquitin- mediated degradation; G-proteinmediated signaling; and cell ... circadian-regulated genes ('C+E intersection') at the intersection of the combined Covington and Edwards datasets contains almost all of the circadian genes found by analysis of the individual Covington and Edwards...
- 18
- 400
- 0
Báo cáo y học: "Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo" ppsx
Ngày tải lên :
14/08/2014, 21:20
... between multiple signaling pathways, the ability to detect the activation status of individual pathways within a complex network of other pathways in the cell is of paramount importance In this manner, ... performed by heating sections in pH 6.0 citrate buffer Sections were then rinsed in PBS and incubated in blocking buffer (5% bovine serum albumin, 0.3% Triton X-100, 10% normal goat serum, in PBS) for ... pathway activation following short-term Ras induction in the mammary gland (a) Mapping of mammary glands expressing activated Ras for increasing times (filled triangles) or uninduced controls (open...
- 11
- 262
- 0
characterization of signaling pathways and significance of the axon guidance molecule plexin b3 in glioma progression
Ngày tải lên :
11/09/2015, 09:11
... in semaphorins include PSI (plexin, semaphorin and integrin) domains, immunoglobulin (Ig) -like domains, thrombospondin domains and PDZ-domain binding sites Additional domains present in plexins ... Identification of fascin-1 binding regions in the intracellular domain of plexin-B3 122 3.4.4 Identification of CIPP binding regions in the intracellular domain of pleinx-B3 ... of interaction with, and linkage to the cytoskeletal and signaling partners Many different proteins such as talin, vinculin, and ERM (ezrin, radixin, moesin) actin-binding proteins, act as linker...
- 286
- 266
- 0
Báo cáo khoa học: Meiosis and small ubiquitin-related modifier (SUMO)conjugating enzyme, Ubc9 potx
Ngày tải lên :
07/03/2014, 09:20
... site, the sumoylation target sites are in the C-terminal part of CcLim15 (amino acids 105–347), which contains the ATPase domain [15] Intriguingly, the sumoylation target domain of CcLim15 coincides ... Ubc9-mediated sumoylation [35] In S cerevisiae Zip3, a protein involved in the initiation of SC formation, is a SUMO E3 ligase [33,35] In a Zip3-lacking mutant, a polycomplex was formed instead of the ... CcPCNA may be involved in recruiting the replication polymerase (Fig 1) PCNA is known to interact with Ubc9 and is sumoylated or ubiquitinated at Lys164 Ubiquitination of PCNA is involved in the DNA-damage-tolerance...
- 13
- 411
- 0
Báo cáo khoa học: Characterization of ubiquitin-like polypeptide acceptor protein, a novel pro-apoptotic member of the Bcl2 family pptx
Ngày tải lên :
17/03/2014, 10:20
... mass (38 kDa) of Ubi-L–Bcl-G complex Ubiquitin- like proteins modify intracellular proteins as well as ubiquitin The activities of a number of important transcription factors, including p53, c-Jun, ... Reconstitution of G1 cyclin ubiquitination with complexes containing SCFgrr1 and Rbx1 Science 1, 662–665 Finley, D., Bartel, B & Varshavsky, A (1989) The tails of ubiquitin precursors are ribosomal proteins ... TCR-a chain -like molecule is involved in the mechanism of antigen-nonspecific suppression of a ubiquitin- like protein Immunology 94, 142–148 15 Tam, J.P (1988) Synthetic peptide vaccine design:...
- 7
- 272
- 0
Báo cáo y học: "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains" pps
Ngày tải lên :
14/08/2014, 16:21
... papain -like fold (Figure 3) [13] comment Figure alignment of ThiS/MoaD -like ubiquitin domain containing proteins Multiple2 (see previous page) Multiple alignment of ThiS/MoaD -like ubiquitin domain ... ThiS/MoaD -like proteins are shaded in blue Other than in the classical ThiS and MoaD pathways, ThiS/MoaD /Ubiquitin- like proteins are labeled Ubl for ubquitin -like domain The ThiS/MoaD -like proteins in ... domain is fused to a distinct domain instead of E2 The E2 -like domain has a conserved cysteine in place of the conserved histidine of the classical E2s 6d Uncharacterized operon coding a Ub-like...
- 23
- 620
- 0
Regulation of cullin e3 ubiquitin ligases by the ubiquitin like protein nedd8 and cullin interacting proteins
Ngày tải lên :
09/09/2015, 18:55
... C-terminal RING domains (RING1 and RING2) separated by a cysteine-rich, zinc-binding in between RING (IBR) domain The RING2 domain is indispensable for Parkin E3 ligase activity, as any deletion of ... loss of dopaminergic neurons in the substantia nigra (Samii et al., 2004) The multidomain protein Parkin comprises of an N-terminal ubiquitin- like domain (Ubl), a cysteine-rich RING domain (Hristova ... functions of monoubiquitinated substrate + HS CO-S E1 E1: ubiquitin- activating N E2 Lys E3 enzyme E2: ubiquitin- conjugating enzyme E3: ubiquitin- protein ligase Figure 1.1 The ubiquitin- proteasome...
- 131
- 835
- 0
Regulating Phytonutrient Levels in Plants – Toward Modification of Plant Metabolism for Human Health
Ngày tải lên :
25/10/2013, 05:20
... others being delphinidin, peonidin, pelargonidin, petunidin, and malvidin Of the flavonols, quercetin, kaempferol, myricetin, and isorhamnetin are common in fruits, quercetin being the predominant ... availability of precursors for an introduced pathway, the choice of the right gene to engineer in the case of multigene families, understanding of related competing pathways, prediction of spillover pathways, ... third predominant flavonoid group in fruits is proanthocyanidins and their monomer units, catechins (procyanidin) or gallocatechins (prodelphinidins) Delphinidin-derived anthocyanins are known...
- 42
- 471
- 0
CHAPTER 5 The Logic of Group Behavior In Business and Elsewhere
Ngày tải lên :
17/12/2013, 15:18
... abuse, both in terms of the number of meetings held and in terms of what business people think of most meetings Indeed, business people often chafe when the subject of committee meetings is aired, ... During the winter of 1973-74, the United States was in the midst of an “energy crisis.” Prices of gasoline and other fuels were being held down in spite of the limited imports of fuel coming into ... are in one in which many of the workers might be inclined to misuse their office computers for private gain (entertainment, maintenance of love affairs, and sexual stimulation) In large offices,...
- 50
- 647
- 0
Tài liệu Effect modification of air pollution on Urinary 8-Hydroxy-2’-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions ppt
Ngày tải lên :
17/02/2014, 22:20
... center, including routine physical examinations, laboratory tests, collection of medical history, social status information, and administration of questionnaires on smoking history, food intake ... follow up A total of 320 participants, who still remained in this cohort, were included in our analyses, visiting the clinic between January 2006 and December 2008 for measurement of urinary 8-OHdG ... those carrying variants of the significant genes identified by MTP with significant interactions using the bootstrap method with the combination of coefficients of the main effect and the interaction...
- 9
- 772
- 0
Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx
Ngày tải lên :
20/02/2014, 03:20
... and 3) According to the observation made by Lu and Wolfe [23], who used a combination strategy of 4,6-diamino-2-phenylindole (DAPI) staining for the detection of DNA and Azo dye staining for the ... becomes acidic in the final step of PND [22,23] DePsipher staining of the macronucleus appeared initially during the stage of autophagosome formation, and persisted until resorption of the parental ... presence of a nuclease activity in the mitochondria of Tetrahymena DNase activities of isolated mitochondria In general, mitochondria have signalling pathways that involve either AIF or EndoG, in which...
- 10
- 642
- 0