4principles of tissue engineering a heart valve

... the demanding, complex and interdisciplinary aspects of tissue engineering has to be approached from new ways We have conceptualised Head & Face Medicine therefore as a thematically broad ranged ... field of tissue engineering is a vision of Head & Face Medicine We hope this journal will attract basic researchers and clinicians who are involved in investigating and applying tissue engineering ... journal, including all disciplines involved in the head and neck area By publishing the various aspects of, for example tissue engineering in one journal the reader can gain an overview of the...

Ngày tải lên: 11/08/2014, 23:22

... Iwanami A, Kaneko S, Nakamura M, Kanemura Y, Mori H, Kobayashi S, Yamasaki M, Momoshima S, Ishii H, Ando K, Tanioka Y, Tamaoki N, Nomura T, Toyama Y, Okano H: Transplantation of human neural ... Biomaterials 2006, 27:4461-4469 Kanemura Y, Mori H, Kobayashi S, Islam O, Kodama E, Yamamoto A, Nakanishi Y, Arita N, Yamasaki M, Okano H, Hara M, Miyake J: Evaluation of in vitro proliferative activity ... NeuroEngineering and Rehabilitation 2007, 4:15 118 Koshizuka S, Okada S, Okawa A, Koda M, Murasawa M, Hashimoto M, Kamada T, Yoshinaga K, Murakami M, Moriya H, Yamazaki M: Transplanted hematopoietic stem...

Ngày tải lên: 19/06/2014, 10:20

... concentrations of desired components can be simulated using a series of ordinary differential equations using compartmental analysis A compartment is an amount of material or spatial region that acts ... have identical properties and are equally representative of the system Kinetic homogeneity means that each particle within a chamber has the same probability of taking any exit pathway A compartmental ... blends are receiving a great deal of attention in this thrust area of polymer research and development New materials have been created in recent years at a pace that exceeds the rate at which detailed...

Ngày tải lên: 27/06/2014, 10:20

... by fibroblasts, simultaneously the dermal layer of INTEGRA® Dermal Regeneration Template is degraded Upon adequate vascularization of the dermal layer and availability of donor autograft tissue, ... “matrix” of tests that evaluate cellular function and physical parameters of the scaffold In contrast, lot-testing strategies, statistical sampling, and more routine analytical methods are available ... patient-specific needs Naturally, such innovations will require a combination of analytic approaches Translational Medicine Safety and efficacy evaluation of a TERMP is conducted in animals, and...

Ngày tải lên: 29/06/2014, 09:21

... Tbx1−/− mutants lack both thymus and parathyroid and display a spectrum of cardiovascular abnormalities and craniofacial defects (Jerome and Papaioannou, 2001) The phenotype of Tbx1−/− animals suggests ... cells as a bioartificial pancreas Ann Transplant 2, 27–32 May, M H., and Sefton, M V (1999) Conformal coating of small particles and cell aggregates at a liquid–liquid interface Ann N.Y Acad Sci ... including abnormal patterning of the first pharyngeal arch; hypoplasia of the second arch; and absence of the third, fourth and sixth arches and pouches (Jerome and Papaioannou, 2001) As a result of...

Ngày tải lên: 29/06/2014, 09:21

... have at least DoF and dimension of some cm3 MINIMAN® are piezoelectrically actuated to achieve a resolution in the range of nanometers and also capable of traveling a relatively long distance Many ... Tables Table 3.1: Width of plateaus whose design width are all 60μm 38 Table 3.2: Wall thickness of wall of microparts (sample wafer A) : nominal value and actual value measured (The nominal value ... scaffold as background; (B) image of a naked gripper with scaffold as background; (C) image of gripper with part and part wafer as background; (D) image of naked gripper with part wafer as background...

Ngày tải lên: 11/09/2015, 09:17

... and availability are the main limitations for their wide applications Poor mechanical performance is also a drawback for transplanted scaffolds made from natural polymers On top of that natural ... is regarded as a soft- and hard -tissue compatible biodegradable material and often selected as a suitable material for thermoplastic processing of scaffolds for tissue engineering (Perrin and English, ... Often, additives such as hydroxyapatite (HA) are added to the basic scaffolding material to promote cell attachment In case of tissues that are subjected to stress and strain, e.g arteries, heart...

Ngày tải lên: 14/09/2015, 10:20

... that affects the water contact angle is the processing procedure of the solid surface Substrate that has crystallized in contact with water has a lower contact angle than that which has crystallized ... inter-connectivity Scaffold characteristics can be compared to similar values evaluated for trabecular bone Hildebrand et al (1999) and Kabel et al (1999) measured morphometric parameters for human cancellous ... metabolic waste as well as tissue integration and vascularization It was observed that a highly interconnected channel network in the scaffold was essential for flow transport of nutrients and...

Ngày tải lên: 14/09/2015, 10:23

... 201 Chapter Five: Conclusions and Recommendations 5.2 Recommendations This PhD thesis was the part of a research program that aims to establish a scaffold library that would have a database on ... develop scaffolds as required for the tissue engineering applications Accordingly, some of the areas that deserve further research are listed below: Physical and biomechanical characterization of the ... consistent and predictable mass and material loss The linear mass loss caused uniform and linear increase in porosity that accorded with the decrease in mechanical properties The results indicated that...

Ngày tải lên: 14/09/2015, 10:23

... simultaneous translational movements along the X-, Y- and Z-axes with an additional rotary motion about the Z-axis The three translational movements had positioning accuracy of up to 0.05mm and a ... study was to primarily investigate the variation of degradation kinetics due to the variation of scaffold material as well as scaffold architecture, and ultimately to determine the suitability of ... isofluorane The local area was cleaned with iodine solution and alcohol, and was opened in layers until the cavernosal cavity was reached 1-2mm of the CCSM tissue was biopsied and the wound was...

Ngày tải lên: 14/09/2015, 11:12

... with various architectures utilizing a range of biopolymers Physical (morphological and mechanical) characterization of the scaffolds Evaluation of degradation behavior and kinetics of the scaffolds ... process parameters, lay-down patterns and filament distances on the mechanical properties of the scaffolds The mechanical characterization also reveals the effect of strain rate, simulated physiological ... et al, 1998) These strategies have been studied for the regeneration of many tissues, including bone and cartilage (Perka et al, 2000; Whang et al, 1998) A number of materials as well as scaffold...

Ngày tải lên: 14/09/2015, 11:12

... in advanced stage because of their potential need and relative ease of application Chapter Introduction 1.2 Tissue engineering The acute shortage of human tissues and organs for transplantation ... Subcutaneous, intramuscular, and intraperitoneal implantation of a graft has been reported similar vascular patterns [83] Although generation of vascularized graft is feasible, this tissue is vascularized ... the patient's own body, whereas an allograft is taken from a cadaver In spite of many available treatment modalities for tissue loss, currently, the gold standard is the autograft transplant;...

Ngày tải lên: 14/09/2015, 08:48

... ALP activity and mineral-like nodule formation in hPDLF and hAO 76 Schematic diagram showing the metabolism of ATP and AMP, and the role of ALP on mineralization 76 5.1 Synthesis of (A) DNA and ... epithelium, as a result of an ability of oral epithelium to migrate apically along the root surface (Caton and Nyman, 1980; Caton et al., 1980) Hence, the formation of new epithelial attachment is classified ... and fibre orientation Proteoglycans also regulate 13 Literature review cell adhesion and growth, and have capacity to bind and regulate growth factor activity (Bartold and Narayanan, 1998) Many...

Ngày tải lên: 14/09/2015, 12:07

... unable to address osteochondral defects adequately Given the paucity of available alternatives, the author aims to harness the advances in stem cell and biomaterial research to create a biphasic osteochondral ... inherent advantage of the biphasic design given the flexibility in varying the material, structural and mechanical properties of the phases so as to assist cartilage and bone repair is an appealing ... scaffold to engineer an elastic cartilage implant which exhibited chondrocytic lacuna, GAG deposition and a stiffness that approximated to that of native auricular cartilage [27] Fibrin is a naturally...

Ngày tải lên: 14/09/2015, 14:07

... field of tissue engineering has shown to be a promising alternative in using cell transplantation as a strategy to achieve tissue repair and regeneration for a variety of therapeutic needs One approach ... (lateral collateral ligament and medial collateral ligament), and two interior ligaments (anterior cruciate ligament (ACL) and posterior cruciate ligament), which help control stabilisation and ... bioreactor and ordering of other experimental materials Special thanks to my colleagues at National University of Singapore Tissue Engineering Program iv Laboratory at Defence Science Organisation...

Ngày tải lên: 04/10/2015, 10:25

... World War II era for conversion of cellulose to sugars was again investigated by Battelle-Geneva on a pilot plant basis, particularly of separation of the hydrochloric acid and sugars, as well as ... Valley Authority (Farina 1991) and the U.S National Renewable Energy Laboratory (Wyman 1991) Recent work by ARKENOL in California, USA (Cuzen 1997) and APACE in New South Wales, Australia, have ... it can be converted into chemicals and materials, human population will be able to enjoy material abundance for ages to come Biomass materials are renewable Their utilization creates no net gains...

Ngày tải lên: 23/10/2013, 17:20

Ngày tải lên: 04/11/2013, 10:15

... Komaru et al Novel aggregate formation of an alkaline phosphatase frame-shift mutant Hypophosphatasia is an inborn error of metabolism characterized by defective mineralization of hard tissues and ... alkaline phosphatase gene in Japanese patients with hypophosphatasia J Bone Miner Metab 20, 28–33 Sawai H, Kanazawa N, Tsukahara Y, Koike K, Udagawa H, Koyama K & Mornet E (2003) Severe perinatal ... (ordinate, unit per mL fraction) BSA (b, 68 kDa), alcohol dehydrogenase (a, 141 kDa) and catalase (c, 250 kDa) were loaded on to a separate gradient as molecular mass markers Not only the aggregate...

Ngày tải lên: 19/02/2014, 17:20

... scientific basis and clinical application of tissue engineering Gordana Vunjak-Novakovic R Ian Freshney Preface ix List of Abbreviations AAF ACL ACLF AIM AMP ARC BAMs BDM bFGF BPG BDNF BSA BSS CAT CBFHH ... Rebecca Y Klinger and Laura Niklason) describes tissue engineering of functional blood vessels and their characterization in vitro and in vivo Chapter 13 (by Sandra Hofmann, David Kaplan, GordanaVunjak-Novakovic, ... and small aggregates that is generated will contain a proportion of cells capable of attachment to a solid substrate, forming a monolayer Those cells within the monolayer that are capable of proliferation...

Ngày tải lên: 22/03/2014, 15:20