... of ratings, including subscribers Public Availability of Ratings Many are of the view that the ratings of an NRSRO should be publicly available, at no charge, to assure wide availability of the ... on the role and function of credit rating agencies in the operation of the securities markets in response to the Congressional directive contained in the Sarbanes- Oxley Act of 2002 ( Sarbanes- Oxley ... REPORT ON THE ROLE AND FUNCTION OF CREDIT RATING AGENCIES IN THE OPERATION OF THE SECURITIES MARKETS As Required by Section 702 (b) of the Sarbanes- Oxley Act of 2002 EXECUTIVE SUMMARY The Securities...
Ngày tải lên: 15/03/2014, 07:20
... tabulated) To summarize, Table 10 documents that 1) the lag between insider transactions and the receipt of the Form by the SEC and 2) the lag between the filing date and the market reaction became ... transactions may be reported on the same filing date, I take the mean of the transaction-specific returns weighted by the value of the corresponding trades (transaction price multiplied by the ... value of equity, calculated as of the beginning of the fiscal quarter Size is the natural logarithm of market capitalization as of the beginning of the fiscal quarter R&D is an indicator variable...
Ngày tải lên: 30/09/2015, 17:19
báo cáo hóa học: " Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice" pot
... injury severity between the groups The systemic (i.p.) route of administration and the time window of injection were selected based on the breakdown of the blood-brain barrier (BBB) for up to 24 ... (4 h) and TBI_mAb 1379 (24 h) vs TBI_placebo and sham; unpaired Student's t-test * * * 300 200 100 Co T TB T TB T TB nt I Ip I p BI m BI p BI m ro lac lac mA lac Ab Ab l b eb eb eb 13 13 13 o ... responses by the activation of B- cells C3a and C5a are potent anaphylatoxins with chemotactic and inflammatory properties Generation of C 5b by cleavage of C5 initiates the formation of the membrane...
Ngày tải lên: 19/06/2014, 22:20
Comparison of the obstetric anesthesia activity index with total delivery numbers as a single denominator of workload demand in Israeli maternity units doc
... performance indicator and better reflects the obstetric anesthesia workload than merely measuring the total number of deliveries Use of the annual number of deliveries as the bench-mark comparator ... Lecturer of Anesthesia and Director of the Mother and Child Anesthesia Unit at the Hadassah–Hebrew University Medical Center He is a past Chair of the Israel Association of Obstetric Anesthesia ... to offset this heterogeneity The obstetric anesthesia activity index (OAAI) The majority of anesthesia workload in the labor ward comprises epidural labor analgesia and cesarean delivery The...
Ngày tải lên: 05/03/2014, 15:20
Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
... (DRBT, DRB) inhibitors, shown in the case of DRBT in Fig 3C The two most effective inhibitors of the HCV helicase activity, DRBT and TBBT (Table 1) differ significantly in their mechanisms of action ... the bulkiness of the bromine atoms, these are primarily responsible for the hydrophobic interactions with the apolar chains of CK2 The only polar interaction, mediated by a pair of hydrogen-bonded ... to the reaction medium simultaneously with the enzyme Unwinding and hydrolytic activities in the absence of inhibitor were taken as 100%; DRB (j), DBRB (d), DRBT (.), a-DMRB (m), TCBT (r), TBBT...
Ngày tải lên: 08/03/2014, 02:20
The Benefits and Costs of the Clean Air Act from 1990 to 2020: U.S. Environmental Protection Agency Office of Air and Radiation potx
... steps of benefits analysis c The low benefit/cost ratio reflects the ratio of the low benefits estimate to the central cost estimate, while the high ratio reflects the ratio of the high benefits ... each of the projected years of the with-CAAA scenario by scaling the historical data adopted for the base year (2000) by the ratio of the modeled with-CAAA and base year air quality We use the ... compares the overall health, welfare, ecological and economic benefits of the 1990 Clean Air Act Amendment programs to the costs of these programs By examining the overall effects of the Clean Air Act, ...
Ngày tải lên: 15/03/2014, 16:20
COMMUNITY BANKS AND CREDIT UNIONS : Impact of the Dodd- Frank Act Depends Largely on Future Rule Makings docx
... to conform them to section 404(< /b> c) of the SarbanesOxley Act of 2002, as added by section 989G of the Dodd-Frank Act Section 404(< /b> c) provides that section 404(< /b> b) of the Sarbanes- Oxley Act shall not ... termination would have no impact on their institution or it was too soon to determine the impact Exemption from Section 404(< /b> b) of the Sarbanes- Oxley Act Section 989G of the Dodd-Frank Act eliminates an ... so are not subject to section 404 < /b> of the Sarbanes- Oxley Act of 2002, which was amended by section 989G of the Dodd-Frank Act 41 Pub L No 107-204, 116 Stat 745 (2002) 42 Although the term non-accelerated...
Ngày tải lên: 22/03/2014, 20:20
ORDER CANCELLING REGISTRATIONS OF CERTAIN INVESTMENT ADVISERS PURSUANT TO SECTION 203(h) OF THE INVESTMENT ADVISERS ACT OF 1940 pdf
... GLOBAL ADVISORS, LLC THE CARMACK GROUP, INC THE COLOMA GROUP, L.LC THE DELANCEY CAPITAL GROUP, LP THE OXFORD PRIVATE CLIENT GROUP, LLC THE SPANGLER GROUP, INC THE UNIVERSITY FUNDS, LLC TRIBUTARY ... AMOEBA CAPITAL PARTNERS PTE LTD ANCHOR INVESTMENT PARTNERS LLC ASSOCIATED PROFESSIONAL INVESTMENTS, LLC BEACON CAPITAL MANAGEMENT LIMITED BISCAYNE ADVISORS, INC BLACK KNIGHT ASSET MANAGEMENT BOLI ... MANAGEMENT, LLC BOWMAN FINANCIAL MANAGEMENT CO INC BROADSTREET CAPITAL PARTNERS, LP BRYN MAWR FINANCIAL, LLC C.S ANDERSON FINANCIAL SERVICES, INC C2 ASSET MANAGEMENT L.L.C CABAL CAPITAL MANAGEMENT,...
Ngày tải lên: 30/03/2014, 03:20
báo cáo hóa học: " Leader (L) and L* proteins of Theiler''''s murine encephalomyelitis virus (TMEV) and their regulation of the virus'''' biological activities" docx
... spread L of mengovirus, which also belongs to the genus Cardiovirus, has been reported to inhibit the iron/ferritinmediated activation of NF B [34] The functions of L of Page of (page number not ... at the AA level, that of L shows only 85% identity [5,6]; the low identity of the AA sequence of L between both TMEV subgroups suggests that L may contribute to the determination of the DA subgroup-specific ... from the viral polyprotein [30,31], and the second is cleavage of the p220 component of the cap-binding protein complex [32], resulting in the shut off of host protein synthesis On the other...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo y học: "The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein" doc
... production of PGE2 and that of LTB4 in OA osteoblasts, we then determined the effect of the addition of PGE2 to osteoblasts or of an inhibitor of PGE2 production on the expression of FLAP by real-time ... calculated as the ratio of the number of molecules of the target gene to the number of molecules of GAPDH Western blot analysis of cyclooxygenase-2 (COX-2) levels in OA osteoblasts Cell extracts were ... result of their endogenous production of PGE2 Both 1,25(OH)2D3 and TGF-β modulated the expression of FLAP and thereby that of LTB4 IL-10 is not involved in the regulation of the synthesis of LTs...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "Moderate exercise and chronic stress produce counteractive effects on different areas of the brain by acting through various neurotransmitter receptor" doc
... they negatively activate (feedback mechanism) the left-posterior and right anterior of the brain As such, the exercise effect conteracts the stress effect on the brain Based on the above schematic ... integrate these clues theoretically in order to gain a better overview of the interactions of stress and exercise inside the brain The next section describes our preliminary hypothesis based on ... the brain [25] These couplings are at least partly caused by the activation of Brain Derived Neurotrophic Factor (BDNF) in exercise and the suppression of BDNF in stress [22] BDNF activation and...
Ngày tải lên: 13/08/2014, 23:20
Báo cáo y học: " Performance of the international physical activity questionnaire (short form) in subgroups of the Hong Kong chinese population" doc
... Page of 10 compare the differences in the amount of moderateintensity, vigorous, and total physical activity between IPAQ-C and ActiGraph Because the MET-min/wk measurements of neither the IPAQ-C ... the ActiGraph on average they only did 1.0 minute of vigorous physical activity per day, no more than the vigorous physical activity performed by other respondents Conceivably, however, the Actigraph ... lifting activities This raises the possibility that the accuracy of the IPAQ-C may be improved by separating physical activity into occupational and leisure types (as in the Global Physical Activity...
Ngày tải lên: 14/08/2014, 08:20
Báo cáo y học: "Validity of the International Physical Activity Questionnaire Short Form (IPAQ-SF): A systematic review" docx
... physical activity [28] The IPAQ-SF instrument may also be better at capturing activity of some intensity level but not others, e.g., vigorous rather than moderate activity Because the variability ... measured by the objective standard; and b) whether raw values were reported and if so, the percentage difference between the IPAQ-SF and the objective standard (with the objective standard used as the ... levels of intensity, the correlation between the IPAQ-SF and the objective physical activity measures are shown in Table Table presents under- and over-reporting of physical activity by the IPAQ-SF...
Ngày tải lên: 14/08/2014, 08:21
Expression studies of the proteolytic p10 fragment of the neuronal cdk5 activator in mammalian cells
... lyse the bacteria To avoid of breaking bacterial genomic DNA, solutions were mixed by inverting tubes gently instead of vortex The mixture was incubated at RT for minutes before adding 300µl of ... p35 So the increased ratio of p25/p35 may somewhat contribute to the abnormal increased Cdk5 activity in the AD patients’ brains both by mislocalization of p25 and by prolonged existence of p25 ... pipetted into the Falcon tube followed by addition of original plasmid (about 0.5µg) Then, the tube was incubated on ice for 30 minutes After that, the tube was incubated in 42˚C water bath for 90...
Ngày tải lên: 05/10/2015, 22:32
Expression studies of the proteolytic p10 fragment of the neuronal cdk5 activator in mammalian cells
... lyse the bacteria To avoid of breaking bacterial genomic DNA, solutions were mixed by inverting tubes gently instead of vortex The mixture was incubated at RT for minutes before adding 300µl of ... p35 So the increased ratio of p25/p35 may somewhat contribute to the abnormal increased Cdk5 activity in the AD patients’ brains both by mislocalization of p25 and by prolonged existence of p25 ... pipetted into the Falcon tube followed by addition of original plasmid (about 0.5µg) Then, the tube was incubated on ice for 30 minutes After that, the tube was incubated in 42˚C water bath for 90...
Ngày tải lên: 06/10/2015, 20:35
Tài liệu Sarbanes-Oxley and the Outsourcing of Accounting docx
... available and quality is not sacrificed The outsourcing and offshoring of accounting may have lagged behind the general BPO wave in IT, but FAO may soon become the most profitable portion of the BPO ... covers the contact and contract phase of FAO, there are three contributing factors to estimating transaction costs The first of these is uncertainty Uncertainty is the degree to which the intended ... of time before most accounting functions are capable of being outsourced Save direct contact with the client, the ability of outsourcing firms to provide high level services is being met by the...
Ngày tải lên: 18/02/2014, 01:20
Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... between the Ig -b and GH genes A member of the OCT family transcription factors appeared to be involved in the transactivation of the region which had the highest enhancing activity of the three ... digestion of the genomic DNA with HindIII, homologous recombination and the excision of Bsr gene were confirmed by Southern hybridization using 0.9 kb DNA ()10.1 kb to )9.2 kb) as the probe (Fig 2) The ... kb and )6.5 kb); region II, promoter and upstream region of Ig -b gene ()2.7 kb to +0.05 kb; DHSs, )2.1 kb, )1.0 kb, and kb); region III, in the first intron of the Ig -b gene (+0.6 kb to +1.1 kb;...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt
... terminal glucose of the bglucan substrate in the )1 subsite at the bottom of the active site pocket [20] The entrance to the active site pocket of Exg is flanked by a pair of phenylalanyl residues, ... chain B- factor (A2) ˚ Average side chain B- factor (A2) ˚ Average ligand B- factor (A2) BGC1a ˚ Average ligand B- factor (A2) BGC 2b ˚ Average ligand B- factor (A2) L3-1c ˚ Average ligand B- factor ... 29 3N9K a BGC1 is the glucose residue from the nonreducing end of laminaripentose (L5) bound to the exterior of the protein b BGC2 is the weakly bound glucose residue of L5 bound in the Phe-Phe...
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: Characterization of the bga1-encoded glycoside hydrolase family 35 b-galactosidase of Hypocrea jecorina with galacto-b-D-galactanase activity pdf
... on the concentration of the substrate, as also found in other studies [12,13] Activity of Bga1 on polymeric substrates The ability of Bga1 to hydrolyse b- galactosidic bonds in polymeric substrates ... parameters of H jecorina b- galactosidase with various b- galactosides Substrate o-Nitrophenyl -b- D-galactopyranoside Galactobiose Lactobionic Acid Lactitol Lactose Lactulose Methyl -b- D-galactopyranoside ... To the best of our knowledge, this is the first report of the enzymological properties of a b- galactosidase identified as a member of GH35 H jecorina Bga1 hydrolysed all b- galactosides tested, but...
Ngày tải lên: 16/03/2014, 11:20