4  pathogenesis of vitamin d and calcium insufficiency related diseases

... coupled with reduced sunlight exposure Second, although milk in Ireland is fortified with vitamin D, both patients had limited intake of other dietary sources of vitamin D such as oily fish and eggs ... proximal distribution, the waddling gait, and pain and discomfort due to muscular effort Both cases demonstrated these findings clinically The muscle weakness may develop insidiously over years and ... correct diagnosis can help avoid prolonged and needless investigations for these patients, as the condition is reversible and easily treated with vitamin D and calcium supplementation Page of Frank...

Ngày tải lên: 11/08/2014, 00:23

... blinded, within-subject randomised, active- and vehicle-controlled, repeated dose study, conducted at CPCAD, Nice, France No topical treatment had been applied for four weeks prior to admission and ... calculated with standard assumptions about independence, equivariance and normality Due to heteroscedacity, the logarithm of the following response variables was used: CD3, CD4, CD45, and Ki-67 SCID ... animals were bled and sacrificed The serum levels of calcipotriol and BDP were analyzed and determined to be below the detection limit (data not shown) Discussion The objective of this study was to...

Ngày tải lên: 18/06/2014, 15:20

... acetabulum in parents of children with DDH, and a higher proportion of children with DDH and their first degree relatives were lax-jointed Based on this study, Wynne-Davis proposed two different gene ... between the vitamin D and oestrogen endocrine system have been described 1,25-Dihydroxyvitamin D3 (1,25-(OH) 2D3 ) and 17β-estradiol (E2) have a mutual effect on their biosynthesis [19,20] and receptor ... would be an issue in larger series due to the current known prevalence of DDH and PPA in our population The present study has shown possible genetic associations between DDH and vitamin D and oestrogen...

Ngày tải lên: 11/08/2014, 08:21

... acid (DHA) and docosapentaenoic acid d Sum of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid and α-linolenic acid e Sum of arachidonic and linoleic acids b Age Dietary ... acid d Adjusted for age, total energy intake and dietary intake of vitamin B12, alcohol and dietary intake of fat other than eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid ... eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid and α-linolenic acid hAdjusted for age, total energy intake and dietary intake of vitamin B12, alcohol and dietary intake of other...

Ngày tải lên: 11/08/2014, 16:22

... with the development of COPD are largely speculative: 1) The association of VitD deficiency and reduced lung function could depend on the calcemic effects of VitD The vital capacity and total ... polymorphisms of VitD receptor (VDR) and VitD binding protein (DBP) have been identified that modulate the development of tuberculosis [96] The genotype tt (detected by Taq I digestion) is associated with ... Lauridsen AL, Vestergaard P, Hermann AP, Brot C, Heickendorff L, Mosekilde L, et al: Plasma concentrations of 25-hydroxy -vitamin D and 1,25-dihydroxy -vitamin D are related to the phenotype of Gc...

Ngày tải lên: 12/08/2014, 13:22

... study compared effects of two vitamin D doses The daily dose of 1500 IU resulted in better blood glucose and, although did not absolutely decreased IR, did reduced IR increase for that period ... Review of vitamin D 1.1.1 Chemical nature and metabolism of vitamin D Vitamin D exists in two forms, Cholecalciferol (Vitamin D3 ) and Ergocalciferol (Vitamin D2 ) Vitamin D is converted to 25(OH )D ... vitamin D deficiency There has not been also a widespread concensus on vitamin D supplementation and treatment of vitamin D deficiency Institute of Medicine (IOM) recommended dietary allowance of vitamin...

Ngày tải lên: 11/05/2016, 08:56

... Comparison of mutagenicities of malondialdehyde and the side products formed during its chemical synthesis Cancer Res 1980, 40, 276-282 (5) Marnett, L J Oxy radicals, lipid peroxidation and DNA damage ... calibration curves of their corresponding standard The compounds were quantified by calibration curves of their structurerelated standards when their corresponding standards were not available ... chromatogram of rice bran without germ extract Figure ESI−mass and CID spectra of compound 10 in negative- and positive-ion mode and proposed collision-induced dissociation pathway of vitamin E...

Ngày tải lên: 15/03/2014, 15:33

... studies have documented an age-dependent decline in serum 25hydroxyvitamin D and 1,25-dihydroxyvitamin D, and this age -related decline steadily worsened with institutional placement, decreasing ... winter level of serum 25-hydroxyvitamin D is considered to provide the 33 Vitamin D and Cancer best indication of individual vitamin D status Peak serum 25-hydroxyvitamin D levels are found in late ... interference of intakes of 1,250 àg per day of vitamin D2 and vitamin D3 release from the skin after UVB exposure A recent randomised, placebo-controlled, double-blinded study of healthy adults aged 18-84...

Ngày tải lên: 28/03/2014, 23:20

... proposed that binding of IIG6 disrupts the salt bridges between D6 69 and R168, and between D6 70 and R169 Cooperativity between IIG2 and IIG6 has been suggested to occur as a result of the breaking of ... enhancement determined in EGTA and calcium (about 8% and 30%, respectively) possibly reflects changes in domain conformation and in interfaces produced under these two conditions In order to deduce a ... two binding sites (IIG5 and IIG6, Kd ¼ and 0.2 lM, respectively) detected and measured by equilibrium dialysis [7] Intrinsic fluorescence of G2 domain was also measured as a function of calcium...

Ngày tải lên: 31/03/2014, 01:20

... presence of antibiotics were centrifuged, washed, and resuspended in Dulbecco's modified Eagle's medium (DMEM)/F-12 medium for inoculation in order to remove the antibiotics Preparation of whole and ... manuscript draft AP, AK, KH, and DS all helped in the experimental design and data analysis and provided creative and critical suggestions after reviewing the manuscript MS provided insight into ... washing, horseradish peroxidaseconjugated streptavidin was added onto the membrane and incubated for hours at ambient temperature After extensive washing, the detection buffer was added and the signals...

Ngày tải lên: 09/08/2014, 08:23

... of vitamin D deficiency Beyond bone health, vitamin D deficiency is associated with many chronic diseases such as cancer, cardiovascular disease, diabetes and immunological diseases including ... and LDL level were determined by automated standard laboratory techniques Vitamin D status Plasma 25-(OH )D concentrations are presented using two different cut-offs,

Ngày tải lên: 10/08/2014, 05:21

... studies Food intake patterns: Effect of vitamins on the risk of developing COPD and associated mortality Varraso et al in a study of 72,043 women identified 754 cases of newly diagnosed COPD [44] ... role of vitamins against COPD but did not measure vitamins in serum or with a FFQ Therefore conclusions about the special role of any vitamin in COPD could not be obtained Vitamin D and COPD Vitamin ... other vitamins the mechanism of action is less clear [38-42] Indeed we know that 1,25-dihydroxyvitamin D stimulates both innate and adaptive immunity, in addition to mineralization and calcium...

Ngày tải lên: 12/08/2014, 13:22

... lymphocyte NO production Normal [10] Increased [27] TCR-induced rapid and sustained Ca2+ signal Rapid-increased, sustained-decreased [10] Normal [22] TCRζ expression Decreased [34] Decreased [61] mTOR ... paradigm has been updated following the discovery of a third subset of Th cells, known as Th17 cells Th17 cells have been identified as cells induced by IL-6 and TGF-β and expanded by IL-23 [65] Similarly ... Increased levels of IL-17 have been observed in patients with RA Indeed, IL-17 can directly and indirectly promote cartilage and bone destruction IL-17deficient mice develop attenuated collagen-induced...

Ngày tải lên: 12/08/2014, 14:22

... course of viral transcription and replication, uncapped double-stranded RNA intermediates are generated and these may have served as ligands for the RIG-I and/ or Mda5 Both RIG-I and Mda5 have ... polyriboinosinic:polyribocytidylic acid or poly(I:C) (198) and long dsRNAs (196) 27 TLR3, and have established to recognize dsRNA, ssRNA and CpG DNA respectively A strategy coronaviruses have adopted to avoid detection of ... conserved zinc finger motifs and is able to bind both single- and double- stranded DNA and RNA non-specifically (109) It was also reported that through self-association, nsp10 forms a dodecameric...

Ngày tải lên: 09/09/2015, 18:54

... epithelium and stroma are changed (such as transformation of pseudostratified to stratified epithelium, changes of density of goblet cells, changes of cell infiltration) and polyp is well-developed 1.5 ... were found in the NP [Stoop et al., 1989] In addition, our previous study showed significantly higher levels of CD8+ T cells and an inverse median ratio of CD4+/CD8+ T cells were found in nasal ... Vancheri et al., 1991] In addition, conditioned media from NP derived cell lines has been used to study the roles of GM-CSF Epithelial cells from NP tissue survived and proliferated better than normal...

Ngày tải lên: 10/09/2015, 15:49

... NK-1R-dependent Figure 5.4 PKCα, δ, and ε were involved in mediating SP-induced MIP-2 production by mouse macrophages Figure 5.5 PKCα, δ, and ε were involved in mediating SP-induced MCP-1 production ... prevented activation of NF-κB and chemokine production induced by SP Two kinase pathways, PKCs and PI3K-Akt were further identified to be important for mediating SP-induced ERK1/2 activation PKC isoforms, ... subdivided into three groups based on their molecular structure and mode of activation, namely conventional PKCs (α, βI, βII, and γ), novel PKCs (δ, ε, η, and θ), and atypical PKCs (ζ, λ/ι, and μ)...

Ngày tải lên: 11/09/2015, 09:09

... 25(OH)-1α-hydroxylase CYP27B1 Dietary Vitamin D2 (Ergocalciferol) or Vitamin D3 (Cholecalciferol) CYP24 24,25-dihydroxyvitamin D3 Kidney 1,25-dihydroxyvitamin D3 Vitamin D Receptor (VDR) Function of Vitamin ... • Calcium and bone health • Cases • Recommendations Vitamin D Metabolism 7-dehydrocholesterol Solar UVB Skin Previtamin D3 Heat Vitamin D3 Vitamin D- 25 hydroxylase Liver 25-hydroxyvitamin D3 ... Hypertension Vitamin D and Cardio-metabolic Risk • Study of 3577 adolescents in NHANES survey • 25 OH Vitamin D levels inversely related to systolic blood pressure and fasting glucose • Odds ratio of 3.9...

Ngày tải lên: 18/11/2020, 14:00

... recorded by patients in their diaries at 6, 12, 24, and 48 hours, and 4, 5, and days post-dose, and during scheduled clinic visits at 72 hours, days, weeks, and weeks post-dose Physicians assessed ... Poland, Russia, Switzerland, Turkey, the UK and the USA) were enrolled and 191 patients completed the study (Figure 1) The demographic and baseline disease characteristics of patients enrolled ... results of secondary efficacy endpoints with respect to reduction of signs and symptoms of inflammation during flares and exploratory endpoints regarding HRQoL Results for the primary endpoint and...

Ngày tải lên: 12/08/2014, 15:22

... Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed ... slope), of each standard curve was determined and appeared to be > 95 %, and < 105 %, over a wide dynamic range For each experimental sample the amount of the gene of interest, and of the endogenous ... are based TI histochemically examined all samples described in this manuscript GH performed genotyping on Dobermans and provided theoretical background JR and LP, conceived of the study, and participated...

Ngày tải lên: 13/08/2014, 13:20

... sữa gạn kem, 2% Bánh pút-đinh (pudding) sữa trứng Sữa chua (yogurt), nguyên chất Sữa chua, có trái đáy hủ Sữa chua đông lạnh, loại mềm Cà rem Đậu hủ, làm với calcium sulphate Đậu trắng, nấu chín ... Tây D ơng có xương đóng hộp Cá mòi Thái Bình D ơng có xương đóng hộp Cá hồi có xương đóng hộp Gạo sữa đậu nành có tăng cường thêm chất canxi Nước cam có tăng cường thêm chất canxi sinh tố D Sữa ... xanh (broccoli) Cam Mật đường đen (Blackstrap molasses) Cá khô, cá ốt-me (smelt) Bông hoa hiên (daylily flower) Bánh đậu tương lên men, nấu chín Cải Fat choy (tóc tiên), khô Đậu hủ miếng to, nửa...

Ngày tải lên: 20/07/2015, 23:47