4  mirnas as regulators of development

... 26S proteasome 19S cap Ubiquitin 4315 Quinone reductase as regulator of the proteasome S Sollner and P Macheroux The impact of the 20S proteasome on QR activity raised the question of whether ... Quinone reductase as regulator of the proteasome S Sollner and P Macheroux rase’, reported by Ernster & Navazio [3], is now known as mammalian NAD(P)H:quinone oxidoreductase (NQO1, isozyme ... proteasome and provided evidence that p33ING1b is degraded by the 20S proteasome Quinone reductase as regulator of the proteasome Further results indicate that NQO1 inhibits the degradation of...

Ngày tải lên: 16/03/2014, 02:20

... them, the software outsourcing stands out as one of the most profitable and fast-growing industry This paper studies the current situation of software outsourcing development, some of the favorable ... traditional reason for offshore development Low-level tasks such as coding and software testing can be performed in less-developed countries at costs as low as ten percent of domestic ones Software outsourcing ... protection of IPR as well as good IT infrastructure and software development platforms However, China software industry is desperately seeking for independent core technologies as well as distinctive...

Ngày tải lên: 27/10/2012, 16:41

... schoolchildren of working or studying parents, or in cases where the child has an individual need A place should be offered as close to the child’s home as possible As in the case of pre-school ... system has gone through phases of change, as accounted for above, it seems that transmission of basic skills and knowledge remains the main mission However, and as the account shows, the development ... qualifying task has been complemented with its socializing task But as Isling claims, in the struggle between these two tasks the qualifying assignment has been dominant The double requirement has resulted...

Ngày tải lên: 16/01/2014, 16:33

... polymerization in two kinds of assay In the first assay, the formation of fibrin was followed directly after the addition of thrombin In the second assay, previously prepared fibrin was dispersed and then ... inhibitor of the final step of blood coagulation, fibrin polymerization, and can be used as the basis for the design of new class of antithrombotic agents We found that the mechanism of C-192 inhibition ... 2C) The lag-time was also increased strongly in the presence of C-192, indicating either an decrease of the rate of protofibril formation or, conceivably, an increase of protofibril critical length...

Ngày tải lên: 06/03/2014, 00:21

... areas, as well as to provide a more comprehensive understanding of the mode of action of rural development measures assigned to the new rural paradigm However, "[n]othing is as practical as a ... introduced rural development measures similar to those of the new rural paradigm Three of these communes will serve as case studies to provide an understanding of how the policy measures of the new ... of farms endowed with between 1-2 even increased by 2005 and in the last two years has begun to decrease Also, the number of farms between 2-5 has increased, and at the same time the number of...

Ngày tải lên: 23/03/2014, 08:21

... personal profiles of the academic staff as predictors of professional characteristics which will serve as basis for the improvement of the quality of higher education and trainings Objectives of the ... includes professors of various ranks: assistant professors, associate professors, and (full) professors, usually tenured (or tenuretrack) in terms of their contract of employment Members of university ... the personal profiles of the academic staff as predictors of professional characteristics: Basis for staff development program of Hong Duc University It is the main objective of this study to...

Ngày tải lên: 13/05/2014, 15:15

... adenomas (C) and adenocarcinomas (D) The peak of immunoreactivity is in the healthy tissue In contrast, in the dysplastic lesions, there is a drop in expression as the grade of dysplasia increases ... the postsurgical development of metachronous metastases indicated that levels of CD3+ cells infiltrating into the invasive margin was not an independent Cammarota et al Journal of Translational ... adenomas with low (29 cases) to high (5 cases) grade dysplasia (AD), and 53 infiltrating adenocarcinomas classified using TNM (ajcc, american joint committee on cancer, VI edition) with T1 (7 cases,),...

Ngày tải lên: 18/06/2014, 16:20

... histopathological aspect of the mucosal epithelium of the rabbit #436 that was treated with C14 (1 μM) for 10 days (× 300) (B) Vascular congestion of the mucosal epithelium of the rabbit #435 that was treated ... presence of increasing concentrations of C14 or an unique dose of T 20 (5 μM) for hours at 37°C Cells were then washed and cultured in fresh medium for days DNA was extracted and the viral DNA was ... experiment was named as "C14" C14 was synthesized according to the following steps: 1) Preparation of a solution of organic terpenoid acid using a mixture of pure water and alcohol; 2) Reaction of the...

Ngày tải lên: 10/08/2014, 05:21

... cells, as demonstrated by an increased % of cells in G1-phase, together with a decreased % of cells in S-phase These findings were validated at gene expression profiling that showed increased expression ... expression of cyclin-dependent kinase inhibitors (p18, p19, p21, p27); decreased expression of cyclin-dependent kinases-2, -4, -6, as well as cyclins D1, D2, D3 and E; and increased expression of p53 ... Modifications at the level of miRNAs have recently gained considerable attention in the field of cancer research It has been recently identified an increased expression of miRNAs-363*, -206, -494,...

Ngày tải lên: 10/08/2014, 22:21

Ngày tải lên: 27/03/2015, 14:51

... added The concentration of the Au NPs was estimated to be x 10-5 M (based on the number of gold atoms), by comparing the intensity of the plasmon band to the intensity of the band from NPs produced ... Deposition of osmium clusters onto silver or gold surfaces The detection of the presence of triosmium cluster species in the ToF-SIMS spectra of 1-modifed Ag substrate confirmed the association of with ... the rate association of Ag NPs with clusters is generally very fast, hence accounting for the small size of most of the Ag NPs obtained As indicated in the earlier chapter, ToF-SIMS appears to...

Ngày tải lên: 13/09/2015, 20:59

... three phases as presented by Figure 4.2: the liquid phase of the droplet (L), the solid phase of the substrate (S), and the gas phase of the ambient (G) At equilibrium, the summation of the interfacial ... that of a fluid phase being transported in and out of the solid phase through the pores The result was an increase of the apparent stiffness at higher fluid phase viscosities In the case of the ... increase of temperature or pressure the RW increases and consequently, the porosity decreases On the contrary, with the increase of deposition speed the RW decreases and thus the porosity increases...

Ngày tải lên: 14/09/2015, 10:23

... issues of ssDSSCs fabrication, devices characterization and evaluation Details of conducting glass, mesoporous TiO2 paste, sensitizers, HTMs and counter electrodes, as well as the assembling of ssDSSCs ... glass was treated by O2 plasma for 18 Compact TiO2 layer was prepared by aerosol spray pyrolysis on cleaned FTO conducting glass.[49] To protect the collection area, a piece of glass side was ... (SnO2 :F, FTO) coated glass TEC 15 and TEC purchased from Hartford Glass Co., were used The parameters of TEC 15 and TEC are listed in Table 2.1 TEC 15 glass was used as both TiO2 electrode and...

Ngày tải lên: 26/09/2015, 10:05

... luminescence for ATP detection was assessed using a MicroBeta Trilux (PerkinElmer) A standard curve was used to determine the amount of ATP in mg of protein measured from the number of cells per well After ... Fluorescence emission was recorded at 460 and 580 nm After a 20 sec baseline reading, 0.1 ml of PBS containing 10 µM of the compound investigated was added, and the fluorescence signal was recorder for ... depolarization, as measured by FRET, was calculated As shown in Figure 3, a statistically significant linear relation between the changes in membrane potential and the transport activity of the cells was...

Ngày tải lên: 26/10/2012, 10:04

Ngày tải lên: 20/08/2013, 20:10

Ngày tải lên: 27/09/2013, 23:10

... Kate, can I introduce you to Nga? She’s studying (1) here in London Kate: Hello, pleased to meet you Nga: Pleased to meet you, too Kate: Where are you from, Nga? Nga: I’m from Vietnam Kate: Why ... Yes, and at (4) , too But I’ve forget… Kate: forgotten writing skill Nga: Yes, of course I’ve forgotten a lot of it I want to improve my .(5) letters You know, sometimes I have to write (6) ... Kate, can I introduce you to Nga? She’s studying English here in London Kate: Hello, pleased to meet you Nga: Pleased to meet you, too Kate: Where are you from, Nga? Nga: I’m from Vietnam Kate: Why...

Ngày tải lên: 17/10/2013, 20:11

... faced a historically high flood, as severe as that of 1961 which was the most destructive flood in past 70 years The flood in 2000 was extreme not only in terms of its very high peak level and ... areas are as important as safety helmets for people driving motorbikes on the highways In recent years, hundreds of children have drowned due to lack of life vests Children in the flood areas ... consideration of the activity effectiveness of structural and non-structural measures and analysis of human behaviour on flood risks in the Mekong River Delta REFERENCES Asian Disaster Reduction...

Ngày tải lên: 18/10/2013, 12:15

... Carbon-Rich Biomass Wood gas (or synthesis gas) is another form of biogas produced by thermal gasification of woody biomass or other carbon-rich materials in a gasifier or wood gas generator Usable ... switchgrass, barley, hemp, kenaf, potatoes, sweet potatoes, cassava, sunflower, fruit, molasses, corn, stover, grain, wheat, straw, cotton, biomass in general as well as many types of cellulose waste ... mixture of ethanol is added to gasoline (as is common in E10 gasohol), aldehyde emissions increase by as much as 40%, and these components are not regulated in emissions laws The use of alcohol...

Ngày tải lên: 25/10/2013, 05:20

... more easy, than try itself to understand it Waste time - is the main problem of student who spend a lot of time and force for solving a problem, which can be solved with the help of PC faster ... of the problem of computer illiteracy is the lack of useful information in the course of information science The second cause is unwillingness to learning - many people think that easier to ask ... computer literacy is on of the main requirement at employment Thus we see that the problem of computer illiteracy is one of the main problems for business-students because of it we waste time, we lose...

Ngày tải lên: 26/10/2013, 17:15