3 hrqol in clinical trials for hodgkin lymphoma

... viable instrument for assessing symptom severity and response to treatment in clinical trials of patients with GERD 10 11 12 Competing interests The authors declare that they have no competing interests ... status Ascertaining the minimal clinically important difference Control Clin Trials 1989, 10:407-415 Juniper EF, Guyatt GH, Willan A, Griffith LE: Determining a minimal important change in a disease-specific ... represents a viable instrument for assessing symptom severity, subject selection and response to treatment in clinical trials of GERD Work focusing on the performance of the RDQ for epidemiological...

Ngày tải lên: 18/06/2014, 22:20

... often intuitively more understandable by clinicians Thus, it is typical for a clinical treatment study in psychiatry to be designed mainly 46 Chapter 8: Clinical trials to describe a change in depressive ... aspirin versus streptokinase for prevention of myocardial infarction, with a finding in favor of aspirin In subgroup analyses by astrological sign, the authors found that patients born under Gemini ... kind of measurement, such as points on a depression rating scale This measurement can be defined in various ways; for example, it can reflect the actual change in points on a depression rating...

Ngày tải lên: 01/11/2013, 11:20

... antidepressants, including tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors [5,6] The trials in this analysis all included patients ... Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials Int Clin Psychopharmacol 2002, 17:281-285 ... Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials: a replication analysis Int Clin Psychopharmacol...

Ngày tải lên: 08/08/2014, 23:21

... event For gastrointestinal adverse events, we included an overall measure of gastrointestinal tolerability as well as individual gastrointestinal adverse events of nausea, vomiting, abdominal pain, ... study treatments, dosing, and number and baseline characteristics of patients for the individual trials All trials conformed to good clinical practice guidelines Available online http://arthritis-research.com/content/7/3/R644 ... achieved Trials were scored for quality using a three-item, 1- to 5-point scale [12], and at least two points, one each for randomisation and double blinding, were required for inclusion Trials...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20

... so in clinical practice as in clinical trials, although discontinuations have been mentioned previously in clinical trials in rheumatology, as with meloxicam in ankylosing spondylitis [37] In clinical ... in clinical trials that is paramount There are few comparisons on which to draw, although it is generally assumed that discontinuation rates are higher in clinical practice than in clinical trials ... This analysis demonstrated again that useful and informative information can be obtained from clinical trial reports, which are more detailed in their reporting of the trials than are published papers,...

Ngày tải lên: 09/08/2014, 10:23

... Vorinostat clinical trials have been updated lately [13,74] This review focuses on recent development in clinical trials testing newer HDAC inhibitors as anti-tumor agents PCI-24781 PCI-24781 (formerly ... with ionizing radiation and other DNA-damaging agents in pre -clinical studies [75] Recent pre -clinical data have suggested that it may act, in part, by inhibiting DNA repair resulted in a synergistic ... decitabine at a five day schedule in combination with HDAC inhibitors is ongoing [139,140] A phase II study of hydralazine and VPA in treating patients with advanced solid tumors revealed clinical...

Ngày tải lên: 10/08/2014, 22:20

... databases contain information on all institution-specific research projects, only non-industry studies labelled as clinical trials involving adults will be eligible for inclusion Principal investigators ... aids For information producers, the benefits of presenting DAs online include easy updating compared to print media, and easy dissemination via the internet [55] For patients, advantages include ... How informed is informed consent: the BHAT experience Control Clin Trials 1981, 2:287-303 Joffe S, Cook EF, Cleary PD, Clark JW, Weeks JC: Quality of informed consent in cancer clinical trials: ...

Ngày tải lên: 11/08/2014, 05:21

... databases contain information on all institution-specific research projects, only non-industry studies labelled as clinical trials involving adults will be eligible for inclusion Principal investigators ... aids For information producers, the benefits of presenting DAs online include easy updating compared to print media, and easy dissemination via the internet [55] For patients, advantages include ... How informed is informed consent: the BHAT experience Control Clin Trials 1981, 2:287-303 Joffe S, Cook EF, Cleary PD, Clark JW, Weeks JC: Quality of informed consent in cancer clinical trials: ...

Ngày tải lên: 11/08/2014, 16:21

... both the feasibility of providing information about clinical trials according to informed consent criteria and the understanding of information related to clinical trials The appreciation of children ... minors or young children, the primary target of clinical investigators in clinical studies with an ethical position should be to improve information for minors and not to obtain a "formal" informed ... practice of providing information to parents, children and adolescents in clinical trials or studies can be improved by using structured interviews This increases understanding, even that of...

Ngày tải lên: 13/08/2014, 18:21

... significant treatment effect Inefficient analysis of trials may contribute this the failure • Dichotomous analysis of an ordinal outcome scale in clinical trials results in loss of information Previous ... dichotomising continuous variables BMJ 2006, 332:1080 Machado SG, Murray GD, Teasdale GM: Evaluation of designs for clinical trials of neuroprotective agents in head injury European Brain Injury ... the Pharmos trial in TBI [21] The proportional odds model was used in several neurological trials, for example, in the GAIN International trial [22] and the SAINT I trial [23] Inherent to the proportional...

Ngày tải lên: 14/08/2014, 08:21

... Ideas finding What are some ways to improve their speaking ability? Consider to apply teaching four skill for students included speaking, listening, reading and writing instead of just teaching ... School for Gifted Students questionnaires Instrument interview class observation Everything observed, heard, and experienced during class observation was carefully noted in detail in the following ... Content Warm-up Pre-speaking While-speaking Post-speaking Homework Teacher’s activities Student’s activities Procedure for conducting the questionnaire survey fifteen minutes before the classes began...

Ngày tải lên: 19/09/2016, 07:38

... First Second Interval (months) 10* 11 DCIS Invasive DCIS Invasive Invasive Invasive Invasive Invasive DCIS Unknown Invasive Invasive DCIS Invasive DCIS Invasive Invasive Invasive Invasive Invasive ... carcinoma in- situ; ABVD: doxorubicin, bleomycin, vinblastine and dacarbazine; MOPP: nitrogen mustard, vincristine, procarbazine and prednisone; MRI: Magnetic Resonance Imaging; CI: confidence interval; ... characteristics in women treated with supradiaphragmatic radiation for Hodgkin lymphoma: Mayo Clinic experience Mayo Clin Proc 2003, 78:708-715 Alm El-Din MA, Hughes KS, Finkelstein DM, Betts KA,...

Ngày tải lên: 09/08/2014, 09:22

... radiotherapy in stage I and II Hodgkin lymphoma Clin Oncol (R Coll Radiol) 2005, 17:47-53 Zellmer DL, Wilson JF, Janjan NA: Dosimetry of the breast for determining carcinogenic risk in mantle irradiation ... challenging In particular, the cancer-registry information that proved pivotal in quantifying SC risks after HL [5,7,8] does not generally contain detailed individual-level data on treatment In contrast, ... ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) Approval from the research ethics board was obtained for this study Radiotherapy technique Patients were planned in the supine position,...

Ngày tải lên: 09/08/2014, 10:21

... Pre-flushing × 103 4.5 × 103 Pre-flushing × 102 Post-flushing Bathroom sink Sampling mode Post-flushing Sampling site 3.5 × 102 chlorine of to mg/L) of the hospital water system is now routinely ... fast and easy to perform, this test has caused a decrease in the use of cultures to detect infection, resulting in incomplete surveillance for legionellosis [5] The Binax urinary antigen kit detects ... to those observed before treatment This suggests a need for continuous monitoring and a maintenance regime for the hospital plumbing system, particularly in wards accommodating high-risk patients...

Ngày tải lên: 10/08/2014, 23:20

... valuable information for first-line therapy Infrastructure for clinical trials In the remainder of the article, we have set forward our thoughts on infrastructure issues to support clinical trials ... regulations Financial support for clinical trials The effective conduct of clinical trials requires a major commitment of time and other resources An ongoing commitment to clinical trials in gynecological ... cancer remains a critical goal The Clinical Trials Cooperative Groups represented in the GCIG, both in their individual and in their joint efforts, have made major contributions to this effort Additional...

Ngày tải lên: 13/02/2014, 07:20

... The gingiva is not exposed during smiling, and the situation is favorable for implant placement I ntraoral examination • Jaw opening (Fig 1-6) The first thing to before the intraoral examination ... modifying the situation and reducing or eliminating excessive risk factors (for example, by reducing or eliminating cantilevers, modifying the occlusion, inserting extra implants, etc) 53 Chapter ... another clinical unit This book is intended to show clinicians how to identify, prevent, and avoid problems in implant treatment by following logical clinical protocols Professor Per-Ingvar Branemark...

Ngày tải lên: 16/02/2014, 15:20

... Pediatric clinical trials General considerations for conducting pharmacokinetic studies in pediatric populations Children

Ngày tải lên: 05/03/2014, 10:20

... during their training many clinical psychologists experience research as a painful, alienating process For example, some may feel forced to study something they find uninteresting, or may feel inadequate ... certain interventions used in therapeutic settings Being trained in clinical or counseling psychology also makes one aware of the tension between the scientific and the therapeutic stance: in the former ... behaviour The interviewing skills acquired in clinical and counseling training are also helpful in doing research, but research and therapeutic interviews have crucial differences; therefore researchers...

Ngày tải lên: 06/03/2014, 05:20