3 evolution of breast cancer precursors clonal expansion

... Fig Example of a breast cancer risk profile NSABP ‫ ס‬National Surgical Adjuvant Breast and of breast cancer and was not included in the Bowel Project; UNK ‫ ס‬unknown (Reproduced from Cancer Control ... women, respeccancer was assessed by means of a comparison of the rates of the tively The rates of occurrence of tumors of 2.1–3.0 cm were occurrence of that disease during each of the first yearly ... of invasive breast cancer were calculated for several subgroups of women When age, history of LCIS, history of atypical hyperplasia, and levels of predicted risk of breast cancer were taken into...

Ngày tải lên: 15/02/2014, 04:20

... Development of displays and workstation design for improved image interpretation Discovery of molecular profiles toward goal of precise molecular diagnosis of cancer Breast cancer is one of eight cancers ... risk of developing breast cancer Thus, the lifetime risk of developing breast cancer is 14.4 percent, whereas the absolute risk of developing breast cancer over the decade between the ages of 40 ... BISTIC BRCA BSE Biofield Breast Examination Blue Cross/Blue Shield Association Breast Cancer Progress Review Group Breast Cancer Research Program Breast Cancer Surveillance Consortium Breast Imaging...

Ngày tải lên: 05/03/2014, 12:20

... treatment of breast cancer Clinical practice guidelines for the care and treatment of breast cancer: 14 The role of hormone replacement therapy in women with a previous diagnosis of breast cancer ... Email: sco@breastcancercare.org.uk • www.breastcancercare.org.uk Breast Cancer Care provides information, practical assistance and emotional support for anyone affected by breast cancer CancerBACUP ... there are indications that MRI is useful  MANAGEMENT OF BREAST CANCER IN WOMEN 2.3.2 staging of breast cancer In early operable breast cancer (T1-2, N0-1; see annex 2), there is no current evidence...

Ngày tải lên: 08/03/2014, 14:20

... for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer Cancer Causes Control, 8, pp49-56 18 Collaborative Group on Hormonal Factors in Breast Cancer ... The protective role of pregnancy in breast cancer Breast Cancer Res., 7(3), pp131-42 20 Collaborative Group on Hormonal Factors in Breast Cancer (2002b) Breast cancer and breastfeeding: collaborative ... Risk of breast cancer in relation to lifetime alcohol consumption J Natl Cancer Inst., 87, pp923-929 35 Cancer Research UK (2007) About breast cancer: Breast cancer risks and causes http://www.cancerhelp.org.uk/help/default.asp?page=3285...

Ngày tải lên: 15/03/2014, 01:20

... expression of alternatively spliced isoforms v6 and v9 of CD44 in breast cancer cells, leading to an increase in cell migration [84] In a similar approach, sublines of the breast cancer cell ... initial spreading of cancer cells to local lymph nodes via the lymphatics in human breast cancer Another important aspect to the understanding of breast cancer metastasis is the role of different ... late-stage metastatic cancer [47] The MMTV-PyMT mouse model of breast cancer is furthermore characterized by short Page of 11 (page number not for citation purposes) Breast Cancer Research Vol...

Ngày tải lên: 22/03/2014, 17:20

... Hathaway et al Breast Cancer Research 2011, 13:R108 http:/ /breast- cancer- research.com/content/13/5/R108 Introduction New cases of invasive breast cancer were predicted to exceed ... followed by BT-474 breast cancer cells (2.75 × 106), MCF7 breast cancer cells (0.18 × 106), and MDA-MB-231 breast cancer cells (0.11 × 106) The Chinese hamster ovary (non -breast) cell line has ... level of Prussian blue staining is seen in tumors Hathaway et al Breast Cancer Research 2011, 13:R108 http:/ /breast- cancer- research.com/content/13/5/R108 Page of 13 Her2 noAb A B Figure Binding of...

Ngày tải lên: 22/03/2014, 17:20

... member of this team Guidelines for the diagnosis and treatment of breast cancer are further elaborated in Guidelines for management of breast cancer (2006)1 Guidelines for management of breast cancer, ... diagnosis of breast cancer, improving the treatment and care provided to women with breast cancer is obviously an integral factor in decreasing overall mortality from breast cancer Treatment of breast ... important benefit of an effective breast cancer screening programme is a reduction in breast cancer mortality and an increase in life years of good quality The cost-effectiveness of a breast cancer screening...

Ngày tải lên: 28/03/2014, 23:20

... of breast cancer Figure 12 Bilateral breast cancer Management of special problems in breast cancer Figure 13 Paget’s disease of the nipple-areola complex Figure 14 Cancer of the male breast: diagnosis ... in breast cancer This chapter gives guidelines on management of special problems in breast cancer (Figures 11–16) Figure 11 Phyllodes tumour of the breast 36 Guidelines for management of breast ... diagnosis 37 38 Guidelines for management of breast cancer Figure 15 Cancer of the male breast: management Management of special problems in breast cancer Figure 16 Unknown primary presenting...

Ngày tải lên: 28/03/2014, 23:20

... already have breast cancer Risk of Breast Cancer Most women will never get breast cancer A woman’s risk of breast cancer depends on her age and other risk factors Most women who get breast cancer ... risk of breast cancer What is not covered in this guide? This guide does not cover other ways to lower your risk of breast cancer It does not discuss having surgery to lower the risk of breast cancer ... n Most women will never get breast cancer n A woman’s risk of breast cancer increases with age n Two different medicines can lower the risk of some kinds of breast cancer n Both medicines have...

Ngày tải lên: 29/03/2014, 01:20

... means of each treatment group Discussion The present study of alpha-particle-emitting 227Th-trastuzumab showed a significant dose-dependent inhibition of tumor growth of human SKBR-3 breast cancer ... Treatment of HER2expressing breast cancer and ovarian cancer cells with alpha particleemitting 227Th-trastuzumab Int J Radiat Oncol Biol Phys 2011, 79:563-570 Page 12 of 12 18 Henriksen G, Hoff P, ... Metastasis to bone from carcinoma of the breast Clin Orthop 1958, 11:202-216 24 Thorpe PE, Burrows FJ: Antibody-directed targeting of the vasculature of solid tumors Breast Cancer Research and Treatment...

Ngày tải lên: 21/06/2014, 01:20

... during my periods of leave LIST OF FIGURES Pages Figure 1.1: Anatomy of a Breast Figure 1.2: Anatomy of the Breast Figure 1.3: Benign Breast Image 14 Figure 1.4: Tumour on Left Breast 14 Figure ... behind the breastbone, and in many other parts of the body The lymph nodes trap bacteria, cancer cells, or other harmful substances [11] Figure 1.2: Anatomy of the Breast Breast cancer is a cancer ... point of origin is determined by the appearance of the cancer cells under a microscope In situ (non-invasive) breast cancer refers to cancer in which the cells have remained within their place of...

Ngày tải lên: 14/07/2014, 11:49

... state of the art breast radiotherapy as an adjunct to modern breast conserving surgery Conclusions Early stage breast cancer can be treated with breast conserving therapy and accelerated partial breast ... R, Taylor C, Wang Y, Early Breast Cancer Trialists’ Collaborative Group (EBCTCG): Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence ... treatment of breast cancer N Eng J Med 1995, 333:1456-1461 Pawlik TM, Buchholz TA, Kuerer HM: The Biologic Rational for and Emerging Role of Accelerated Partial Breast Irradiation for Breast Cancer...

Ngày tải lên: 09/08/2014, 01:24

... type of mastectomy for breast cancer treatment Breast Cancer Res Treat 2006, 96:47-51 Gulben K, Yildirim E, Berberoglu U: Prediction of occult nipple-areola complex involvement in breast cancer ... therapeutic benefit of removal of internal mammary lymph nodes (IMN) in patients with breast cancer [217], it is well known that involvement of Table 10 SLN in Recurrent Breast Cancer Author Year ... R, Taylor C, Wang Y: Early Breast Cancer Trialists Collaborative Group (EBCTCG) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence...

Ngày tải lên: 09/08/2014, 03:21

... calibrator consisting of a pool of normal breast tissue specimens For this, specimen of adjacent normal breast tissue from 12 of the breast cancer patients was used as a source of normal RNA Final ... role for AR in breast cancer outcome, AR potently inhibited ERa transactivation activity and 17b-estradiol-stimulated growth of breast cancer cells Transfection of MDA-MB-231 breast cancer cells ... risk of breast cancer associated with allele lengths of 26 CAG repeats or greater [23] On similar lines Giguere et al (2001) examined the inverse association of CAG repeat length on breast cancer...

Ngày tải lên: 09/08/2014, 03:21

... occurs in 15% of cases [6,7] Other less common primary sites leading to secondary metastasis to gall bladder include renal cell cancer, cervical cancer, lung cancer, and breast cancers [8] Figure ... lobular carcinoma of the breast: tumor characteristics and clinical outcome Breast Cancer Res 2004, 6(3):R149-56 Beaver BL, Denning DA, Minton JP: Metastatic breast carcinoma of the gallbladder ... first case of breast cancer initially presenting as a gallbladder perforation We postulate that the rupture may be the result of increased pressure in the gallbladder due to obstruction of the cystic...

Ngày tải lên: 09/08/2014, 04:21

... and also no FDG Uptake of the benign both breast cancer and in metastatic axillary and FDG PET scans, First Column of the Figure showed increased FDG uptake in both breast cancer and in metastatic ... cancer The lung is the second most common organ for metastasis of breast cancer after the bone [5] We present herein a patient with breast cancer who had also bilateral pulmonary multiple masses in ... variety of other pulmonary lesions especially metastatic lesions to the lung In women, the appearance of metasta- http://www.wjso.com/content/6/1/7 sis is a frequent complication of breast cancer...

Ngày tải lên: 09/08/2014, 07:21

... recurrence of breast cancer, and iv) no other cancer except for basal cell carcinoma, carcinoma in situ of the uterine cervix, or prior or simultaneous surgery for contralateral breast cancer stage ... reported survey The measurement of the thyroid gland volume represents the main limitation of this small study On the background of the lack of contrast the delineation of the individual thyroid gland ... with breast cancer Acta Oncol 1986, 25:167-170 Bruning P, Bonfrer J, Jong-Bakker MD, et al: Primary hypothyroidism in breast cancer patients with irradiated supraclavicular lymph nodes Br J Cancer...

Ngày tải lên: 09/08/2014, 09:20

... the delay of DFS was calculated by the date of surgery until the date of revealing of a progress or until the date of death, or until the date of last news The median follow-up, the rate of disease ... adjuvant treatment in operable breast cancer N Engl J Med 1976, 294:405-410 Early Breast Cancer Trialists' Collaborative Group Systemic treatment of early breast cancer by hormonal cytotoxic, ... non operable and recurrent breast cancer In early breast cancer, the previous published studies failed to show superiority of concurrent chemo-radiotherapy in term of survival From the present...

Ngày tải lên: 09/08/2014, 09:22

... difference between breast cancer after Hodgkin's lymphoma and primary breast cancer; log-rank test: P = 0.4 Abbreviations: BC, breast cancer; HL, Hodgkin's lymphoma majority of cancers being metachronous ... JT: Cancer in the contralateral breast after radiotherapy for breast cancer N Engl J Med 1992, 326:781-785 Hildreth NG, Shore RE, Dvoretsky PM: The risk of breast cancer after irradiation of the ... prognosis of synchronous and metachronous bilateral breast cancer J Clin Oncol 2007, 25:4210-4216 Robinson E, Rennert G, Rennert HS, Neugut AI: Survival of first and second primary breast cancer Cancer...

Ngày tải lên: 09/08/2014, 09:22

... HER2-positive breast cancers Breast Cancer Res 2009, 11:R15 doi:10.1186/gm202 Cite this article as: Iwamoto T, Pusztai L: Predicting prognosis of breast cancer with gene signatures: are we lost in a sea of ... gene-expression profiles of breast cancers that recurred (mostly the ERnegative and the high grade, ER-positive cancers) and those that did not (low grade, ER-positive cancers) in the absence of any systemic ... prognosis of ER-positive breast cancers relatively accurately because prognosis is closely related to the proliferative status of these cancers and proliferation affects the expression of several...

Ngày tải lên: 11/08/2014, 12:21