3 ductoscopy in breast cancer cases lessons learned

... as an independent prognostic factor for disease-free survival in patients with breast cancer Am J Clin Oncol 2004, 27:304-306 15 Truong PT, Olivotto IA, Kader HA, et al: Selecting breast cancer ... primary breast carcinomas from patients at high risk for local recurrence after breast- conserving therapy Clin Cancer Res 2006, 12:5705-5712 26 Fisher B, Wolmark N, Redmond C, et al: Findings from ... crude way of defining a potential indication for PMRT More information may come from other clinicopathologic parameters (e.g., capsule and lymphovascular invasion, malignancy grading, etc.) Moreover,...

Ngày tải lên: 09/08/2014, 09:20

... involved in a telomerase-independent pathway of telomere maintenance that involves recombination (reviewed in 29,30) Components of the DNA damage response associated with DNA end-to-end joining ... reduction of signal following incubation with increasing amounts of the single-strand-specific Mung Bean nuclease (Fig 1B) To ensure the integrity of double-stranded genomic DNA following nuclease treatment, ... chromosome numbers presented in parentheses b Numbers presented with incidence per cell are indicated in parentheses in the second row In the third row, percentage of cells having aberrations are presented...

Ngày tải lên: 12/09/2015, 08:16

... COL-3 bind mainly to albumin So protein-binding interaction, where competition for the protein-biding site involves, could be a good reason to explain this phenomenon Some cases of protein displacement ... Chapter In Vitro Studies 5.1 PROTEIN BINDING STUDY 5.1.1 Introduction The binding of drugs to plasma and tissue proteins is a major determinant of drug distribution throughout the body Protein binding ... an in vitro investigation would be conducted to examine the effects of COL-3 and tamoxifen, in single agent or in combination against human breast cancer cell lines, MDA-MB-231 and MCF-7 Finally,...

Ngày tải lên: 09/10/2015, 11:24

... Clinical breast examination in primary care Each primary care team should include at least one practitioner who has had specific training in carrying out clinical breast examination (CBE) in ... to breast clinics for investigation of possible or suspected breast cancer are referred by GPs; the remaining 20% are identified by routine screening For historical reasons, breast screening in ... Co-ordinating Group Cancer Services Co-ordinating Group 2000 22 Dewar JA, Twelves CJ, Thomson CS for the Scottish Breast Cancer Focus Group and the Scottish Cancer Therapy Network Breast Cancer in...

Ngày tải lên: 14/02/2014, 22:20

... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring...

Ngày tải lên: 15/03/2014, 00:20

... antihormoneresistant human breast cancer cells to estrogen-induced apoptosis Breast Cancer Res 10(6): R104 Lewis, J S., K Meeke, et al (2005) Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells ... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible ... efficient in apoptosis induction DNA-damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006)...

Ngày tải lên: 23/03/2014, 17:20

... progestin administration was thus associated with the beginning of growth inhibition by progestins GPR30 mRNA is regulated according to the dose of progestin, which also correlated with progestin-induced ... and C-C chemokine receptors Chemokines [27,28] and angiotensin II [29] have both shown growth-inhibiting properties with different cancers Interestingly, an orphan receptor (GPR41 in the rat), ... steroid hormones Progestin administration causes an initial increase in cell proliferation lasting about 12–24 h and subsequent GPR30 and progestin (Eur J Biochem 269) 2489 inhibition of proliferation...

Ngày tải lên: 24/03/2014, 00:21

... delay in operable breast cancer patients Eur J Cancer Prev 2001, 10:53-59 Ebrahimi M, Vahdaninia M and Montazeri A: Risk factors for breast cancer in Iran: a case-control study Breast Cancer ... Medicine 2000, 30:174-177 Montella M, Crispo A, Botti G, De Marco M, De Bellis G and Fabbrocini G et al.: Assessment of delay in obtaining definitive breast cancer treatment in southern Italy Breast ... regarding breast cancer concluded that since older age is a risk factor for both developing breast cancer and subsequent delayed presentation, any intervention program should target older women in...

Ngày tải lên: 28/03/2014, 14:20

... proteins involved in various cellular processes, including inhibition of apoptosis Hypoxia has been reported to inhibit apoptosis induced by tumor necrosis factor-related apoptosisinducing ligand ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer cells ... hypoxia in MDA-MB-468 cells (Fig 2B), resulting in a 35% decrease in nuclear BRCA1 relative to the level in normoxic cells in the presence of 2E5 The decrease in C Fig Hypoxia-induced changes in BRCA1...

Ngày tải lên: 30/03/2014, 03:20

... serum protein features of a number of cancers in the near future [47] Translational research in breast cancer Breast cancer Breast cancer is the most common malignancy among women in the Western ... known to be deregulated in various cancers, including breast cancer [81–85] Both p53 and GSK-3b have been implicated in regulating the levels of b-catenin [86] As shown in Fig 5A, tumour 14 depicts ... (2003) Circulating interleukin-6 predicts survival in patients with metastatic breast cancer Int J Cancer 103, 642–646 62 Bray GA (2004) Medical consequences of obesity J Clin Endocrinol Metab 89,...

Ngày tải lên: 30/03/2014, 15:20

... Bin1 in colon cancer Expression of IDO and Bin1 in colon cancer IDO is expressed in primary colon cancer cells (A), in adjacent non-cancerous epithelium (B) in lymph node metastases (C), and in ... frequency percentage) The intensity of membrane staining was grouped into the following categories: no staining/background of negative controls (score = 0), weak staining detectable above background ... Margreiter R, Königsrainer A, Fuchs D, Amberger A: Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells Clin Cancer Res 2006, 12(4):1144-1151...

Ngày tải lên: 18/06/2014, 15:20

... p-value less than 0.05 Injection of free DiD resulted in no increase in fluorescent intensity within the tumor at any time point post-infusion Figure labeling (a) Optical imaging of DiD-labeled cells ... adaptive and innate immune cells during breast cancer progression Breast Cancer Res 2007, 9:212 Balkwill F, Charles KA, Mantovani A: Smoldering and polarized inflammation in the initiation and ... human breast cancer Clin Cancer Res 2000, 6:3282-3289 Jin H, Su J, Garmy-Susini B, Kleeman J, Varner J: Integrin alpha4beta1 promotes monocyte trafficking and angiogenesis in tumors Cancer Res...

Ngày tải lên: 18/06/2014, 15:20

... measurement in randomized clinical trials in breast cancer – taking stock Journal of the National Cancer Institute 2003, 95(4):263-281 Montazeri A: Health-related quality of life in breast cancer ... oncology clinical research [29-31] It has also been validated [32] and found to be responsive [33] specifically in breast cancer patients and is widely used in breast cancer research investigating HRQoL ... Patients were included in the trial after finalizing treatment and after giving written informed consent Treatment included surgery and/or radiotherapy and/or chemotherapy Followup appointments took...

Ngày tải lên: 18/06/2014, 19:20

... antihormoneresistant human breast cancer cells to estrogen-induced apoptosis Breast Cancer Res 10(6): R104 Lewis, J S., K Meeke, et al (2005) Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells ... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible ... efficient in apoptosis induction DNA-damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006)...

Ngày tải lên: 27/06/2014, 11:20

... [22] There is a growing interest in the possible role of exercise in enhancing QOL, reducing recurrence and other diseases, and extending survival in cancer survivors Preliminary research suggests ... research using rigorous methodology is needed to definitively answer questions concerning the role of exercise in enhancing QOL in cancer survivors both during and after treatment [12] Breast cancer ... exercise training and natural killer cell cytotoxic activity in breast cancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma prognosis Cancer...

Ngày tải lên: 08/08/2014, 16:23

... invasion begins with inflammation around cancer cells Thus, it has been reported that serum CRP levels are higher in cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal ... TNM staging system of breast cancer thus indirectly correlating with the prognosis of the patient CRP estimation does not seem to be very useful in evaluating the patient with breast cancer, ... significance of interleukin serum levels in patients with ovarian cancer Br J Cancer 1995, 71:354-356 De Vita F, Orditura M, Auriemma A, Infusino S, Roscigno A, Catalano G: Serum levels of interleukin as...

Ngày tải lên: 09/08/2014, 01:24

... tumors originating from the interstitial cells of Cajal, which are pacemaker cells regulating autonomic motor activity in the gastrointestinal tract The majority of the GISTs arise in the stomach ... present with abdominal pain, satiety, obstruction, or GI bleeding However, Figure Pre-operative CT scan showed gastric mass with curvilinear calcification penetrating into surrounding soft tissue ... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ...

Ngày tải lên: 09/08/2014, 01:24

... survival in invasive breast cancers [24] In conclusion, we found that the incidence of sentinel lymph node metastasis in cases of pure DCIS was 0.39% This incidence was lower than that in IDC-predominant ... Rome Breast Cancer Study Group: Sentinel lymph node biopsy in women with pT1a or “microinvasive” breast cancer Breast 2008, 17:395-400 Zavagno G, Belardinelli V, Marconato R, Carcoforo P, Franchini ... stromal invasion Furthermore, having less than 0.5 cm of stromal invasion increases the incidence of sentinel lymph node metastases [15,16] As a result, many investigators insist that sentinel lymph...

Ngày tải lên: 09/08/2014, 03:21

... of cancer recurrence or new breast cancer than women who did not use HRT (RR, 0.62) In this study, we did not evaluate these factors and recommend evaluating in the future Number of all cases in ... new era in breast cancer Invasion, size, and nodal involvement dramatically decreasing as a result of mammographic screening Arch Surg 1996, 131(3):301-308 Fisher B, Slack NH, Bross ID: Cancer ... of the National Cancer Institute early breast cancer trial J Natl Cancer Inst Monogr 1992, 11:27-32 27 Saphner T, Tormey DC, Gray R: Annual hazard rates of recurrence for breast cancer after primary...

Ngày tải lên: 09/08/2014, 03:21

... Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in Guilin city of China The specimens were fixed in 10% neutral-buffered formalin (pH7.4) ... found in 35 cases (27.1%) and discordance in 94 cases (72.9%) [15] Lan et al used FISH to ascertain the prevalence of erb-b2 gene amplification in 221 cases of breast cancer specimens read as 2+ in ... concordance between IHC and FISH in 50 cases of invasive ductal carcinoma of breast Methods Study Design The study population consists of 50 cases of invasive ductal carcinoma of breast treated between...

Ngày tải lên: 09/08/2014, 04:21