2role of il 1 beta in gastric cancer risk

... have no competing interests Received: 24 January 2 011 Accepted: 14 June 2 011 Published: 14 June 2 011 References Stock M, Otto F: Gene deregulation in gastric cancer Gene 2005, 360 (1) :1- 19 Folkman ... location of midkine in gastric carcinomas of Chinese patients Cell Mol Immunol 2007, 4(2) :13 5 -14 0 Page of 13 Wang Q, Huang Y, Ni Y, Wang H, Hou Y: siRNA targeting midkine inhibits gastric cancer ... regulated in metastasizing canine mammary adenocarcinomas J Comp Pathol 2009, 14 1(2-3) :11 3 -12 0 He et al Journal of Biomedical Science 2 011 , 18 :39 http://www.jbiomedsci.com/content /18 /1/ 39 Page of 33...

Ngày tải lên: 10/08/2014, 05:21

... above in vivo findings PI3K/Akt is involved in PrPC-mediated MDR in gastric cancer In order to study whether activation of the PI3K/Akt signaling pathway played a role in PrPC-induced MDR in gastric ... inhibition of PrPC-induced cell drug resistance in gastric cancer cells PI3K/Akt is involved in the activation of P-gp by PrPC in gastric cancer To further investigate the underlying mechanism of PI3K/Akt-mediated ... SGC79 01 by increasing ADR stepwise from 0. 01 to 0.8 lgÆmL )1, and has been characterized previously [26] The cells were maintained in RPMI -16 40 containing 10 % heat-inactivated newborn bovine serum...

Ngày tải lên: 07/03/2014, 03:20

... enhancing effect of A77 17 26 on IL- 1 -induced IL- 1Ra production was due to inhibition of COX-2 activity, then the effect of indomethacin on IL- 1Ra production should be comparable to that of A77 17 26 ... functions of the different IL- 1Ra isoforms are still not clear [25–27] The major role of secreted IL- 1Ra is to block the effects of IL- 1 by binding competitively to IL- 1 receptor I without inducing ... of IL- 1Ra over IL- 1 Even higher molar ratios of IL- 1Ra : IL- 1 were obtained when IL- 1 was combined with TNF-α Although large amounts of IL- 1 are needed to obtain maximal catabolic effects in vitro,...

Ngày tải lên: 09/08/2014, 01:23

... Journal of Surgical Oncology 2 010 , 8: 71 http://www.wjso.com/content/8 /1/ 71 Page of Through the feeding tube, a complete polymeric isotonic enteral nutrient was administered, in a dose of 1. 5 grams of ... of protein per kilogram of weight per day, by using an infusion bomb during 20 hours, (with a resting time of hours) Results The complete closing of the fistula was evident in day 8, 14 and 25 ... factors in gastric carcinoma: results of the German Gastric Carcinoma Study 19 92 Cancer 19 93, 72:2089-2097 Budisin N, Budisin E, Golubovic A: Early complications following total gastrectomy for gastric...

Ngày tải lên: 09/08/2014, 03:22

... purposes) 13 14 15 16 17 Martinon F, Tschopp J: Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases Cell 2004, 11 7:5 61- 574 Martinon F, Tschopp J: NLRs join ... reduced the inflammatory response in the same model Coadministration of MSU crystals with two different IL- 1 inhibitors (anti -IL- 1RI mAb or IL1 R antagonist (anakinra)) had similar and marked inhibitory ... effectiveness of IL- 1 inhibition in preventing neutrophil trafficking to the peritoneum, whereas TNF inhibition did not have any effect Indeed, TNF inhibition aggravated neutrophil influx At present...

Ngày tải lên: 09/08/2014, 10:20

... Carcinogenesis 20 01, 22 :11 11- 111 7 46 Kundu JK, Shin YK, Kim SH, Surh YJ: Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NFκB in mouse skin by blocking IκB kinase ... proliferation and induction of apoptosis Blood 2003, 10 1 :10 53 -10 62 38 Chen YR, Tan TH: Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin Oncogene 19 98, 17 :17 3 -17 8 39 Li WQ, ... http://arthritis-research.com/content /11 /6/R165 Figure 12 Inhibitory effects of resveratrol and curcumin on IL- 1 -induced NF-κB activation and apoptosis in primary human chondrocytes in vitro IL- 1 stimuvitro lates the IL- 1 receptor,...

Ngày tải lên: 09/08/2014, 14:22

... Histological grading Low 34 11 23 16 18 Moderate 18 13 0. 916 10 0.703 9.03 ± 4.37 9.88 ± 5 .15 Well 3 8 .14 ± 2.69 36 20 12 24 15 0. 516 17 19 12 0.602 0. 919 10 0 .15 9 15 24 0.7 21 Depth of invasion T1+T2 T3+T4 ... staining of D2-40 is similar to that of the COX-2 staining at a dilution of 1: 100 Evaluation of immunohistochemical staining Fifty-six patients with histologically proven gastric adenocarcinoma ... T3+T4 8.37 ± 3.85 10 .80 ± 5.24 0.052 6.64 ± 3. 01 0.003 Lymph node metastasis No 17 12 Yes 39 12 27 I+ II 34 11 23 III+IV 22 16 10 .37 ± 4. 61 TNM stage 0.686 18 16 15 0 .12 8.40 ± 3.95 10 .53 ± 5.08 0.084...

Ngày tải lên: 10/08/2014, 10:21

... in gastric cancer patients Med Oncol 2 010 , 27 :13 19 -13 23 [34] Kerem M, Ferahkose Z, Yilmaz UT, Pasaoglu H, Ofluoglu E, Bedirli A, Salman B, Sahin TT, Akin M Adipokines and ghrelin in gastric cancer ... acetylation of histone and tubulin in a scirrhous gastric cancer cell line J Exp Clin Cancer Res 2 010 , 29 :14 9 [30] Japanese Gastric Cancer Association Japanese classification of gastric pg 23 carcinoma ... Expression of AdipoR1/R2 and effect of adiponectin on gastric cancer cells To determine the expression of AdipoR1/R2 in gastric cancer cell lines, western blotting analysis was performed As shown in...

Ngày tải lên: 10/08/2014, 10:21

... INTRODUCTION 1. 1 Gastric cancer 1. 1 .1 Epidemiology 1. 1.2 Risk Factors 1. 1.3 Classification 1. 1.3 .1 Types of gastric cancer ... relatives with gastric cancer (Dhillon et al., 20 01) 1. 1.3 Classification 1. 1.3 .1 Types of gastric cancer In terms of the origins of neoplastic cells, gastric cancers can be divided into different types ... Microsatellite instability: 10 Involvement of p53: 11 HER-2: 12 E-cadherin: 12 1. 1.6 Treatment of gastric cancer: conventional and targeted therapies 14 1. 2...

Ngày tải lên: 09/09/2015, 08:13

... levels of 11 p13 non-amplified, 11 p13 amplified, and fusion positive samples 12 7 10 8 11 2 11 7 xiv Figure 3. 21 Unsupervised clustering of GC expression profiles reveals clustering of SLC1A2-high ... CD44-SLC1A2 silencing sensitizes GC cells to chemotherapy CD44-SLC1A2 fusion in primary gastric tumors 3.4 .1 98 10 5 10 9 11 1 Screening of CD44-SLC1A2 fusion in breakpoint positive 11 1 samples (Index ... Introduction 1. 1.2 Histological subtypes 1. 1.3 Risk factors 1. 1.4 Prevention and early detection 1. 1.5 Treatment 1. 1.6 1. 2 Gastric cancer Genetic and genomic alterations in GC 10 Fusion gene 13 1. 2 .1 Introduction...

Ngày tải lên: 09/09/2015, 18:49

... ……49 3 .1. 2 Cell Reduction of 17 Gastric Cancer Cell Lines Induced by TSA………… 51 v 3 .1. 3 Growth Inhibition of 17 Gastric Cancer Cell Lines Induced by TSA………53 3 .1. 4 Apoptosis of 10 Gastric Cancer ... Sensitivity of Gastric Cancer Cell Lines to Vorinostat (SAHA)……………. 61 3.2 .1 Growth Inhibition of Gastric Cancer Cell Lines Induced by SAHA… 61 3.2.2 Apoptosis of Gastric Cancer Cell Lines Induced ... Deacetylase Inhibitor Resistance in Gastric Cancer Cells Oncogene, 2 013 Apr 15 doi: 10 .10 38/onc.2 013 .10 4 [Epub ahead of print] xiii List of Figures Figure 1. 1 Global variation in cancer incidence for gastric...

Ngày tải lên: 10/09/2015, 09:06

... of 5-fluorouracil (5-FU) alone versus combination of irinotecan and cisplatin (CP) versus S -1 alone in advanced gastric cancer (JCOG9 912 ) Annual meeting of ASCO 2007; (aLBA4 513 T) 10 Imamura H, ... study of irinotecan plus S -1 (IRIS) versus S -1 alone as first-line treatment for advanced gastric cancer (GC03 01/ TOP-002) ASCO Gastrointestinal Symposium 2008; (a5) 12 Arkenau HT Gastric cancer in ... comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer J Clin Oncol 2002; 20 :19 96-2004...

Ngày tải lên: 06/03/2014, 02:21

... NaBu 1. 3 1. 1 1. 4 VD3 NaBu + VD3 1. 1 1. 6 α-PTEN α-actin 6.58% 10 2 10 0 B3 B4 8.84% 10 0 10 1 10 2 Annexin V-FITC 10 3 B1 10 3 16 . 31% 10 10 3 10 3 6.35% 4. 71% 10 10 1 B4 10 0 B3 25.09% 10 0 10 1 10 2 Annexin ... V-FITC 10 3 VD 7.09% 1. 53% 10 1 NaBu 10 0 15 .65% 10 2 B2 3. 51% 6.63% 10 1 10 0 B3 24 .12 % 10 2 10 1 10 0 Annexin V-FITC 10 3 N + VD3 N + VD3 10 3 5.59% 10 0 10 1 10 2 Annexin V-FITC 10 3 B1 10 1 B4 B4 B3 10 3 34.20% ... 34.20% 1. 91% 10 0 B3 1. 55% 10 1 10 2 10 0 Annexin V-FITC 10 2 B2 B1 T + VD3 B4 VD ntr ol B4 10 0 10 1 10 2 Annexin V-FITC B2 T + VD3 10 0 B3 10 1 10 0 B3 PI 10 1 7.79% 0.86% B2 NaBu 2.65% 10 0 10 1 10 2 Annexin...

Ngày tải lên: 22/03/2014, 21:20

... (14 .1% ) 99 ( 51. 6%) 61 ( 31. 8%) 17 (8.6%) 15 (7.8%) 17 (8.9%) 10 7 (55.7%) 13 (6.8%) 55 (28.6%) 65 (34%) health subscale consists of two items: (1) How would you rate your physical condition during ... 71. 2 80 .1 8.3 (0.0) 70.9 77.7 6 .1 (7.7) 0.79 0.78 0.80 0.02 (0 .14 ) 0 .16 Moderate-large improvement (n = 72) 58.2 85.6 27.4 (11 .9) 65.0 77.4 12 .1 (12 .7) 0.95 0. 71 0.83 0 .13 (0.20) 0.62 SRMs of ... extent, but cut-off points for effect sizes or discriminative ability are less relevant in the context of economic evaluations http://www.hqlo.com/content/7 /1/ 11 10 11 Conclusion In this study...

Ngày tải lên: 18/06/2014, 19:20

... (250 mg) contains an oral preparation of a minimum of 10 00 million of lactobacillus acidophilus viv Lyophilisat and minimum of 10 00 million of bifidobacterium bifidum viv Lyophilisat Patients ... treatment of diarrhea induced by E Coli, salmonella or shigella [11 ] In vitro studies have indicated that part of this effect may be due to lactobacillus strains [12 -15 ] Since dysbiosis of the intestinal ... changes in intestinal flora mediated through fermented milk intake FEMS Immunol Med Microbiol 19 94, 10 :55-64 19 Salminen E, Elomaa I, Minkkinen J, Vapaatalo H, Salminen S: Preservation of intestinal...

Ngày tải lên: 09/08/2014, 08:23

... Insulin-like growth factor binding protein 81. 6 7.4 249.9 10 .4 Insulin-like growth factor binding protein 17 4.4 569.0 737.8 229.5 IL- 1 1. 5 3.2 17 5.3 4.5 IL- 1 - 2.4 11 9.4 2.7 IL- 6 57.3 53.4 17 17.8 ... IL- 1 and/or glucosamine Gene Treatment group No glucosamine, no IL- 1 Glucosamine, no IL- 1 IL- 1, no glucosamine A disintegrin and metalloproteinase domain 15 14 2.9 12 1.3 64.9 98.3 A disintegrin ... GTPase inhibiting protein 10 5.0 11 6.5 18 9.4 12 4.4 Colony-stimulating factor 12 6.9 51. 1 307.8 14 0.8 Colony-stimulating factor - 20 .1 1 210 .7 17 .6 Colony-stimulating factor - 6.0 12 53.7 6.5 CXCL1 (GROa)...

Ngày tải lên: 09/08/2014, 08:23

... Seminars in oncology 19 91, 18 : 411 -420 12 Pettavel J: Protracted arterial chemotherapy of liver tumors: an experience of 10 7 cases over a 12 -year period Progress in Clinical Cancer 19 78, 217 -233 13 Finlay ... 27 45 :17 19 :8 25-80 (57) 23-66 (53) A or B 13 ( 21% ) (11 %) C 49 (79%) 24 (89%) I or II 28 (45%) 14 (52%) III 34 (55%) 13 (48%) (15 %) 51 (82%) (15 %) 21 (78%) (3%) (7%) Positive 10 (16 %) (11 %) Negative ... colostomy in metastatic rectal cancer International journal of radiation oncology, biology, physics 20 01, 49 :10 7 -11 6 doi :10 .11 86 /17 48- 717 X-5-75 Cite this article as: Kim et al.: The role of adjuvant...

Ngày tải lên: 09/08/2014, 09:20

... 69 69 61 61 19 19 0 1 > 0.0 01 CC CT 11 11 1 11 13 0.009 GG GA AA 14 21 28 47 15 0.027 CC CT 75 12 1 0 0.043 CC CT 64 20 0 0.0 01 CC CT 51 35 2 0 0.002 CC CT 32 25 16 0.022 a) Pleural thickening Exon ... http://www.ro-journal.com/content/2 /1/ 25 25 26 31 27 28 29 30 32 33 38 67 11 12 10 16 39 34 20 15 22 48 42 24 51 52 53 47 43 44 55 46 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 46 ... 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 36 ATG 19 14 17 21 45 23 18 3536 13 40 49 50 56 41 54 37 ATM gene Ser-367 Ser -18 93 Ser -19 81 P P P 45 10 11 12 13 14 15 ...

Ngày tải lên: 09/08/2014, 10:21

... This is in line with the more resistant phenotype of HIV-2 over HIV -1 in dualinfected persons [40] The pronounced increase in the gp120 V3 charge in effector memory cells in three out of four ... function of memory T cell subsets Curr Opin Immunol 2005, 17 :326-332 13 Picker LJ, Butcher EC: Physiological and molecular mechanisms of lymphocyte homing Annu Rev Immunol 19 92, 10 :5 61- 5 91 14 Eckstein ... Immunity 20 01, 15 :6 71- 682 15 Kinter A, Moorthy A, Jackson R, Fauci AS: Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents...

Ngày tải lên: 10/08/2014, 05:21