2non genomic actions by steroid hormones
Báo cáo Y học: Endogenous cardiac glycosides, a new class of steroid hormones pot
... c-fos is regulated by a number of hormones, growth factors, and mitogens associated with cell proliferation and differentiation, it is not surprising that other cardiotonic steroids, namely bufalin ... have profound effects on cell function [101] BINDING OF CARDIOTONIC STEROIDS TO SERUM PROTEINS As hydrophobic substances, steroid hormones are transported in blood as complexes bound to specific binding ... increases the rate of synthesis of the cardiotonic steroid or, if given in their radioactive form, leads to the formation of radioactive cardiotonic steroids Progesterone and pregnenolone have been...
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Báo cáo khoa hoc:" A critique of the WHO TobReg''''s "Advisory Note" report entitled: "Waterpipe tobacco smoking: health effects, research needs and recommended actions by regulators" ppt
... Effects, Research Needs and Recommended Actions by Regulators" http://www.jnrbm.com/content/5/1/17 Consequently, the aim of the present article is to highlight, one by one, where these weaknesses and ... these studies were carried on by Habib et al [26] and Medhat et al [27] As for tuberculosis, they were carried on, recently, by Munckhof et al [28] and long before by Salem et al [29] Besides, ... entitled "Waterpipe tobacco smoking: health effects, research needs and recommended actions by regulators" was published by the Tobacco Free Initiative in 2005 TobReg is the WHO study group on Tobacco...
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Báo cáo y học: "Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling" pot
... probesets NODk = 37 probesets (d) Upregulated by positive selection, further by negative selection (j) Downregulated by positive selection, further by negative selection B 10k = 48 probesets NODk ... file Genomic localization of gene expression changes induced by selection on the B10k background Recent studies have found that sets of genes induced by similar stimuli can co-localize in genomic ... http://genomebiology.com/2007/8/1/R12 ( a ) Upregulated by selection (g) Downregulated by selection B 10k = 531 probesets NODk = 787 probesets B 10k = 692 probesets NODk = 994 probesets (b) Upregualted by positive selection,...
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Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
... containing 0.1% bovine serum albumin Steroids produced were measured by radioimmunoassay (RIA) Determination of progesterone production by RIA and of steroids by fluorometry showed comparable results ... production by RIA and of steroids by fluorometry showed comparable results Therefore, data are shown as progesterone production (ngÆmL)1) in the incubation medium Basal steroid production is denoted by ... significant (P < 0.001) by ANOVA, and indicated values (*) significantly different (P < 0.05) by Student-Newman-Keuls post test triacsin C, thereby indicating a synergistic effect on steroid production...
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Báo cáo khoa học: Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibodies recognizing the deamidated a subunit of the heterotrimeric GTPase Gq potx
... Ga11 are highlighted by a yellow background Identical amino acid residues are denoted by asterisks, highly conserved residues by double dots, and modestly conserved residues by dots (B) Western ... GTPase-dependent signaling pathways by deamidating Gai2, Gai1 and Gaq Although the deamidation of Gai2 by PMT was identified by MS [16], that of Gai1 and Gaq was only supported by indirect evidence, such ... deamidated by dermonecrotic toxin from Bordetella bronchiseptica by using rabbit antibodies specifically recognizing the deamidated residues [27] The deamidation catalyzed by PMT and by dermonecrotic...
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Báo cáo khoa học: Epigenetics: the study of embryonic stem cells by restriction landmark genomic scanning pptx
... observed by comparing their epigenetic profiles Analysis by RLGS revealed that DNA methylation profiles at T-DMRs are totally different between ES and TS cells [9] Compared with TS cells, 20 genomic ... Dnmt3b in maintaining DNA methylation at the repeat sequences By contrast, further analysis by bisulfite sequencing of loci studied by RLGS determined that extensive and almost complete demethylation ... larger genomic sample than is necessary for microarray-based methods, it has advantages for analyzing genome-wide methylation states: (a) it is a highly reproducible quantitative method; (b) genomic...
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Báo cáo hóa học: " Testing the potential of a virtual reality neurorehabilitation system during performance of observation, imagery and imitation of motor actions recorded by wireless functional nearinfrared spectroscopy (fNIRS)" potx
... followed by IM_right, O_R, and O_L Mean Δ[HHb] were largest in condition IM_L, followed by IM_R, O_L and O_R On the right hemisphere, mean Δ[O2Hb] were largest in condition IM_L, followed by IM_R, ... actionobservation system as described by the simulation hypothesis during performance of observation, motor imagery and imitation of hand actions elicited by a VR environment Further, in accordance ... interfaces (BCIs) Such a VR-fNIRS based BCI could enhance patients’ motivation by providing real-time neurofeedback thereby allowing therapists to record pre-post treatment progress assessing training-induced...
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Báo cáo hóa học: " Chromosomal 16p microdeletion in Rubinstein-Taybi syndrome detected by oligonucleotide-based array comparative genomic hybridization: a case report" doc
... characterized by mental retardation, broad thumbs and toes, short stature and specific facial features [1] The syndrome is, at least in part, caused by a microdeletion at chromosome 16p13.3 or by mutations ... with a de novo microdeletion on the short arm of chromosome 16, identified by oligonucleotide array-based comparative genomic hybridization Our patient showed mild to moderate global developmental ... 20 metaphase cells showed a normal 46, XX karyotype Further investigation by high resolution array-based comparative genomic hybridization revealed a 120kb microdeletion on chromosomal band 16p13.3...
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Báo cáo y học: "Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays" docx
... subpopulations bearing different genomic alterations (subclones) coexisting in most tumor samples The tumor genomic profile is thus due to (a) genomic alterations shared by all tumor cells and producing ... BRCA1 [27], a key protein for DNA repair [28] Analysis of breast carcinomas by SNP-arrays is complicated by the numerous genomic rearrangements associated with these tumors [29], their high stromal ... whole-genome profile of genomic rearrangements in the BLC_B1_T45 sample measured by 300K Illumina SNP-array and corresponding GAP (a) Allelic imbalances are represented by Ballele frequency (BAF)...
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Báo cáo y học: "Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates" pdf
... Experimental validation of the BPGA was achieved by performing a series of array-based comparative genomic hybridization (aCGH) experiments, hybridizing to the BPGA genomic DNAs from strains of known genome ... rapidly identify genomic regions of species- and strainspecificity in a single hybridization experiment Genomic variation in the B thailandensis genome Numerous studies have analyzed genomic variation ... number DSO/IACUC/07/42 Bacterial strains and genomic DNA extraction Bacterial cultures were grown in LB media and genomic DNA was extracted using the Qiagen Genomic DNA kit (Qiagen, Hilden, Germany)...
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Báo cáo y học: " Ring chromosome 13 syndrome characterized by high resolution array based comparative genomic hybridization in patient with 47, XYY syndrome: a case report." doc
... numeric and structural chromosomal abnormalities which are characterized by a high resolution array based comparative genomic hybridization (aCGH) Case presentation Our patient was a 10-month ... control criteria by Affymetrix In order to avoid the loss of copy number variant (CNV) discovery, we merged the results from two software packages: Genotyping Console and Partek Genomics Suite, ... Cite this article as: Liao et al.: Ring chromosome 13 syndrome characterized by high resolution array based comparative genomic hybridization in patient with 47, XYY syndrome: a case report Journal...
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Báo cáo y học: "Multi-organ damage induced by anabolic steroid supplements: a case report and literature review" pps
... could be explained by the hypercalcemia that had occurred most probably as a result of anabolic steroid injections Anabolic steroids modulate steroid hydroxylase activity thereby precipitating ... abused by anabolic steroid users as a means to reduce the pain induced by heavy training [10] This could potentially explain the observation that our patient Table 2: Commonly abused anabolic steroids ... skeletal muscle mass by enhancing the uptake of amino acids and increasing the serum level of insulin growth factor IGF I [11] This non -genomic action of testosterone is mediated by secondary messengers...
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báo cáo khoa học: " Identification of three wheat globulin genes by screening a Triticum aestivum BAC genomic library with cDNA from a diabetes-associated globulin" doc
... (RGDEAVEAFLRMATA) The purity was determined by mass spectral and HPLC analyses performed by SigmaGenosys The polyclonal antibody production was performed by Sigma-Genosys Pre-immune serum was collected ... identification Contigs from clones 1333A17 and 895N14 contained full genomic sequences for a globulin gene as determined by open reading frame analysis The globulin gene open reading frame starts ... regulated by abscisic acid (ABA) Abscisic acid is a hormone that has been shown to regulate maize Glb1 expression [35] Maize Glb1 synthesis and accumulation are positively regulated by ABA through...
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Báo cáo khoa học: " Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination" pot
... N-terminal products are cleaved by PLpro and rest of the C-terminal products are cleaved by 3CLpro [15] The putative domains and their cleavage sites (Fig 1) are predicted by comparison of amino acid ... was collected 72 h post inoculation The fluid was clarified by low speed centrifugation and clear supernatant was stored at -80°C Genomic RNA was extracted from virus-infected allantoic fluid ... independent clones were sequenced for each amplicon to exclude errors that can occur from RT and PCR reactions The assembly of contiguous sequences and multiple sequence alignments were performed with...
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Báo cáo khoa học: "Steroid hormone receptors ERα and PR characterised by immunohistochemistry in the mare adrenal gland" ppt
... with reproductive hormones also influencing adrenal function The presence of adrenal sex steroid hormone receptors in the adrenal gland may give an answer to whether sex steroid hormones can act ... decrease in adrenal ER binding sites followed by a gradual rise, as assessed by a LBA, indicating several days may be needed for changes in plasma sex steroid concentrations to have an effect on ... synthesis by environmental estrogenic pollutants Endocrinol 2004, 146:265-272 Guiochon-Mantel A, Delabre K, Lescop P, Milgrom E: Intracellular traffic of steroid hormone receptors J Steroid Biochem...
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Báo cáo y học: "Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways" ppt
... Cheng YK, Leung KW, Ng TB, Fan DT, Yeung HW, Wong RN: Pharmacogenomics and the Yin/Yang actions of ginseng: antitumor, angiomodulating and steroid- like activities of ginsenosides Chin Med 2007, 2:6 ... control of the ARE by Nrf2 [7] Nrf2 is a key regulator of ARE-mediated gene expression and a potential target for chemopreventive compounds [43-45] Nrf2 is inhibited in the cytoplasm by the anchor ... reduction of GSH content and GST activities induced by BaP in rats [8] Moreover, various isoforms of phase II gene GSTs were significantly induced by the ginseng extract via activating the Nrf2-ARE...
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Báo cáo y học: "Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice" ppt
... clusters The tiling path of BAC clones is indicated by black lines with accession numbers listed Predicted genes are represented by triangles, pseudogenes by rectangles Predicted genes are numbered from ... chromosome Y, for example, are caused by NAHR between HERV15 elements [36] We thus predict that the central cassette repeat unit was formed by recombination between nearby ERV elements We have sequenced ... of change over these regions [53,58], whereby gene copies are created by duplication and either acquire functionality or else undergo pseudogenization By this model, the differences between the...
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Báo cáo y học: "A genomic view of methane oxidation by aerobic bacteria and anaerobic archaea" doc
... pathway (c) and the latter by reduction to methylene-H4F (d) and thus directed into the serine cycle CO2 produced in any of these reactions can be converted to biomass by either (e) the serine ... single-carbon compounds in M capsulatus (Figure 2) has been greatly simplified by the addition of data available from pre -genomic analyses [7-9,21] and from the initial analysis of the genome of M ... pathways by which formaldehyde can be oxidized to CO2 (Figure 2b); all the enzymes in this pathway were identified [2], pointing to the importance of this pathway, as suggested previously by enzyme-activity...
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Báo cáo y học: "The regulation of endocytosis by kinases: cell biology meets genomic" pps
... representation of two endocytosis pathways (a) Cargo trafficking mediated by clathrin-dependent endocytosis This pathway is typically initiated by the recruitment of cargo into clathrin-coated pits at the ... http://genomebiology.com/2005/6/13/245 Genome Biology 2005, interactions information Genome Biology 2005, 6:245 refereed research Genomic approaches are increasingly being used to address many ... for all such genomic screens will be the directness of the effects shown In particular, identification of the most proximal endocytotic pathway substrates of the kinases identified by Pelkmans...
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Báo cáo y học: "Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions" ppsx
... of genomic regions Our analyses of this uniquely comprehensive dataset suggest that distinct developmental fates are specified not by which genes are bound by a set of factors, but rather by ... bound by a transcription factor if it was overlapped by at least 300 bp by one of the factor's 1% FDR bound regions, or for CRMs less than 300 bp long, if the CRM was completely overlapped by a ... overlapped by 1% FDR regions bound by each of the other factors in turn (c, d) Each row shows the Genome Structure Correction z scores for the likelihood that the overlap plotted in (a, b) occurs by...
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