2deregulation of the pi3k pathway and prostate cancer

... depend on the trigger type and on the level of interference with the Wnt pathway We conclude that the type of the trigger and the regulation level within the Wnt pathway decide about the gene ... cells We conclude from these findings that the activating trigger and the level of activation within the pathway are crucial for the selection of a target gene and the trend of the promoter regulation ... the right sides of the gels these of the two other isoforms (Fig 6) These results correlate to the protein bands of  38 kDa (Plf1) and 27 kDa (Mrp4) [27], which were detected in the western blot...

Ngày tải lên: 30/03/2014, 16:20

... dual inhibitor of the mTOR pathway and telomerase in breast cancer cells, and yield enhanced anticancer therapeutic efficacy, the objectives of the study are to: Validate breast cancer cells as ... HYPOTHESIS AND SIGNIFICANCE OF STUDY The literature explored thus far highlights the relevance and importance of the mTOR pathway and telomerase in initiating, regulating and driving cancer phenotypes, ... IMR-90 cells Altogether these results suggest that while breast cancer cells may be a useful model to study the dual inhibition of the mTOR pathway and telomerase, the activation of these two players...

Ngày tải lên: 05/10/2015, 13:53

... distribution, prevalence of lifestyle factors, histologic type of lung cancer, stage of lung cancer and so on The random effects model incorporates an estimate of the between-study variance and tends to ... are: 1) low frequency of the "at-risk" genotype, which would reduce the statistical power of the studies and 2) small size of the studies Ethnic differences in the roles of the polymorphism may ... alteration of the ERCC5/XPG activity and modulation of lung cancer susceptibility The Asp/Asp genotype of the Asp1104His polymorphism was associated with a significantly decreased risk of lung cancer...

Ngày tải lên: 31/10/2012, 14:59

... 36% of the interaction of the full peptide with the binding cavity of SM3 The sizes of the surfaces were determined using distances between ligand ˚ atoms and protein atoms of less than A These ... a distance of A or less to the ligand The C-terminal part of the peptide (RPAP) has close contacts to the next protein in the crystal cell and is therefore stabilized on the surface of SM3 It ... reference pairs The build-up of the trNOE between Asp2-b and b¢ is much faster than that of the other two reference points indicating differences of the rotational correlation times of these proton...

Ngày tải lên: 21/02/2014, 15:20

... quartile (1/4 of the population) who ate the least amount of fruits and vegetables had about twice the risk of cancer compared to those who in the upper quartile who ate the most fruits and vegetables ... high fruit and vegetable diet would reduce cancers of the mouth and pharynx, esophagus, lung, stomach, and colon and rectum; evidence of probable risk reduction was found for cancers of the larynx, ... urinary secretion of isothiocyanates, was inversely related to the risk of breast cancer; the quartile with the highest intake only had 50% of the risk of the lowest intake group [89] In the Nurses'...

Ngày tải lên: 06/03/2014, 02:21

... quantitative analysis of the most critical parameters of the pathway regarding this goal requires the knowledge of the intracellular concentrations of all metabolites involved and a kinetic model ... minimization of the difference between experimental time course data and the corresponding values predicted by the solution of the differential equations derived from a mathematical model of the kinetic ... extreme modulations of enzyme activities In particular, in the combinations involving the decrease of glyoxalase II activity the effect is equivalent to the modulation of the other parameters alone,...

Ngày tải lên: 23/03/2014, 13:20

... promoter in lung cancer factors that control the use of the p73 P1 promoter and, subsequently, the relative expression of p73 isoforms in lung cancer by using lung cancer cell lines and tumour samples ... processes Therefore, all of these issues should be addressed in the future Taken together, our findings make it clear that there is a link between the expression of Sp1 and p73 isoforms in lung cancer ... for the identification of the exact TAp73 isoform expressed in these samples (D) The mean levels of TAp73c and Sp1 in 26 NSCLCs samples were compared with the corresponding mean levels in the...

Ngày tải lên: 29/03/2014, 09:20

... Biological Therapy of Cancer Acknowledgements From the iSBTc Executive Office, Chloé Surinak monitors and supports the subsection interactions with the iSBTc leadership, its membership and BioMed ... Director of the iSBTc provides executive management and development of the Society Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most ... development for disseminating the results of biomedical researc h in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical...

Ngày tải lên: 18/06/2014, 15:20

... with radiotherapy The aim of this study was to investigate the effect of the combined treatment of perifosine and radiotherapy on human prostate cancer Methods Cell culture The human prostate ... collected the data, interpreted the results of the study, performed the statistical analysis and drafted the manuscript BX and BT oversaw the project completion, analyzed the data and completed the ... prostate cancer PC-3 cells Cells were irradiated in the absence (control) or in the presence of perifosine and the colony formation assay was conducted Shown are the means and standard deviation of...

Ngày tải lên: 09/08/2014, 09:20

... Background Patients and methods Prostate cancer is the leading form of cancer diagnosed among Canadian men and accounts for approximately 27% of new cancer cases and 11.4% of cancer deaths [1,2] ... localized prostate cancer during the period January 2000 to December 2002, in the department of Radiation Oncology at the Allan Blair Cancer Center (ABCC), in Regina, Canada One of the standard ... margin of 0.7–1 cm and received a dose of 26–30 Gy in 13–15 fractions (2-Gy per fraction) over two and half to three weeks at the discretion of the treating Radiation Oncologist None of the patients...

Ngày tải lên: 09/08/2014, 09:22

... domains, FAT domain and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative of the sizes/distances in the gene/protein) cases ... VNK and ALBD designed the study - TT, LJ and PV genotyped the samples from the American Breast cancer patients - LJ and PV genotyped the samples from the Norwegian breast cancer patients and the ... protective effect of the A allele The contradictory between our study and that of [28] may be a consequence of the different ethnicity of the populations or possibly a result of the limited study...

Ngày tải lên: 09/08/2014, 10:21

... for prostate cancer therapy Materials and methods Cell lines and cell culture A human prostate epithelial cell line (RWPE-1) and prostate cancer cell lines (LNCaP, DU145 and PC3) were used and ... mimic the development of prostate cancer clinically Understanding the regulating effects of XAF1 during the whole progression may help us find potential therapeutic strategies for prostate cancer ... [15,32,33] Human prostate epithelial cells (RWPE-1) and prostate cancer cells (LNCaP, DU145 and PC3), which exhibit different features of prostate cancer progression from early stages to androgen independent...

Ngày tải lên: 10/08/2014, 10:20

... in the PI3K signaling pathway Recombinant microRNA-126 was shown to downregulate the expression of p85b (a regulatory subunit of PI3K related to the stabilization and transmission of the PI3K ... arrest and promoted apoptosis in A549 cells PI3K is composed of a p110asubunit and p85 subunit and the PI3K/ AKT signaling pathway has been shown to play a role in the development and progression of ... of the cell cycle and apoptosis is a major determinant dictating the development and progression of a number of cancers PI3K/ AKT inhibitors such as Tipifarnib, cause cell cycle arrest at the...

Ngày tải lên: 10/08/2014, 10:21

... acetone in the presence of approximately mg of NaCO3 [37] The extent of lipid peroxidation in the leaves was estimated by measuring the amount of MDA, a decomposition product of the oxidation of polyunsaturated ... stress (BiPD and CNX) and osmotic stress (SMP) marker genes were included in the assay to ensure the efficiency of the tunicamycin and PEG treatments The combination of ER stress and osmotic stress ... effect on the accumulation of GmNAC6 transcripts in a fashion similar to the induction of the NRP-A and NRP-B genes (Figure 1B) These results indicate that the integration of ER-stress and osmoticstress...

Ngày tải lên: 11/08/2014, 11:21

... reported expression of Notch family members in adult and even OA cartilage raised the issue of the involvement of this pathway in the physiopathology of OA and especially in the changes that chondrocytes ... 1, and These constitute the DSL (Delta/Serrate/Lag2) family (Figure 1) Activation of the Notch pathway The first described Notch activation cascade consists of a series of cleavages leading to the ... disease and the degradation of the articular cartilage is a complex process involving several actors, including signaling pathways like the Notch pathway Further work is required to understand the...

Ngày tải lên: 12/08/2014, 15:22

... Accordingly, the great and urgent need presently is to investigate the role of each of the plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear ... Conventional drugs and the pathways they influence have been the subject of immense interest to biologists, and there has been some headway in understanding the signal transduction pathways these drugs ... Pervaiz, Professor, Department of Physiology, Yong Loo Lin School of Medicine, NUS Their encouragement and guidance and their critique has been of paramount importance in directing the course of the...

Ngày tải lên: 14/09/2015, 14:04

... superficial sensation in the bilateral upper limbs and trunk above the umbilicus, muscle wasting of the bilateral thenar and upper limbs, grade III muscle power of the upper and lower limbs, reduced ... fossa and excision of the arachnoid cyst were then surgically performed A straight median incision was made on the skull via the posterior temporal route The occipital squama was cut off and the ... within the cyst The cyst tightly adhered to the cerebrum, pons and cervical spinal cord The compartments were then separated and the posterior wall of the cyst was excised to break down the cystic...

Ngày tải lên: 25/10/2012, 11:00

Ngày tải lên: 18/09/2013, 06:10

... “Introduction” states the rationale of the study, Semantics can be simply defined as the study of meaning It defines the aims, objectives and the significance, presents the is central to the study of communication ... review of the research Chapter 3: “Methodology and Procedures” mentions the method and procedures of the research Chapter 4: “Findings and Discussions” is the main frame of need to understand semantics ... element of the meaning of a word; a description of the characteristic feature of what the word refers to E.g the sense of “grasshopper” is “an insect which can jump high the study, which describes and...

Ngày tải lên: 26/11/2013, 13:21

... approx 1.5 m The study site Hoa An is located in an area where an interaction of the tidal regimes of the South Chinese Sea and of the Gulf of Thailand eliminate each other Here, the tidal amplitude ... from the irrigation ditches of the rice fields At both study sites the values for the pH, BOD, NH4 and phosphate are conform to the requirements of the Vietnamese standards for the use of surface ... following the Vietnamese standards for ground water TCVN 5944 –1995 (see table 3) The results of the analyses of the surface water samples were compared to the Vietnamese standards for the use of surface...

Ngày tải lên: 16/01/2014, 17:20