2 targeting strategies for metal based therapeutics

... Reaching 0.55 20 10 15 Training session 20 Severe Activeassist Supported FS 12 24 12 24 12 24 12 24 12 24 12 24 Moderate 12 24 12 24 12 24 12 24 Severe 12 24 12 24 12 24 12 24 12 24 12 24 Free Reaching ... Robotics: 20 03; Daejeon, Korea 20 03:55-58 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 Hesse S, Schulte-Tigges G, Konrad M, Bardeleben A, Werner C: Robot-assisted arm trainer for the passive ... Rehabilitation 20 06, 3: 12 http://www.jneuroengrehab.com/content/3/1/ 12 Table 2: Univariate ANOVA statistics for planned comparison of pre- to post-training 0.430 (0. 12) 1.114 (0. 32) 1.400 (0. 32) 0.768...

Ngày tải lên: 19/06/2014, 10:20

... obesity on health and productivity J Bus Psychol 20 10; 25 (2) : 23 9 -24 5 http://www.medsci.org Int J Med Sci 20 11, 8 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Preuss HG, DiFerdinando D, Bagchi M, et al ... ±7.3 0.84 ±0.05 0.81 ±0.04* 60.9 ± 12. 1 56.7 ±10.9 60.0 ± 12. 6 55.0 ±7.3 118.8 ± 12. 5 74.6 ±7.0 119.8 ± 12. 2 74.7 ±7 .2 118.9 ±16 .2 75 .2 ±7 .2 116.1 ±11.1 76.9 ±6 .2 89.3 ±8.1 89.7 ±8.3 89.8 ±9.5 90.0 ... 65.9 ±13 .2 65.1 ±13.1 70 .2 ±13.8 65.5 ± 12. 4 117.9 ± 12. 6 117 .2 ± 12. 6 1 12. 8 ± 12. 4 116 .2 ±10.3 76.3 ±10.5 76.1 ±8.9 90.1 ±10.4 89.8 ±9.5 87.1 ±9.4 91.7 ±7.0 0.86 ±0.08 0.85 ±0.05 0.84 ±0.05 0. 82 ±0.09...

Ngày tải lên: 25/10/2012, 11:10

... ozonation, Chemosphere, 72( 2), 20 5 -21 2 Cui, R and Jahng, D (20 04) Nitrogen control in AO process with recirculation of solubilized excess sludge, Water Res., 38(5), 1159-11 72 Ebie, Y., Kondo, T., ... treatment system (Chu et al., 20 08; Cui and Jahng, 20 04; Kamiya and Hirotsuji, 1998; Nagare et al., 20 08; Sakai et al., 1997; Saktaywin et al., 20 05; Suzuki et al., 20 06; Yasui et al., 1996; Yasui ... accumulated by DNPAOs, like previous studies (Ahn et al., 20 02a, b; Kuba et al., 1996, 1997; Soejima et al., 20 06; Tsuneda et al., 20 06) Therefore, it was suggested that DNPAOs contributed to not...

Ngày tải lên: 05/09/2013, 09:38

... Kielbasa W, Fung HL (20 00) Pharmacokinetics of a model organic nitrite inhalant and its alcohol metabolite in rats Drug Metab Dispos 28 :386–391 12) Seger DL (19 92) Methemoglobin-forming chemicals ... conditions: transfer line temperature: 28 0 °C; ion source temperature: 20 0 °C; ionization mode: EI; electron energy: 70 eV; ionization current: 60 µΑ Procedure A 0 .25 -mL volume of a specimen d, 0.5 ... glass tuberculin syringe with a 25 G × 1″ needle (0.50 × 25 mm, Terumo, Tokyo, Japan and other manufacturers) and rapidly injected into GC iv Quantitation: a 0 .25 mL of the same matrix e (without...

Ngày tải lên: 18/10/2013, 00:15

... m/z 114 625 626 VX and its decomposition products In the mass spectrum of DAEMS, other fragment ions at m/z 72, 128 and 75, due to [(iPr)N = CH2]+, [(iPr)(CH3C = CH2)NHC2H5]+ and [CH3SCH2CH2]+, respectively, ... both compounds highly enhances the reliability for verification of VX exposure 621 622 VX and its decomposition products ⊡ Figure 2. 2 GC/MS analysis for DAEMS in serum (a) a total ion chromatogram ... respectively, are used for SIM measurements m) The base peak for DAEMS appearing at m/z 114 in the EI mass spectrum ( > Figure 2. 2) is a fragment ion due to [(iPr )2 N=CH2]+ Since the same fragment...

Ngày tải lên: 18/10/2013, 00:15

... Figure 2. 2 Gas chromatogram for cannabinoids 1: CBD; 2: CBC; 3: ∆9-THC; 4: CBN; 5: 5α-cholestane (IS) Assessment and some comments on the method > Figure 2. 2 shows a gas chromatogram for ∆9-THC, ... cannabichromene (CBC) obtained under the GC conditions The peaks of ∆9-THC (22 .2 min), CBD (20 .6 min) and CBN (23 .2 min) are separated well; but the peak of CBC may overlap that of CBD When the ... 1,710 cm–1; NMR (CDCl3) δ: 1.10, 1.38 (s, 3H × 2, gem-CH3), 1.70 (s, 3H, C9-CH3), 3 .22 (dd, 1H C10a-H), 5. 42 (m, 1H, C8-H), 6.07, 6 .24 (s, 1H × 2, aromatic-H); MS, m/z 330 (M+) The solution of...

Ngày tải lên: 24/10/2013, 19:15

... A 50-µL volume of BSA is added to 20 µg each of opiates for derivatization [see the section 2- 3)-(1)-vi)]; a 0.4-µL aliquot each is injected into GC/MS 20 1 20 2 Morphine and its analogues • • • ... samples by GC/MS as evidence for heroin use J Anal Toxicol 9:134–138 7) Stefano GB, Goumon Y, Casares F et al (20 00) Endogenous morphine Trends Neurosci 23 :436–4 42 205 20 6 Morphine and its analogues ... plasma and urine using ion-pair high-performance liquid chromatography J Chromatogr 23 0: 427 –4 32 12) Mason JL, Ashmore SP, Aitkenhead AR (1991) Simple method for the determination of morphine and...

Ngày tải lên: 24/10/2013, 19:15

... 45: 129 –134 10) Miller LW (1971) Methemoglobinemia associated with well water JAMA 21 6:16 42 1643 11) Colomy HH (1987) Cyanosis in infants caused by nitrates in well water JAMA 25 7 :27 88 27 92 12) ... edn Saunders, Philadelphia, pp 22 6 23 0 2) Standefer JC, Jones AM, Street E et al (1979) Death associated with nitrite ingestion, report of a case J Forensic Sci 24 :768–771 3) Tanaka J, Horigome ... reaction for nitrate being used in this method; 2- nitromesitylene formed is analyzed by GC The same reaction method is used for analysis of nitrite after its conversion into nitrate Therefore, when...

Ngày tải lên: 24/10/2013, 19:15

... reagent 325 2- bromohexanoylurea 29 5, 29 7 2- bromoisobutyrylurea 29 8 bromovalerylurea 29 3 bromperidol 26 3, 26 5, 26 8 brompheniramine 320 brotizolam 28 4, 28 5 Brovarin 29 3 BSA 198, 20 1 BSTFA 75, 191, 20 5 ... 20 8, 22 0, 23 1, 23 4, 23 6, 24 2, 25 8, 26 4, 26 5, 27 1, 27 4, 28 3, 304, 317, 331, 371, 373, 374, 408, 417, 427 , 437, 443, 444, 449, 456, 478, 483, 499, 509, 511, 527 , 536, 545, 563, 584, 585, 600, 6 02, ... 179, 20 1, 20 4, 26 5, 27 3, 27 5, 27 7, 27 9, 28 1, 29 3, 29 5, 29 6, 306, 308, 309, 319, 320 , 395, 398, 400, 327 , 330, 335–338, 343–346, 3 52, 353, 355, 371, 391, 393, 411, 426 , 433, 477, 478, 485, 5 02, ...

Ngày tải lên: 24/10/2013, 19:15

... 81.5 (0 .27 ) 764 (2. 52) 82. 4 (0 .27 ) 41.1 (0.14) 103 (0.34) 44 (0.15) 148 (0.49) 171 (0.56) 109 (0.36) 71.3 (0 .24 ) 655 (2. 16) EME 30.9 (0.16) 24 2 (1 .22 ) 66 (0.33) 47 (0 .24 ) 2. 9 (0. 02) 28 .5 (0.14) ... 32. 4 (0.16) 41.5 (0 .21 ) 51.1 (0 .26 ) 25 .9 (0.13) 30.7 (0.15) BE 28 .5 (0.01) 487 (1.69) 155 (0.54) 20 .3 (0.07) 5.8 (0. 02) 41.5 (0.14) 5.1 (0. 02) 23 .0 (0.08) 160 (0.55) 46.3 (0.16) 15.8 (0.06) 27 .4 ... 27 .4 (0.10) Total cocaine** 96.5 (0. 32) 9 62 (3.17) 1, 027 (3.39) 175 (0.58) 51.6 (0.17) 190 (0.63) 58.9 (0.19) 22 2 (0.73) 403 (1.33) 23 5 (0.78) 127 (0. 42) 730 (2. 41) * Unit: µg/mL or g and µmol/mL...

Ngày tải lên: 29/10/2013, 01:15

... [ 12] 22 1 SIM chromatograms for pentazocine (peak 2) and dextromethorphan (IS, peak 1) extracted from whole blood and urine In this system, ions at m/z 27 1 plus 21 4 (IS) and at m/z 28 5 plus 21 7 ... infants Bull Int Assoc Forensic Toxicol 24 (1):38–39 11) Yamazaki F, Mori H (eds) (20 00) Guide to Acute Poisonings by Medical Drugs Van Medical, Tokyo, p 22 2 (in Japanese) 12) Moffat AC, Jackson ... (17) 21 7 (45) 21 4 (9) 27 0 (9) 27 1 (17) 28 5 (9) Poisoning case, and toxic and fatal concentrations A 17-year-old female [11] ingested about 100 tablets of pentazocine (total amount estimated, 2. 5...

Ngày tải lên: 29/10/2013, 02:15

... from light ⊡ Figure 6.1 EI mass spectrum of LSD ⊡ Figure 6 .2 Fragmentation pathways for ions observable in the EI mass spectrum of LSD 22 7 22 8 Lysergic acid diethylamide (LSD) Toxicity, and concentrations ... plate, for example, Kieselgel (0 .25 µm thickness, Merck, Darmstadt, Germany and other manufacturers) Developing solvents: (A) acetone/chloroform (4:1, v/v); (B) chloroform/methanol/n-hexane (4 :2: 1, ... Cody JT (20 00) Hallucinogens In: Bogusz MJ (ed) Handbook of Analytical Separations, Vol 2, Forensic Science Elsevier, Amsterdam, pp 143–1 62 4) Karch SB (1996) The Pathology of Drug Abuse, 2nd edn...

Ngày tải lên: 08/11/2013, 01:15

... MDMA 120 MDMA 62 290 310 320 350 330 320 29 0 140 300 MDMA 160 MDMA 100 MDMA 81 MDMA 120 , caffein MDMA 180, caffein MDMA 120 MDMA 88 MDMA 64 MDMA 95, MA 25 , ketamine 330 340 340 340 300 27 0 27 0 ... 330 340 340 340 300 27 0 27 0 310 20 0 160 25 0 27 0 27 0 27 0 25 0 MDMA 110, MA 1.7, ketamine MDMA 130 MDMA 65 MDMA 98 MDMA 160 MDMA 93 MDMA 90 MDMA 130 MDMA 140 MDMA 52 MDMA 89, MA 1.0, AP 6.9, ketamine, ... optimized for high-volume laboratories J Anal Toxicol 26 :25 3 26 1 15) Gill JR, Hayes JA, deSouza IS et al (20 02) Ecstasy (MDMA) deaths in New York City: a case series and review of the literature J Forensic...

Ngày tải lên: 08/11/2013, 01:15

... chromatographic mode vi Combined ions at m/z 24 2 plus 20 0 are analyzed for PCP and those at m/z 24 6 plus 23 2 plus 21 8 are analyzed for IS from to 12 of retention time vii A calibration curve is ... 100 % for whole blood [18] ⊡ Figure 8 .2 Mass chromatograms for PCP and pethidine (IS) extracted from whole blood In this system, ions at m/z 20 0 plus 24 2 (PCP) and at m/z 24 6 plus 23 2 plus 21 8 ... combined ions at m/z 24 2 ([M–1]+) plus 20 0 and those at m/z 24 6 ([M–1]+) plus 23 2 plus 21 8 are used for PCP and IS, respectively The mass chromatograms of PCP and IS are shown > Fig 8 .2 The detection...

Ngày tải lên: 08/11/2013, 01:15

... C18 cartridges and wide-bore capillary gas chromatography of some barbiturates Med Sci Law 29 :24 2 24 8 26 1 ... its concentration 25 7 25 8 Phenothiazines Assessment of the method > Figure 1.1 shows a TIC and MCs for phenothiazine drugs obtained by GC/MS Panels A and B show a TIC and an MC for the authentic ... Pharmacological Basis of Therapeutics, 10th edn McGrawHill, New York, pp 485– 520 2) Meredith TJ, Vale JA (1985) Poisoning due to psychotropic agents Adverse Drug React Acute Poisoning Rev 4:83– 126 3) Geraut...

Ngày tải lên: 15/12/2013, 12:15

... ethanol HPLC and LC/MS analysis vii For quantitation, the selected ion monitoring (SIM) mode of GC/MS is employed using ions at m/z 22 4 for haloperidol and m/z 26 8 for bromperidol; peak area ratios ... each) (A) and for a serum extract from a poisoned patient (B) m/z 22 4: haloperidol (HP) and reduced haloperidol (RHP); m/z 26 8: bromperidol (BP, IS) and reduced bromperidol (RBP) 26 5 26 6 Butyrophenones ... phase of HPLC or LC/MS For HPLC-DAD and LC/MS, 50 and 20 µL of the above solution are injected, respectively For the SIM of LC/MS, the ions at m/z 376, 378 and 422 are used for detection of haloperidol,...

Ngày tải lên: 15/12/2013, 12:15

... MW 22 7.18 313.10 23 6.10 314.15 22 6.18 29 5.14 28 0.19 418.18 27 7.18 26 4.16 26 3.17 26 1.15 29 4 .21 RI** 22 05 (21 96) 22 85 (22 90) 24 55 (24 06) 22 25 (22 42) 23 85 (23 80) 22 15 (22 23) 23 90 (23 56) 22 10 (22 11) ... (22 11) 22 55 (22 10) 22 25 ( 22 01) Mass fragmentation ions (m/z)*** 58 20 2 21 5 91 24 5 25 7 193 22 8 193 23 6 165 58 26 9 85 314 195 23 5 20 8 71 58 22 1 20 2 29 5 58 85 23 4 193 58 23 5 193 418 59 70 27 7 20 3 ... 58 85 23 4 193 58 23 5 193 418 59 70 27 7 20 3 193 72 264 165 20 2 22 0 189 91 83 26 1 70 20 2 58 24 9 193 99 27 7 313 22 7 26 6 23 4 28 0 20 8 191 178 26 3 21 7 29 4 *: molecular weight **: retention index [7]...

Ngày tải lên: 15/12/2013, 12:15

... (75), 29 5 (68), 324 (46) 24 1 (36) 26 7 (100), 29 4 (77), 24 8 (63), 29 5 ( 62) , 22 0 (34) 25 1 (100), 25 3 (30), 70 (22 ), 139 (11), 23 6 (9) 86 (100), 99 (7), 58 (6), 387 (2) 28 0 (100), 25 3 (95), 23 4 (80), ... 22 1 (36), 110 (31) 24 2 (100), 27 0 (69), 103 (34), 89 (33), 76 (30) 28 2 (100), 124 (20 ), 24 7 (16), 22 0 (14), 89 (11) 25 1 (100), 25 3 (30), 70 (30), 105 (13), 77 ( 12) 310 (100), 3 12 (30), 325 (20 ), ... (80), 26 4 (61), 20 6 (58) 28 0 (100), 314 (87), 315 (68), 28 8 (54), 89 ( 52) 25 9 (100), 29 3 (65), 29 4 (64), 20 5 (59), 89 (50) 27 9 (100), 27 3 (90), 308 (88), 20 4 (84), 1 02 ( 82) 3 82 (100), 326 (87),...

Ngày tải lên: 15/12/2013, 12:15

... high-performance liquid chromatography/mass spectrometry (LC/MS) Med Sci Law 37 :24 8 25 3 18) Kudo K On the synthesis of an internal standard for bromisovalum ml-poison 22 8 (http://maple-www2.med ... Sci Int 74 :20 5 21 1 8) Higuchi T, Kogawa H, Satoh M et al (1996) Application of high-performance liquid chromatography/mass spectrometry to drug screening Am J Forensic Med Pathol 17 :21 23 9) Okamoto ... Therefore, when bromisovalum is detected, various possibilities of concomitant ingestion of other drugs should be taken into consideration 29 5 29 6 Bromisovalum ⊡ Figure 5.3 HPLC chromatogram for...

Ngày tải lên: 15/12/2013, 12:15