2 do patients with complete surgical response to first line treatment require additional salvage chemotherapy
Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" ppsx
Ngày tải lên :
12/08/2014, 15:22
... 20.5 TCZ, TNF3, ADA TCZ to 6 51 to 58 51 to 54 11 to 15 11 to 13 [17,32,36] [32] 5,736 19.1 ADA to 12 54 to 56 11 to 16 [36,51] 1,686 12.0 ADA, ETN, TCZ, TNF2 to 12 49 to 57 to 17 [5,17,32,34,36,37,47,51,53] ... 54 11 to 13 [32,52] 41.1 ADA to 12 54 to 56 11 to 16 [36,51] 1,699 30.1 ETN, TCZ, TNF2, ADA, IFX to 12 45 to 57 to 17 [14,15,17,32,34,36,37,47,51] 1,078 23.5 GLM, ABA, RTX to 12 52 to 55 to 12 ... TNF2 to 12 45 to 57 to 17 [14,15,17,30,32,34,36,37,51-53] 2+ 772 53.3 ABA, RTX to 12 52 to 53 12 [39,41,42] 339 40.6 ADA, GLM, TCZ, TNF3 to 51 to 58 11 to 15 [17,32,36,52] GLM, TCZ to 51 to 54...
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Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" pps
Ngày tải lên :
12/08/2014, 15:22
... classification criteria [22], 81 patients with SSc according to the ACR criteria of 1980 [23] and 26 patients with myositis [24] All patients were recruited from the Department of Rheumatology and Clinical ... reduced to statistically significant findings to increase readability Significance with regard to any feature was always found for increased values of autoantibody assays The number of patients with ... sera of patients with SSc [18] Up to now, nearly all commercially available antidsDNA ELISA kits have used protamine sulfate or polyL-lysine as linkers to attach dsDNA to the plates To minimize...
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Báo cáo y học: "Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases" pdf
Ngày tải lên :
12/08/2014, 12:20
... ischemia in patients with CTD Conclusions Anti-ACE2 autoantibodies may be associated with constrictive vasculopathy in patients with connective tissue disease Additional material Additional file ... also Additional file 3) First, the RFU value of the ACE2 enzyme activity, which was blocked by DX600 (Additional file 1), was determined in 18 patients with vasculopathy, in 16 control patients without ... inhibitor By preincubation with DX600 for 30 minutes, the enzyme activity was almost completely blocked (P < 0.01) H, healthy volunteer; P, patients with vasculopathy; CP, control patients without...
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Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"
Ngày tải lên :
26/10/2012, 09:39
... characteristics and laboratory data between patients with and without sustained virological response (SVR) Characteristics Male gender, n, (%) Patients with SVR Patients without SVR (n=13) P-Value ... 78 patients started on therapy Twenty four patients were not included in the study analysis due to fail to complete treatment and evaluation Of these, 13 failed to return for follow-up, stopped ... response to treatment associated independently with HCV genotype1 infection but a better response with weight loss (18) Limited knowledge exists regarding the influence of on -treatment factors during...
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
Ngày tải lên :
18/06/2014, 15:20
... tumors are known to be more resistant to immunotherapy and often require nephrectomy before or after treatment to optimize response [20] We also included four patients with papillary histology in the ... Representative effector CD8+ T cell and Treg responses in patients (A-C) Figure Representative effector CD8+ T cell and Treg responses in patients (A-C) effector/regulatory T cell ratio in all patients ... Only of 11 (27%) patients with progressive disease exhibited an increase in T cell response compared to 10 of 12 patients (83%) with stable disease (Fig 1) Positive T cell responses to MVA and a...
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Báo cáo hóa học: " Vaccination with a plasmid DNA encoding HER-2/ neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial" pptx
Ngày tải lên :
18/06/2014, 16:20
... trastuzumab treatment was safe, well tolerated and induced specific endogenous antibody responses as well as late-onset CD4+ T-cell responses in patients with advanced breast cancer Patients, Materials ... Her2 molecule administered together with lowdoses of the cytokines granulocyte macrophage colony stimulating factor (GM-CSF) and interleukin (IL)-2 in eight patients with metastatic breast carcinoma ... corresponding T-cell receptors, pDNA immunization may activate immune responses to a broad repertoire of epitopes Also, while peptide immunization could induce T-cell tolerance and thus enhanced...
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Báo cáo khoa học: "Relationship of cognitive function in patients with schizophrenia in remission to disability: a cross-sectional study in an Indian sample" pps
Ngày tải lên :
08/08/2014, 23:20
... There is some evidence to suggest that older patients with schizophrenia (>65) show a progressive decline in cognitive functioning compared to younger patients [30] Symptomatology and functional ... verbal commands conflict with visual sensory information), go/no go (tests the ability to inhibit an inappropriate response to tasks anticipated to elicit a false alarm motor response) , and prehension ... in patients with schizophrenia under remission when compared to normal controls The cognitive deficits are not associated with symptomatology and disability It is possible that various factors...
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Báo cáo y học: "Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study" doc
Ngày tải lên :
09/08/2014, 08:22
... selected 22 patients with lupus nephritis that was refractory to conventional therapy with combinations of different immunosuppressive drugs with or without glucocorticoids Two patients with disease ... different laboratory Effect of Rituximab therapy onlupus erythematosusand clinical parameters in patients with systemic lupus erythematosus Twenty-two systemic lupus erythematosus patients with active ... therapy on the apoptosis of peripheral blood monoEffect ofcells (PBMNCs) in patients with systemic lupus erythematosus nuclear cells (PBMNCs) in patients with systemic lupus erythematosus Freshly...
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Báo cáo y học: "Relationship between inflammatory markers, metabolic and anthropometric variables in the Caribbean type 2 diabetic patients with and without microvascular complications" pptx
Ngày tải lên :
11/08/2014, 08:21
... high-density lipoprotein (HDL), and grey top tubes (with fluoride) were used to collect the sample for glucose estimation Green top tubes (with heparin) were used to collect the blood sample for HbA1c ... also wished to investigate the relationship between sialic acid and lipid profiles and to determine whether sialic acid concentrations were increased in patients with diabetes with and without microvascular ... death in Trinidad and Tobago with 1306 deaths [1] According to the World Health Organization, it costs each diabetic an average of 533 US$ per annum in direct cost with respect to health care, which...
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báo cáo khoa học:" Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases" ppt
Ngày tải lên :
12/08/2014, 01:21
... occasionally used with those patients unable to respond due to the severity of the health condition leading to cognition or communication difficulties, such as aphasia Analytical strategy Exploratory and ... subsample (n2) The model to be confirmed was also imposed to have a general (global) second order factor; related with the specific factors On this type of models, the general factor (2nd level) explains ... robust-weighted least squares estimators were used[41,42] The first subsample (n1) was used to perform an EFA with oblique (quartimin) rotation[43] The factor structure obtained by the EFA was...
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Báo cáo y học: "Risk of incident or recurrent malignancies among patients with rheumatoid arthritis exposed to biologic therapy in the German biologics register RABBIT" pdf
Ngày tải lên :
12/08/2014, 11:22
... 95% CI: 0.54 to 1.01) No difference was found for patients not exposed to biologics Comparison of patients with and without incident tumors in patients with no prior cancer Overall, patients who ... For all patients prior malignancies were reported by the rheumatologist at study entry Patients with or without prior malignancy were compared with respect to patient characteristics and treatment ... likely to prescribe cytokine inhibitors for patients with prior malignancy than for those without such a history Furthermore, our data indicate that physicians might have made different treatment...
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Báo cáo y học: "Association of HMGB1 polymorphisms with outcome in patients with systemic inflammatory response syndrome" ppsx
Ngày tải lên :
13/08/2014, 11:22
... levels tended to increase when moving from patients with only SIRS to patients with sepsis of increasing severity, although only reaching a near-significant level (P = Table Patient baseline characteristics ... follow-up was 698 days (range, to 1,458 days), with an overall survival of 41% Patients were admitted to the ICU for a median of days (range, to 38 days) and 48 patients died while in the ICU ... genotypes were associated with differences in survival, patients with the 982C/T genotype had nearsignificant (P = 0.08) decreased day 28 survival as compared with patients with the 982C/C genotype...
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Báo cáo y học: "Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database" pdf
Ngày tải lên :
13/08/2014, 18:22
... (0.9 to 6.4) 3.9 (1.1 to 7.7) 2.8 (0.7 to 7.4) All 3.4 (1.2 to 7.2) 2.7 (1.1 to 6.4) 3.0 (1.1 to 7.9) 2.9 (1.1 to 7.7) Hospital survivor 24 (12 to 44) 29 (15 to 53) 32 (17 to 63) 34 (18 to 55) ... to 6.1) Hospital survivor 38 (27 to 62) 39 (21 to 61) 19 (11 to 41) Hospital nonsurvivor 15 (3 to 27) 23 (8 to 45) (3 to 24) All 22 (8 to 39) 29 (13 to 51) 15 (7 to 33) 28 (4.5) 14 (5.2) 18 (5.8) ... survivor 2.8 (1.0 to 5.6) 2.2 (1.0 to 4.9) 2.2 (1.0 to 6.1) Unit nonsurvivor 1.5 (0.6 to 4.4) 3.4 (1.0 to 10.2) 1.5 (0.4 to 6.3) All 1.9 (0.8 to 5.3) 2.6 (1.0 to 6.7) 1.9 (0.8 to 6.1) Hospital...
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Báo cáo y học: "Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication" docx
Ngày tải lên :
13/08/2014, 20:21
... consumption (and CO2 production) in patients with lactic acidosis due to biguanide intoxication Materials and methods We reviewed the data sheets of patients admitted to 12 intensive care units and ... nephrology unit of 11 hospitals from January 2005 to June 2009, with a discharge diagnosis of lactic acidosis due to biguanide intoxication Patients with a concomitant primary diagnosis of septic ... correlated with plasma lactate (R2 = 0.43; P < 0.001, n = 32) Major findings remained valid when the analysis was restricted to the patients monitored with a pulmonary artery catheter From day to 4,...
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Báo cáo y học: "The effect of window rooms on critically ill patients with subarachnoid hemorrhage admitted to intensive care" ppsx
Ngày tải lên :
14/08/2014, 07:21
... (0.0%) 0.22 All (6 to 12) (5 to 12) 0.75 (5 to 10) (4 to 9) 0.05 Survived (6 to 12) (6 to 13) 0.80 (5 to 10) (4 to 9) 0.07 Died 4.5 (1 to 6) (2 to 6) 0.44 NA NA 0.32 Of those with MV, n (%) PEG, ... stay (IQR) All 13 (9 to 20) 13 (8 to 20) 0.80 11.5 (9 to 15) 11 (9 to 15) 0.49 Survived Died 14 (10 to 21) (1 to 8) 14 (10 to 24) (3 to 7) 0.90 0.54 11 (9 to 15) NA 11 (9 to 15) NA 0.63 0.22 ICU ... 12) (5 to 12) 0.47 Survived 690 (6 to 13) (5 to 12) 0.21 Died 99 (1 to 6) 4.5 (1 to 9) 0.14 Median hospital length of stay (IQR) All 789 13 (8 to 20) 13 (9 to 19) 0.97 Survived 646 14 (10 to 22)...
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Báo cáo khoa học: "Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis" docx
Ngày tải lên :
09/08/2014, 03:21
... efficacy and toxicities of the docetaxel and S-1 combination as a first- line treatment for patients with advanced or recurrent gastric cancer and to analyze prognostic factors in these patients Patients ... Eighty-two patients were available for the response evaluation There were no patients showing complete response, 44 (52.4%) patients showing partial response (PR), 37 patients (44.0%) with stable ... better for patients with good performance status, tumor response and second -line chemotherapy In the Cox proportional hazard model, the only independent prognostic factor for OS was the tumor response...
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Báo cáo y học: "Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment – a prospective, controlled study" pps
Ngày tải lên :
09/08/2014, 08:22
... compared with controls; #p < 0.05 compared with pretreatment values patients, suggesting that these patients are possibly exposed to a higher risk of atherosclerosis The lipid profile of patients with ... is not correct to attribute the increased prevalence of atherosclerosis observed in RA patients to these factors In our study, we tried to exclude patients with classic risk factors for atherosclerosis ... for periods up to 10 years have shown a sustained clinical response and an acceptable toxicity profile for MTX treatment [43-46] In addition, patients with severe RA who not respond to MTX have...
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Báo cáo y học: "Exogenous glucagon-like peptide-1 attenuates the glycaemic response to postpyloric nutrient infusion in critically ill patients with type-2 diabetes" ppsx
Ngày tải lên :
14/08/2014, 07:21
... markedly attenuates the glycaemic response to enteral nutrients in critically ill patients with stress-hyperglycaemia [8,9] The primary aim of this study was to evaluate the effects of an acute, ... (1.2 pmol/ kg/minute) on the glycaemic response to a postpyloric nutrient infusion in critically ill patients with known type-2 diabetes Secondary aims were to explore mechanism(s) underlying glucose-lowering ... calculations were performed using previous data [8] complete data were required in 10 subjects to detect an absolute difference in the glycaemic response to nutrient (that is, AUC 30-270 ) of 345 mmol/l/minute...
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How to do everything with web 2.0
Ngày tải lên :
27/08/2012, 13:55
... information to the API Test Tool and execute a call Generating the Token To generate the token, go to http://developer.ebay.com/tokentool, as shown in Figure 18-2 If you are using REST, make certain to ... Unregistered Two steps are needed to use the API Test Tool First, you need to create a token that links together your three keys (for either the Sandbox or Production environment) with a specific eBay User ... attribute Within that is the photos element, representing the page requested (or all photos if there is only one) Within the photos element are the photo elements, each representing a single photo The...
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Báo cáo hóa học: " Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032" potx
Ngày tải lên :
18/06/2014, 16:20
... melanoma patients appears to be higher than is commonly assumed It can be present in up to 30% of patients bearing BRAF V600 mutations, potentially representing up to 10% of all melanoma patients Patients ... the cutaneous lesions before and after treatment with PLX4032 A portion of the tumor was also collected for laboratory research studies according to a protocol approved by Yale University Human ... available for review by the Editorin-Chief of this journal Upon retesting for BRAF Figure Chest wall lesions before treatment with PLX4032 (A) and on the first day of the fifth treatment cycle (B) Rubinstein...
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