2 disadvantages of systemic antibiotic therapy in periodontics

... the adequacy of early EA in PP patients In our population, patients receiving IA therapy seem to be at risk of emergence of MDR strains and at high risk of inadequate EA In presence of this risk ... Emergence of antibiotic- resistant bacteria in cases of peritonitis after intraabdominal surgery affects the efficacy of empirical antimicrobial therapy Clin Infect Dis 1996, 23:486-494 Seguin P, ... methicillin-resistant staphylococcus or amoxicillin-resistant enterococcus carriage Adequacy of EA was assessed according to the regimen used and the number of antibiotics in the case of combination therapy...

Ngày tải lên: 13/08/2014, 20:21

... problem of increasing clinical significance Interferon (INF) therapy is the mainstay of HCV treatment HCV and HIV have been associated with the development of autoimmune markers and disease; INF therapy ... serum-ascites-albumin gradient of more than 12 which was non-infective Meloxicam and tenofovir were ceased because of worsening renal function and zidovudine was instituted in place Perindopril was ... Discussion The occurrence of SLE in the setting of HCV and INF administration is now well established [1-3] and represents an accentuation of the underlying cytokine changes described in SLE pathogenesis...

Ngày tải lên: 11/08/2014, 17:21

... a deteriorating clinical state In the present study, using two different approaches, delayed initiation of adequate antibiotic therapy was an independent predictor of impairment in inflammatory ... Delta-SOFA correlated significantly with delayed initiation of adequate antibiotic therapy (P < 0.0001; Figure 1) By multiple linear regression, the only independent predictor of an increase in SOFA ... delayed initiation of adequate antibiotic therapy (OR 1.14, 95% CI 1.06–1.24) SOFA score increased in 111 patients (median increase in score [range 1–6]) This increase was significantly greater in...

Ngày tải lên: 13/08/2014, 01:20

... duration of antibiotic treatment, if interpreted in the clinical context including the underlying disease This can substantially improve to determine adequate duration of antibiotic therapy with ... The frequency of multi-resistant pathogens in patients undergoing long-term antibiotic therapy is clearly increased [11] In this context, newly arising fungal infections in seven-day antibiotic ... length of therapy Controls PCT-guided antibiotic therapy Antibiotic classes (%) P >0.05 Acylaminopenicillin + BLI 51.8 55.2 Acylaminopenicillin + nitroimidazole 19.6 15.5 Carbapenem 8.8 10.4 Aminobenzylpenicillin...

Ngày tải lên: 13/08/2014, 16:21

... duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial Crit Care 2009, 13:R83 Hausfater P: Procalcitonin measurement in adult clinical practice [in French] ... French] Rev Med Interne 2007, 28:296-305 McLean A: Procalcitonin: seeking a niche Crit Care 2009, 13: 149 Christ-Crain M, Müller B: Procalcitonin and pneumonia: is it a useful marker? Curr Infect Dis ... Graf JD, Rohner P, Pugin J: Use of procalcitonin to shorten antibiotic treatment duration in septic patients A randomized trial Am J Respir Crit Care Med 2008, 177:498-505 Page of (page number not...

Ngày tải lên: 13/08/2014, 18:22

... explaining the link between availability of guidelines and prognosis This point was clearly emphasized in the studies assessing the effects of implementation of the guidelines of the surviving ... Decision-making process of AT In each center, the presence and number of empiric AT protocols were assessed The period of initiation of AT was defined by categorizing the week into day shifts and out -of- hours ... universally in the intensive care unit? Crit Care 2010, 14:205 doi:10.1186/cc9961 Cite this article as: Montravers et al.: Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive...

Ngày tải lên: 14/08/2014, 07:21

... measuring patients’ experiences of care rather than satisfaction per se Pre-testing of the questionnaire in 16 patients at NHNN undergoing relapse management resulted in minimal changes in wording ... friends were not closely involved in their care experiences Two domains (attitude of health care professionals; interpersonal care) were combined to form a single domain (interpersonal care) because ... information concerning the construct being measured, except for one item in the 11-item Coordination of Care scale These findings support the summing of items to generate subscale score Targeting (Table...

Ngày tải lên: 20/06/2014, 15:20

... reason to think that ongoing infliximab therapy may be harmful, good data are lacking) Another finding of our study is that discontinuation of infliximab therapy seems justified, since we found ... within 12 weeks after discontinuation of infliximab infusions, 37 within 24 weeks, and 38 within 36 weeks By week 48, of the 42 patients had not needed retreatment and 41 were again receiving infliximab ... coordination MR: Monitoring and investigation of the patients, study coordination JS: Investigator, writing of the manuscript JB: Idea, writing of the manuscript, principal investigator, responsible...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 06:23

... schematically defined in the activation of EGFR-dependent intracellular signaling First, the binding of a receptor-specific ligand occurs in the extracellular portion of the EGFR or of one of the EGFR-related ... II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFRexpressing advanced non-small-cell lung cancer Ann Oncol 2008 in press ... result primarily in G1 cell arrest in cancer cell lines with wild type EGFR, versus induction of apoptosis in cell lines with mutant EGFR [22] The combination of chemotherapy and TKI in some cases...

Ngày tải lên: 10/08/2014, 22:20

... attempting to determine the best mode and type of mental health treatment in these settings An increasing number of studies show the potential of group interventions for mental disorders in LAMICs ... effective in reducing depressive symptoms in women [52] In Iran, group CBT was superior to fluoxetine in treating depression and anxiety of infertile women [53] In addition, group based interventions ... self-examination therapy of Bowen et all [43] In ‘’self-examination therapy ’ subjects learn to take control of their problems and their lives by (1) determining what really matters to them, (2) investing...

Ngày tải lên: 11/08/2014, 16:20

... molecules in a process equivalent to epitope spreading [14] The presence of antinuclear antibodies (ANAs) was shown to predate the development of SLE in a small study conducted in Finland [15] In the ... development of clinical manifestations of thrombosis by a number of years [16] The aim of this study was to analyse, using multiplex technology, the autoantibodies predating the onset of symptoms of SLE ... identification of antinuclear autoantibodies in the serum of normal blood donors Clin Exp Rheumatol 1993, 11:393-397 31 Myckatyn SO, Russell AS: Outcome of positive antinuclear antibodies in individuals...

Ngày tải lên: 12/08/2014, 15:22

... isolate of clindamycin-resistant C difficile was associated with increased use of clindamycin despite the presence of infection control practices [32] To restrict the use of clindamycin, all ... consultant in infectious diseases This resulted in an overall reduction in its use, a sustained reduction in the Kollef et al examined the influence of a scheduled change in antibiotic on the incidence ... emergence of bacterial meeting abstracts Combining antibiotic therapy research Outbreaks of diarrhoea associated with Clostridium difficile are often linked to antibiotic use and misuse In one experience,...

Ngày tải lên: 12/08/2014, 18:21

... preparation, administration and monitoring of IV antibiotic therapy Gaining insight into all the factors that contribute to the actual total overall costs of drug therapy may help increase awareness into ... administration while observing 76 single (ICU) nurses performing the 103 procedures of preparation and administration of the antibiotics The preparation and administration of IV antibiotics in ... costs of imipenem-cilastatin monotherapy were considerably higher compared with clindamycin/aminoglycoside combination therapy for treatment of serious lower respiratory infections, intra-abdominal...

Ngày tải lên: 12/08/2014, 20:20

... role of activated NF-κB in the pathogenesis of euthyroid sick syndrome J Clin Invest 2000, 106:393-402 De Groot LJ: Dangerous dogmas in medicine: the nonthyroidal illness syndrome J Clin Endocrinol ... seriously in a prospective randomized trial Competing interests The author(s) declare that they have no competing interests References 334 Wartofsky L, Burman KD: Alterations in thyroid function in ... roles of the iodothyronine selenodeiodinases Endocr Rev 2002, 23:38-89 Iltumur K, Olmez G, Ariturk Z, Taskesen T, Toprak N: Clinical investigation: thyroid function test abnormalities in cardiac...

Ngày tải lên: 12/08/2014, 22:22

... from continuous arteriovenous hemofiltration (CAVH) to the last generation of continuous renal replacement therapy machines (a) CAVH machine; (b) the BSM32 machine; (c) the PRISMA machine; (d) ... cut-off hemofilters, which are characterized by an increased effective pore size Most commercially available hemofilters not permit a substantial elimination of cytokines because of the low cut-off ... effect of dialysis dose, no randomised trial has evaluated the effect of HVHF on clinical outcome, or the effect of different modalities of CRRT on length of stay and recovery of renal function in...

Ngày tải lên: 12/08/2014, 23:22

... work-up of airway samples consisted of rapid Gram-staining and semi-quantitative culturing of tracheal aspirate On clinical request (in cases of discrepancy between likely clinical diagnosis of VAP ... for Part of the controversy of whether involvement of MDR in nosocomial infection is an independent risk factor for mortality possibly stems from inclusion of different sets of covariates in regression ... ᮀDelta SOFA: SOFA two days after VAP minus SOFA two days before VAP † Other Gram-negative: Haemophilus influenzae in 11, Moraxella catarrhalis in β-lactam antibiotics (penicillins and cephalosporins),...

Ngày tải lên: 13/08/2014, 11:23

... vancomycin by continuous infusion (Pea F, Viale P, unpublished data) In a recent meta-analysis of nine randomized controlled trials comparing continuous intravenous infusion with intermittent intravenous ... goal of appropriate antibiotic therapy must be pursued resolutely and with continuity, in view of the ongoing explosion of antibiotic- resistant infections that plague the ICU setting and of the ... curve (AUC) of piperacillin after a single standard g intravenous dose were several fold lower, either in plasma or in the interstitium of soft tissues, in patients with septic shock than in correctly...

Ngày tải lên: 13/08/2014, 16:20

... reporting of hypotensionassociated adverse events, including discontinuation of treatment, initiation of vasopressor therapy and any other intervention in response to intradialytic hypotension during ... of days managed using IHD was calculated by dividing the number of days in the IHD phase by the total number of days of study therapy consensus in clinical practice regarding the optimal timing ... for the timing of kidney injury While the interval between intensive care unit admission and initiation of RRT was 6.7 ± 9.0 days, the interval between the clinically assessed onset of AKI and...

Ngày tải lên: 13/08/2014, 16:21

... AKI occurred in to 6% of all ICU admissions, with 70% of these eventually receiving RRT Recent data indicate the incidence of AKI is rising [21-23] Historically, however, establishing incidence ... edema) in the presence of acute kidney injury Adapted from [16] evaluation of response to initial (non-RRT) therapy We emphasize again this algorithm is not intended to direct all aspects of initial ... clinical practice; however, in many circumstances, the risks of not providing RRT may exceed those of initiation of RRT Mild to moderate acute kidney injury The decision of if, and when, to initiate...

Ngày tải lên: 13/08/2014, 19:20