2 common genetic variants as modifiers of arrhythmia risk in the context of monogenic diseases
Báo cáo y học: "Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region" pot
Ngày tải lên :
09/08/2014, 13:22
... significantly increased in SLE compared with healthy controls (Table and Figure 1) These SNPs were located in the introns of STAT4 and in LD with each other In contrast, significant association was not ... Diagnosis of SLE and classification of the patients into clinical subsets were carried out according to the American College of Rheumatology criteria for SLE [22] There was no overlap in cases or ... role in the pathogenesis of SLE A possible role of SNPs in the STAT1-STAT4 region other than the haplotype tagged by rs7574865T has recently been excluded in Caucasians [10] However, in view of...
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Báo cáo y học: "TLR7 single-nucleotide polymorphisms in the 3’ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study" ppsx
Ngày tải lên :
12/08/2014, 15:22
... and the intronic SNPs are independently associated with SLE In contrast, the association of rs179019 and rs179010 was eliminated when they were adjusted for each other as expected on the basis of ... haplotype containing all of the three SLE risk alleles, but not of the other haplotypes All of these results support the possibility that the possession of both the 3’UTR and intronic risk alleles ... Genotyping Eight tag SNPs in the TLR7 region were selected on the basis of the HapMap Phase II JPT (Japanese in Tokyo) data obtained from the HapMap database [9] with the criteria of minor allele...
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Báo cáo y học: "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians" potx
Ngày tải lên :
09/08/2014, 07:20
... involving differences in disease phenotype, in lifestyle, and in environmental and genetic factors Conclusion There was no detectable effect of variation in the number of D residues in ASPN in ... susceptibility in Spanish Caucasians This result reinforces the overall lack of association reported in other studies in Caucasians The association between variation in the number of D residues ... Program for the Training of University Professors of the Spanish Ministry of Education AG was supported by the Instituto de Salud Carlos III (Spain) References Our results were similar to the UK study...
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Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx
Ngày tải lên :
09/08/2014, 10:23
... enrolled at the Center of Physical Examination All individuals included in the study were Han Chinese living in and around Nanjing None dropped out during the study In addition, a population of 750 ... studies The minor allele frequencies of TXNDC3 in East Asian individuals were significantly different from those in UK control individuals The corresponding German frequency was 13%, which was within ... G allele of rs585017 was similar in Chinese and Japanese individuals, and was low (< 4%), unlike that in European Caucasians (> 20%) [8,10] No GG genotype was detected in East Asian individuals...
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Báo cáo y học: "Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study" ppt
Ngày tải lên :
09/08/2014, 13:22
... out during the process of the study The study was approved by the ethical committee of the participating institutions, and informed consent was obtained from patients and controls The ages of patients ... to the Medical School of Nanjing University, China The controls had no symptoms or histories of CDH All subjects included in the study were of Han Chinese origin living in and around Nanjing ... a key role in the aetiology and pathogenesis of CDH To evaluate this possible association, we examined the genetic association of the GDF5 SNP with CDH in people of Han Chinese origin and found...
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Báo cáo y học: "Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study" docx
Ngày tải lên :
09/08/2014, 07:20
... an independent classification based on information regarding occupation and the branch of industry during the period of the stated exposure to mineral oils The industrial hygienist was blinded ... with an increased risk for RF+ RA and anti-CP+ RA in man Further exploration of this finding may be of interest in elucidating whether other types of adjuvants, such as microbial agents and other ... to the interpretation of results and the writing of the manuscript CB contributed to the design of the study, to the collection of the data, to statistical analysis and to the writing of the...
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Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study" docx
Ngày tải lên :
09/08/2014, 07:20
... polymerase chain reaction product were deactivated using shrimp alkaline phosphatase The amplification of the SNP site was carried out using the MassExtend primer and involved the use of specific ... were performed by simulating cases and controls assuming a multiplicative model for disease risk, and varying the genetic risk associated with each copy of the high -risk variant Observed allele ... molecular genetic studies, participated in study design, and drafted the initial manuscript LP assisted in genotyping some of the control individuals SH aided in recruitment and clinical phenotyping of...
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Báo cáo y học: "Association of the microsatellite in the 3'''' untranslated region of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case-control study" ppsx
Ngày tải lên :
09/08/2014, 10:21
... samples included in the non24CAs group, in spite of the inclusion of several different alleles, was as homogeneous as that in the 24CAs samples, validating our stratification of patients by 24CAs ... hours of anti-CD3 stimulation As shown in Figure 2a, scattering of the data in the non-24CAs group was similar to that in the 24CAs group This indicated that the functional behavior of the samples ... multivariate binary logistic regression model The final model included DR4, 24CAs and sex as independent variables, and disease as the dependent variable As can be seen in Table 2, the association of CD154-24CAs,...
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Báo cáo y học: "Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study" pps
Ngày tải lên :
09/08/2014, 14:20
... second cohort of 100 French family trios A decrease in P value in the combined French cohorts was taken as strong evidence in favor of association These polymorphisms were further analyzed in a German ... 2) In combined analysis of both French family cohorts, association of MICA-250 was comparable with the association in the first French family cohort in standard analysis and in analysis of the ... Analysis of linkage disequilibrium LD was analyzed within parents of the family cohorts and in the case-control cohort As the German cohort was smaller, power to detect LD was decreased compared...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
Ngày tải lên :
11/08/2014, 10:23
... occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro ... location of staining, it is tempting to hypothesize that the CSF1R protein plays a role in differentiation of intestinal epithelial cells as it does in macrophages The most intense cytoplasmic staining ... (green arrow) B Staining of the superficial epithelium of the colon C Staining of the superficial epithelium of the ileum with an epithelial cell being sloughed off into the lumen (green arrow)...
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báo cáo khoa học: " The association of aggressive and chronic periodontitis with systemic manifestations and dental anomalies in a jordanian population: a case control study" pdf
Ngày tải lên :
11/08/2014, 20:20
... classifies dens invaginatus into: • Type I: an enamel-lined invagination within the crown and not extending beyond the cementoenamel junction (CEJ) • Type II: the enamel invagination into the ... loss in whom plaque deposits were consistent with the amount of destruction were diagnosed as having CP Cases where there was uncertainty in the diagnosis of AP or CP were not included in this ... investigated in the present study including dens invaginatus, dens evaginatus, pegshaped lateral incisors and congenitally missing lateral incisors Interestingly, the dental anomalies investigated in this...
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báo cáo khoa học:" Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region" pdf
Ngày tải lên :
11/08/2014, 23:22
... early diagnosis of CD [12]; in fact among the atypical aspects of CD (extra-intestinals), in the international literature has been reported some affections interesting the oral cavity, the most common ... Medicine 2007, 3:25 of intestinal mucosa [7] It is also well recognized the association of CD with several complications, as lymphomas, autoimmune and degenerative nervous system diseases [8-10] The ... part of the diagnostic process In conclusion, our data from central Italy confirming the higher prevalence of RAS or aphthous-like ulcers in patients with CD validate the hypothesis of their...
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Báo cáo y học: "Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study" doc
Ngày tải lên :
12/08/2014, 14:21
... life In a study [34] that compared the correlation between self-reported and observed tasks at work, the coefficient of determination (r2) was as low as 0.15, meaning that in some of the cases ... cases This was dictated by the fact that the current study is a part of a larger project studying the effect of genes and environment on the risk of OA in the Icelandic population Any bias introduced ... whose father was also in our database and 629 men and 887 women whose mother was also in our database By cross tabulating this we were able to determine how occupation was inherited to the next...
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Báo cáo y học: "Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese" potx
Ngày tải lên :
12/08/2014, 15:22
... and ASPN is an important regulator in pathology of DDH It may influence the susceptibility of DDH via TGF-b signaling Table Association of the D-repeat of ASPN in patients with DDH in a Han Chinese ... No subjects dropped out during the process of the study The study was approved by the ethical committee of the participating institutions, and informed consent was obtained from all subjects Patients ... Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese J Hum Genet 2006, 51:1068-1072 24 Valdes AM, Loughlin...
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Báo cáo y học: "Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies" doc
Ngày tải lên :
12/08/2014, 23:23
... three of these five studies a statistically significant increase in the length of stay in the ICU was reported for the cases with A baumannii infection [14,17,21], whereas in the remaining two ... difference was found in the length of stay in the ICU between cases and controls Data on the length of stay of cases and controls in the ICU was reported in all five studies that examined the effect of ... population from the studies selected In addition, the site of infection, the numbers of cases and controls, the methodology for the matching of controls to cases, and clinical outcomes of interest were...
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THE VALUE OF RE USING PRIOR NESTED CASE CONTROL DATA IN NEW STUDIES WITH DIFFERENT OUTCOME
Ngày tải lên :
12/10/2015, 17:36
... contribution of individual i given by the following: (5) with yi being the binary indicator taking the value one if individual i is a case in study B The weight ωi is calculated as the inverse of the ... the number of cases with the current disease of interest We are also partly inspired by the huge amount of existing NCC data in many areas, such as Genome-wide association studies (GWAS) in genetic ... The existing studies mentioned above with huge amount of information emphasize the needs and the importance of studying the re-using method We want to look into the details of the impact of the...
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Báo cáo y học: "Comparative study of control selection in a national population -based case-control study: Estimating risk of smoking on cancer deaths in Chinese men"
Ngày tải lên :
26/10/2012, 09:48
... and the area of the residence Confidence intervals (CIs) were used in this study, as in clinical trials,7–10 to evaluate the equivalence of the two case-control studies in assessing the risk of ... smoking habits in the cases should similarly affect assessment of smoking habits in the control group,1 however, insisting on a dead control group violates the study base principle, since the base ... pattern of the effect of smoking on risk of cancer deaths TABLE Characteristics of cases and two control groups: Population-based case-control study of smoking on risk of cancer deaths among Chinese...
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Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study pptx
Ngày tải lên :
06/03/2014, 02:21
... from other studies of non-occupational risk factors for breast cancer related to the lifetime load of endogenous estrogens [6] These include the finding of an increased risk with duration of fecundity, ... of cases Each unique NAICS/NOC combination was further assigned an exposure classification code signifying the likely presence and intensity of carcinogen and/or EDC exposures in the manner of ... internationally, in the 1970’s To test for a role of chemicals in canning, we defined canning exposure as work in the canning industry NAICS codes after 1973 by which time epoxy coatings were being widely introduced...
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Occupation and Breast Cancer: A Canadian Case–Control Study docx
Ngày tải lên :
06/03/2014, 02:21
... cancer in experimental mammals exist in high concentrations in occupational settings.11 In spite of the continuing increase in the incidence of cancer in Canada and the existence of carcinogens in ... underestimate the actual risks.58 Another limitation of the LOHR study was the small sample size, which necessitated the grouping of occupational categories thereby increasing the risk of misclassification ... status.2 The recent increase in incidence may be linked to the combination of identified risk factors and those requiring further study, such as occupational and environmental exposures.3 Increasing...
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