2 clinical applications of cartilage engineering in omfs
Báo cáo y học: "Quantitative ultrasound can assess the regeneration process of tissue-engineered cartilage using a complex between adherent bone marrow cells and a three-dimensional scaffold" docx
Ngày tải lên :
09/08/2014, 06:22
... tissue engineering in the treatment of cartilage defects of the knee J Bone Joint Surgr 2002, 84:571-578 Shieh SJ, Terada S, Vacanti JP: Tissue engineering auricular reconstruction: in vitro and in ... regeneration of the cartilage surface in tissue engineering Further studies using lowfrequency ultrasound may provide a better assessment of the deeper layers in tissue-engineered cartilage Second, ... Histological findings In the histological findings, the defect area in group C was filled with fibrous tissue None of the defects from group C contained any fibrocartilage or hyaline-like cartilage...
- 8
- 355
- 0
Báo cáo y học: "The Influence of Hyperbaric Oxygen Treatment on the Healing of Experimental Defects Filled with Different Bone Graft Substitutes"
Ngày tải lên :
25/10/2012, 11:15
... five minutes of diving to 15 m (50 feet) in which the rats were exposed to 2.4 ATA pressure for 60 minutes, five minutes of re-surfacing and 10 minutes of air ventila- http://www.medsci.org Int ... Ultrastructural findings of extensive degeneration in the periosteum of CPCBB + HBOT group at one week time point It is clear that the the integrity of the cell membrane could not be maintained and there ... significant increase in the new bone formation following three weeks 2,8 ATA once daily 120 minutes of HBOT Penttinen et al.(33)investigated the effects of 2,5 ATA twice daily 120 minutes of HBOT...
- 12
- 698
- 0
Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
Ngày tải lên :
19/02/2014, 06:20
... MAP kinase signaling pathway TAM67 retains the DNA binding and leucine-zipper region of c-Jun, but it lacks the transactivation domain of c-Jun (amino acids 1–122) It thus blocks the binding of ... event in determining the susceptibility to apoptosis through maintaining the integrity of the mitochondria and inhibiting activation of the caspase cascade [37] High expression levels of antiapoptotic ... apoptosis by increasing Bcl-XL expression Many studies have implicated PtdIns3-K ⁄ Akt signaling in the inhibition of apoptosis of a variety of cells through the increased phosphorylation of Bad and...
- 13
- 493
- 0
Investigation of au and in as solvents for the growth of silicon nanowires on si(1 1 1)
Ngày tải lên :
16/03/2014, 15:17
... explain differences in droplet formation between indium and gold, we will consider in the following the effects of different diffusion coefficients of gold and indium on silicon, the solubility of ... the UHV chamber in spite of the preceding HF-dip There are hints in the literature [11] that deposition of gold onto a thin layer of SiO2 on Si(1 1) favors the decomposition of SiO2, i.e that ... nanowires after flooding the chamber with diluted silane and explained the absence of nanowires by considering the surface tension of indium and the low solubility of silicon in indium Iacopi et...
- 6
- 565
- 0
báo cáo hóa học:" SPECT/CT-plethysmography – non-invasive quantitation of bone and soft tissue blood flow" ppt
Ngày tải lên :
20/06/2014, 01:20
... in minute http://www.josr-online.com/content/3/1/36 RS – scintigraphic reading within the soft tissue compartment RL – scintigraphic reading within the entire limb compartment During the infinitesimal ... blood volume within bone compartment (including bone marrow) υs – blood volume within soft tissue compartment υL – blood volume within the volume that is confined within the 100 ml cylinder Based ... and blood pool activity of the bone (including bone marrow) and soft tissue were determined using segmentation based on thresholds within a virtual cylinder consistent of 3–4 slices (slice thickness...
- 8
- 406
- 0
báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
Ngày tải lên :
20/06/2014, 04:20
... examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less than 10% of cells were positive), (intermediate staining; ... and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF...
- 8
- 445
- 0
báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
Ngày tải lên :
20/06/2014, 07:20
... examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less than 10% of cells were positive), (intermediate staining; ... and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF...
- 8
- 244
- 0
Báo cáo y học: "Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget''''s disease of bone in an Italian family" pps
Ngày tải lên :
09/08/2014, 07:20
... within affected families The findings described in this paper are of interest with regard to both issues The p62/SQSTM1 protein binds non-covalently to ubiquitin, co-localizing with ubiquitinated ... M404V is able to cause the loss of monoubiquitin binding and impair in vitro Lys48-linked polyubiquitin binding, although these effects were reported only when the binding experiments were performed ... a carrier of multiple bone deformities and pain by living members of the family, strongly suggesting the presence of PDB disease in this individual Figure 2a contributes to sustaining this hypothesis...
- 7
- 355
- 0
Báo cáo y học: " Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis" ppt
Ngày tải lên :
09/08/2014, 07:20
... inflammatory scoring system included the following three parameters: hyperplasia/enlargement of synovial lining layer (intima), activation of fibroblastic cells in the sublining stroma, and inflammatory ... network of morphogen action and regulation in the joint, because injection of BMP-2 induced osteophyte formation in a murine model [9] Thus, the interaction of BMPs and inhibitors not only in the ... release of inflammatory cytokines and destructive proteases [2] Increases in knowledge about inflammatory cytokines and cytokine networks in chronic joint diseases has promoted the development of...
- 10
- 530
- 0
Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps
Ngày tải lên :
09/08/2014, 08:22
... significance of tissue-specific variations in glucocorticoid metabolism was investigated by determining whether increased 11β-HSD1 activity was able to mediate autocrine regulation of the cytokine IL-6 in ... Analysis of IL-6 protein secretion by ELISA in synovial fibroblasts confirmed that the findings observed at the RNA level were also reflected at the protein level Because of variability in baseline ... control; IFN, interferon; IL, interleukin; TNF, tumour necrosis factor uate distinct immune responses in an autocrine fashion [37,38,40], but the manner in which they are likely to interact in specific...
- 10
- 438
- 0
Báo cáo y học: "Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts" potx
Ngày tải lên :
09/08/2014, 08:23
... H, Onishi Y, Inukai K, Anai M, Fukushima Y, et al.: 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain J Biol Chem ... Discussion As an increasing amount of literature is demonstrating the involvement of bone tissue in the initiation/progression of OA, a better understanding of this tissue is clearly of utmost importance ... in OA Obs, unlike in normal cells Since there is an increase in IGF-1 production in OA Obs with a concomitant decrease of the major insulin-like growth factor binding proteins, namely BP-3, BP-4...
- 12
- 391
- 0
Báo cáo y học: " A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab" docx
Ngày tải lên :
09/08/2014, 10:20
... observed in clinical nonresponders to infliximab is in accordance with the findings of a recent study [8] that demonstrated protective effects on joint destruction in the absence of clinical response ... patients were included in several analysis of covariance models for bone mineral density (BMD) variations (final values minus initial values) to analyze the effect of cofactors (continuous variables ... ilarly, patients receiving steroids exhibited lower levels of markers of bone formation markers Our findings of these usual correlations provide validation of the data at baseline In the study, we...
- 7
- 498
- 0
Báo cáo y học: "Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling" pot
Ngày tải lên :
09/08/2014, 10:21
... breakdown of the cartilage and joint space narrowing, there is thickening and sclerosis of subchondral bone, development of cysts and bony overgrowth at the margins of the joint Despite an increase in ... with the increased levels of bone remodelling seen in OA bone and perhaps a net gain of under-mineralized bone rather than the net loss of bone volume seen in OP Interestingly, and in contrast ... Page of 21 (page number not for citation purposes) ORM1 3.982 -7.756 -3.878 Cortistatin -6.713 -3.843 IGFBP3 Insulin-like growth factor binding protein -3.772 -3.893 YWHAG WNT 4.284 Insulin induced...
- 21
- 402
- 0
báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc
Ngày tải lên :
11/08/2014, 00:23
... B: Diagnostic and prognostic role of the insulin growth factor pathway members insulin-like growth factor-II and insulin-like growth factor binding protein-3 in serous effusions Hum Pathol 2009, ... http://www.jnanobiotechnology.com/content/9/1/36 Page of 14 Kim JH, Cho YH, Park YL, Sohn JH, Kim HS: Prognostic significance of insulin growth factor-I receptor and insulin growth factor binding protein-3 expression in primary breast ... view of a cell indicating the contact surfaces of the source and the drain is shown to the right of the wafer Gate voltage is applied at the back of the wafer Also indicated are the aligning markers...
- 6
- 329
- 0
Báo cáo y học: " Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx
Ngày tải lên :
13/08/2014, 09:21
... βcasein) (D and E) Involvement of Stat3 and Stat5 in the formation of SIE- (D) and β-casein- (E) binding complexes in HTLV-1-infected T-cell lines EMSA was performed with nuclear extracts of the indicated ... involved in the induction of Stat3 and Stat5 phosphorylation in T-cells AG490 reduces constitutive activation of Stat3 and Stat5 through inhibition of Jak kinases in HTLV-1-infected T-cell lines ... Amounts of actin are shown as loading controls (B) Stat-DNA binding activities in HTLV-1-negative and HTLV-1-infected T-cell lines were detected by EMSA using SIE or β-casein probe Arrows indicate...
- 10
- 271
- 0
Báo cáo y học: "Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis." pptx
Ngày tải lên :
13/08/2014, 19:20
... age, 55 years; 73% men) were included Matrix metalloproteinases (MMPs) are a family of zinc-containing endoproteinases implicated in degradation and remodelling of the extracellular matrix (ECM) ... remains unclear; but the results of some studies indicate that MMPs play a certain role in the recruitment of leukocytes from the bloodstream to the site of infection [26-28], and in the inflammation ... its induction in normal human fibroblasts by inflammatory cytokines J Clin Invest 1991, 88:1656-1662 35 Wahl LM, Corcoran ME, Mergenhagen SE, Finbloom DS: Inhibition of phospholipase activity in...
- 9
- 302
- 0
Suitability of insulin like growth factor 1 (IGF1) as a measure of relative growth rates in lingcod
Ngày tải lên :
04/09/2015, 17:15
... The number of individuals in the analysis differed from the number stocked at the beginning of the experiment owing to mortality Variation in IGF1 in Wild Lingcod We collected 146 lingcod (97 ... growth rates of juvenile lingcod reared in the laboratory to confirm whether IGF1 acts as an index of relative growth in lingcod as it does in other fish Next, we evaluate spatial variation in plasma ... Friday Harbor, Washington, in the San Juan archipelago during the summer of 2007 (Figure 2) Lingcod were collected at 4–50 m depth using the hook-and-line methods of Beaudreau and Essington (2007)...
- 12
- 428
- 0
Differentiation of bone marrow derived mesenchymal stem cells (BM MSCs) using engineered nanofiber substrates
Ngày tải lên :
11/09/2015, 09:57
... Nanofibres for Bone Tissue Engineering Scaffolds Bioceramics 19, 19th International Symposium on Ceramics in Medicine, The Annual Meeting of the International Society for Ceramics in Medicine,10-13 ... Alizarin red staining of various substrates after 14 days of culture in normal and osteogenic media Scalebar: 100 µm Fig 4.16: Alizarin red staining of various substrates after 28 days of culture in ... explosion in tissue engineering research has revolutionized our understanding in modulating stem cell fate and behavior, translating into potential clinical applications for regenerative medicine Such...
- 241
- 446
- 0