2 arterial infusion chemotherapy for locally advanced breast cancer
báo cáo hóa học:" Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs" potx
... of assay performed Sequencing of both the RT and PR genes was also employed to determine the subtypes of these viral isolates in concert with the Stanford database http://hivdb.stanford.edu/ Nucleotide ... copies/mL and in whom genotypic analysis was performed (n = 51) Plasma was obtained during 20002001 All subjects harbored subtype-B HIV-1 viruses and provided informed consent Sequencing of the RT and ... Statistical Analysis The distribution of nucleotide substitutions was determined for each patient and the mean value for each type of substitution was calculated Differences among types of nucleotide...
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báo cáo hóa học:" Trends in the clinical characteristics of HIVinfected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009" pdf
... stage documented for the patient before ART initiation “Programme” is defined by a single administrative unit and “site” is defined by a single physical location for ART services For example, a ... 2008-09 (p for trend < 0.001), but rose in Uganda from 33% to 36% (p for trend = 0.02) in the same period No change was seen in Tanzania (p for trend = 0.21) (Figure 2) Presentation with advanced ... at advanced disease In contrast, women with a history of treatment for PMTCT (compared with women with no history of treatment for PMTCT) and older age were associated with decreased risk of advanced...
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Báo cáo y học: "Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study" potx
... (58.33%) for infliximab-treated RA patients, of 15 (40%) for AS patients and of 30 (6.7%) for control RA patients All patients who became positive for anti-dsDNA autoantibodies were also positive for ... presented a remission, the timing of infusions was dictated by disease relapse [25] Follow-up of autoantibodies Tests for autoantibodies were performed at baseline before the start of infliximab treatment ... Detection of anti-dsDNA autoantibodies Tests for anti-dsDNA autoantibodies were performed at the start of infliximab treatment and, depending on the formation of ANA, at 6, 12, 18 and 24 months...
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Báo cáo y học: "Is there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious infection" ppt
... for, and so these data raise concerns about an increased risk for this tumour that will require longer term follow up of much larger cohorts The risk for infection was less marked than that for ... screened to exclude pre-existing malignancy, for example with chest radiography Thus, in such patients there is a ‘telescoping’ of ascertainment of malignancy before study entry, with the consequence ... threshold for these interventions might differ both between trials and between treatment arms within a trial; if an individual has a good response to the drug, then there may be a lower threshold for...
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Báo cáo y học: "HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form" pdf
... (ART); these patients therefore had lower CD4 counts (median CD4% of 13 for the ART group, 35 for the non-ART group) Additional patient details are given in Table For this second group of patients, ... outer forward) and MO044, 0.208 U/μl RNase inhibitor, μl of the Titan One Tube enzyme mix and 10 μl of extracted RNA Reverse transcription proceed at 50°C for 30 min, followed by 95°C for min, ... conditions were identical to those used above for fragment (A), but using primers MO193 and MO194 For fragment (B), reverse transcription was performed in a 20 μl reaction containing 1× Qiagen...
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Báo cáo y học: " Distinct expression profiles of TGF-β1 signaling mediators in pathogenic SIVmac and non-pathogenic SIVagm infections" pot
... infections In order to search for further early differences, we quantified the transcript levels of t-bet and gata-3, which encode for essential transcription factors for the commitment towards ... cell activation levels from the initial stage of infection have a predictive value for AIDS progression even before seroconversion [4,5] The precise mechanisms leading to the aberrant chronic T-cell ... those recorded for pathogenic HIV-1/SIVmac infections [6] and SIVagm replicates in lymphoid tissues, including the gut [6,7] Despite high VLs, natural carriers Page of (page number not for citation...
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Báo cáo y học: "Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock - does the dose matter" pps
... prolonged infusion or continuous infusion in comparison with 30-minute intermittent infusion (around 90% versus 80%) This suggests that, under the same daily dose, extended infusion or continuous infusion ... administration schedule (6.6% for extended infusion versus 3.7% for intermittent infusion; P = 0.5), but among critically ill patients (APACHE II score ≥17) it was significantly lower for those patients ... mg/kg q12h for to doses; MD mg/kg q12h [81,82]b LD 12 mg/kg q12h for to doses; MD to mg/kg q12h [81,83]b LD 12 mg/kg q12h for to doses; MD to mg/kg q12h [81,83]b LD 12 mg/kg q12h for to doses;...
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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc
... given just mg E2, and the remaining women were given mg E2 for 12 days, then mg E2 plus mg norethisterone acetate for 10 days, and then mg E2 for days The investigators in the rheumatology departments ... (LUA) We thank Nycomed for providing the calcium and vitamin D3 used in the study We thank Maud Pettersson and Lena Svensson for their laboratory help and Anders Oden for statistical advice References ... synovial fluids from rheumatoid arthritis patients are responsible for osteoclastlike cell formation J Bone Miner Res 1996, 11:88-95 27 Forsblad d’Elia H, Larsen A, Waltbrand E, Kvist G, Mellström...
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Báo cáo y học: " Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya" doc
... attempted for all 19 participants with a detectable viral load and was successful for PR in 17 Page of (page number not for citation purposes) AIDS Research and Therapy 2009, 6:12 (89.5%) and for RT ... submitted to Genbank [Genbank EU872121–EU872135 and 878548 for PR and EU872136–EU872150 and 878549 for RT] All statistical analyses were performed using SPSS 15.0 (SPSS, Illinois, USA) Results The ... collected for CD4 cell count (FACScount Becton & Dickinson Immunocytometry, Oxford, UK) The remainder of the blood was centrifuged to collect plasma, which was stored at -80°C until processing for...
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Báo cáo y học: " Pre-treatment mortality and loss-to-follow-up in HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients eligible for antiretroviral therapy in The Gambia, West Africa" doc
... providing information on ART to patients in the cohort and assessing them for ART eligibility at the planning phase for introduction of ART in June 2004 Adult patients were considered eligible for ART ... patient’s eligibility for ART [17,18], our data suggest that it is an important clinical assessment tool and we therefore advocate for the development of better training materials for ascertainment ... the efforts of Gilleh Thomas in acquisition of the data and John Townend for his advice in the statistical analysis Support for the MRC HIV clinic staff was provided by the Global Fund for AIDS,...
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báo cáo khoa học: "The efficacy of computer reminders on external quality assessment for point-of-care testing in Danish general practice: rationale and methodology for two randomized trials" pot
... below) of adherence to the split test procedures for the baseline period and for each of the follow-up periods for each practice Background information on practices and GP was retrieved by the ... testing and is a prerequisite for receiving fees for this service Apply number 010158-6006 for ordering external quality assessment analysis in WebQuality system For questions, please contact ... is used with GEE methods to account for the repeated measurements To identify predictors for adhering to split test procedure guidelines, adjusted effects for the GP and practice characteristics...
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báo cáo khoa học: "Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy" ppt
... critical parameter impaired in cancer cells, and this induction is selectively exerted in cancer and transformed cell lines, while being less active toward normal nontransformed cells [16-18] Thus, ... used as loading control for cytosol and nucleus fractions, respectively For mitochondria fraction verification was performed as detailed in Methods Page of (page number not for citation purposes) ... recent years, LA has gained considerable attention in the cancer field as an anticancer agent [14,15] Results from antiproliferation studies on cancerous cell-based models have suggested that the tumor-suppressive...
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Báo cáo y học: " Co-receptor usage and prediction of v3 genotyping algorithms in hiv-1 subtype b’ from paid blood donors experienced anti-retroviral therapy in chinese central province" pps
... collected for viral load, CD4 + T count detection and the peripheral blood mononuclear cells (PBMCs) for isolating primary HIV strains All subjects signed informed consent forms before blood ... According to the formula (V3 net charge = (R + K)-(D + E)), net charge of V3 loop was calculated In the formula, the R and K was short for argentine and lysine, respectively; D and E short for aspartic ... 7(4.02 ± 1.02), of which 4.53 ± 0.74 for X4/R5 strain, 3.91 ± 1.05 for R5 strain (see table 3) In both ART and treatment-naïve group, number of net charge of V3 for R5-tropic viruses distributed...
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Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
... 20 serum-free medium for the indicated time points Cell-free supernatants were either untreated (for active TGF-β) or treated with N HCl (for total TGF-β) followed by ELISA for TGF-β1 measurement ... azide For the staining of cell surface markers, cells were incubated with FITC or PE antibodies for 30 mins at 4°C Isotype-matched negative controls were used for all flow cytometric analysis For ... cultured for 48–72 hours RNA was isolated and cDNA synthesized for assessing the expression of Foxp3 by real-time PCR Freshly isolated CD4+CD25+ T cells were used as a positive control for Foxp3...
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Báo cáo sinh học: "A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma" ppsx
... emission for the other tumors (R2 = 0.99 and p = 0.002 for tumors on the back and the right flank; R2 = 0.98 and p = 0.011 for the tumor on the left flank), R2 was 0.90 (p = 0.050) for this large ... of DNA were analyzed for cytotoxic and bioluminescent activity (A) Cytotoxic activity of cells transfected with HSV-TK-Luc or HSV-TK For reasons of clarity only the graphs for 0.1 µg and µg of ... render this imaging method particularly attractive for studying therapeutic strategies in animal models of cancer In addition, high costs, the need for a radiopharmacy and considerable technical...
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Báo cáo y học: "HIV DNA and Dementia in Treatment-Naïve HIV-1-Infected Individuals in Bangkok, Thailand"
... prior study conducted in Bangkok; therefore feasibility was established [17] We substituted the Brief Visual Memory Test-revised for the Picture Memory Test for logistical reasons as the latter ... Therefore, since an excellent congruence was achieved, we completed the analysis using the original diagnoses for the purpose of this evaluation Viral load and CD4 lymphocyte counts were performed ... p
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... were mandated for ANC < 750/mL or platelets < 45,000/mL and ANC < 500/mL or platelets < 20,000/mL, respectively Ribavirin dose was decreased for hemoglobin < 10 g/dL and discontinued for hemoglobin ... chronic hepatitis C virus and liver transplantation: a role for interferon therapy before transplantation Liver Transpl 2003;9:905-15 17 Forns X, Garcia-Retortillo M, Serrano T, Feliu A, Suarez ... randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon therapy Treatment of advanced liver disease...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... currently known Therefore, the recently performed study in Michael Cleary’s laboratory was quite a surprise [41] Wang and co-workers demonstrated that active GSK3 is necessary for MLL-mediated leukemia ... Kronnie and Theo Dingermann for critically reading the manuscript I want to apolo- Role of MLL in human malignancies gize for not-citing many references due to a citation limit for this minireview This ... on cancer- associated target genes Cancer Cell 14, 36–46 22 Caslini C, Yang Z, El-Osta M, Milne TA, Slany RK & Hess JL (2007) Interaction of MLL amino terminal sequences with menin is required for...
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Tài liệu IMPLANT AND REGENERATIVE THERAPY IN DENTISTRY A GUIDE TO DECISION MAKING docx
... to form Wiley-Blackwell Editorial Office 2121 State Avenue, Ames, Iowa 50014-8300, USA For details of our global editorial offices, for customer services, and for information about how to apply for ... the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added ... if regenerative therapy is required for implant placement Possible need for endodontic intervention Greater difficulty in plaque control efforts Potential need for periodontal surgical therapy on...
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Tài liệu ACCOUNTING FOR HETEROGENEITY, DIVERSITY AND GENERAL EQUILIBRIUM IN EVALUATING SOCIAL PROGRAMS pptx
... are aligned for adult women Results for youth are mixed For male youth, for whom the mean experimental impact is significantly negative, the difference in integrated CDF's is negative for most values ... distributions of outcomes for persons who sought to go into the program For non-negative y° this form of rationality implies that (IV-i) f F1(y ID = 1)dy'
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