2 actual trends and organ preservation

... standard of care Standards of care are determined on the basis of all clinical data available for an individual case and are subject to change as scientific knowledge and technology advance and ... population of Scotland should be discouraged from smoking or chewing tobacco The Smoking Cessation Guidelines for Scotland: 2004 Update,15 commissioned by NHSScotland and ASH Scotland makes recommendations ... Pathologists standards and minimum data set for reporting head and neck cancers (www.rcpath.org).85  Pathologists are advised to use the Royal College of Pathologists standards and minimum data...

Ngày tải lên: 14/02/2014, 22:20

... dissection classification and TNM staging of head and neck cancer — 3rd ed / Committee for Head and Neck Surgery and Oncology, American Academy of Otolaryngology—Head and Neck Surgery [and] Neck Dissection ... NECK DISSECTION CLASSIFICATION AND TNM STAGING OF HEAD AND NECK CANCER Committee for Head and Neck Surgery and Oncology American Academy of Otolaryngology– Head and Neck Surgery Neck Dissection ... classification and TNM staging of head and neck cancer / Committee for Neck Dissection Classification, American Head and Neck Society [and] Committee for Head and Neck Surgery and Oncology, American Academy...

Ngày tải lên: 15/03/2014, 00:20

... DIAGNOSIS AND STAGING D Fine needle aspiration cytology should be used in the investigation of head and neck masses D All patients with head and neck cancer should have direct pharyngolaryngoscopy and ... laryngectomy with or without postoperative radiotherapy an initial organ preservation strategy reserving surgery for salvage A Treatment for organ preservation or non-resectable disease should be concurrent ... dentist Speech and language therapy C Head and neck cancer patients with dysphagia should receive appropriate speech and language therapy to optimise residual swallow function and reduce aspiration...

Ngày tải lên: 15/03/2014, 01:20

... variety of different patient pathways and experiences This is partly because “head and neck” is a catch-all category and not a single cancer, and a variety of organs and functions are involved Some ... implications for safe and effective surgical practice and clinical organisation The question of centralisation inevitably arises because many types of head and neck cancer are rare and the main treatment ... mouth, lip and tongue (oral cavity), the upper part of the throat and respiratory system (pharynx), and the voice-box (larynx) Other UAT sites include the salivary glands, nose, sinuses and middle...

Ngày tải lên: 22/03/2014, 16:21

... contributions TJC and CHC conceived the study design, carried out and coordinated immunohistochemical examinations of tumor specimens and data analysis, and drafted the manuscript CYC and HTT participated ... tissues were cut to mm and deparaffinized with xylene and rehydrated in a series of ethanol washes (100, 90, 80, and 70%) Slides were washed with phosphate-buffered saline (PBS) and treated with 3% ... kinase and EGFR and then delayed the DNA repair [37-39] Oxaliplatin induced double-strand breaks [40] When cetuximab was combined with oxaliplatin, cetuximab reduced the expression of ERCC-1 and...

Ngày tải lên: 18/06/2014, 19:20

... contributions TJC and CHC conceived the study design, carried out and coordinated immunohistochemical examinations of tumor specimens and data analysis, and drafted the manuscript CYC and HTT participated ... tissues were cut to mm and deparaffinized with xylene and rehydrated in a series of ethanol washes (100, 90, 80, and 70%) Slides were washed with phosphate-buffered saline (PBS) and treated with 3% ... kinase and EGFR and then delayed the DNA repair [37-39] Oxaliplatin induced double-strand breaks [40] When cetuximab was combined with oxaliplatin, cetuximab reduced the expression of ERCC-1 and...

Ngày tải lên: 20/06/2014, 03:20

... was feasible and accurate for 14 patients with locally recurrent head and neck cancers [42] The 1- and 2-year local control rates were 78% and 57%, respectively, and the actuarial 1- and 2-year ... lasted several days Radium226 and iridium-192 have been used for T1 and T2 patients with oral cavity and oropharynx carcinomas and produced excellent control rates and functional results [29-33] ... history and physical condition of all the patients, hematological and chemical tests, and obtained CT images of the head and neck and radiographs of the chest Patient characteristics are shown in...

Ngày tải lên: 09/08/2014, 09:20

... 5.5 months for time to progression The 1-year and 2-year local control and overall survival rates for all patients were 51.2% and 30.7%, and 48.5% and 16.1%, respectively Overall, the MST for ... 1- and 3-year local failure-free survival rates were 70% and 51% for the SRS group and 91% and 83% for the SRT group (P = 0.003) Although the overall survival rates were similar (66% in SRS and ... of patients with recurrent and second primary tumors, limited and advanced tumors, curative and palliative treatment, squamous cell carcinoma and other histologies, and variable treatment strategies...

Ngày tải lên: 09/08/2014, 09:21

... patients were candidates for curative surgery Fifteen patients were candidates for combined radiotherapy and platinum-based chemotherapy and patients for radiotherapy alone Image acquisition and fusion ... mean and range values of the additional volumes analyzed to compare PET/CT and CT alone are reported in Table and Figure In particular, the mean PEToutCT volume was 27% of the mean CT-GTV and ... http://www.ro-journal.com/content/3/1/29 ment planning also of patients with head and neck carcinoma [17-20] the extra laryngeal and pre-epiglottic space, and the thyroid gland In our experience, the primary tumor was identified...

Ngày tải lên: 09/08/2014, 09:22

... LRFS and OS at and years was margin status, p = 0.0007 and p = 0.0002, respectively Figure Doses at skin were measured and where in the range of 32–60% Four patients (19.4%) experienced acute and ... 52.4% (11/21 patients) The 5- and 8-year overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively, as shown in Figures and There was no local failure ... shortening the overall treatment time and conformability of the procedure Patients and methods All patients admitted for treatment at the Radiation Oncology and Head and Neck Surgery Departments, Hospital...

Ngày tải lên: 09/08/2014, 10:21

... Salivary Glands 64 5.4 Face and scalp (soft tissue) 63 5.3 Ear 16 1.3 glands and palate, while the only other common site for sarcomas was the mandible Lymphomas also occurred in the maxilla and tonsil ... contributions AO, AO and JO were involved in the conception and design of the study AO acquired the data AO and BF participated in the analysis and interpretation of the data BF, EEU and B were involved ... Pathology and Pathology U.C.H Ibadan and records of all malignant lesions involving the oral and nasal cavities, the paranasal sinuses, oropharynx, nasopharynx, hypopharynx, larynx, trachea, ear and...

Ngày tải lên: 11/08/2014, 20:21

... alterations and the biological and clinical significance of NF-κB activation and of multiple NF-κB-regulated genes and cytokines expressed in HNSCC tumor specimens and serum [18,32,33,42,80,81], and ... inhibitor-kappaB kinase (IKK)α/β/γ and casein kinase complexes modulating NFκB1, RELA and cREL, and alternative pathways involving NF-κB inducing kinase and IKKα modulating NFκB2 and RELB [1,2,11,24-26] ... R53.15 Binding activityprevious page) of RELA and NFκB1 Figure (see and motif logo Binding activity and motif logo of RELA and NFκB1 (a) The basal and inducible binding activity of RELA or NFκB1...

Ngày tải lên: 14/08/2014, 08:20

... Wendlandt, M., Neuenschwander, P., and Suter, U.W (2007) Surface-textured PEG-based hydrogels with adjustable elasticity: synthesis and characterization Biomaterials, 28, 567–575 Tang, Z.G and ... cartilage and equipped with an endoluminal epithelium in 2003 Cartilage and epithelial cells were harvested from the septal cartilage of sheep and grown in vitro After proliferation and cultivation ... the airways including transport of fluids and ions and for the mucociliary clearance and the patency of the airways [75] The early development of a complete and 317 318 13 Regenerative Medicine functionally...

Ngày tải lên: 25/10/2013, 08:20

... oropharynx, thyroid, parathyroid, hard palate, parotid gland, nasopharynx, trachea, submandibular gland, lacrimal gland, and conjunctiva.179 Head and neck involvement has been reported as a cause of ... tract, the eyes, and the testes, and disease manifestations are a result of the inflammatory reaction to the organism leading to scarring and deformities Involvement of the nasal cavity and paranasal ... membranes, and in patients with neurosyphilis, meningitis and dementia may develop Oral lesions in primary and secondary syphilis are nonspecific and characterized by squamous hyperplasia and a plasma...

Ngày tải lên: 19/02/2014, 08:20

... contributions J-YC and SMH conceived of the study and devised the experimental design SMH and CM designed and build the tissuemicroarrays MT, J-YC, and YK performed experiments RX, HC, J-YC and SMH performed ... had 1-, 3-, and 5-year survival rates of 66%, 33%, and 24%, respectively, whereas those with negative membranous Her3 expression had 1-, 3-, and 5-year survival rates of 74%, 51%, and 40%, respectively ... expression of Her2 in primary HNSCC and corresponding metastatic tissues by IHC techniques With a cut-off level between score (negative) and score 1, 2, and (positive) and found Her2 protein expression...

Ngày tải lên: 18/06/2014, 22:20

... and GL provided study materials or patients HSB, PS, JG, AB, CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and ... Informatics, Biometry and Epidemiology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany Authors’ contributions CB designed the study and participated in data analysis and interpretation ... Germany) at 95°C for 30 s, 61°C for 30 s and 72°C for 30 s Digestion with BccI at 37°C (New England Biolabs Inc., Ipswich, MA, USA) and results in fragments of 77 bp and 63 bp for the G-allele vs 140...

Ngày tải lên: 18/06/2014, 22:20

... contributions J-YC and SMH conceived of the study and devised the experimental design SMH and CM designed and build the tissuemicroarrays MT, J-YC, and YK performed experiments RX, HC, J-YC and SMH performed ... had 1-, 3-, and 5-year survival rates of 66%, 33%, and 24%, respectively, whereas those with negative membranous Her3 expression had 1-, 3-, and 5-year survival rates of 74%, 51%, and 40%, respectively ... expression of Her2 in primary HNSCC and corresponding metastatic tissues by IHC techniques With a cut-off level between score (negative) and score 1, 2, and (positive) and found Her2 protein expression...

Ngày tải lên: 20/06/2014, 04:20

... and GL provided study materials or patients HSB, PS, JG, AB, CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and ... Informatics, Biometry and Epidemiology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany Authors’ contributions CB designed the study and participated in data analysis and interpretation ... Germany) at 95°C for 30 s, 61°C for 30 s and 72°C for 30 s Digestion with BccI at 37°C (New England Biolabs Inc., Ipswich, MA, USA) and results in fragments of 77 bp and 63 bp for the G-allele vs 140...

Ngày tải lên: 20/06/2014, 04:20