1overview of the immunoglobulin heavy chain genomic organization

... repertoire is increased by the addition of or the deletion of nucleotides at the junction between the different gene segments and by random pairing of the heavy chains and light chains Additional diversity ... analysed the results and drafted the manuscript CK participated in the design and coordination of the study, and performed the characterisation of cells AP was involved in the molecular analysis of the ... relapsed 15 months after the beginning of the study The patient therefore received another rituximab treatment (four once-weekly doses of 375 mg/m2) at the time point of 17 months Except for mg...

Ngày tải lên: 09/08/2014, 06:22

... method This thematic report contains the main following sections: I The definition of the supply chain II The supply chain of marine fishing products 2.1 The chart of the supply chain for marine ... that purpose The thematic report of “Assessing the fisheries supply chains in Viet Nam” within the framework of this research project focuses on the assessment of the supply chain of fisheries ... for the sea trip of the vessel owners, therefore, they not suffer from losses In fact, all the investments that the middle men spend in the sea trips of the vessel owners are the loans that they...

Ngày tải lên: 28/03/2013, 13:51

... codes, making them an important part of the landscape of the company The increasing relevance of the cost regardless of business ethics is recorded Emphasis is placed on the importance of stressing ... assessment of the consequences of action, but unlike the selfish, selfinterest focused on determining the course of action will produce the best for the greatest number of people Therefore, it is the ... declared lower cost of debt or moving costs - the debt of the period to the next accounting period, or declaration of income Conversely, if the company is focused on reducing the problem of enterprise...

Ngày tải lên: 13/03/2014, 14:20

... manner among the various participants of the MRO supply chain for the paper mill On the soft side, we studied organizational issues such as the integration across various supply chain partners, ... comprehensive view of drivers of supply chain performance across the paper industry The purpose of the mail survey was to gather comprehensive information from a larger number of paper mills about their supply ... specifically, in the context of the MRO supply chain for paper mills, our goals were: 1) to develop an understanding of current practices including the challenges of integrating supply chains across organizations;...

Ngày tải lên: 24/03/2014, 05:20

... collection, the end of the duodenum and the cranial part of the cecum were tied and both ends were cut One end of the small intestine was at the stand and a conical tube was placed at the other end Then ... mucosal surface The major effect of serum immunoglobulin A is to prevent the attachment of bacteria and viruses to the mucosal surface [11] The major biologic function of serum immunoglobulin ... compare to that of control Over-dosage of CLA may affect the depression of immune production However, the addition of vitamin ADE and/or selenium to CLA increased the level of immunoglobulin production,...

Ngày tải lên: 07/08/2014, 17:22

... with TAP Induction of HLA-B27 heavy chain- homodimers after dendritic cell stimulation We then determined the ability of the HLA-B27-expressing KG-1 cells to form the heavy- chain homodimer structures ... characteristics as the lower of the dimer-region bands seen in Figures 3a and 3b We were unable to detect any other significant spots that would allow us to determine the nature of the other bands present ... succumbs to disease when removed from these conditions [26] Both of these could be interpreted as sequelae to the induction of large numbers of HLA-B27 heavy- chain dimers on antigen-presenting cells,...

Ngày tải lên: 09/08/2014, 13:21

Ngày tải lên: 21/08/2014, 18:20

... systems, the blood system and the lymph system (Parham, 2001) These two systems are intertwined throughout the body and they are responsible for the transport of the agents of the immune system The ... structure can hold the two heavy chains together Therefore, myosin II has two heads It also contains light chains (2 per head), which bind the heavy chains in the "neck" region between the head and ... chemokines Further investigation of the underlying mechanism showed that the wide type E coli K1 can inhibit the phosphorylation of NF-κB thereby prevents the translocation of NF-κB to the nucleus The...

Ngày tải lên: 03/10/2015, 20:32

... inventory of the equipments and services are a vital requirement for the supply chain function as the output of one activity is the input for the second phase of activity The total supply chain management ... corporate context and the total supply chain process of the Company ü Part 2: o Investigate the total supply chain process of Lam Son JOC; address the issues on the current challenges of the process o ... overall picture of the supply chain management context, the company profile, and its process CHAPTER 1: THE CONTEXT OF SUPPLY CHAIN MANAGEMENT Describe the concept of supply chain management...

Ngày tải lên: 25/11/2016, 09:51

... homologues to heavy- chain partners of the light -chain subunits of the HAT system of chordates, have been identified and analysed, which should enable the experimentalists in the field to direct their research ... lack of domain B protruding out of the TIM barrel in the place of loop connecting the b3-strand to the a3-helix [9,21] Sharing domain B by rBATs and GH13 enzymes, and especially the sequence of the ... is the light subunit that possesses the amino acid transportation activity, although without interacting with the heavy subunit it is unable to reach the plasma membrane Thus, the role of the heavy...

Ngày tải lên: 18/02/2014, 13:20

... result of the present work is that the N-terminal cleavage of the S1 heavy chain completely prevents the changes in the thermal unfolding of S1, i.e a significant increase in the protein thermal ... obtained by addition of 0.5 mM BeCl2 in the presence of mM NaF The formation of the complexes was controlled by measuring the K+-EDTA ATPase activity of the protein The ATPase activity of S1, t-S1, or ... compared the thermal unfolding of S1 species with the heavy chain cleaved by trypsin at specific, welldefined sites Thermal unfolding of S1 cleaved by trypsin in the absence of nucleotides First, the...

Ngày tải lên: 17/03/2014, 10:20

... located in the 3¢ region but also for two of them by deletion of the central repetitive domain Until now, because of the lack of knowledge on the genomic organization of the 3¢ region of MUC4, the precise ... with the nucleotide sequence of the MUC4 gene allowed us to establish the nature of the mechanisms responsible for the diversity of transcripts They were generated by the combination of either ... responsible for these events could not be defined In the present paper, we described the genomic structure of the 3¢ region of the human MUC4 gene A comparison of the nucleotide genomic and cDNA...

Ngày tải lên: 17/03/2014, 23:20

... analysis addressed the nature of these mutations The R/S ratio of the nonproductive Vκ and Vλ repertoire could not be assessed individually because of the small number of mutations in the nonproductively ... ratio Because of the significant differences in the mutational frequencies of productively rearranged VL genes from the peripheral blood and from the parotid gland of the SS patient, further analysis ... detected in the salivary glands of patients with SS [3,6], but it is not known whether the microenvironment of these cell clusters is sufficient for the induction of a germinal center response Of note,...

Ngày tải lên: 09/08/2014, 03:24

... band on the basis of its size, to normalize the intensity of the staining for the different sizes of the fragments The final percentage content of each MHC gene in the total sample was then calculated ... paradigm To correct for any differences in the efficiency of the reactions for each isoform, the intensity of the MHC band was divided by the intensity of the control fragment in that reaction A ... expression toward slower isoforms were limited by the technologies then available, which did not allow the evaluation of the expression of each of the type II MHC isoforms with specific probes...

Ngày tải lên: 12/08/2014, 18:20

... Table shows that the average monthly rainfall in Shah Alam is 185.1mm The estimated roof catchment area of the school is about 690m2 Thus, the average volume of water fell on the roof is about 125m3 ... harvesting tank would be the amount of water not release to the drainage systems Thus, less amount of water becomes runoff This will reduce the amount of stormwater runoff, which will result in ... shows that the average potential monthly storage of about 53m3 This indicates about 42% as the average rate of capture Therefore, on average there is only 57% of rainwater discharged to the drainage...

Ngày tải lên: 01/04/2013, 22:43

... recommended that the outer harder and shiny part of the palm fronds be used for the fabrication of PFCBB Other factors like water absorption of the PFCBB be conducted to determine its other properties ... value of “t” were less than the tabular value of “t” at 5% level of significance, this implies that there is no significant difference between their compressive strengths V Conclusion : Based on the ... 0 4 6 1 (days) The greatest compressive strength of the uncured and cured PFCBB was achieved in 28 days and the least was in days Similarly, the greatest compressive strength of the uncured and...

Ngày tải lên: 01/04/2013, 22:44

... more   than 37°C in April, the hottest month The division of the season in the north more clearly than in the southern, where the only exception of the highlands, seasonal temperature difference ... currently the source of sand for cement concrete is ultilize from rivers, sand resources depleted day by day by mining as well as the rapid growth of the construction industry Therefore the using of ... the present sea level will must be renovated again, even have to move to another place The railway north - south roads and near the seaside of road systems will be affected The rising level of...

Ngày tải lên: 01/04/2013, 22:45

... hypothesis is accepted Therefore there is no significant difference between the means of the flexural strength of the board using the method of water immersion Flexural strength which has the ... Mixing of binder and rice hull The samples III RESULTS AND DISCUSSION The following tables present the results of the compressive tests of the samples from the Universal Testing Machine (UTM) and the ... 0.12 The findings on the density of the board showed that 60:40 had the greatest density of 0.27 and the lowest value for 70:30 of 0.086 Table Flexural Strength by Water immersion Treatment of...

Ngày tải lên: 01/04/2013, 22:46

... with an advantage even under these conditions, such as the minimization of the risk of loss, the maximization of the chance of gain, or the minimization of the regret the decision maker may suffer ... requiring a sequence of interrelated decisions to be made over a certain period of time The more complex the chain, the more essential becomes the use of such technique The concept of the network diagram ... implementation of the laws necessary for the reform of the economic system These include the National Assembly (NA), the country's legislature; the Standing Committee (SC) of the National Assembly,...

Ngày tải lên: 13/04/2013, 10:32

... of Vietnam and the South of Vietnam The structure of Vietnam’s SFC organization The supply chain quality management of interviewed SFCs The fish chain in the Netherlands The shrimp chain in the ... all stages of the chain – from the hatchery to distribution – the development of the seafood supply chain quality management framework is crucial Among the chain actors, the role of the SFC is ... at the Faculty of Management and Organization, Centre for Development Studies (CDS), the Faculty of Economics of the University of Groningen in the Netherlands, and the School of Economics and...

Ngày tải lên: 23/04/2013, 09:34