1997 brk tyrosine kinase expression in a high proportion of human breast carcinomas oncogene 15 7 799 805
báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc
Ngày tải lên :
11/08/2014, 00:23
... a pattern of progressive adenocarcinoma with similar genetic changes and pathophysiology as seen in human breast cancers associated with BRCA1-mutations [11,12] Additionally, as in human BRCA1-associated ... conditions in the University of Maryland, Baltimore animal facility and maintained in accordance with institutional guidelines approved by the University of Maryland, Baltimore Animal Care and Use ... pathway as a selective target of familial breast cancer therapy Curr Mol Med 2008, 8 :72 7 -74 0 26 Vadgama JV, Wu Y, Datta G, Khan H, Chillar R: Plasma insulin-like growth factor-I and serum IGF-binding...
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Báo cáo y học: " Tuberculosis contact investigation with a new, specific blood test in a low-incidence population containing a high proportion of BCG-vaccinated persons" pdf
Ngày tải lên :
12/08/2014, 16:20
... Respiratory Research 2006, 7: 77 http://respiratory-research.com/content /7/ 1 /77 Table 1: Demographic and behavioral characteristics of the study participants Variables Age of contacts (years) – mean ... the statistical analysis CL and MF participated in the design of the study and the data interpretation KM recruited patients, obtained medical data and assessed results All authors read and approved ... Bering, Marburg, Germany; equivalent to about TU of PPD-S) was injected intradermally into the volar aspect of the forearm and transverse induration diameter was measured 72 hours later Individuals...
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Regulation of substance p and neurokinin 1 receptor expression in a mouse model of acute pancreatitis
Ngày tải lên :
09/09/2015, 17:54
... pancreatic inflammation is a hall-mark of acute pancreatitis (AP) A majority of AP cases can be attributed to gallstones and alcohol abuse, making up for more than 80% of total cases (Sakorafas and ... GCTGCCCTTCCACATCTTCT-3’ 5’- CGCGATGCAGAACTACGAAA-3’ 5’- CAGCCTCAGCCGAAACTACA-3’ 223 282 156 2.2.9 Whole cell lysate preparation and Western blot analysis After treatment of pancreatic acinar cells, ... are critical pro-inflammatory mediators in AP and the associated lung injury SP-NK1R interaction is also a determinant of inflammatory edema in acute interstitial pancreatitis (Maa et al., 2000b)...
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Báo cáo y học: "Normalization of boutique two-color microarrays with a high proportion of differentially expressed probes" ppt
Ngày tải lên :
14/08/2014, 17:22
... used as a moderately high throughput assay to systematically interrogate genes of maximal interest at low cost [6 ,7] Boutique arrays are almost always two-color cDNA arrays because cDNA arrays are ... Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, et al.: Genome-wide expression profiling of mid-gestation placenta and embryo using a 15, 000 mouse developmental cDNA microarray Proc Natl Acad ... normalization, particularly as genes are often selected on the basis of having a changing role in the samples being compared A natural way to normalize these arrays is to train the lowess curve on a set of...
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Functional effects of a novel BIM deletion polymorphism in mediating resistance to tyrosine kinase inhibitors in cancer
Ngày tải lên :
10/09/2015, 09:04
... extracellular domain that contains a ligand-binding site, a transmembrane helix and a cytoplasmic domain The cytoplasmic domain contains a kinase active site that catalyzes tyrosine phosphorylation ... participate in intramolecular interactions to inhibit ABL1’s kinase activity9 Apart from intramolecular interactions, the kinase activity of ABL1 can also be regulated by protein-protein interactions ... homolog (ABL1), v-src sarcoma viral oncogene homolog (SRC) and Janus kinases (JAKs) are examples of non-receptor tyrosine kinases In an inactive state, the kinase activity of ABL1 and SRC are repressed...
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A case-study in IVF - paternalism and autonomy in a ‘high-risk’ pregnancy
Ngày tải lên :
01/11/2013, 08:20
... pregnancy There was a significant further advance of her renal disease, necessitating the initiation of haemodialysis (a kidney machine) two years later, and a living, related donor renal transplant ... remaining remarkably stable The pregnancy was complicated at 20 weeks’ gestation by a right deep vein thrombosis, affecting the femoral and external iliac veins, and anti-coagulation with heparin ... IVF in women with renal transplants, but specialists were becoming increasingly reluctant to advise women with transplants against trying for a baby, as medical care for high risk’ pregnancies...
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Báo cáo Y học: Human bile salt-stimulated lipase has a high frequency of size variation due to a hypervariable region in exon 11 pot
Ngày tải lên :
24/03/2014, 03:21
... number of repeats are fewer compared to BSSL Naturally occurring variants of BSSL, differing in apparent molecular mass, have been described in human milk [ 27 29] Variants of higher, as well as lower, ... feto-acinar pancreatic protein (FAPP), has been detected in human embryonic and fetal pancreas and in pancreatic tumoral cell lines [35,36] FAPP and BSSL are structurally closely related, but are ... 5¢-GACCCCAACATGGGCGACTC-3¢ 5¢-GTCACTGTGGGCAGCGCCAG-3¢ 10621±10640 1 079 3±1 077 4 5¢-tctagaagcttGGCGCCGTGTACACAGAAGGTGGG-3¢ 5¢-GTTGGCCCCATGGCCGGACCCCAT-3 40 47 4069 475 2 472 9 5Â-cgggatccGAAGCCCTTCGCCACCCCCACG-3Â...
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helpful expression in a biz letter
Ngày tải lên :
08/05/2014, 20:04
... very pleased to inform you that… We have much pleasure in informing about… Enclosing documents • We have pleasure in enclosing… • We are enclosing a catalogue… • Please find enclosed / attached ... Apologizing and expressing regret • • • • • • • We regret our inability to … We are regretful that we shall not be able to… I regret that I cannot… I am afraid that … We are sorry that … Please accept ... 1 Stating the reference, explaining the reason for writing • • • • With reference to … In reply to … I would like to thank you for… I am writing to apply/inform/request… Acknowledging • We acknowledge...
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Báo cáo khoa học: "Enhanced tyrosine hydroxylase expression in PC12 cells co-cultured with feline mesenchymal stem cells" pps
Ngày tải lên :
07/08/2014, 20:23
... improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon Brain 1994, 1 17, 4 87- 499 26 Pittenger MF, Mackay ... differential effects of cell density and NGF on the expression of tyrosine hydroxylase and dopamine beta-hydroxylase in PC12 cells Brain Res Mol Brain Res 1991, 11, 79 - 87 Crigler L, Robey RC, Asawachaicharn ... LC, Carvalho KA, Rebelatto C, Senegaglia A, Hansen P, Furuta M, Miyague N, Francisco JC, Olandoski M, Faria-Neto JR, Oliveira SA, Brofman PR Cell transplantation: differential effects of myoblasts...
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Báo cáo y học: "High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis" potx
Ngày tải lên :
09/08/2014, 01:23
... CAA AAT GGC GGA TGG-3′ and 5′-CGA TGA AGG CGT AGA TGA TGG-3′, at 60°C annealing temperature The primer pairs 5′-TGG GCA ACA ATA CAG CAA ACT-3′ and 5′-GAG CAG GAA GAT GAG GAC GAC-3′, at 58°C annealing ... individual patients within Table Staining of the indicated proteins on parallel blots is shown Equal loading of tissue extracts was controlled by β-actin protein staining MW indicates a protein from ... blocking buffer at 4°C overnight To assess equal loading of protein lysate for each sample, a parallel blot was incubated with an anti-β-actin antibody (Clone AC15, 1:50000; Sigma) Bound primary antibodies...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
Ngày tải lên :
09/08/2014, 07:20
... for 72 hours at 37 C DNase activity in the supernatants was measured by DNA-MG assay, as set out below DNA-methyl green assay DNase I activity in urine and supernatant samples was quantified using ... levels are expressed as arbitrary ELISA units (AEU) relative to a standard positive sample that was assigned a value of 100 AEU The data are presented as mean ± standard error of the mean Statistics ... with DNA-MG in a 96well microtitre plate (Nunc) and then incubated for 15 hours at 37 C The absorbance was read in a plate reader using a 620 nm filter DNase activity in the samples was calculated...
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Báo cáo khoa học: "Transhiatal esophagectomy in a high volume institution" pdf
Ngày tải lên :
09/08/2014, 07:21
... complications, and the fashioning of a cervical anastomosis so that the clinical consequences of any anastomotic leak are minimized [12,13] Critics of the transhiatal approach argue that there is a risk of ... bleeding (both of these patients had active intrathoracic bleeding although none were associated with an azygous vein injury) Clinically apparent anastomotic leaks occurred in 6% of patients and all ... Transhiatal esophagectomy has been the favoured operative approach in our institution for managing both carcinoma of the oesophagus below the level of the carina and type I and II tumours of...
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Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
Ngày tải lên :
09/08/2014, 14:22
... nucleic acid-associated autoantigens in SLE Competing interests In the past years, PJU has served as a consultant to Centocor, Inc (Horsham, PA, USA), Biogen Idec (Cambridge, MA, USA), Avanir Pharmaceuticals ... following Additional files are available online: Additional data file A table providing a description of the autoantigens used on the protein microarrays, which includes the source, origin, tag information, ... common feature of human SLE [ 57] Therefore, disease pathogenesis in the pristane model recapitulates several key features of human SLE, including kidney pathology, IFN-I pathway activation, autoantibody...
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Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance docx
Ngày tải lên :
09/08/2014, 20:20
... was a gene called 573 0453H04Rik, which shares 95% identity (over 480 amino acids) with human desmoplakin, a major protein of desmosomes involved in the anchoring of keratin intermediate filaments ... reciprocally labeled arrays (r designation) was greater than twofold (up or down, but in a reciprocal manner) in at least one experimental comparison The average expression ratios were calculated as ... in iT3, down in RTH (PV) 618 271 histocompatibility 2, class II antigen A, beta A 76 44 97 interleukin receptor, gamma chain 574 303 lymphocyte cytosolic protein 571 328 protein tyrosine phosphatase,...
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Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx
Ngày tải lên :
11/08/2014, 08:22
... emerge as a central mediator of the resolution of inflammation and induction of healing and in the bladder Our results therefore argue in favor of evaluating urinary TGF-β1 in IC patients in order ... Figure Urine levels of active and latent/total TGF-β1 at baseline and after CYP Urine levels of active and latent/total TGF-β1 at baseline and after CYP Active and latent/total TGF-β1 values are reported ... reported as pg/mg of creatinine Panel A Urine levels of TGF-β1 at baseline In the absence of CYP injection, male and female rats excreted very low amounts of TGF-β1 Total (empty black triangle) and active...
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Báo cáo y học: "Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice" pot
Ngày tải lên :
12/08/2014, 11:22
... beadchip contains > 24,000 well annotated RefSeq transcripts and allows samples to be interrogated in parallel To minimize array to array variability, a cRNA sample from each of the sham, GMA-MS ... takes advantage of the technical replicates available on an Illumina microarray Data normalization proceeds using the robust spline normalization algorithm, which combines the features of quantile ... expression analysis Data were analyzed by one-way analysis of variance (ANOVA) generating a least squares means table by Student's t-test using JMP® Statistical Discovery Software Results and Discussion...
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Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx
Ngày tải lên :
12/08/2014, 14:22
... luminal surface of endothelial cells in sections of normal human arteries and veins [44] A2 M has also been implicated in hemostasis as a regulator of thrombin [45] and in the development of thromboembolism ... metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2macroglobulin and chicken ovostatin Binding kinetics and identification of matrix metalloproteinase cleavage sites J ... (Abcam Inc, Cambridge, MA, USA) or 1:50 dilution of rabbit anti-rat melanoma inhibitory activity (MIA) polyclonal antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA) According to the manufacturer's...
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Báo cáo y học: " Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment" pdf
Ngày tải lên :
12/08/2014, 14:22
... this inflammatory and catabolic cascade and demonstrated that curcumin (6) has the capacity to block the action of pro-inflammatory cytokines in the joint thus disrupting the inflammatory cycle inhibit ... Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research Altern Med Rev 2009, 14:141 -153 12 Aggarwal BB, Kumar A, Bharti AC: Anticancer ... Colaianne JJ, Gough A, Rubin RA, Miller DK: Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factoralpha Development and use of a...
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Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'''' pps
Ngày tải lên :
12/08/2014, 15:22
... 10: 172 7- 173 7 20 Matsubara S, Li G, Takeda K, Loader JE, Pine P, Masuda ES, Miyahara N, Miyahara S, Lucas JJ, Dakhama A, Gelfand EW: Inhibition of spleen tyrosine kinase prevents mast cell activation and ... Structure of spleen tyrosine kinase (Syk) protein Syk includes two tandem SH2 domains and a tyrosine kinase domain Interdomain A is between the two SH2 domains, and interdomain B is between the tyrosine ... erythematosus; SLP76, SH2 domain-containing leukocyte proteins 76 ; Syk, spleen tyrosine kinase; TCR, T-cell receptor; TNF, tumor necrosis factor; ZAP70, ζ-chain-associated protein kinase of 70 -kDa...
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Báo cáo y học: "Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis" pot
Ngày tải lên :
12/08/2014, 15:23
... requires that the Mer is an intact membranespanning protein and depends on activation of the intracellular kinase domain of Mer The presence of fluid phase sMer in the extra-cellular space can compete ... Published: 15 April 2011 References Linger RM, Keating AK, Earp HS, Graham DK: TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer Adv Cancer ... receptor tyrosine kinase, comprising the extra-cellular domains, has been found in plasma and shown to inhibit macrophage clearance of apoptotic cells and platelet aggregation [10] Soluble forms of...
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