16 38 reduce safety stocks by accelerating the flow of internal information
annual report 1999 holderbank by accelerating the construction of new cement plants and kiln lines we aim to strengthen market and cost leadership and enhance environmental efficiency
... Schmidheiny Markus Akermann The term of office for all members of the Board of Directors expires on the day of the 2002 General Meeting of Shareholders The Area Managers and the CEO of “Holderbank” Management ... consolidat- further enhanced by the takeover of cement ed in the second half of 1998, merged with terminals on several islands of the eastern Juan Minetti at the beginning of 1999 Caribbean The five ... capable of loading 1,200 tonnes in The local winegrowers’ cooperative is justifi- just 75 minutes; on the other, there is the ably proud of its harvest: their quality has natural environment of vineyards...
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Accelerating the development of biomarkers for srug safety
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... reduce the costs of developing drugs, enhance the safety of drugs, and speed the movement of drugs to market The use of biomarkers in drug development raises a number of issues As a measure of ... president of the Institute of Medicine The National Research Council was organized by the National Academy of Sciences in 1 916 to associate the broad community of science and technology with the Academy’s...
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Diffusing all by pattern - the reading of saintly lives
... “be Undone, / By the departure of a star, / while they enjoy the Sun” (Meserole ) The living God who had authored the sanctity of the dead was poised to fill the space created by their leaving ... reaction to the vision of the valley of dry bones, the divine question and the human answer describe the Puritan response to the challenge of writing resurrections for the dry bones of the holy ... these poems indeed prepared readers to take the place of the deceased, this would occur only if the spirit of the dead infused the living Only through the survivor’s genuine assimilation of the...
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Tài liệu Accelerating the Deployment of VoIP and VoATM pdf
... VoP is growing, there is still considerable debate about whether the underlying network technology will be ATM or IP At the edge of the network the choice, driven primarily by the regional Bell ... resources are reserved all the way from sender to receiver before the start of the transfer, thereby creating a circuit The resources are dedicated to the circuit during the whole transfer Control ... than the architecture of today's circuit switches There is significant debate in the industry about the definition of a softswitch, its role within the network, how it should interface with other...
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The future of internal audit is now Increasing relevance by turning risk into results pot
... members of the C-suite and the Audit Committee in a better context The internal controls information Internal Audit was providing wasn’t enough for the CFO to truly gauge the health of the organization,” ... the context of the time they were made ED 0414 Internal audit case study: is co-sourcing the right move? Four leaders of fictional XYZ Technology Group consider co-sourcing as part of their internal ... to other parts of the company Three of my positions are rotations, with the stated purpose of staying for two years, gaining the experience of working in an audit department and learning how they...
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Báo cáo khoa học: Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony stimulating factor and inducible nitric oxide synthase expression in macrophages by reducing the levels of octamer-binding factor-2 doc
... Mutation of the octamer in the iNOS and G-CSF promoters results in a reduction of more than 90% in the LPS-induced promoter activities of these genes [13,30], suggesting the essential role of the ... attributed to the decrease in Oct-2 expression caused by these reagents The involvement of Oct-2 in iNOS and G-CSF expression was further supported by the finding that knockdown of Oct-2 expression ... concentration of G-CSF protein in the medium was measured by ELISA (B) The values for the LPS-treated cells were divided by those for the non-LPS-treated cells and are shown as a percentage of the values...
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Báo cáo khoa học: Structural determinants of protein stabilization by solutes The importance of the hairpin loop in rubredoxins pdf
... (n) The lower plots show the difference of the coefficients in the presence of (B) DGP or (C) MG relative to water The points on the horizontal axis cover the entire sequence of residues of the ... for some of these residues (Fig 3) In particular, the exposure of the residues that comprise the lower part (relative to the orientation depicted in Fig 2) of the hydrophobic core of the native ... series of mutants of RdDg was constructed to investigate the importance of these mutations on the degree of stabilization rendered by solutes It is well-documented that the thermal denaturation of...
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BÀN VỀ VẤN ĐỀ ĐẨY MẠNH TIẾN TRÌNH HỘI NHẬP VÀO NỀN KINH TẾ THẾ GIỚI ACCELERATING THE PROCESS OF INTEGRATION INTO THE WORLD’S ECONOMY
... trạng chấp nhận khai thác tài nguyên tác động đến môi trường, phương thức tăng trưởng theo lối quảng canh theo diện rộng mà không đầu tư chất xám mức Do đó, chuyển biến bước phát triển vào bế ... dựng kinh tế chất lượng khoa học công nghệ không cao, ý thức bảo vệ môi trường không tốt, đơn chạy theo lợi nhuận nên phá hoại môi trường nghiêm trọng, lãng phí tài nguyên Kinh nghiệm giới rằng, ... đổi ngoại thương nhiều, công ty, người tiêu dùng quốc gia thu nhiều lợi ích nhờ vào lợi kinh tế theo quy mô, học hỏi thông qua kinh nghiệm thực tế khả phân chia chi phí nghiên cứu nhiều đơn vị...
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Báo cáo hóa học: "Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference" pdf
... to the standards of animal care as outlined in the Guide for the Care and Use of Experimental Animals of the Medical College of Shanghai Jiaotong University The study protocol was approved by the ... counting the cells that migrated to the lower side of the filter with optical microscopy at 400× A total of five visual fields at the center and in the surrounding areas were counted, and the average ... efficiency of the target gene after RNAi The cell line with stable transfection and effective inhibition of the ADAM 10 gene was named SACC-ADAM 10-RNAi, and the cell line with stable transfection of the...
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báo cáo hóa học: "On the identification of sensory information from mixed nerves by using single-channel cuff electrodes" pot
... half of the signals was used to train the parameters of the classifiers; their performance was then assessed on the second half of the data The performance of the classifiers was measured by comparing ... However, the main goal of these studies was to identify the onset (and offset) of a specific neural activity, with the aim of triggering stimulation The aim of our work was to investigate the ability ... the value that occurs most as a corresponding estimation Thus, the value of the final output is the class with the greatest number of occurrences in this point window of the decision stream The...
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báo cáo hóa học: " Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines" pdf
... experiments, analyzed the data, generated the figures, and wrote the manuscript JW did parts of the animal surgery JW, YS, LW, EB performed the experiments PEK provided advice in the design of the study ... (MCAO) was produced by filament occlusion of the right MCA following a modification of the method reported by Clark and colleagues [21] In brief, mice were anesthetized with isoflurane (induction ... regulator of macrophage activation [15] Further investigations by our group and others indicated that MCPIP1 can play a significant antiinflammatory role by inhibiting the generation of a set of major...
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báo cáo hóa học:" Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB" doc
... however the role of genistein in chemo-resistant ovarian cancer cells has not been investigated Therefore, the intent of this study was to evaluate the effect of genistein for sensitization of ovarian ... sensitize even the drug-resistant cell line and cause inhibition of cell viability Further, to assess whether the loss of overall cell viability could also be due to the induction of apoptotic ... on the DNA binding activity of NF-κB Genistein inhibits NF-κB DNA binding activity Specifically, the effects of pretreatment followed by the combination treatment were studied in the context of...
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Báo cáo y học: " b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryo" docx
... output The induction of apoptosis of the endocardium and erythrocytes by b-lapachone is mediated through an NQO1- and calcium-dependent pathway This study further demonstrated the importance of the ... artery of DMSO- and b-lapachonetreated embryos by tracing the distance they traveled in a fixed period of time via time-lapse fluorescence microscopy Flow rate (Q) was then calculated based on the ... in both erythrocytes and the endocardium of b-lapachone-treated embryos Furthermore, we demonstrated that the induction of apoptosis of the endocardium and erythrocytes by b-lapachone is mediated...
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Báo cáo y học: "Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of" ppt
... associated with the expression of pro-inflammatory cytokines To determine whether the inhibition of IL-6 and IL-8 expression was mediated by inhibition of MAPK, we examined the effect of POMx on the activation ... reduced the PMA plus A23187-induced luciferase activity (Fig 4C) To further strengthen the relation of NF-κB pathway and the expression of IL-6 and IL-8 in KU812 cells, we next investigated the ... μg/ml of POMx significantly decreased the PMACI-induced IL-6 and IL-8 production in the culture supernatant of activated KU812 cells Effect of POMx on the activation of MAPK Activation of MAPKs...
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báo cáo khoa học: " Ethylene is involved in pistil fate by modulating the onset of ovule senescence and the GA-mediated fruit set in Arabidopsis" docx
... patterns of genes of the ethylene biosynthesis and GUS activity in the ACS2:GUS line closely matched the unfertilised ovule senescence [4] In view of the fact that the up-regulation of those genes of ... degradation of all tissues in the ovule Despite all this evidence, the independence of the pistil responsiveness to GA of the ovule fate cannot be completely ruled out Elucidation of the location of the ... consequently, the window of GA fruit set responsiveness Therefore, the final parthenocarpic fruit length would depend on the number of viable ovules present in the pistil at the time of GA treatment...
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báo cáo khoa học: " Identification of novel maize miRNAs by measuring the precision of precursor processing" ppsx
... families in the current version of miRBase (release 17) [31] These 84 miRNAs are the products of 167 precursors All of these miRNAs were originally identified by searching with known miRNA from other ... sequences of known miRNAs of other species [31-34] Out of the 84 unique miRNA sequences, 49 can be confirmed by our sequencing Table Summary of small RNA sequencing No of reads No of unique No of unique ... library The expressions of the newly identified miRNAs were validated by Northern blot using RNAs from kernel of mixed stages (Figure 4) As additional evidence to support the annotation of some of these...
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Báo cáo y học: " Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats" ppsx
... Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European ... 0.01) In accordance with the results of p27kip1, there was no significant change of the Skp-2 relative level between the normoxia group and the normoxia+b-E2 (Figure 3a) To further confirm if p27kip1 ... in the process of chronic hypoxia-induced pulmonary artery remodeling, the lysates of each group of PASMCs were used to WB assays As the results showed, compared with the normoxia group, the...
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Báo cáo y học: "Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral RN" ppsx
... with the reduced production of infectious virions, thereby reducing the overall infectivity of the virus In support of this hypothesis, we found that the compensatory mutations did not rescue the ... base-pairing of the DIS of two RNA molecules is a major determinant in the selection of the copackaged RNA partners, and the identity of the DIS plays an important role in the copackaging of RNAs ... packaging [9-11] The four SLs in the 5′ untranslated region (UTR) of the viral genome act as the primary recognition sites for the nucleocapsid (NC) domain of the Gag polyprotein [7,11 -16] The NC has...
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Integrating process planning and scheduling by exploring the flexibility of process planning
... Once the machine utilization rate and job tardiness are displayed on the screen, the user may request the system to improve the schedule by the following two ways: (1) Reduce the total number of ... operation of Job‘j’ 33 Chapter The Facilitator for Integration StartT(j, k) – The starting time of the ‘k’th operation of Job‘j’ EndT(j, k-1) – The ending time of the ‘k-1’th operation of Job‘j’ ... reverse the order of the two sequential operations on a machine; reverse the order of the two sequential operations within a job; change the method used to perform an operation With SA, the trade-off...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008