14 focus on breast cancer detection

... utilization of an oncolytic vector [82], are also under experimentation Table NIS expression in extrathyroidal cancer tissues Induction of endogenous NIS Primary cancer Induction of NIS expression ... focusing on breast and urological cancers, and emphasizing the most relevant developments in both gene therapy and endogenous NIS stimulation strategies NIS and breast cancer NIS expression in breast ... Induction of endogenous NIS Though NIS expression has been demonstrated in most BCs, only in very few patients would spontaneous NIS expression allow efficient radioiodine uptake For this reason,

Ngày tải lên: 05/11/2020, 00:15

... cells continuously proliferated for five passages and were used for further experiments Production of functional dendritic cells from bone marrow-derived mononuclear cells with breast cancer ... supernatant containing the expected protein was collected and stored at -80°C Protein concentration was determined by Bradford assay Generation of DCs from mouse bone marrow-derived mononuclear cells ... fresh medium containing the same cocktail of cytokines every days On day 8, antigens were added into the cultured medium at a concentration of 500 ng/mL On day 10, nonadherent fractions of DCs were

Ngày tải lên: 16/12/2017, 00:33

... especially tanshinone I and Tanshinone IIA have been proved to exert inhibitory action on proliferation and migration of breast cancer cells effectively [4–7] Recently, cryptotanshinone (CPT), another ... negative breast cancer remains poor [3] Thus, further exploration on the effective therapeutic methods against breast cancer are still required Besides the above clinical approaches in breast cancer ... Background Breast cancer becomes one of the most common malignancies and an important public health problem worldwide It also stands in the second place among the most common causes of death from cancer

Ngày tải lên: 30/05/2020, 21:26

... breast cancer compared to ovarian cancer (breast cancer cluster regions = BCCRs) and, one region with an increased risk for ovarian cancer compared to breast cancer (OCCR) [19–21] The mutational ... et al Spontaneous and therapeutic abortions and the risk of breast cancer among BRCAmutation carriers Breast Cancer Res 2006;8:R15 Narod SA Modifiers of risk of hereditary breast cancer Oncogene ... hereditary breast and ovarian cancer Nat Rev Cancer 2002;2:113–23 Thompson D, Easton D Variation in cancer risks, by mutation position, in BRCA2 mutation carriers Am J Hum Genet 2001;68:410–9 Thompson

Ngày tải lên: 17/06/2020, 17:00

... al BMC Cancer (2018) 18:654 Background Studies investigating the influence of metabolic differences on breast cancer prognosis often show contradictory results, and information on breast cancer ... addition, different lipoprotein subfractions vary by progesterone receptor expression [29], suggesting the influence of HDL-cholesterol on breast cancer prognosis may differ by breast cancer ... (all breast cancer stages included, stages 1–4); 2) breast cancer- free interval: the time interval from date of diagnosis to breast cancer recurrence or breast cancer mortality (stages 1–3 breast

Ngày tải lên: 23/07/2020, 02:39

... concentrations Conclusions: Local anesthetics at high concentrations significantly inhibited breast cancer cell survival At 10 × plasma concentrations, the effect of local anesthetics on cancer cell ... equipotent nerve block concentrations to lidocaine [9, 10] These concentrations correspond to the plasma concentrations following regional block and are referred as “plasma concentration” in this paper ... migration of breast cancer cells Ropivacaine at 10 times of plasma concentration arrests breast cancer cell cycle in G2 phase Overall, we demonstrated that local anesthetics at high concentrations

Ngày tải lên: 24/07/2020, 01:38

... mucosal immune function in breast cancer patients and survivors Also the interaction of a diagnosis of cancer causes significant stress contributing to the reduction in immune function [71], increasing ... responses to breast cancer control Breast Cancer Res Treat 2017;162(3):399–408 35 Ewer MS, Lippman SM Type II chemotherapy-related cardiac dysfunction: time to recognize a new entity J Clin Oncol ... salivary alpha-amylase Psychoneuroendocrinology 2007;32(4):392–401 Antonova L, Aronson K, Mueller CR Stress and breast cancer: from epidemiology to molecular biology Breast Cancer Res 2011;13(2):208

Ngày tải lên: 20/09/2020, 19:04

... al Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium Hum Mol Genet 2014 25 Cai Q et al Genome-wide association analysis ... (Table 4) In addition, no statistically significant association was observed between APOBEC3 deletion and breast cancer risk (Table 5) Discussion In this population-based case–control study, we ... Genet 2012;8, e1002532 10 Long J, Cai Q, Shu XO, et al Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium PLoS Genet 2010;6,

Ngày tải lên: 21/09/2020, 02:06

... a percentage of control cultures, with blank values subtracted Concentration-response SI data were used to calculate the 50% inhibitory concentrations, i.e the drug concentration producing a SI ... Capecitabine 5-FU alone Missing data on drug Abbreviations: CRC colorectal cancer, PCI peritoneal cancer index, IPC intraperitoneal chemotherapy, SPIC sequential postoperative intraperitoneal chemotherapy, ... mitomycin C one may only reach intraperitoneal concentrations that approximate the tumor cell IC50 values whereas with oxaliplatin, one might reach 18 times greater a concentration ip Thus, oxaliplatin

Ngày tải lên: 05/11/2020, 05:05

... associations of SNPs with breast cancer needs to be tested in a Japanese population Current findings suggest that the interactions between breast cancer susceptibility SNPs and breast cancer risk ... National Statistics of Cancer Registries by Region (1975–2004) indicate that the prevalence of breast cancer in Japan has increased steadily since 1975 More than 60,000 patients had breast cancer ... “convincing” However, the evidence of a relationship of other foods with breast cancer risk remains at the level of “limited-no conclusion” Thus, it is important to identify risk factors for breast

Ngày tải lên: 05/11/2020, 05:41

... Disparities and the Impact on Breast Cancer The Louisiana Experience Augusto Ochoa, MD Director, Stanley S Scott Cancer Center Al Copeland - Cancer Crusaders Chair Professor of Pediatrics ... have even fewer options for prevention, early detection, and follow-up Choices from the Community Oncologist Perspective • Use standard of care • Enroll patient on a pharmaceutical trial provided ... Designated Cancer Centers Realities for Oncology Patients in the Community in Louisiana • More than 90% Adult Cancer patients not participate in a clinical trial • Most community oncology practices

Ngày tải lên: 04/11/2022, 06:48

... LINCS) and Lapatinib Breast cancer drug Menadione has been examined on its antiproliferative action on breast cancer cells50 Finally in HER2 subtype, Palbociclib is also a Breast cancer drug that ... potential anticancer drugs for breast cancer stages and subtypes Based on this analysis, we have concluded to 63 potential unique drugs for breast cancer stages and 58 for breast cancer subtypes ... prostate, colon and breast cancer One study found that carcinogen-induced mammary tumors in mice were reduced by coconut oil too (http://foodforbreastcancer.com/) Moreover, in Stage I, Sepantronium

Ngày tải lên: 24/11/2022, 17:46

... in their response on radiation. Int J Oncol 1997, 11:993-997. 21. Chambers AF, Wilson SM, Kerkvliet N, O’Malley FP, Harris JF, Casson AG: Osteopontin expression in lung cancer. Lung Cancer 1996, ... of uPA expression in response to OPN treatment and an association of uPA expression with OPN-induced invasion and migra- tion in human breast cancer cells. These findings are consistent with ... osteopontin inhibition on radiosensitivityof MDA-MB-231 breast cancer cells. Radiation Oncology 2010 5:82. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online

Ngày tải lên: 09/08/2014, 09:20

... incubation in a 1:2000 dilution of secondary antibodies conjugated to horseradish peroxidase (Zhongshan Golden Bridge Biotechnology, China) Protein bands were detected using ECL detection system (Zhongshan ... results of incision with restriction endonucleases and sequencing showed correct plasmids Observation of transfection results After transfection with the recombinant plasmid, the breast cancer cell ... proliferation speed(P > 0.05) positive ion of histone, and degrade DNA combined to acetylation domain, then open the chromatin structure and promote transcription, on the contrary, deacetylation of

Ngày tải lên: 10/08/2014, 10:21

... STUDY ON POSTMASTECTOMY BREAST CANCER PATIENTS UNDERGOING RADIATION THERAPY SHARON WONG MEI MEI THE NATIONAL UNIVERSITY OF SINGAPORE 2011 A DOSIMETRIC SKIN STUDY ON POSTMASTECTOMY BREAST CANCER ... advanced breast cancer In S E Motwani S B, Breast Cancer 353-379 New York: Hamilton 81 Wolfgang, J R (1988) Sonographic findings following conservative surgery and irradiation for breast carcinoma ... Quality assurance in radiation oncology A study of feasibility and impact on action levels of an in vivo dosimetry program during breast cancer irradaition Radiotherapy & Oncology.; 29-36 13 Delaney,

Ngày tải lên: 10/09/2015, 15:53

... dose-response relationship [57] 10 mg twice daily 38 Median duration of response, months [58] 10 mg twice daily 44 Response duration, months [59] 20 mg twice daily 43 Median response duration, 20 months ... Response observed despite incomplete suppression of ovarian function [53],[54] 20 mg twice daily 74 Median duration of response, 13 months [55] 10 mg twice daily 21 Response duration, to 18 months ... Introduction 1.1 BACKGROUND 1.1.1 Overview of Current Breast Cancer Therapy The current treatment of breast cancer is a multidisciplinary effort, with goals dependent on the specific clinical situation

Ngày tải lên: 09/10/2015, 11:24

... decision analyses examined the cost-effectiveness of breast cancer gene expression assays, and overall were inconclusive Conclusions: Oncotype DX is furthest along the validation pathway, with strong ... clinical settings, and three breast cancer gene expression assays are now available in the U.S The Oncotype DX™ Breast Cancer Assay, the MammaPrint® Test, and the Breast Cancer Profiling test (BCP ... of evidence on economic outcomes was inconclusive Limitations of the Report The report included only English publications and was restricted to three gene expression tests Limitations of the Literature...

Ngày tải lên: 06/03/2014, 01:20

... Transactions on Biomedical Engineering, vol 49, no 8, pp 812–822, 2002 [21] E C Fear and M Okoniewski, “Confocal microwave imaging for breast cancer detection: Application to hemispherical breast ... Early Detection of Breast Cancer, Institute of Medicine, National Academy Press, Washington, DC, USA, 2001 [2] E C Fear, S C Hagness, P M Meaney, M Okoniewski, and M A Stuchly, “Enhancing breast ... [15] E J Bond, X Li, S C Hagness, and B D Van Veen, “Microwave imaging via space-time beamforming for early detection of breast cancer, ” IEEE Transactions on Antennas and Propagation, vol 51,...

Ngày tải lên: 22/06/2014, 23:20

... seen
between
the
highest
and
lowest
quartiles
of
soy
isoflavone
consumption.
 23
 
 
 Ionizing
Radiation
 From
historical
observations,
an
excess
of breast cancer was
observed
in
persons
 exposed
to
ionizing
radiation
from
sources
such
as
radiotherapy
to
the
thymus
or
for
 ... Women
with breast cancer have
a
fivefold
increased
incidence
of
developing cancer in
the
contralateral breast (46).
In
a
meta-analysis
of
55
trials on tamoxifen
therapy
 for
early breast cancer, 
the
incidence
rate
of
contralateral breast cancer in
women
 not on tamoxifen
(the
control
group)
was
5
per
1000
women
per
year
(47).
The
 ... 
AGE
AT
LAST
BIRTH
AND BREAST CANCER RISK 59
 5.3.3
 
PARITY
AND BREAST CANCER RISK 59
 5.3.4
 
EFFECT
OF
ETHNICITY ON BREAST CANCER RISK 59
 5.3.5
 
EFFECT
OF
ETHNICITY
AND
PARITY ON BREAST CANCER RISK...

Ngày tải lên: 05/10/2015, 21:29

... Group on Hormonal Factors in Breast Cancer Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 without breast cancer ... respected Breast reconstruction Surgeons should discuss breast reconstruction with all patients Reconstruction should be available at the initial surgical operation If this cannot be provided within one ... Collaborative Group on Hormonal Factors in Breast Cancer Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer...

Ngày tải lên: 14/02/2014, 22:20