11c toluene in nonhuman primates and mice

... CII induces reproducible autoimmune-mediated arthritis in a variety of genetically susceptible strains of mice and rats and in macaques [18,19] Interestingly, immunization with bovine CII induced ... contain different quantities of the major crosslinks hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP), which are degradation products of collagen contained in cartilage and bone and are ... CIA-affected joints For routine histology, the patellae of both knee joints and the proximal interphalangal and distal interphalangeal joints of the third digit of the hand and foot were processed and analyzed...

Ngày tải lên: 09/08/2014, 06:23

... protein serine/threonine kinase protein serine/threonine kinase transmembrane receptor protein tyrosine kinase adaptor 3-phosphoinositidedependent protein serine/threonine kinase phosphorylation and ... observed Fasting hyperglycemia and glucose (30% ) intolerance observed in IUGR Table 1: Summary of studies using IUGR rodent model and exhibit changes in organs and gene involving in insulin-glucose ... SLC2A4RG, and fold decrease in MSTN, indicating elevated insulin-glucose signaling All these conclude that the insulin glucose metabolism in IUGR subjects were accelerated at the beginning and thus...

Ngày tải lên: 02/10/2015, 17:14

... protein serine/threonine kinase protein serine/threonine kinase transmembrane receptor protein tyrosine kinase adaptor 3-phosphoinositidedependent protein serine/threonine kinase phosphorylation and ... observed Fasting hyperglycemia and glucose (30% ) intolerance observed in IUGR Table 1: Summary of studies using IUGR rodent model and exhibit changes in organs and gene involving in insulin-glucose ... SLC2A4RG, and fold decrease in MSTN, indicating elevated insulin-glucose signaling All these conclude that the insulin glucose metabolism in IUGR subjects were accelerated at the beginning and thus...

Ngày tải lên: 04/10/2015, 16:03

... protein serine/threonine kinase protein serine/threonine kinase transmembrane receptor protein tyrosine kinase adaptor 3-phosphoinositidedependent protein serine/threonine kinase phosphorylation and ... observed Fasting hyperglycemia and glucose (30% ) intolerance observed in IUGR Table 1: Summary of studies using IUGR rodent model and exhibit changes in organs and gene involving in insulin-glucose ... SLC2A4RG, and fold decrease in MSTN, indicating elevated insulin-glucose signaling All these conclude that the insulin glucose metabolism in IUGR subjects were accelerated at the beginning and thus...

Ngày tải lên: 04/10/2015, 16:12

... fasting glucose and plasma insulin secretion in obese-diabetic mice Glucose (mmol/l) Treatment with extract fraction Starting point Final Change Plasma insulin (pmol/l) of glucose Starting point ... diabetic STZ induced HFD fed mice were expressed diabetic disease and a insulin resistance However, plasma insulin in HFDfed mice injected STZ was lower as compared to HFD mice without STZ injection ... control (ND mice) While, HDLc in HFD mice decreased 34.63% in comparision with the control (ND mice) Moreover, blood glucose and insulin concentration unusually increase in obese mice in comparison...

Ngày tải lên: 12/02/2014, 17:20

... expressed insulin mutinously insulin resistance Therefore, the carbohydrate metabolic disorder and insulin resistance were proved in the STZ induced diabetic mice Table Blood glucose and insulin concentration ... effect of CGE in STZ induced diabetic mice On the final day of weeks care, fasting blood glucose levels of mice fed ND and fed HFD were determined, then obese mice were given single i.p injection ... grandis peel extract fractions on enzymatic activities of lipase (A) and CPT(B) in treated obese mice (↑ Increases) 3.4 Effect of STZ on ND-fed and HFD fed mice Injection of STZ (120 mg/kg) into...

Ngày tải lên: 14/03/2014, 10:20

... protein unfolding, many aromatic amino acids forming the protein core become exposed with the concomitant increase in the molar extinction coefficient of the protein, and thus the increase in absorbance ... protein is shown in Fig 3A indicating good dispersion of the backbone and side-chain signals (the latter including those assigned to tryptophane indole groups in the 5594 Fig Structure determination ... CD69 in buffers with neutral or slightly alkaline pH under conditions compatible with binding of potential ligands We succeeded in crystallizing the very stable CD69NG70 protein using l-arginine...

Ngày tải lên: 16/03/2014, 04:20

... settle for grooming partners of adjacent rank and trade grooming in kind In species that form matrilineal dominance hierarchies, kin occupy adjacent ranks Thus, kin biases in grooming reflect the ... partners, then kin biases in interactions patterns among siblings, cousins, grandmothers and grandchildren, and other kinds of maternal kin may emerge The dynamics of social interactions 39 40 ... of interest between egotism and nepotism by maximizing their own rank among their kin on the one hand, and by maximizing the rank of their kin in relation to non-kin on the other (p 129) 2.4 Kin...

Ngày tải lên: 08/04/2014, 12:58

... mice were divided into 10 randomly assigned groups: untreated control group, single agent rapamycin, single agent asparaginase, combination asparaginase plus rapamycin, single agent vincristine, ... vincristine, combination vincristine plus rapamycin, single agent sunitinib, combination sunitinib plus rapamycin, single agent bevacizumab, and combination bevacizumab plus rapamycin As soon as ... following cohorts: untreated, rapamycin treated, asparaginase treated, asparaginase plus rapamycin combination treated, vincristine treated, vincristine plus rapamycin combination treated, sunitinib...

Ngày tải lên: 18/06/2014, 16:20

... recombinant influenza HA protein in the face of influenza pandemic threat Keywords: Hemagglutinin, H1N1, Pichia pastoris, secreted expression, Influenza recombinant vaccine Background Influenza ... distribution, and reproduction in any medium, provided the original work is properly cited Yeast expressed recombinant Hemagglutinin protein of Novel H1N1 elicits neutralising antibodies in rabbits and mice ... of mice and rabbits with yeast derived H1N1HA recombinant protein To evaluate the elicitation of neutralising antibodies against the yeast expressed Hemagglutinin recombinant protein, BALB/c mice...

Ngày tải lên: 18/06/2014, 18:20

... (4°C) in 4% paraformaldehyde in 0.1 m PBS and cryoprotected in 20% sucrose in PBS at 4°C for 24 h The spinal column was freeze mounted and cut into 30 μm sections and placed on poly-L-lysine-coated ... 0.50) and right (18.83 ± 1.16) hindlimb Collectively, these results indicate that spinal cord injury procedure used in the current study was reliable in inducing behavioral signs of the injury ... calculating the fidelity index, which is the ratio of spinal response to muscle twitch force The dCMS-induced changes in the fidelity index were opposed in control and injured animals While this index...

Ngày tải lên: 19/06/2014, 08:20

... maximum-intensity algorithm and in some cases using depth-coding and surface-rendering algorithms http://www.jneuroinflammation.com/content/2/1/22 Thioflavine-S staining Thioflavine-S staining consisted ... staining consisted of reacting section in 0.015% aqueous thioflavine-S for 10 min, followed by differentiation in 50% ethanol, rinsing in water, air draining and clarification into xylene Thereafter ... Brain amyloid plaque load was determined in APP [V717I] mice and completely in line with previous studies [6,7] Amyloid plaques were undetectable by Thioflavin-S or Aβ immunostaining in brains...

Ngày tải lên: 19/06/2014, 22:20

... recombinant influenza HA protein in the face of influenza pandemic threat Keywords: Hemagglutinin, H1N1, Pichia pastoris, secreted expression, Influenza recombinant vaccine Background Influenza ... distribution, and reproduction in any medium, provided the original work is properly cited Yeast expressed recombinant Hemagglutinin protein of Novel H1N1 elicits neutralising antibodies in rabbits and mice ... of mice and rabbits with yeast derived H1N1HA recombinant protein To evaluate the elicitation of neutralising antibodies against the yeast expressed Hemagglutinin recombinant protein, BALB/c mice...

Ngày tải lên: 20/06/2014, 01:20

... Ni2+-nitrilotriacetate sensor chip and cardiolipin vesicles were injected olipin-binding activity of 4B7 mAb Binding of rhNPM to cardiolipin and effects of nucleophosmin on cardiolipin-binding activity of 4B7 ... anti-nucleophosmin and anti-cardiolipin antibodies in lupus mice A positive correlation between anti-nucleophosmin and anti-cardiolipin antibody reactivities in 38 sera from male WB mice (a) and 20 sera ... nucleolar staining (Fig 2b,d) sera Nucleophosmin-binding activity of WB lupus-prone and control mouse sera (a) Sera from male (◆) and female (■) WB mice, and from male CD1 (▲) mice, collected during months...

Ngày tải lên: 09/08/2014, 07:20

... mitogen concanavalin A in round-bottomed 96 well plates (Corning Limited) and incubated for days at 37°C in a humidified CO2 incubator Cells were incubated during the last 18 hours in the presence ... temperature and permeabilized in 0.1% Triton X-100 in PBS for 15 minutes at 4°C After washing (10 mM TRIS HCl pH 7.6, containing 150 mM NaCl, TBS buffer) and blocking (normal rabbit serum 1:5 in TBS ... data and error bars denoting 95% confidence interval are presented effect of amiloride and cytochalasin D was independent of NFκB inhibition Dose-response data obtained in the absence of inhibitors...

Ngày tải lên: 09/08/2014, 08:22

... generation 33 & randomly paired within lines Beginning on day 19 after mating, females were checked daily at 0700 and 1500 h for littering Crossfostering sets were formed by choosing dams at random, one ... estimates of a prenatal line effect (a and a ) ; postnatal line effect (p Prenatal line refers to the line into which an individual ) ; female was born, and postnatal line is the line of the dam that ... rate in swine : Correlated response in litter size and weight J Anim Sci., 48, 509-516 ISEN E E.J., 1978 Single-trait and antagonistic index selection for litter size and body weight in mice...

Ngày tải lên: 09/08/2014, 22:22

... (Serotec) and biotinylated anti-Mig (R&D Systems) The Mig staining was achieved using a tyramide staining kit (Invitrogen) Endothelial cells were stained on frozen sections using biotinylated ... grown in wild type and knockout mice Weight of tumors grown in wild type and knockout mice One million tumor cells were injected subcutaneously in wild type (WT) and Egr-1 knockout (KO) mice Tumors ... Francalanci M, Manetti R, Marra F, Vanini V, Maggi E, Romagnani S: Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible Tcell alpha chemoattractant...

Ngày tải lên: 10/08/2014, 22:20

... functional roles in cellular stress responses and/ or cell death and included DnaJ homolog subfamily B member 1(DNAJB1), heat shock protein 105 kDa (HSPH1) and zinc finger and BTB domain containing 16 (ZBTB16) ... behavior and nervous system development and function These genes including D site of albumin promoter (albumin D-box) binding protein (DBP), period circadian protein homolog (PER2), and nuclear ... from welding fume-induced lung inflammation Additionally, our results provide unique insight into strain- and welding fume-dependent genetic factors involved in the lung response to welding fume...

Ngày tải lên: 12/08/2014, 11:22

... macrolide in CF mice attenuated cellular infiltration in spontaneous and induced inflammatory conditions and inhibited proinflammatory cytokine release in LPS-induced inflammation We show that, in the ... Inflammatory cytokine and chemokine concentrations in airways from CF and wild-type (WT) mice in the absence of induction with P aeruginosa LPS, with and without pretreatment with azithromycin ... characterized by a self-sustaining cycle of airway obstruction, inflammation and infection The high morbidity and mortality in CF is due to chronic respiratory infection, culminating in colonization with...

Ngày tải lên: 12/08/2014, 16:20

... presented in this paper contains, in addition to all mouse Cyp2c enzymes, human CYP2C18 and CYP2C19 The inserted human CYP2C18 and CYP2C19 genes are expressed at the mRNA and protein levels, and the inserted ... were dehydrated, embedded in paraffin and cut into μm sections before they were stained with haematoxylin and eosin for microscopic evaluation Clinical pathology parameters and analytical methods ... Parathyroid glandsb Pituitary gland Prostate gland-ventral Retriperitoneal fat deposit Salivary gland-parotid Salivary gland-submaxillary/lingual Seminal vesicles Skin Spleena Spinal cord-lumbar and cervical...

Ngày tải lên: 12/08/2014, 18:22