... 263–265 p107, 18 3, 18 5, 18 7 19 2, 19 4 19 6, 19 8, 19 9, 205– 210 , 232 p130, 15 8, 16 1, 16 2, 18 3, 18 7 19 2, 19 4 19 6, 19 8, 19 9, 205– 210 , 232 p14ARF , 259, 263, 265 p15INK4B , 2 41 p16INK4A , 18 4, 19 0, 19 2 19 4, ... knockouts, 12 – Cdk6 knockouts, 12 – S phase, 15 9, 16 8 Cdk inhibitor (CKI), 15 9, 16 1, 16 2, 16 6, 16 8, 230 Cdk1, 14 9, 15 9, 16 1, 16 4, 16 5 Cdk2, 15 3, 15 9, 16 4, 16 5, 18 4, 18 5, 18 7, 18 8, 19 3, 19 6, 208, ... 19 2 19 4, 19 6, 19 7, 19 9, 240, 2 41, 285, 290, 309 p18INK4C , 2 41 p19ARF , 19 3 19 9 p19INK4D , 2 41 p 21, 15 8, 16 1, 16 2, 16 6, 2 41, 333, 335 p27, 10 , 15 8, 16 1, 16 2, 2 41, 2 71, 273, 282, 286, 289, 293–3 01, ...
Ngày tải lên: 25/10/2013, 21:20
... American October 19 96 Copyright 19 96 Scientific American, Inc Electronic Publishing Martin Paul, DIRECTOR Scientific American, Inc 415 Madison Avenue New York, NY 10 017 -11 11 ( 212 ) 754-0550 PRINTED ... inFriction at the Atomic Scale 10 10 10 10 10 SHEAR STRESS (NEWTONS PER SQUARE METER) 10 10 10 10 struments Collectively, they have recorded a range of stress spanning 12 orders of magnitude, all ... American, Box 318 7, Harlan, Iowa 515 37 Reprints available: write Reprint Department, Scientific American, Inc., 415 Madison Avenue, New York, N.Y 10 017 -11 11; fax: ( 212 ) 355-0408 or send e-mail to...
Ngày tải lên: 12/05/2014, 15:15
báo cáo hóa học:" Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells" pot
... paclitaxel, we treated 1A9 and PTX10 cells with DMSO (control) and 10 , 25, 50, 75, and 10 0 nM of VE-465 in the presence of 15 ng/mL paclitaxel for 96 hours In the parental 1A9 cell line, paclitaxel ... for 1A9 and PTX10 cell lines, and Merck & Co and Vertex 19 Weaver BA, Cleveland DW: Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell ... genes to be Affymetrix Probe ID Gene Name 3 910 9_at 11 25_s_at; 11 26_s_at 36863_at 3 215 7_at 40757_at 19 85_s_at 38370_at TPX2 CD44 HMMR PPP1CA GZMA NME1 TIAM1 TPX2, microtubule associated, homolog CD44...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells" potx
... http://www.translational-medicine.com/content/7 /1/ 63 Table 1: In Vitro Response of EOC Cells Cell line A2780 CP70 01 28 R182 01 19 b R 114 0 GI50 for ARRY-520, μM GI50 for Paclitaxel, μM 0.0 015 0.0 015 0.0 015 >3 >3 >3 0.2 0.2 ... (R182, 01 28, 01 19 b, R 114 0) were treated with increasing concentrations of ARRY-520 (up to μM) or Paclitaxel (up to 20 μM) for 24 and 48 hours and cell viability was determined using the CellTiter ... minimal effect on Paclitaxel-resistant Type I EOC cell lines R182, 01 19 b, and R 114 0 (Fig 1A– B) In Type II cell lines, the most prominent effect on cell viability was observed following 48 hours...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function" pptx
... Logan, UT) and penicillin, streptomycin, and amphotericin B OV4 and SKOV3 cells were cultured and grown in Dulbecco's modified Eagle's MEM/Ham's F -12 50:50 (DMEM/F12) supplemented with 10 % FBS, ... vector-transduced (EV) cells were cultured in serum-free DMEM/F12 media for 48 hours Cells were disengaged from the culture flasks using CellStripper solution (Cellgro, Herndon, VA) and × 10 4 cells were ... http://www.ovarianresearch.com/content /1/ 1/3 10 11 12 Conclusion In this study, we have shown that cell behaviors consistent with a metastatic phenotype can be induced in ovarian tumor cells by upregulation of...
Ngày tải lên: 20/06/2014, 07:20
báo cáo hóa học:" Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB" doc
... stem- cell biology to cancer Nat Rev Cancer 2003, 3:895-902 Reya T, Morrison SJ, Clarke MF, Weissman IL: Stem cells, cancer, and cancer stem cells Nature 20 01, 414 :10 5 -11 1 15 16 17 18 19 20 21 ... cancer cells MDA-MB-2 31 by genistein Oncogene 19 99, 18 : 316 6- 317 2 Davis JN, Kucuk O, Sarkar FH: Genistein inhibits NF-kappa B activation in prostate cancer cells Nutr Cancer 19 99, 35 :16 7 -17 4 Wu ... 2008, 1: 9 http://www.ovarianresearch.com/content /1/ 1/9 Figure The expression of c-IAP1, Bcl-2, Bcl-xl, survivin and PARP in A2780 and C200 cells The expression of c-IAP1, Bcl-2, Bcl-xl, survivin and...
Ngày tải lên: 20/06/2014, 07:20
báo cáo hóa học:" Trastuzumab Sensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics" docx
... < 10 -5 p < 10 -4 p < 10 -4 p < 10 -5 p = 0.002 Cetuximab H3 .10 5 μg/ml 1. 000 ± 0.0 71 1.000 ± 0.022 1. 000 ± 0.050 1. 000 ± 0.050 1. 000 ± 0. 011 1. 000 ± 0.028 1. 000 ± 0.040 1. 000 ± 0. 018 10 μg/ml 0. 913 ... p = 0.0004 p < 10 -4 p = 0.0 01 p < 10 -6 p = 0.0007 p = 0.0 01 p = 10 -6 p < 10 -27 1. 000 ± 0.007 1. 000 ± 0.027 1. 000 ± 0.048 1. 000 ± 0.062 1. 000 ± 0.070 1. 000 ± 0.023 1. 000 ± 0 .10 8 1. 000 ± 0.047 Lapatinib ... Parental OVCAR-7 T100 SKOV-3 Parental T100 Parental T100 Gefitinib μM 1. 000 ± 0.055 1. 000 ± 0.008 1. 000 ± 0. 017 1. 000 ± 0.057 1. 000 ± 0. 010 1. 000 ± 0.034 1. 000 ± 0.008 1. 000 ± 0.002 μM 0. 812 ± 0.006...
Ngày tải lên: 20/06/2014, 07:20
báo cáo hóa học:" Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth" pot
... to cisplatin? Cell Cycle 2008, 7 :13 53 -13 59 Yallapu et al Journal of Ovarian Research 2 010 , 3 :11 http://www.ovarianresearch.com/content/3 /1/ 11 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 ... Research 2 010 , 3 :11 http://www.ovarianresearch.com/content/3 /1/ 11 Page of 12 where it binds with the TCF transcription factor and upregulates the expression of cell survival genes such as cMyc and c-Jun, ... labeled cellulose nanocrystals for bioimaging applications J Am Chem Soc 2007, 12 9 :13 810 -13 811 Gavert N, Ben-Ze'ev A: beta-Catenin signaling in biological control and cancer J Cell Biochem 2007, 10 2:820-828...
Ngày tải lên: 20/06/2014, 07:20
báo cáo hóa học:" Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells" pptx
... Research 2 010 , 3 :13 http://www.ovarianresearch.com/content/3 /1/ 13 15 16 17 18 19 20 21 22 23 24 25 26 expressed in the normal human breast and in breast cancer Med Oncol 2004, 21: 123- 31 Wente W, ... Research 2 010 , 3 :13 http://www.ovarianresearch.com/content/3 /1/ 13 Page of 10 Figure Effect of the LXR agonist T09 013 17 on cellular morphology CaOV3 cells were cultured and treated with DMSO (1% , A) ... and collected and × 10 5 cells per sample were stained with 10 μl of FLICA reagent and 7-AAD and Rough et al Journal of Ovarian Research 2 010 , 3 :13 http://www.ovarianresearch.com/content/3 /1/ 13...
Ngày tải lên: 20/06/2014, 07:20
báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt
... markers and functional regulators of stem cells Stem Cells 2002, 20 :11 -20 Ponnusamy et al Journal of Ovarian Research 2 011 , 4:7 http://www.ovarianresearch.com/content/4 /1/ 7 Page 10 of 10 15 Kim ... cancer side population defines cells with stem cell- like characteristics and Mullerian Inhibiting Substance responsiveness Proc Natl Acad Sci USA 2006, 10 3 :11 154 -11 159 14 Bunting KD: ABC transporters ... signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2 Mol Biol Cell 2006, 17 :29 31- 29 41 doi :10 .11 86 /17 57-2 215 -4-7 Cite this article as: Ponnusamy...
Ngày tải lên: 20/06/2014, 07:20
báo cáo hóa học:" Gene Expression and Pathway Analysis of Ovarian Cancer Cells Selected for Resistance to Cisplatin, Paclitaxel, or Doxorubicin" docx
... SERPIND1 A2M MTMR 11 PSG 11 PAM NOS3 GAGE6 CLYBL GAGE7B SERPINE2 CECR5 ADAM15 DPYSL3 REG4 GALR2 TFF2 EEF1A2 PRSS3 GNG 11 CD96 LPXN SGK MLLT 11 CFB GADD45A MYH4 CXCL6 GABARAPL1 POU2F2 PRSS1 CYR 61 TNFRSF11B ... CLCA1 APOE PRSS3 C20orf75 RPIB9 APOA1 CCL26 RFTN1 MSMB CCL26 CCL26 PRSS2 WFS1 GNG 11 IL8 TXNIP GAGE6 XAGE1 TCN1 SCARF2 ANKRD38 CDH 11 PRSS1 RHOU MFGE8 CEACAM6 ABCB1 PRSS2 SCRG1 GAGE7B MAPK13 LDHA ... ECAT 11 SPP1 DDIT4L APOE SPOCK2 NINJ2 THBS1 SOX 21 CD44 RGS4 DDIT4 IGF2 GPC3 PRSS8 APOC1 ITIH2 MAF FABP5 IGSF4 SOX 21 NPC2 SCD MT1F RRAGD SPOCK2 RENBP SPINT2 RFTN1 TCN1 PRNP FKBP 11 MSMB LCP1 NNMT...
Ngày tải lên: 20/06/2014, 08:20
Báo cáo sinh học: "TBP2 is a general transcription factor specialized for female germ cells" doc
... expression during oogenesis and early mouse development Reproduction 2007, 13 4: 51- 62 Published: 30 November 2009 doi :10 .11 86/jbiol196 © 2009 BioMed Central Ltd Müller and Tora: Journal of Biology ... 450 :10 82 -10 85 Xiao L, Kim M, DeJong J: Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice Gene Expr Patterns 2006, 6: 409- 419 ... in [4-7,9 ,10 ] http://jbiol.com/content/8 /11 /97 Müller and Tora: Journal of Biology 2009, 8:97 97.4 formed [5] In contrast to mammals, a large amount of TBP mRNA is produced maternally and seems...
Ngày tải lên: 06/08/2014, 19:21
Báo cáo y học: "On the number of founding germ cells in humans" ppt
... differentiation Annu Rev Genet 19 74, 8: 411 -70 Page of (page number not for citation purposes) Theoretical Biology and Medical Modelling 2005, 2:32 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 http://www.tbiomed.com/content/2 /1/ 32 ... 14 32 36 78980 25300 214 50 7320 18 80 15 580 4860 2650 14 50 310 Ratio Index ˆ a 19 –30 years 31 35 years 36–40 years 41 45 years >45 years 10 4 5 .1 2 .1 4.7 0.8 1. 0 10 3 10 2 10 20 30 40 50 age Shown ... allocation of cells to the somatic and germ cell linkages Cell 19 86, 46 :19 -29 Wilkie TM, Brinster RL, Palmiter RD: Germline and somatic mosaicism in transgenic mice Dev Biol 19 86, 11 8:9 -18 Bailey...
Ngày tải lên: 13/08/2014, 23:20
Báo cáo y học: "Enigma variations: control of sexual fate in nematode germ cells" docx
... http://genomebiology.com/2006/7/7/227 Genome Biology 2006, References 10 12 13 14 15 16 17 18 19 21 Acknowledgements 22 23 24 25 I thank E Moss, Y Guo and E Haag for critical reading of this manuscript This ... Dev 19 96, 10 :2 314 -2325 Pilgrim D, McGregor A, Jackle P, Johnson T, Hansen D: The C elegans sex-determining gene fem-2 encodes a putative protein phosphatase Mol Biol Cell 19 95, 6 :11 59 -11 71 Ahringer ... tra -1 and its functional consequences Genetics 19 96, 14 4:587-595 Chen P, Ellis RE: TRA-1A regulates transcription of fog-3, which controls germ cell fate in C elegans Development 2000, 12 7: 311 9- 312 9...
Ngày tải lên: 14/08/2014, 16:21
Interactions between early germ cells and inner germarial sheath cells in drosphila ovary
... .1 1 .1 GSCs and the GSC Niche in Drosophila Ovary 1. 1 .1 GSCs and Their Intrinsic Factors 1. 1 .1. 1 Drosophila GSCs 1. 1 .1. 2 Intrinsic Factors for GSC Maintenance 1. 1 .1. 3 ... 16 -cell cyst (Panels C and D in Figure 1. 1) Among the 16 -cell cyst, one cell cyst develops into an oocyte while the remaining 15 cell- cystocytes adopt the cell fate of nurse cells GSCs, CBs and ... 32 2 .1. 1 PCR, Quantitative Real-time PCR, Inverse PCR and Primers 32 2 .1. 1 .1 PCR .32 2 .1. 1.2 Quantitative Real-time PCR 33 2 .1. 1.3 Inverse PCR 33 2 .1. 1.4 PCR...
Ngày tải lên: 14/09/2015, 08:42
Tài liệu Báo cáo khoa học: Expression and secretion of interleukin-1b, tumour necrosis factor-a and interleukin-10 by hypoxia- and serum-deprivation-stimulated mesenchymal stem cells Implications for their paracrine roles ppt
... (2005) Paracrine action accounts for marked protection 10 11 12 13 14 15 of ischemic heart by Akt-modified mesenchymal stem cells Nat Med 11 , 367–368 Kinnaird T, Stabile E, Burnett MS, Lee CW, ... mesenchymal stem cells and mononuclear cells Stem Cells 25, 11 66 11 77 Li L, Zhang S, Zhang Y, Yu B, Xu Y & Guan Z (2009) Paracrine action mediates the antifibrotic effect of transplanted mesenchymal stem ... global heart failure Transpl Int 21, 11 81 11 89 Tang J, Wang J, Guo L, Kong X, Yang J, Zheng F, Zhang L & Huang Y (2 010 ) Mesenchymal stem cells modified with stromal cell- derived factor alpha improve...
Ngày tải lên: 18/02/2014, 04:20
Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... 33.6 93.3 96.2 15 .4 63.3 Blood population PE1 (%) Siglec-FITC1 (%) FITC1 and PE1 (%) PBMC CD2 01 CD1 41 CD4lo CD4hi CD 31 CD2 81 Granulocytes 8.3 12 .1 11. 7 63.0 65.0 47.5 19 .9 2.4 12 .0 12 .0 0 2.0 88.6 ... staining(%) Blood population PE1 (%) ALCAM–hIg CD5 –hIg Siglec -10 –hIg PBMC CD2 01 CD1 41 CD4lo1 CD4hi1 CD 31 Granulocytes 11 12 63 65 0 0 0 0 11 0 Expression of siglec -10 Northern blot Northern blot ... cells and their signaling potential will offer opportunities to target and inhibit inflammatory cells at sites of inflammation Immune-restricted siglec -10 (Eur J Biochem 268) 6095 10 11 12 13 14 ...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo hóa học: "Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference" pdf
... (SACC-Mock) cells, both mRNA and protein expression of ADAM 10 were significantly reduced in SACC-ADAM10-RNAi (1) , (2), and (3) cells (all, p < 0.0 01; Figure 4A, B) Gene silencing of ADAM 10 reduces cell ... Mol Cells 2007, 24 :13 9-47 doi :10 .11 86 /14 79-5876-8 -13 6 Cite this article as: Xu et al.: Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using ... Medicine 2 010 , 8 :13 6 http://www.translational-medicine.com/content/8 /1/ 136 as ADAM 9, 10 , 17 , are closely involved in the tumorigenesis, development, and metastasis of tumors [5-7] Recently, ADAM 10 ...
Ngày tải lên: 18/06/2014, 16:20