1 in f minor
Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx
... In uence of the binding of distamycin on the DNA conformation One of the most important effects of drug binding on the DNA conformation is the widening of the minor groove as illustrated in Fig The ... Amidinium end A15 T8 G9 Formamide end A5 T18 C4 G19 Interaction energy (kJÆmol )1) Correlation component (kJÆmol )1) ) 81. 1 )48.5 2.5 )23.4 )1. 3 )19 .6 )19 .6 )12 .5 10 .9 0.0 )18 .8 )1. 3 )5.4 )14 .6 ... (10 0.0–2.38 A) ˚ 46.3 (2.42–2.38 A) P 212 1 21 a ¼ 25.289, b ¼ 36.439, c ¼ 53.047 43223 4223 1. 85 4.3 1. 142 ˚ 4.9 (10 0.0 1. 85 A) ˚ 19 .5 (1. 92 1. 85 A) ˚ 93.0 (10 0.0 1. 85 A) ˚ 96.9 (1. 92 1. 85 A) 21. 1...
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Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx
... the full length VRL -1 mRNA is present in F -11 cells we examined the rat VRL -1 corresponding to Acc No AF12 911 3 in overlapping PCR fragments after reverse transcription of F -11 total RNA (fragment ... in individual F -11 cells fits well with this result In F -11 parental cell line N18TG2 we detected the expression of mouse VRL -1 due to its murine origin Therefore we propose that in the F -11 fusion ... VRL -1 has 22 71 bp This results in a protein of 7 61 amino acids for rVRL -1 and of 756 amino acids for mVRL -1 which cannot be separated by SDS/PAGE The primers we chose to examine rat VRL -1 in F -11 ...
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Báo cáo sinh học: "Effects of major histocompatibility complex on antibody response in F 1 and F 2 crosses of chicken lines" ppt
... bias in estimates of genotype effects from selected lines et al, 19 93), an F was produced In fact, results of estimation of genotype effects in the F were more similar to the estimated effects in ... given in table III The overall effect of MHC genotypes was greater in the F than in the F population The range of estimates was higher in the F than in 1 the F population, but the SE of differences ... confounding effects between MHC genotype and the effects of the sex and of U! It is, therefore, better to look at the difference in R between a z full model with and without MHC effect Including...
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Báo cáo sinh học: " Identification of a major gene in F and F data when alleles 1 2 assumed fixed in the parental lines" pps
... variance from F to F can result in a putative major gene being i detected An increase in variance of 10 %, for instance, gave 25% false detections when 10 00 F and 10 00 F observations were combined ... 10 0 and various values for fp and fm The genotype probabilities in parents (F and offspring (F ) ) have been given in table VI For the first situations, genotype probabilities in the F were 1/ =1, ... combining all combinations of non-normality in F and increased variance in F (table I) In general, 500 F and 10 00 F observations i simulated For situation 3, data sets with 10 00 F and 10 00 F observations...
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Structures for writing task 1 in IELTS
... For describing the lowest point The number of students hit a trough/plunged to a trough of 2000 For describing a fluctuation The number fluctuated between and The number fluctuated ... fluctuation The number fluctuated between and The number fluctuated wildly around and Some words for describing “approximately” About/around/approximately/well over/roughly ...
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Báo cáo y học: "Hb J- Meerut [α 120 (H3) Ala -Glu (α1)] In A Turkish Male"
... 12 0 might interact with the side chain of arginine residue at β 30 of one of the two β chains to form a weak salt bridge, thereby causing a slightly increased oxygen affinity Conflict of interests ... globin genes Hemoglobin 19 82; 6 (1) : 27-46 10 Molchanova TP, Pobedimskaya DD, Postnikov Y A simplified procedure for sequencing amplified DNA containing the α2- or α1globin gene Hemoglobin 19 94; 18 (3):2 51- 255 ... stable hemoglobins only [3] Position 12 0 is external and is not involved in heme binding or subunit contacts but is involved in the 1 1 contacts in Hb molecule [11 ,12 ] The amino acid substitution...
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Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
... Y., and Furukawa Y Involvement of claudin -1 in the beta-catenin/Tcf 10 1 signaling pathway and its frequent upregulation in human colorectal cancers Oncol Res 20 01; 12 (11 -12 ): 469-476 19 Dissanayake ... β-tubulin (1: 1000), Lamin-A (1: 1000), Phospho- PKA (1: 1000) and PKC substrate (1: 200) antibodies were obtained from Cell Signaling (Beverly, MA) Claudin -1 antibody (1: 1000) was obtained from Zymed ... pattern of claudin -1 (Figure 3A) Upon treatment with PKA inhibitors for 15 minutes, claudin -1 shuttles into the nucleus (Figure 3B) After hour of treatment with PKA inhibitor, claudin -1 is still highly...
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Tài liệu Evidence-based Series 15-1 IN REVIEW : Screening for Skin Cancer doc
... Screening for cutaneous melanoma by skin self-examination J Natl Cancer Inst 19 96;88 (1) :17 -23 PRACTICE GUIDELINE – page EBS 15 -1 IN REVIEW Funding The PEBC is supported by the Ontario Ministry of ... cell carcinoma of the skin be offered surveillance by a physician, including total-body skin examination and counselling to perform skin self-examination? What characteristics should clinicians ... perform skin self-examination for early detection of melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin? Should individuals at high risk for melanoma, basal cell carcinoma,...
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Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx
... 2008 FEBS V Tiwari et al Nectin -1 mediates HSV -1 entry into RPE cells FITC stained CHO-HVEM RPE D Events B 11 4 A C 10 1 10 2 11 9 10 0 10 3 10 4 FITC stained CHO-nectin -1 Events RPE 10 0 10 1 10 2 FITC 10 3 ... C Fig Binding of HSV -1 to filopodia Cells were infected with HSV -1 (K26GFP) at 10 0 PFU per cell The images were acquired at 30 postinfection (A) An infected RPE cell stained for actin (red) using ... syndrome Am J Ophthalmol 12 0, 11 5 11 7 40 Atherton SS & Streilein JW (2007) Two waves of virus following anterior chamber inoculation of HSV -1 1987 Ocul Immunol In amm 15 , 19 5–204 41 LaVail JH, Tauscher...
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Tài liệu Báo cáo khoa học: Caveolin-1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells docx
... 2007 FEBS 3023 Caveolin -1 and P2X7 expresssion in lung cells K Barth et al A Triton X -10 0 soluble insoluble P2X7R Cav -1 Flotillin -1 T1 B 10 11 12 13 Cav -1 P2X7R Flotillin -1 PDI -Cop TfR T1 Fig ... P2X7 expresssion in lung cells K Barth et al A Cav -1 P2X7R Flotillin -1 PDI -Cop TfR B1 10 11 12 13 14 Cav -1 P2X7R Flotillin -1 PDI -Cop TfR Fig (A) Characterization of the membrane fractions prepared ... Rassendren F (19 98) Membrane FEBS Journal 274 (2007) 30 21 3033 ª 2007 The Authors Journal compilation ª 2007 FEBS 30 31 Caveolin -1 and P2X7 expresssion in lung cells 10 11 12 13 14 15 16 17 18 19 20...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... expression levels of HO -1 Effects of HO -1 or HO-2 short interfering RNA (siRNA) on the expression of HO -1 Fig Effects of SA and SnPP on cellular heme content in human cell lines YN -1 erythroleukemia, ... addition of actinomycin D The half-life of HO -1 mRNA was about h in untransfected and siGAPDH-treated HeLa cells (Fig 7A,B), which is in good agreement with the halflife of HO -1 mRNA determined in HeLa ... KG1 and Jurkat cells were maintained in RPMI -16 40 medium (Sigma) Each medium contained 10 % heat-inactivated fetal bovine serum, penicillin G (10 0 UÆmL )1) , and streptomycin sulfate (10 0 lgÆmL )1) ...
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Báo cáo khoa học: Effect of priming on activation and localization of phospholipase D-1 in human neutrophils potx
... range of brefeldin A (0–300 lgÆmL )1) and wortmannin (0 10 0 nM) concentrations (inserts in Fig 3) These results indicate that PI3-kinase-sensitive and brefeldin A-sensitive GEFs (ARF1 or ARF3) play ... were minimal when either priming agent (TNFa) or activating agent (fMLP) were added alone However, if cells were incubated with TNFa (200 UÆmL )1, 30 min) before fMLP stimulation (10 0 nM, 10 min), ... pharmacological inhibitors were used to assess the role of PI3-kinase and ARF proteins on the activation of PLD As illustrated in Fig 3A,B, the PI3-kinase inhibitor wortmannin (10 0 nM) [11 ] markedly...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... domains, probably as a result of recombination processes; this signature is missing in DIDO1 and SPP1 The absence of the CXXC signature distinguishes SPP1 from the CGBP family (Figs 1, and S1); ... models Bioinformatics 19 , 15 72 15 74 Supplementary material The following material is available online Fig S1 Multiple alignment of DIDO, CGBP and SPP1 proteins Additional proteins were included ... representatives of the CGBP family, and seven fungal representatives (Fig 1) To root the tree, we used inhibitor of growth protein (ING3) PHD, which is another domain involved in chromatin binding and clearly...
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ENGLISH FOR AUTOMOBILE ENGINEERING- UNIT 1: IN A WORKSHOP pot
... two cars in parking lot Tom has three cars Machine V + ing Example: Lapping, Milling, drilling Terminologies Planning machine ['pleiniη mə'∫i:n] Milling machine ['miliη] Lathe ≈ turning lathe ... ['miliη] Lathe ≈ turning lathe [‘tɜ:nɪŋ leið] Drilling machine ['driliη] Grinding machine ['graindiη] Lapping machine ['læpiη] Boring machine ['bɔ:riη] Terminologies Tool boxes [tu:lbɔks] Spanners [spænə] ... cylinder block is cylinder head between the sump and the The prop shaft is between the gearbox and the differential The differential is between the two half shafts Development Look at Figure 1. 2...
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Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
... effect of minor groove opening (2.6 A increases with the size of the minor groove binder The ˚ ˚ average H4¢-H5¢ distance is 5 .1 A (10 mer), 5.8 A ˚ (10 -Nt) and 6.3 A (10 -Dst) ˚ (DAPI), 6 .1 A Furthermore, ... TA (19 94) Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA Biochemistry 33, 7033–7040 Welch JJ, Rauscher FJ & Beerman TA (19 94) Targeting ... Targeting DNA-binding drugs to sequence-specific transcription factor DNA complexes – differential effects of intercalating and minor groove binding drugs J Biol Chem 269, 310 51 310 58 Wanhert U,...
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Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc
... Raynaud F, Benyamin Y & Roustan C (20 01) Binding of gelsolin domain to actin An actin interface distinct from that of gelsolin domain and from ADF ⁄ cofilin Eur J Biochem 268, 616 5– 617 5 FEBS Journal ... loop in dIII also offers Ca2+-binding capacity [11 ], which affords 11 EF-hand sites and one acidic cluster in the whole molecule, corresponding to at least eight effective Ca2+-binding sites [12 ] ... tested a titin recombinant fragment corresponding to the N-terminal part of the 15 0 kDa fragment and spanning domains Z9 to I1 of titin (Fig 1) , which are included in this region In a coimmunoprecipitation...
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Báo cáo khoa học: Dynamic reorganization of the motor domain of myosin subfragment 1 in different nucleotide states docx
... of ADP In the nucleotide-free S1, the temperature induced change in f was substantially smaller for IAEDANSFHSS1 than for either the ANN IAFS1 or the ANNFHSS1 ADP binding had only minor effects ... binding to serine -18 1 in myosin subfragment as revealed by FRET spectroscopy and molecular modeling Biochemistry 40, 14 80 614 811 41 Hiratsuka, T.K.T (2003) Chemical identication of serine 18 1 ... the increase in molar volume for skeletal muscle S1 binding to ADP was half of that observed for smooth muscle S1 [59] ADP-induced movement of the light-chain binding domain was also found in...
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