1 7 scattering by pure water and by pure sea water

Tài liệu Báo cáo khoa học: Plasticity of S2–S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis pdf

Tài liệu Báo cáo khoa học: Plasticity of S2–S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis pdf

... 87 .16 18 7. 42 12 0 50–2 .14 295 498 44 77 8 97. 6 (80.2)a 24.0 (3.2) 7. 2 ( 31. 9) 2QL7 P32 21 87. 94 18 7. 55 12 0 50–2.4 90 499 31 049 92.3 (59 .7) 12 .2 (2.2) 9.8 (39.2) 2QLB P32 21 88.25 18 8.29 12 0 50–2.25 12 6 ... 94.3 (68.3) 16 .0 (2.6) 9.0 (34.3) 2QL5 P32 21 87. 26 18 7. 71 120 50–2.34 13 6 298 32 11 7 90.2 (52.0) 15 .5 (3.0) 9.8 (34.2) 2QLF P32 21 87. 46 18 5.83 12 0 50–2.8 63 618 18 0 47 90.3 ( 91) 13 .8 (2.6) 9.2 ... (43.0) 2QLJ P32 21 88.50 18 7. 22 12 0 50–2.6 86 15 1 24 974 92 .1 (60 .7) 16 .7( 3.3) 6 .7 (34.8) 50–2 .14 19 .1 22.5 45.3 50–2.4 19 .6 23 .7 51. 0 50–2.25 18 .7 22.3 49.4 50–2.34 21. 2 23.3 62.3 50–2.8 19 .6 22.9...

Ngày tải lên: 18/02/2014, 16:20

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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

... FASEB J 11 , A839 11 Babe, L.M., Pichuantes, S & Craik, C.S (19 91) Inhibition of HIV protease activity by heterodimer formation Biochemistry 30, 10 6– 11 1 12 Restle, T., Muller, B & Goody, R.S (19 90) ... 3984–3989 61 Engelman, A., Mizuuchi, K & Craigie, R (19 91) HIV -1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer Cell 67, 12 11 12 21 62 Asante-Appiah, E & Skalka, A.M (19 99) ... likened to that of a Ôright-handÕ [35] The major subdomains of the polymerase domain of p66 are termed fingers (residues 1 85, 11 8 15 5), palm (86 11 7, 15 6–2 37) and thumb (238– 318 ) The DNA polymerase...

Ngày tải lên: 08/03/2014, 09:20

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Báo cáo khoa học: Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells pot

Báo cáo khoa học: Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells pot

... HO -1 mRNA, D4 07 and ARPE -19 cells were cultivated in fresh medium for 24 h and then exposed to the following three cytokines: interferon-c (10 0 UÆmL )1) , TNF-a (20 ngÆmL )1) and IL-1b (10 ngÆmL )1) , ... Cell Biol 13 , 78 81 78 91 51 Panchenko, M.V., Farber, H.W & Korn, J.H (2000) Induction of heme oxygenase -1 by hypoxia and free radicals in human dermal fibroblasts Am J Physiol 278 , C92–C1 01 52 Oyake, ... regulation of HO -1 expression in RPE (Eur J Biochem 2 71 ) 3 077 visible light [22] and in cultured human RPE cells by transforming growth factor-b1 (TGF-b1) [23] and oxidative stresses [ 21, 24,25] These...

Ngày tải lên: 23/03/2014, 13:20

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Báo cáo khoa học: Structural function of C-terminal amidation of endomorphin Conformational comparison ofl-selective endomorphin-2 with its C-terminal free acid, studied by 1 H-NMR spectroscopy, molecular calculation, and X-ray crystallography pot

Báo cáo khoa học: Structural function of C-terminal amidation of endomorphin Conformational comparison ofl-selective endomorphin-2 with its C-terminal free acid, studied by 1 H-NMR spectroscopy, molecular calculation, and X-ray crystallography pot

... 1. 94 1. 86 2. 07 2.04 2 .19 1. 93 2. 01 2 .16 1. 87 1. 90 15 4 15 5 15 4 15 7 14 6 17 4 16 5 15 8 14 8 13 9 13 9 16 7 14 8 16 7 17 3 17 2 16 2 13 8 14 5 16 4 15 6 14 6 17 0 16 4 x,y,z x +1, y,z x +1, y,z 1- x,y +1 ⁄ 2,-z x,y,z ... 2 .77 3(4) 2.8 71 ( 4) 2 .75 6(5) 2.822(4) 2.682(5) 2.9 81( 5) 2 .79 6(4) 3. 016 (4) 2 .7 91( 5) 2 .76 5(5) 2.886(5) 2 .76 0(5) 2.8 31( 4) 1. 85 1. 97 1. 91 1.66 2 .13 1. 88 1. 98 2.02 1. 97 1. 75 2.28 1. 76 1. 98 1. 82 1. 94 1. 86 ... )92.2(4) )10 9.3(4) )10 5.8(4) )13 6.3(4) )76 .1( 4) 14 0 .7( 4) 13 4 .1( 4) )1. 5(4) 9.4(4) )50.4(4) )13 9.6(4) )20 .1( 4) )32.5(4) 4 .7( 4) 8.0(4) 17 7. 7(4) 17 3 .7( 4) ) 17 6 .1( 4) 16 7. 4(4) 16 9.8(4) ) 17 6 .7( 4) 36.5(4) 37. 8(3)...

Ngày tải lên: 30/03/2014, 20:20

19 314 0
Báo cáo sinh học: " Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix" docx

Báo cáo sinh học: " Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix" docx

... virus egress J Virol 2005, 79 :6392-6399 Page of (page number not for citation purposes) Virology Journal 20 07, 4:66 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Urata S, Noda ... motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG1 01 and VPS-4 J Virol 2003, 77 :18 12 -18 19 Patton GS, ... other hand, AIP1 (424–628) had no effect on HTLV -1 budding AIP1 (424–628) appears to be sufficient for the function of AIP1 in HTLV -1 budding, suggesting that HIV1 and HTLV -1 utilize AIP1 in different...

Ngày tải lên: 18/06/2014, 18:20

5 303 0
báo cáo hóa học: " Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms" pptx

báo cáo hóa học: " Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms" pptx

... E ε4 A 1- 40 1. 0 ± 0.l-fold 1. 0 ± 0.l-fold 1. 0 ± 0.l-fold 1. 2 ± 0.l-fold A 1- 42 1. 7 ± 0. 27- fold 1. 6 ± 0 .18 -fold 1. 7 ± 0.22-fold 1. 8 ± 0 .19 -fold E and Aβ, at least at the concentrations and proportions ... C, Stimson E, Maggio J: Aluminum, iron and zinc ions promote aggregation of physiological concentration of β-amyloid peptide J Neurochem 19 93, 61: 1 17 1 -11 74 Page of (page number not for citation ... apolipoprotein E Molecular Medicine 19 96, 2 : 17 5 -18 0 Rail SC, Weisgraber KH, Mahley RW: Isolation and characterization of apolipoprotein E Meth Enzymol 19 86, 12 8: 273 -2 87 LeVine H: Thioflavine T interaction...

Ngày tải lên: 19/06/2014, 22:20

4 428 0
Báo cáo hóa học: " Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix" docx

Báo cáo hóa học: " Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix" docx

... virus egress J Virol 2005, 79 :6392-6399 Page of (page number not for citation purposes) Virology Journal 20 07, 4:66 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Urata S, Noda ... motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG1 01 and VPS-4 J Virol 2003, 77 :18 12 -18 19 Patton GS, ... other hand, AIP1 (424–628) had no effect on HTLV -1 budding AIP1 (424–628) appears to be sufficient for the function of AIP1 in HTLV -1 budding, suggesting that HIV1 and HTLV -1 utilize AIP1 in different...

Ngày tải lên: 20/06/2014, 01:20

5 309 0
Báo cáo hóa học: "Research Article The Problem of Scattering by a Mixture of Cracks and Obstacles" pptx

Báo cáo hóa học: "Research Article The Problem of Scattering by a Mixture of Cracks and Obstacles" pptx

... SD 1 , S 1 1 , and KΓ2 1 We have mapping properties see 5, 11 SD 1 : H 1/ 2 ∂D −→ H 1/ 2 1 , S 1 1 : H 1/ 2 1 −→ H 1/ 2 1 , 2. 27 SΓ2 1 : H 1/ 2 Γ2 −→ H 1/ 2 1 , KΓ2 1 : H 1/ 2 Γ2 −→ H 1/ 2 ... H 1/ 2 ∂Ω H 1/ 2 1 T1 d, d c c d H 1/ 2 ∂Ω H 1/ 2 Γ2 d H 1/ 2 Γ2 3 .11 16 Boundary Value Problems Similarly, Re K 1 Γ2 b, d Γ2 − KΓ2 1 d, b | 1 Re b, KΓ2 1 d | 1 − KΓ2 1 d, b | 1 Re KΓ2 1 d, ... Define S1 positive SΩΩ LT ϕ, ϕ ≥C ϕ − TΩΩ LΩ and T1 H 1/ 2 ∂D 1/ 2 ∂Ω LT , then S1 and T1 are bounded below up and Take a ∈ H 1/ 2 ∂D , and let b ∈ H 1/ 2 ∂Ω , c ∈ H 1/ 2 ∂Ω , and d ∈ H 1/ 2 ∂Ω...

Ngày tải lên: 21/06/2014, 20:20

19 271 0
7 Step by Stepby Joan Preppernau and Joyce Cox pdf

7 Step by Stepby Joan Preppernau and Joyce Cox pdf

... 800×600 10 15 10 24 76 8 15 22 12 80 10 24 20 29 16 00 12 00 26 39 Pointing to a taskbar button displays large thumbnails of each open window of that type The currently active window is indicated by a ... videos, and music, complete with chapters, titles, and special effects This is a great way to preserve baby photos and videos and share them with family and friends 978 -0 -73 56-26 67- 6 by Joan ... Appearance and Personalization Network and Internet Clock, Language, and Region Programs Ease of Access System and Security Hardware and Sound User Accounts and Family Safety 978 -0 -73 56-26 67- 6 by Joan...

Ngày tải lên: 28/06/2014, 14:20

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Number "e" (Natural Log) to Approximately 1 Million Places, by Robert Nemiroff and Jerry Bonnell docx

Number "e" (Natural Log) to Approximately 1 Million Places, by Robert Nemiroff and Jerry Bonnell docx

... Robert Nemiroff or Jerry Bonnell Code 668 .1 Code 668 .1 NASA Goddard Space Flight Center NASA Goddard Space Flight Center Greenbelt, MD 2 07 71 Greenbelt, MD 2 07 71 Internet: nemiroff@grossc.gsfc.nasa.gov ... *** ***** This file should be named 12 7. txt or 12 7. zip ***** This and all associated files of various formats will be found in: http://www.gutenberg.org /1/ 2 /12 7/ Updated editions will replace the ... requirements of paragraphs 1. E .1 through 1. E .7 or obtain permission for the use of the work and the Project Gutenberg-tm trademark as set forth in paragraphs 1. E.8 or 1. E.9 1. E.3 If an individual...

Ngày tải lên: 28/06/2014, 19:20

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Báo cáo y học: " HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector" ppt

Báo cáo y học: " HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector" ppt

... tropism, and disease Annu Rev Immunol 19 99, 17 :6 57- 700 Page 11 of 12 (page number not for citation purposes) AIDS Research and Therapy 2005, 2 :1 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 ... Virol 19 97, 71 : 470 7-4 71 6 Ding SF, Lombardi R, Nazari R, Joshi S: A combination anti-HIV -1 gene therapy approach using a single transcription unit that expresses antisense, decoy, and sense RNAs, and ... 20 01, 17 :385-399 22 23 24 25 26 27 28 29 30 31 32 33 Bai J, Banda N, Lee NS, Rossi J, Akkina R: RNA-based anti-HIV -1 gene therapeutic constructs in SCID-hu mouse model Mol Ther 2002, 6 :77 0 -78 2...

Ngày tải lên: 10/08/2014, 05:20

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Báo cáo y học: "Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-B-dependent transcription of TNF-a and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA" ppsx

Báo cáo y học: "Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-B-dependent transcription of TNF-a and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA" ppsx

... crg-2 Mol Cell Biol 19 94, 14 :2 914 -2925 Page 11 of 11 45 Sheikh NM, Philen RM, Love LA: Chaparral-associated hepatotoxicity Arch Intern Med 19 97, 15 7: 913 - 919 doi :10 .11 86 /14 76 -9255 -7- 59 Cite this article ... Regulation by Egr -1, c-Jun, and NF-kappaB transcription factors J Biol Chem 19 97, 272 : 17 79 5 - 17 8 01 Oyegunwa et al Journal of Inflammation 2 010 , 7: 59 http://www.journal-inflammation.com/content /7 /1/ 59 ... TMP 15 00 MCP -1/ 10 GAPDH G Copies TNF /10 3 GAPDH Page of 11 10 00 * 500 * 400 * 200 10 0 * * * MEDIA TMP LPS LPS+TMP 300 * 0 Time (hrs) 10 15 20 25 Time (hrs) Figure TMP inhibits TNF-a and MCP -1/ CCL-2...

Ngày tải lên: 11/08/2014, 03:20

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Báo cáo khoa học: "Detection of anatid herpesvirus 1 gC gene by TaqMan™ fluorescent quantitative real-time PCR with specific primers and probe" pps

Báo cáo khoa học: "Detection of anatid herpesvirus 1 gC gene by TaqMan™ fluorescent quantitative real-time PCR with specific primers and probe" pps

... 0 . 17 8 .11 ± 0 . 17 7. 82 ± 0 .18 7. 51 ± 0. 21 7. 79 ± 0 .11 8.33 ± 0. 07 7.48 ± 0 .18 8 .15 ± 0 .18 7. 86 ± 0 .14 7. 73 ± 0 . 17 7. 72 ± 0 .16 8.06 ± 0.20 5d 7. 47 ± 0 .10 7 .18 ± 0.20 7. 72 ± 0.09 7. 38 ± 0.22 7. 21 ... 0.06 7. 83 ± 0 .14 7. 26 ± 0 .16 7. 78 ± 0. 27 7. 57 ± 0 .16 7. 71 ± 0 .11 7. 48 ± 0 .13 7. 94 ± 0 . 17 7. 77 ± 0.05 8.03 ± 0. 01 7. 62 ± 0. 21 7. 50 ± 0 .16 7. 58 ± 0 .14 8. 07 ± 0. 81 7. 31 ± 0. 27 8 .12 ± 0.24 7. 61 ± 0 .18 ... ± 0.05 7. 70 ± 0 .18 6.64 ± 0 .11 7. 61 ± 0 .19 7 .14 ± 0 .18 7. 23 ± 0 .12 7. 24 ± 0. 07 7 .76 ± 0 .14 7. 39 ± 0 .15 7. 84 ± 0.08 7 .11 ± 0 .15 7. 30 ± 0 .16 6.84 ± 0.06 7. 53 ± 0 .12 7. 29 ± 0 .11 7. 87 ± 0 . 17 6.69...

Ngày tải lên: 12/08/2014, 04:21

10 294 0
Báo cáo y học: " Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis" ppt

Báo cáo y học: " Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis" ppt

... January 2 010 Revised: 24 March 2 010 Accepted: June 2 010 Published: June 2 010 Page of 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 ArthritisRiepl et access articlehttp://arthritis-research.com/content /12 /3/R 110 ... HNP1-3 in chronic inflammatory joint diseases Riepl et al Arthritis Research & Therapy 2 010 , 12 :R 110 http://arthritis-research.com/content /12 /3/R 110 In a previous report, the presence of HNP1 ... frozen tissue and a similar blocking procedure to that Riepl et al Arthritis Research & Therapy 2 010 , 12 :R 110 http://arthritis-research.com/content /12 /3/R 110 mentioned earlier For HNP1-3 and HBD-2,...

Ngày tải lên: 12/08/2014, 14:22

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Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx

Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx

... of eIF5A -1 and eIF5A-2 in human cancer cells Febs J 2006, 273 :11 02 -11 14 Page 15 of 17 (page number not for citation purposes) Retrovirology 2009, 6:90 31 32 33 34 35 36 37 38 39 40 41 42 43 44 ... HIV -1 Tat protein increases transcriptional initiation and stabilizes elongation Cell 19 89, 59:283-292 Page 16 of 17 (page number not for citation purposes) Retrovirology 2009, 6:90 71 72 73 74 75 ... leukemias identified by a proteomics approach Blood 20 07, 10 9 : 17 01- 1 71 1 Klier H, Csonga R, Joao HC, Eckerskorn C, Auer M, Lottspeich F, Eder J: Isolation and structural characterization of different isoforms...

Ngày tải lên: 12/08/2014, 23:22

17 353 0
Redox regulation of estrogen receptor alpha and sodium hydrogen exchanger 1 gene expression by hydrogen peroxide

Redox regulation of estrogen receptor alpha and sodium hydrogen exchanger 1 gene expression by hydrogen peroxide

... REGULATION OF NHE1…………… 11 0 3B .1 DOWN-REGULATION OF NHE1 BY H2O2 11 0 3B .1. 1 Identification of crucial region in the promoter of NHE1 11 0 3B .1. 2 H2O2 down-regulates 0 .15 kb proximal NHE1 promoter ... modification 14 1. 2.4 Regulation of protein turnover 16 1. 3 ESTROGEN RECEPTOR 17 1. 3 .1 Estrogen and estrogen receptors: Introduction 17 1. 3.2 Estrogen receptor and genomic ... activity 11 4 3B .1. 3 Oxidation is involved in the down-regulation of 0 .15 kb proximal NHE1 promoter activity and endogenous mRNA level by H2O2 11 8 3B .1. 4 Peroxynitrite down-regulates 0 .15 kb NHE1...

Ngày tải lên: 10/09/2015, 15:49

253 317 0
Applications of adaptive integral method in electromagnetic scattering by large scale composite media and finite arrays

Applications of adaptive integral method in electromagnetic scattering by large scale composite media and finite arrays

... 21 1 η2 −n 21 × M1 J 31 + n 21 × L1 K 31 1 (3 .18 ) n 31 × E inc = n 31 × ( 1 L1 + η3 L3 )J 31 + n 31 × (M1 + M3 )K 31 +n 31 × 1 L1 J 21 + n 31 × M1 K 21 n 31 × H inc = −n 31 × (M1 + M3 )J 31 + n 31 × ... 3 .1( b), we can obtain n 21 × E inc = n 21 × ( 1 L1 + η2 L2 )J 21 + n 21 × (M1 + M2 )K 21 +n 21 × 1 L1 J 31 + n 21 × M1 K 31 n 21 × H inc = −n 21 × (M1 + M2 )J 21 + n 21 × ( 26 (3 . 17 ) 1 L1 + L2 )K 21 ... 27 medium ( 1 , 1 ), thus { J 21 = n 21 × H = n 21 × H inc + (M1 J 21 − { } L1 K 21 ) 1 } K 21 = −n 21 × E = −n 21 × E inc + (− 1 L1 J 21 − M1 K 21 ) (3. 21) (3.22) and on the inner surface S21...

Ngày tải lên: 11/09/2015, 09:16

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Characterization of electromagnetic and light scattering by nano scaled objects

Characterization of electromagnetic and light scattering by nano scaled objects

... important Re a1 Re a2 q 0 .1 q 0 .1 0.8 0.8 0.6 q 0.2 0.6 q 0.2 0.4 q 0.3 0.4 q 0.3 0.2 1. 3 1. 25 1. 2 1. 15 1. 1 1. 05 (a) 0.2 Ε' 1. 05 (a1 ) versus 1. 04 (b) 1. 03 1. 02 Ε' 1. 01 (a2 ) versus Figure 1. 10: Properties ... + 1/ n i−n (2n + 1) r 1 · (k0 a)2n +1 · · , (2n − 1) !!(2n + 1) !! n(n + 1) r + (1 + 1/ n) + 1/ n µr − i−n (2n + 1) bn = −j · (k0 a)2n +1 · · (2n − 1) !!(2n + 1) !! µr + (1 + 1/ n) n(n + 1) an = −j (1. 12) ... a1 Re a1 Ε '' Ε '' 0.8 0.8 0.6 Ε '' 0. 01 0.6 Ε '' 0. 01 0.4 Ε '' 0 .1 0.4 Ε '' 0 .1 0.2 1. 1 1. 05 (a) 0.2 0.95 (a1 ) versus Ε' 0.9 1. 4 1. 3 (b) 1. 2 1. 1 0.9 0.8 Ε' 0 .7 (a2 ) versus Figure 1. 11: Properties...

Ngày tải lên: 12/09/2015, 09:55

164 366 0
Giáo án luyện tập cho ngưới mới tập (Từ 0 - 1 năm)- Upload by Trong Nhan.pdf

Giáo án luyện tập cho ngưới mới tập (Từ 0 - 1 năm)- Upload by Trong Nhan.pdf

... Gia nhập: Sep 2 010 Bài gửi: 374 sonvalentine cảm ơn 16 tuổi,1m75- 70 kg Dù thiếu thước không chùn bước Trích d ẫn #11 4-0 -20 11 12 : 17 PM giangnam233 WTH Mem Gia nhập: May 2 011 Bài gửi: Anh em ... nhập: Jul 2 010 Nơi cư ngụ: QuangZ hou Bài gửi: 1, 75 2 Sửa sonvalentine : 04-06-2 011 lúc 12 :10 PM mrdang89, lionmonkey, Vnn_68 and 12 others like this Canon EOS 1Ds Mark III,Lens:Canon EF 70 - 200mm/2.8L ... Jul 2 010 Nơi cư ngụ: QuangZ hou Bài gửi: 1, 75 2 Canon EOS 1Ds Mark III,Lens:Canon EF 70 - 200mm/2.8L IS II, Canon EF 85mm Honda CBR 600cc 2008 Tôi Đi tim đẹp Trích d ẫn 4-0 -20 11 12 :16 PM #10 PDFmyURL.com...

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