1 the promise of pluripotent stem cells in tissue engineering
Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... secretion of IFN-γ at sites of HSV-1 infection Several clinical case reports indicate that NK cells (a major potential source of IFN-γ) are essential for innate defense against HSV-1 infection in humans ... NK cells and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate ... in HSV-1 infected tissues just 24 hours post inoculation (p.i.; Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body...
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báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... secretion of IFN-γ at sites of HSV-1 infection Several clinical case reports indicate that NK cells (a major potential source of IFN-γ) are essential for innate defense against HSV-1 infection in humans ... NK cells and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate ... in HSV-1 infected tissues just 24 hours post inoculation (p.i.; Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body...
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Báo cáo khoa học: Epigenetics: the study of embryonic stem cells by restriction landmark genomic scanning pptx
... establishment of embryonic stem (ES) cells, which maintain the ability to form all types of cells in the body, and can differentiate into a variety of cell types in vitro [8] The use of ES cells in epigenetic ... Fig Involvement of Dnmts in establishing and maintaining DNAmethylation profiles Dnmt3a ⁄ 3b have an indispensable role for maintaining DNA methylation in gene areas, which are constituents of ... and EG cells, the ED of TS cells to ES cells (77) is greater than that of EG cells to ES cells (49), confirming the similarity of EG cells to ES cells DNA methylation profiles that are obtained from...
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HOMINOID EVOLUTION AND CLIMATIC CHANGE IN EUROPE VOLUME 1 The Evolution of Neogene Terrestrial Ecosystems in Europe ppt
... ocean connections of the Paratethys were interrupted The gigantic inland sea of the Paratethys turned into continuously shrinking basins A reduced salinity and the alkaline chemistry of the aquatic ... bipedal hominids DiVering from the Pliocene hominid evolution in Africa, the changing environments did not result in Eurasia in the emergence of bipedal apes, but in the extinction of generalised ... Madrid, Spain Salvador Moya-Sola ` ` Institute of Pakontology, M Crusafont, Escola Industrial 23, E-08201 Sabadell, Spain Valentin A Nesin Institute of Zoology, Ukrainian Academy of Sciences,...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... development of CD4+CD25+ TR cells may occur in the periphery in man Induction of CD4+CD25+ TR cells in the periphery The induction of TR cells that resemble the ‘natural’ or thymically derived TR cells ... CD4+CD25– T cells capable of differentiating into TR cells following activation are derived from a separate lineage of CD4+ T cells, and whether their induction is a result of the initial activation ... CD4+ T cells through coengagement of CD3 and the complement regulator CD46 in the presence of IL-2 These conditions resulted in IL-10producing cells capable of inhibiting the activation of bystander...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... advantage of the AIA model is that the time point of induction of arthritis is known, allowing manipulation of CD4+CD25+ Treg cell number in vivo at defined stages in the disease Using depletion of ... a lack of suppression of these cells by Treg cells In accordance with this view, CD4+CD25+ Treg cells are able to suppress innate immune cells in a model of bacteriainduced colitis [20] In later ... in inflammatory colitis in severe combined immunodeficient (SCID) mice [31] Interestingly, two recent papers [32,33] reported an accumulation of functional Treg cells in the inflamed joints of...
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The signals of FGFs on the neurogenesis of embryonic stem cells ppsx
... the neural induction of ES cells (Fig 2A) We further investigated the expression of FGFRs in ES cells during neural induction and found that the expression of FGFR4 gradually declined (Fig 2B), ... Nuclei of all cells are revealed by DAPI staining in blue Scale bar, 10 μm in C *, p < 0.01, Anova test into neuroblast cells Immunocytostaining revealed that both FGFR1 and FGFR3 were detected in ... phosphorylated isoforms of JNKs and ERKs in the differentiating ES cells, respectively Specific pharmacological inhibitors of MAPKs, shown affecting their respective kinase targets in Fig 4B, were administrated...
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báo cáo khoa học: " The HPB-AML-I cell line possesses the properties of mesenchymal stem cells" ppt
... this cell line resembles marrow stromal cells [12] Moreover, in the presence of methylisobutylxanthine, hydrocortisone, and indomethacin, but not troglitazone, an increase in the number of lipid ... droplets was observed in these cells [12] In view of these features, we further investigated the possibility of HPB-AML-I being a neoplasm of MSC origin Recently, some human MSC lines have been established ... MSCs Inverted microscopic examination (Figure 1A) and May Grünwald-Giemsa staining (Figure 1B) of HPBAML-I cells revealed that this cell line is composed of round-polygonal and spindle-like cells...
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báo cáo khoa học: " Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling" doc
... of MSCs to cancer cells, nature of tumour cells and cancer stem cells, integrity of immune system, number of stem cell passages and site of injection; all can affect the outcome of MSCs use in ... series of complex interactions exist between BMDC and injured tissues, including the liver Microvesicles are mediators of cell reprogramming Following injury, tissues release chemokines attracting ... tissues by assessing the gene expression profile of some of the Wnt signaling target genes:cyclin D, PCNA, survivin, b-catenin Methods Ninety albino female rats inbred strain (Cux1: HEL1) of matched...
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báo cáo khoa học: " Transcriptomic analysis of pluripotent stem cells: insights into health and disease" potx
... chromatin-binding proteins and modifiers, proteinmodifying factors, and chromatin assembly proteins Importantly, knockdown of Oct4 protein levels is known to cause the loss of co-binding activity of ... embryonic stem cell; hiPSC, human induced pluripotent stem cell; iPSC, induced pluripotent stem cell; lincRNA, long-intergenic non-coding RNA; lncRNA, long non-coding RNA; mESC, mouse embryonic stem ... expression signature of cancer cells [9] LIN28 Maintains ESC pluripotency by binding and inhibiting the maturation of pro-differentiation let-7 miRNA; LIN28 is also a hiPSC reprogramming factor [74]...
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Báo cáo y học: " Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment" pdf
... inhibition of IκB kinase Page of 15 [13,18] There is increasing interest in curcumin as a therapeutic option for OA and RA, with evidence that curcumin inhibits the IL-1β-induced activation of ... the action of pro-inflammatory cytokines in the joint thus disrupting the inflammatory cycle inhibit IL-1β induced activation of degradative pathways in MSCs It must be noted that in this study ... β1-integrin receptor signalling pathway Several studies have suggested that curcumin interacts with the TGF-β signaling cascade, modulating the action of TGF-β For example in renal cells curcumin...
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Báo cáo y học: " Influence of hypoxia on the domiciliation of Mesenchymal Stem Cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies " doc
... perspective of cellular therapy by intravenous stem cells infusion The participation of stem cells in several vascular diseases pathogenesis was first proved with haematopoietic stem cells (HSCs) In this ... Mesenchymal stem cells used during this study Mesenchymal stem cells used during this study Typical morphological aspects of mesenchymal stem cells observed through culture flask (A) Mesenchymal stem cells ... (Becton-Dickinson) Isotopic labeling and Indium-111 labeled MSCs intravenous infusion The cells were incubated with 11 1In- oxine (37 MBq/106 cells) and incubated for 60 minutes as previously described...
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Báo cáo y học: "Identification and isolation of embryonic stem cells in reproductive endocrinology: theoretical protocols for conservation of human embryos derived from in vitro fertilization" ppsx
... The end of the beginning for pluripotent stem cells Nature 2001, 414:92-97 23 24 25 26 Doerflinger RM: The ethics of funding embryonic stem cell research: a Catholic viewpoint Kennedy Inst Ethics ... Foundation This type of federal research funding strategy involving existing embryonic stem cell lines is consistent with the President's belief in the fundamental value and sanctity of human life The ... destruction of additional human embryos Indeed, the embryos from which the existing ESCs originated have already been destroyed Federal funding of medical research on these existing stem cell lines...
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Báo cáo y học: "On the number of founding germ cells in humans" ppt
... model distinct rate of female germ cells in humans undergoes three The number changes, as diagrammed here and defined in the The number of female germ cells in humans undergoes three distinct rate ... months of gestation (t = – 0.42 year) The declining phases begin later in fetal life and continue into adulthood (t = 0.42 – 52 years) with an accelerated rate of oocyte depletion beginning at ... contains a single autopsy individual [16,19] obtained byoocyte in adult follicles per Shown in this diagram are published counts of follicles per individual [16,19] obtained by autopsy in adult...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... al., 2010) In humans, during the course of an infection or in the presence of macrophage colony-stimulating factor (M-CSF) treatment, there is an increase first of the intermediate cells followed ... CD8 T -cells and the importance of their Th1-inducing responses 239 8.4 Challenges of characterizing monocyte-derived cells into DCs or macrophages 241 8.5 Potential role of Tip-DCs in allergic ... resulted in a larger significant increase in immune cell infiltration into the challenge site 205 Fig 7.7 DNCB elicitation resulted in significant infiltration of TNF/iNOS-producing DCs...
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Characterization of the secretion of mesenchymal stem cells and its relevance to cardioprotection
... Bioengineering, Faculty of Engineering, NUS, Engineering Drive 1, 117574 Singapore g Department of Pathology, YLL School of Medicine, NUS, Lower Kent Ridge Road, 119074 Singapore h Department of Surgery, ... scattering F1 contained 4% of total protein input but contained ∼ 50% of the CD9 in the input (Fig 5B) Proteins were distributed among F2, F3, and F4 fractions according to the principle of size-exclusion ... rate of AMI in Germany reduced from 16.2% in 1994 to 9.9% in 2002 in tandem with the increasing use of reperfusion therapy6 The efficacy of reperfusion therapy has led to increasing survival of...
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báo cáo khoa học:" Prospects of micromass culture technology in tissue engineering" pot
... and self-organisation of multipotential stem cells in combination with the self-assembly of determined cells are the basis for such an engineering design option Technically, cells are dissociated ... maturation in vivo The inductive properties of the implantation site may also be beneficial when a stem cell-based micro -tissue strategy is chosen Stem cell tissue engineering using fetal or adult stem ... vivo transfer of such reaggregates, tissue healing is improved in sense of a repair tissue that mimics the features of the original skeletal tissue [1,24] Especially preclinical and clinical cartilage...
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Applications of prolyl hydroxylase inhibitors in tissue engineering and regenerative medicine
... applications of PHIs in tissue engineering As reviewed in chapter 1, clinical applications of engineered tissues are currently limited mainly to thin or avascular tissues due to a difficulty in stimulating ... number of obstacles preventing the realization of this goal 1.1.2 Vascularization is a major obstacle in tissue engineering While the field of tissue engineering has come a long way since its original ... for Tissue Engineering Applications 33 3.1 Introduction As explained in chapter 1, inadequate vascularization is a major bottleneck limiting widespread clinical applications of tissue engineering, ...
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Application of rapid prototyping technology to the fabrication of 3d chitosan scaffold for tissue engineering
... Chapter Introduction Perhaps the most challenging and promising strategy of tissue engineering is the in- vitro generation of autologous tissues by using cells isolated from donor tissues in combination ... matrices, in the form of thin films, have special applications in tissue engineering The earliest and most successful application of 2D matrices in tissue engineering is the regeneration of skin As ... 2.1 Scaffolds in Tissue Engineering 2.1.1 Two-dimensional Scaffolds in Tissue Engineering 2.1.2 Three-dimensional Bioresorbable Scaffolds in Tissue Engineering 2.2 Three-dimensional...
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