... reaction of malonaldehyde with two molecules of 1-methyl-2-phenylindole at 45°C (Gasparovic et al., 2013) The reaction mixture consisted of 0.64 mL of 10.3 mM 1-methyl-2-phenylindole, 0.2 mL of sample ... three groups of ten animals each: Control, METH and (CoQ10+METH) Group control received saline, group METH received 20 mg of METH/kg i.p., group (CoQ10+METH) received (20 mg of METH+10 mg of CoQ10)/kg ... effects of CoQ10 on brain tissues The METH-induced brain injury significantly increased lipid peroxidation and decreased the level of the thiol group, the glutathione total and the activity of
Ngày tải lên: 15/12/2017, 22:56
... Mechanisms of Irradiation Hardening Tensile Behavior Effects of Neutron Spectrum Tensile Ductility Effect of Test Temperature Ferritic–Martensitic Alloys Introduction Tensile Behavior Helium Effects ... is a result of recovery of the coldworked microstructure of the 20% cold-worked type 316 stainless steel presented in Figure Figure 102 Effect of Radiation on Strength and Ductility of Metals and ... welded,63 it offers a method to simulate the production of helium expected in the very hard spectrum of a fusion reactor In the case of vanadium and other refractory metal alloys, the effect of helium
Ngày tải lên: 03/01/2018, 16:05
Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells
... information for further design of new neuroprotective ligustrazine derivatives Protective effect of? ?VA‑06 on injured PC12 cells To further characterize the protective effect of VA06 on injured PC12 ... wpl581@126.com; hm_lei@126.com School of? ?Chinese Pharmacy, Beijing University of? ?Chinese Medicine, Beijing 100102, China Full list of author information is available at the end of the article Meanwhile previous ... to develop new generation of neuroprotective agents with neural repair-promoting effect Ligustrazine (tetramethylpyrazine, TMP) (Fig. 1) is a major effective component of the traditional Chinese
Ngày tải lên: 29/05/2020, 14:52
Lack of a protective effect of cotton dust on risk of lung cancer: Evidence from two populationbased case-control studies
... representation of lifetime smoking history, in contrast to multivariable modelling of separate effects of several dimensions of smoking behavior [31] We have previously described smoking characteristics of ... of the contrasts Nor the analyses by histologic type provide clear evidence of protective effects of cotton dust; indeed the strongest association indicated an excess risk of adenocarcinoma of ... evaluation of exposures by a team of experts; detailed lifetime history of smoking; and information on a host of other covariates While there were large numbers of proxy respondents, the results of analyses
Ngày tải lên: 30/09/2020, 11:20
Protective effect of coenzyme q10 on methamphetamine induced neurotoxicity in the mouse brain
... reaction of malonaldehyde with two molecules of 1-methyl-2-phenylindole at 45°C (Gasparovic et al., 2013) The reaction mixture consisted of 0.64 mL of 10.3 mM 1-methyl-2-phenylindole, 0.2 mL of sample ... three groups of ten animals each: Control, METH and (CoQ10+METH) Group control received saline, group METH received 20 mg of METH/kg i.p., group (CoQ10+METH) received (20 mg of METH+10 mg of CoQ10)/kg ... effects of CoQ10 on brain tissues The METH-induced brain injury significantly increased lipid peroxidation and decreased the level of the thiol group, the glutathione total and the activity of
Ngày tải lên: 17/03/2021, 09:00
functional ingredients and cardiovascular protective effect of pumpkin seed oils
... plant (Cucurbita sp.) of the Cucurbitaceae family is a native of Asia; however, it is now grown extensively in many of the temperate and warmer climates of the world Species of pumpkin available ... 2 cm·min-1 Identification of the fatty acid methyl esters was carried out by the direct comparison of the retention times of each of the separated compounds with authentic samples of the fatty acid methyl ... with the Ethics Committee of the National Research Centre, Cairo, Egypt, and followed the recommendations of the National Institutes of Health Guide for Care and Use of Laboratory Animals (Publication
Ngày tải lên: 02/11/2022, 10:40
protective effect of butin against ischemia reperfusion induced myocardial injury in diabetic mice involvement of the ampk gsk 3 nrf2 signaling pathway
... future in the treatment of DM TCM treatment has certain advantages of less toxicity and/or side effects, and provides multiple therapeutic effects11 Flavonoids, a group of naturally occurring ... antioxidant gene expression Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China 2College of Pharmacy, Shaanxi University of Chinese Medicine, XianYang 712083, ... injury Inhibition of AMPK and AKT signaling by relative inhibitor or specific siRNA decreased the level of BUT-induced Nrf2 expression, and diminished the protective effects of BUT The interplay
Ngày tải lên: 04/12/2022, 16:13
protective effect of ethyl acetate fraction of biophytum sensitivum extract against sodium oxalate induced urolithiasis in rats
... prevented the elevation of serum levels of these markers indicating prevention of renal damage Out of all extracts again EA-MBS was found to most effective in this regard This effect of EA-MBS is considered ... include a young age of onset, family history, frequent infections and underlying medical conditions.7 The current medical management of urolithiasis involves administration of symptomatic drugs ... are also reported to be effective in the treatment as well as prevention of recurrence of renal calculi with minimal or no side effects.10 In Ayurveda, the whole plant of Biophytum sensitivum
Ngày tải lên: 04/12/2022, 16:15
protective effect of quinacrine against glycerol induced acute kidney injury in rats
... injection of quinacrine at the dose of mg/kg, 10 mg/kg and 30 mg/kg of body weight After 30 of first injection of quinacrine, rats in group 2,3,4 and received a single intramuscular injection of 25% ... reversal of glycerol induced AKI by quinacrine points towards a role of phospholipase A2 (PLA2) in the pathogenesis of renal injury The result of this study suggests that quinacrine may offer an ... 0.001) doses of quinacrine showed a significant attenuation of glycerol induced increase in MDA level in kidney tissues (Fig 2b) Table Effect of quinacrine on glycerol-induced AKI; level of serum
Ngày tải lên: 04/12/2022, 16:17
Báo cáo khoa học: Adeno-associated virus gene transfer in Morquio A disease – effect of promoters and sulfatase-modifying factor 1 pot
... future long-term in vivo studies: (a) evaluation of silencing of the promoter, and the resultant level of coexpression of SUMF1 and GALNS; and (b) confirmation of tar- geting of the expressed enzyme into affected ... all in vitro cotransduction experiments, because of the non-tissue-specific profile of the CMV promoter, which may allow comparison of the effects of SUMF1 coexpression on different cell types. All ... about 10 13 vgÆmL )1 of viral titers, and there was no effect of vector genome size on viral titers. The yield of the vector packing process was 60–80% (Fig. 1). Fig. 1. Structure of CMV–GALNS, AAT–GALNS,
Ngày tải lên: 29/03/2014, 21:20
Báo cáo hóa học: " The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin" pptx
... ii) the effect of CDM on interferons action. Results Antiviral effect of IFN- α , IFN- γ and IFNs combination on HSV-2 plaque formation Since there is no published data on the effect of IFNs ... a syner- gistic effect of IFN combination on HSV-1 virus replica- tion confirming previous studies [36,20]. Effect of CDM on the antiviral action exerted by IFNsFigure 3 Effect of CDM on the antiviral ... 87.5% of vehicle-treated cells by 48 h p.i. (Figure 2b). Treatment with IFN-α or IFN-γ delayed the onset of CPE in MS-infected cultures and increased the fraction of via- Table 1: Effect of IFN-α
Ngày tải lên: 20/06/2014, 01:20
Journal of retailing and consumer services volume 19 issue 1 2012 modeling the effect of self efficacy on game usage and purchase behavior
... the effect of self-efficacy on game usage and purchase behavior Robert Davis a,n, Bodo Lang b,1 a b Faculty of Creative Industries and Business, Unitec Institute of Technology, Department of Management ... active player in the co-creation of experience (Bandura, 1982) A review of the existing research shows that much of the work to date has focused on the effect of advertising within a game on the ... the individual effects of self-efficacy on purchase and usage separately The second step measured the simultaneous effect of selfefficacy on purchase and usage together 6.1 Individual effects In the
Ngày tải lên: 23/06/2014, 15:22
Báo cáo y học: "Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1" pdf
... expression profile of aggrecan mimicked that of type II collagen but with a slight delay of a couple of days The decline in expression of both chondrocyte markers coincided with the onset of late-stage ... protein expression expression Effect of tyrphostin AG490 and Tkip on NO production and NOS II protein expression The effect of tyrphostin AG490 was evaluated in terms of (a) nitrite accumulation ... terms of (d) NOS II protein expression The effect of Tkip was evaluated by nitrite accumulation in (b) leptin/IL-1 ATDC5 co-stimulated cells and in (c) IL-1 stimulated cells (panel c) (e) Effect of
Ngày tải lên: 09/08/2014, 06:22
Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk pot
... However, TXA2 failed to reverse the effect of NS398 on either 27-hydroxylase or ABCA1 message Further verifying the ineffectiveness of TXA2, NS398-induced diminution of 27-hydroxylase protein level ... excretion of only PGI-M (but not other major metabolites of TXA2, TXB2, or prostacyclin) was reduced by COX-2 inhibition Thus, effects Page of 11 (page number not for citation purposes) of disturbance ... cardiovascular-sparing coxib drugs Although the withdrawal of rofecoxib has spawned an interest in the cardiovascular effects of COX-2 inhibition, it is of note that this observed heightened risk is not
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx
... (p46 and p54), particularly the level of the p46 isoforms. Diacerein and rhein, however, had no effect on the activation level of either kinase. Effect of diacerein and rhein on metalloprotease-13 ... investigation. Figure 4 Effect of diacerein and rhein on the osteoclastic levels of (a) metallo-protease-13 (MMP-13) and (b) cathepsin KEffect of diacerein and rhein on the osteoclastic levels of (a) metallo- ... metabolism of bone cells may be indicated for OA. We therefore explored the effects of diacerein and rhein on OA subchondral bone and osteoclasts to determine whether Figure 2 Effect of diacerein
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice" ppt
... Gopalakrishnakone1 1Department of Anatomy, Yong Loo Lin School of Medicine, Medical Drive, National University of Singapore, 117597 Singapore of Immunology, Biomedical Sciences Research Center, ... standard error of the mean of the combined data of triplicate determination of triplicate experiments performed on a pool of RA SF cultures from five RA patients One-way analysis of variance with ... inhibitor of metalloproteinase (TIMP)-1, (f) TIMP-2 Results are the mean ± standard error of the mean of the combined data of triplicate determination of triplicate experiments done on a pool of RA
Ngày tải lên: 09/08/2014, 14:22
Báo cáo khoa hoc:" The effect of linkage on the additive 1 by additive covariance between relatives" ppt
... linkage. The effect of linkage on the covariance was examined for several pairs of relatives. In the absence of inbreeding, linkage has no effect on the parent- offspring ... the pair of alleles from I is of the non-recombinant type. This pair is a copy of either one of the two non-recombinant or one of the two recombinant gametes of D. Thus, ... with allele n of individual J and allele of I is IBD with allele p of J. The additive x additive relationship coefficient (!I,!) is one-fourth of the sum of the 16 IBD
Ngày tải lên: 09/08/2014, 18:21
A practical guide to the management of medical emergencies - part 1 ppt
... capillary refill time of >2 s is abnormal Jugular venous pressure Auscultation: added heart sounds, murmurs or pericardial rub? Major pulses: present and symmetrical? Signs of pulmonary and/or ... Management of circulatory failure: general principles • Stabilize airway and breathing: maintain arterial oxygen saturation >90% • Correct major arrhythmia... management of the airway ... Table 1. 5; pp 10 4–9 for management of respiratory failure 3 Arterial oxygen saturation Arterial oxygen saturation 220 >13 0 >30 3 A score of 3 or more suggests potential critical
Ngày tải lên: 10/08/2014, 18:21
Báo cáo y học: "Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation" ppt
... hepatic and macrophage levels of pro-inflammatory cytokines [16-18], as effectively as their circulating levels [17, 19]. A certain number of clinical effects of SR141716A have been attributed ... adiponectin levels to those of the control cells Effect of SR141716A on pre -adipocyte differentiation and gene expression In order to understand the effect of the CB1 receptor ... effect on mature human adipocytes, but the mode of action is specific to each cytokine Anti -inflammatory effect of SR141716A is not TLR4-, nor TLR2-dependant The secretion of
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: Beneficial effect of IL-2 and GM-CSF immunotherapy" pptx
... hyperactivation of both CD4 and CD8 T lym- phocytes, and associated with a lack of naïve CD4 T cells possibly due to absence of thymic function. Discussion Immune reconstitution after initiation of ART ... defect of CD4 T-cell responses is likely to be an underlying mechanism causa- tive of anergy and subsequently IRIS, due to defective anti- gen presentation and lack of T-cell help. The use of immunotherapy ... diagnosis, lower levels of naïve CD4 T-cells, increased expression of immune activation markers, and weak CD4 T-cell responses. In contrast, CP had a median CD4 T-cell counts of 76 cells/µl at baseline,
Ngày tải lên: 11/08/2014, 10:23