1 polygenic studies in the risk of arrhythmias

... located in the introns of STAT4 and in LD with each other In contrast, significant association was not detected for SNPs in the STAT1 region (P > 0.05) To confirm the association detected in the ... Pe represents the risk genotype frequency in the population and RR represents relative risk of the risk genotype [23] Given the low prevalence of SLE, Pe can be estimated based on the genotype ... role in the pathogenesis of SLE A possible role of SNPs in the STAT1-STAT4 region other than the haplotype tagged by rs7574865T has recently been excluded in Caucasians [10] However, in view of...

Ngày tải lên: 09/08/2014, 13:22

... haplotype containing all of the three SLE risk alleles, but not of the other haplotypes All of these results support the possibility that the possession of both the 3’UTR and intronic risk alleles ... between the two (Table and Figure 1) In agreement with these findings, when only the patients and controls carrying the risk genotypes of the 3’ UTR SNP were analyzed, possession of both of the intronic ... 5.68), which also contained the 3’UTR risk allele but not both of the intronic SNPs, were not associated These results suggest that the combination of the intronic and 3’UTR risk alleles may be...

Ngày tải lên: 12/08/2014, 15:22

... Program for the Training of University Professors of the Spanish Ministry of Education AG was supported by the Instituto de Salud Carlos III (Spain) References Our results were similar to the UK study ... involving differences in disease phenotype, in lifestyle, and in environmental and genetic factors Conclusion There was no detectable effect of variation in the number of D residues in ASPN in ... susceptibility in Spanish Caucasians This result reinforces the overall lack of association reported in other studies in Caucasians The association between variation in the number of D residues...

Ngày tải lên: 09/08/2014, 07:20

... enrolled at the Center of Physical Examination All individuals included in the study were Han Chinese living in and around Nanjing None dropped out during the study In addition, a population of 750 ... Aliabadi P, Niu J, Felson DT: Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: the Beijing Osteoarthritis Study Arthritis Rheum 2006, ... ratios of 2.1 and 1.5 in our study TXNDC3 Frequencies of the susceptible T allele of rs4720262 were different between Chinese (9.7% in control individuals) and Japanese (14.2% in control individuals),...

Ngày tải lên: 09/08/2014, 10:23

... to the Medical School of Nanjing University, China The controls had no symptoms or histories of CDH All subjects included in the study were of Han Chinese origin living in and around Nanjing ... out during the process of the study The study was approved by the ethical committee of the participating institutions, and informed consent was obtained from patients and controls The ages of patients ... compare the GDF5 genotype with the allele distributions in the case-control study The differences in the clinical information between the genotypes were tested using the Mann-Whitney test, the Kruskal-Wallis...

Ngày tải lên: 09/08/2014, 13:22

... to the interpretation of results and the writing of the manuscript CB contributed to the design of the study, to the collection of the data, to statistical analysis and to the writing of the ... information regarding occupation and the branch of industry during the period of the stated exposure to mineral oils The industrial hygienist was blinded with regard to the disease status of the individuals ... with an increased risk for RF+ RA and anti-CP+ RA in man Further exploration of this finding may be of interest in elucidating whether other types of adjuvants, such as microbial agents and other...

Ngày tải lên: 09/08/2014, 07:20

... amplification of the SNP site was carried out using the MassExtend primer and involved the use of specific d/ddNTP termination mixes, which were also determined using MassARRAY assay design software The ... assisted in genotyping some of the control individuals SH aided in recruitment and clinical phenotyping of PsA patients PR and DG conceived the study, participated in its design and coordination, ... Competing interests The authors declare that they have no competing interests Authors' contributions CB carried out molecular genetic studies, participated in study design, and drafted the initial...

Ngày tải lên: 09/08/2014, 07:20

... scattering of the data in the non-24CAs group was similar to that in the 24CAs group This indicated that the functional behavior of the samples included in the non24CAs group, in spite of the inclusion ... replications of a single individual to estimate the variation inherent in the assay, but it is likely that a significant amount of the scattering in the data is produced by interindividual variations in ... panels) of stimulation with anti-CD3/anti-CD28 PE, phycoerythrin To assess the influence of the microsatellite in the kinetics of surface expression of the CD154 protein, PBMCs from both groups of...

Ngày tải lên: 09/08/2014, 10:21

... according to their genotype The transmission ratio under the null hypothesis of no association within these parents will differ from a 50/50 ratio reflecting the different risk levels of both ... observed protective effect of MICA-250A in our data As there are many links between the innate and adaptive immune systems and involvement of pathogens in the initiation of RA is discussed (reviewed ... 2) In combined analysis of both French family cohorts, association of MICA-250 was comparable with the association in the first French family cohort in standard analysis and in analysis of the...

Ngày tải lên: 09/08/2014, 14:20

... occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro ... epithelium of the terminal ileum with cytoplasmic staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining ... deletions in the CSF1R gene [25-27] There is a paucity of literature regarding the expression of the CSF1R protein in the intestine despite documentation of its presence in the epithelium of a variety...

Ngày tải lên: 11/08/2014, 10:23

... dens invaginatus into: • Type I: an enamel-lined invagination within the crown and not extending beyond the cementoenamel junction (CEJ) • Type II: the enamel invagination into the root, beyond the ... where there was uncertainty in the diagnosis of AP or CP were not included in this study The investigated dental anomalies included dens invaginatus, dens evaginatus, congenitally missing and ... investigated in the present study including dens invaginatus, dens evaginatus, pegshaped lateral incisors and congenitally missing lateral incisors Interestingly, the dental anomalies investigated in this...

Ngày tải lên: 11/08/2014, 20:20

... early diagnosis of CD [12]; in fact among the atypical aspects of CD (extra-intestinals), in the international literature has been reported some affections interesting the oral cavity, the most common ... enamel defects Indeed, a wide range of frequencies of enamel defects in CD patients has been reported in other studies [17,43-48]; our data are in agreement with other studies performed in Italy (Table ... part of the diagnostic process In conclusion, our data from central Italy confirming the higher prevalence of RAS or aphthous-like ulcers in patients with CD validate the hypothesis of their...

Ngày tải lên: 11/08/2014, 23:22

... were relatives of the cases This was dictated by the fact that the current study is a part of a larger project studying the effect of genes and environment on the risk of OA in the Icelandic population ... chance these founders were farmers Taking into account the strong inheritance of the farming profession, this might lead to an enrichment of genes associated with OA amongst the farmers of today ... relatives to the cases, thus coming from the same genetic pool Furthermore, we explored the inheritance of different professions within the cohort Materials and methods The study was approved by the Ethics...

Ngày tải lên: 12/08/2014, 14:21

... affiliated to the Medical School of Nanjing University All subjects studied in the study were Chinese Han living in and around Nanjing No subjects dropped out during the process of the study The study ... DDH It may influence the susceptibility of DDH via TGF-b signaling Table Association of the D-repeat of ASPN in patients with DDH in a Han Chinese population Groups compared D14 vs Others OR P-value ... mechanisms, defected soft tissues around hip joint and delayed skeletal development of the hip joint On the other hand, the D13 allele had a significant weaker inhibition on TGF-b signaling, so it exhibited...

Ngày tải lên: 12/08/2014, 15:22

... three of these five studies a statistically significant increase in the length of stay in the ICU was reported for the cases with A baumannii infection [14,17,21], whereas in the remaining two studies ... In addition, the site of infection, the numbers of cases and controls, the methodology for the matching of controls to cases, and clinical outcomes of interest were extracted Outcomes The main ... found in the length of stay in the ICU between cases and controls Data on the length of stay of cases and controls in the ICU was reported in all five studies that examined the effect of acquisition...

Ngày tải lên: 12/08/2014, 23:23

... The existing studies mentioned above with huge amount of information emphasize the needs and the importance of studying the re-using method We want to look into the details of the impact of the ... contribution of individual i given by the following: (5) with yi being the binary indicator taking the value one if individual i is a case in study B The weight ωi is calculated as the inverse of the ... estimate In practice, locating this pair of points involves an approximation using the approx function in R The added benefit of expressing the number of prior subjects in terms of the number of newly...

Ngày tải lên: 12/10/2015, 17:36

... used in this study, as in clinical trials,7–10 to evaluate the equivalence of the two case-control studies in assessing the risk of cancer deaths due to smoking We first defined a range of equivalence ... http://www.medsci.org Int J Med Sci 2009, for rural male spouses indicating the relative risk analyses will not exaggerate the hazard of tobacco The third issue involves the validity of smoking data obtained ... uncertain of the age when smoking began A validity study in Shanghai was conducted where the surviving spouse was the informant and both husband and wife had reported their smoking habits in the...

Ngày tải lên: 26/10/2012, 09:48

... volunteered their time The funding bodies played no role of the design, collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript ... of breast-feeding [45] Similarly, the 28% increase associated with a 20 pack-year smoking history is consistent with other studies [46] indicating a general validity of the approach and findings ... Changing trends in technology and manufacturing are a further source of misclassification, possibly playing a role in some sectors like food manufacturing and dry cleaning In the case of the food...

Ngày tải lên: 06/03/2014, 02:21

... cancer risk. 10 Many substances shown to induce breast cancer in experimental mammals exist in high concentrations in occupational settings.11 In spite of the continuing increase in the incidence of ... underestimate the actual risks.58 Another limitation of the LOHR study was the small sample size, which necessitated the grouping of occupational categories thereby increasing the risk of misclassification ... outside the home In the final step of the model all the occupations interacted with age, but only four occupations remained within the model (agriculture, retail, and the interactions of agriculture...

Ngày tải lên: 06/03/2014, 02:21