1 experimental tissue engineered growth of cartilage

... with cartilage defects treated with cell/scaffold implants Group C, control defect group; Group T-4, tissue- engineered- cartilage group at weeks after implantation; Group T-12, tissue- engineered- cartilage ... human cartilage However, it is of great significance to evaluate the surface layer of tissue- engineered cartilage, since this layer plays an important role in the biomechanical function of the ... regeneration of the cartilage surface in tissue engineering Further studies using lowfrequency ultrasound may provide a better assessment of the deeper layers in tissue- engineered cartilage Second,...

Ngày tải lên: 09/08/2014, 06:22

... grafted using aforementioned types of bone substitutes (13) To overcome these issues, the fabrication of tissue engineered biomaterials, different combinations of bone grafts and systemic supportive ... filled with new bone tissue in spite of the grafted sites In β – TCP groups, the residual bone graft particles were surrounded by a combination of newly formed bone and cartilage tissue The new bone ... inflammatory cell reaction in any of the three groups Loose connective tissue and new bone trabeculae were found together with small islands of isolated cartilage tissue and abundant new vessels...

Ngày tải lên: 25/10/2012, 11:15

... mutations of the p53 tumor suppressor gene, and overexpression of oncogenes [9,10] In addition, several studies indicate that growth factors such as nerve growth factor, insulin-like growth factor, ... that the activation of PtdIns3-K and its downstream effector Akt were associated with the antiapoptotic signaling of various growth factors [22,23] One of the downstream targets of Akt is Bad, a ... signaling in the inhibition of apoptosis of a variety of cells through the increased phosphorylation of Bad and caspase or through the transcriptional activation of NF-jB [33–35,51] Surprisingly,...

Ngày tải lên: 19/02/2014, 06:20

... effects of different diffusion coefficients of gold and indium on silicon, the solubility of substrate atoms in the two metals, the surface tension of gold and indium and the surface energy of silicon ... from indium by means of PVD were found In our case, the growth of nanowires from indium seems to be rather insensitive to change of parameters like substrate temperature, rate of metal and silicon ... enhancement of decomposition of a silicon oxide layer by indium were found From the phase diagrams In–Si and Au–Si (Fig 4), it can be seen that the solubilities of silicon in gold and indium at our growth...

Ngày tải lên: 16/03/2014, 15:17

... apparently it is the soft tissue volume that is changed in response to venous occlusion, it is the venous vasculature congestion within the soft tissue rather than soft tissue congestion per-se ... scan using an in-house software that performs segmentation of the bone and soft tissue for each CT slice, subsequently creating corresponding regions of interest The regions of interest are copied ... limb (green) Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research 2008, 3:36 The limb (and thus the)virtual cylinder is composed of soft tissue (mainly muscles...

Ngày tải lên: 20/06/2014, 01:20

... microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6], fresh tumor tissues were ... possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University School of Medicine, ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF...

Ngày tải lên: 20/06/2014, 04:20

... microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6], fresh tumor tissues were ... possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University School of Medicine, ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF...

Ngày tải lên: 20/06/2014, 07:20

... by other members of the family and of the fact that progeny of II-3 and II-8 carried the M404V mutation In these three cases the description of bone deformities was suggestive of multiple bone ... III-6 died because of an osteogenic sarcoma within or in a Pagetic bone This patient was diagnosed as being affected by PDB at the age of 62 years because of the presence of bone pain, elevated ... hyperplasia of the prostate (Table 1) Male subject II-3, the father of a III-6 affected individual (Fig 1), was referred to as a carrier of multiple bone deformities and pain by living members of the...

Ngày tải lên: 09/08/2014, 07:20

... osteoarthritic cartilage suggests that a loss of BMP signal might reduce the regenerative capacity of cartilage [12,30] However, the role of BMPs in the homeostasis of joints and the regeneration of cartilage ... expression values: all values of RA tissues were lower than the minimum level found in ND tissues In OA, expression values of of 12 synovial tissues were within the range of ND expression values For ... reduced expression of BMP-4 and BMP-5 in OA tissue in comparison with normal tissue This variance of BMP expression levels in OA tissue in comparison with normal or RA synovial tissue may be explained...

Ngày tải lên: 09/08/2014, 07:20

... Hardy et al Figure Expression of 11β-HSD1 in synovial tissue Co-localization of 11β-HSD1 with markers of endothelial cells (vWF), fibroblasts (ASO2/CD90), T-cells tissue (CD3), dendritic cells ... Expression of 11β-HSD1 occurs primarily in GR-rich tissues, where the enzyme acts to increase local levels of active glucocorticoids, thereby providing a system for autocrine induction of GR-mediated ... using Microsoft Excel Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol No Hardy et al Figure Tissue- specific fibroblasts cortisol levels inexpression of 11β-HSD1...

Ngày tải lên: 09/08/2014, 08:22

... to number of molecules and the values for each sample calculated as the ratio of the number of molecules of the target gene/number of molecules of GAPDH Phenotypic characterization of human subchondral ... participation of subchondral bone in the initiation and progression of cartilage damage [2,3] They proposed that the thickening of the subchondral bone plate, resulting from repeated healing of microfractures, ... activation of Syp phosphatase to IRS-1 Discussion As an increasing amount of literature is demonstrating the involvement of bone tissue in the initiation/progression of OA, a better understanding of...

Ngày tải lên: 09/08/2014, 08:23

... analysis of covariance models for BMD variations (final values minus initial values) were built to analyze the effect of cofactors (continuous variables and discrete variables) on that of infliximab ... analysis of covariance models for bone mineral density (BMD) variations (final values minus initial values) to analyze the effect of cofactors (continuous variables and discrete variables) on that of ... Npropeptide of type I procollagen) increased quickly at weeks and after initiation of infliximab treatment The long-term effect of infliximab at year was recently described in a small population of patients...

Ngày tải lên: 09/08/2014, 10:20

... with the breakdown of the cartilage and joint space narrowing, there is thickening and sclerosis of subchondral bone, development of cysts and bony overgrowth at the margins of the joint Despite ... (1,000 × g for min) After addition of 0.1 vol of mol/l sodium acetate (pH 4.0), the mixture was vortexed and the RNA extracted with vol of phenol and 0.2 vol of chloroform/isoamylalcohol (49:1) Total ... could interfere with cartilage metabolism Although many of the genes identified in this analysis have pleiotropic effects in bone and other tissues, it was of interest that many of the top-ranking...

Ngày tải lên: 09/08/2014, 10:21

... cancer, increased expression of several components of the IGF axis is seen in liver, normal mammary tissue and mammary tumors of these mice along with increased levels of IGF-1 in serum [13] Currently, ... and lower) An enlarged view of a cell indicating the contact surfaces of the source and the drain is shown to the right of the wafer Gate voltage is applied at the back of the wafer Also indicated ... month of age when both p53 alleles are intact but is increased significantly (37-80%) by p53 haploinsufficiency [10,11] The presence of the floxed Brca1 alleles, of wild-type Brca1 alleles, and of...

Ngày tải lên: 11/08/2014, 00:23

Ngày tải lên: 13/08/2014, 01:20

... reporting induction of apoptosis by ectopic expression of a dominantnegative form of Stat5 in MT-2 cells [25] Our data of a weaker effect of AG490 on the growth of normal PBMCs than that of ATL cells ... or βcasein probe AG490 inhibits the cell growth of HTLV-1-infected T-cell lines and primary ATL cells Next we examined the effect of AG490 on the growth of HTLV-1-infected T-cell lines and primary ... expression of anti-apoptotic proEffects of AG490 on the expression of anti-apoptotic proteins (A) HTLV-1-infected T-cell lines were treated with increasing concentrations of AG490 for 24 h Amounts of...

Ngày tải lên: 13/08/2014, 09:21

... development of modulators of MMP/TIMP activity could be used as a new class of drugs for the treatment of severe sepsis, as suggested by the beneficial effect of targeting MMPs with the administration of ... higher levels of TIMP-1, reduced Figure and SOFA score as predictors of mortality Receiver operation characteristic analysis using TIMP-1, lactic acid, and SOFA score as predictors of mortality ... TIMP = tissue inhibitor of matrix metalloproteinase Page of (page number not for citation purposes) Critical Care Vol 13 No Lorente et al higher levels of MMP-9 were observed in the group of patients...

Ngày tải lên: 13/08/2014, 19:20

... index of body growth for lingcod Ophiodon elongatus using plasma insulin-like growth factor (IGF1) with the ultimate goal of measuring spatial differences in relative growth rates Insulin-like growth ... measure growth One of the principal hormones regulating growth is insulin-like growth factor (IGF1) In the laboratory, positive relationships between the concentration of plasma IGF1 and growth ... rates of return of adults (Beckman et al 1999) Beckman (2010) concluded, based on a review of the current literature on IGF1 and growth in fish, that IGF1 could provide a valid index of growth...

Ngày tải lên: 04/09/2015, 17:15

... 2.2.3 Tissue- engineered bone grafts 39 2.2.3.1 Types of polymers used for tissue- engineered bone grafts 40 2.2.3.2 Types of n-HA/Collagen-based composites used for tissue- engineered ... inflammation, (2) angiogenesis and cartilage formation, (3) calcification of cartilage, (4) removal of cartilage, (5) bone formation and finally (6) bone remodeling This type of fracture healing is contributed ... grafts 42 2.2.4 Potential of electrospun nanofiber scaffolds (NFS) as tissue- engineered bone grafts 47 2.2.4.1 Techniques of fabricating NFS 48 2.2.5 Peptide-based...

Ngày tải lên: 11/09/2015, 09:57