1 experimental tissue engineered growth of bone

... Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee J Bone Joint Surgr 2002, 84:571-578 Shieh SJ, Terada S, Vacanti JP: Tissue engineering auricular ... T-4, tissue- engineered- cartilage group at weeks after implantation; Group T-12, tissue- engineered- cartilage group at 12 weeks after implantation The error bars represent the standard deviation of ... cartilage However, it is of great significance to evaluate the surface layer of tissue- engineered cartilage, since this layer plays an important role in the biomechanical function of the joint Therefore,...

Ngày tải lên: 09/08/2014, 06:22

... with new bone tissue in spite of the grafted sites In β – TCP groups, the residual bone graft particles were surrounded by a combination of newly formed bone and cartilage tissue The new bone formation ... grafted using aforementioned types of bone substitutes (13) To overcome these issues, the fabrication of tissue engineered biomaterials, different combinations of bone grafts and systemic supportive ... necessity of multidisciplinary study designs which take into account different characteristics of the tissues involved in host tissue – bone graft interactions The use of adjunctive HBOT to improve bone...

Ngày tải lên: 25/10/2012, 11:15

... mutations of the p53 tumor suppressor gene, and overexpression of oncogenes [9,10] In addition, several studies indicate that growth factors such as nerve growth factor, insulin-like growth factor, ... that the activation of PtdIns3-K and its downstream effector Akt were associated with the antiapoptotic signaling of various growth factors [22,23] One of the downstream targets of Akt is Bad, a ... signaling in the inhibition of apoptosis of a variety of cells through the increased phosphorylation of Bad and caspase or through the transcriptional activation of NF-jB [33–35,51] Surprisingly,...

Ngày tải lên: 19/02/2014, 06:20

... effects of different diffusion coefficients of gold and indium on silicon, the solubility of substrate atoms in the two metals, the surface tension of gold and indium and the surface energy of silicon ... from indium by means of PVD were found In our case, the growth of nanowires from indium seems to be rather insensitive to change of parameters like substrate temperature, rate of metal and silicon ... enhancement of decomposition of a silicon oxide layer by indium were found From the phase diagrams In–Si and Au–Si (Fig 4), it can be seen that the solubilities of silicon in gold and indium at our growth...

Ngày tải lên: 16/03/2014, 15:17

... of Orthopaedic Surgery and Research 2008, 3:36 The limb (and thus the)virtual cylinder is composed of soft tissue (mainly muscles and skin) and "hard" tissue (bone and bone marrow) The soft tissue ... require delivery of nutrients and oxygen through blood flow to bone tissue [21] Interruption of normal bone and soft tissue blood flow has been shown to be responsible for the development of severe ... scintigraphic readings) Bone volumes, including the bone marrow (VB), were derived from the CT scan using an in-house software that performs segmentation of the bone and soft tissue for each CT slice,...

Ngày tải lên: 20/06/2014, 01:20

... microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6], fresh tumor tissues were ... possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University School of Medicine, ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone- resorbing OCs (data not shown) To determine the immunolocalization of VEGF...

Ngày tải lên: 20/06/2014, 04:20

... microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6], fresh tumor tissues were ... possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University School of Medicine, ... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone- resorbing OCs (data not shown) To determine the immunolocalization of VEGF...

Ngày tải lên: 20/06/2014, 07:20

... other members of the family and of the fact that progeny of II-3 and II-8 carried the M404V mutation In these three cases the description of bone deformities was suggestive of multiple bone localization ... III-6 died because of an osteogenic sarcoma within or in a Pagetic bone This patient was diagnosed as being affected by PDB at the age of 62 years because of the presence of bone pain, elevated ... L, Anderson D, Van Hul W: Evaluation of the role of RANK and OPG genes in Paget's disease of bone Bone 2001, 28:104-107 Sparks AB, Peterson SN, Bell C, Loftus BJ, Hocking L, Cahill DP, Frassica...

Ngày tải lên: 09/08/2014, 07:20

... expression values: all values of RA tissues were lower than the minimum level found in ND tissues In OA, expression values of of 12 synovial tissues were within the range of ND expression values For ... reduced expression of BMP-4 and BMP-5 in OA tissue in comparison with normal tissue This variance of BMP expression levels in OA tissue in comparison with normal or RA synovial tissue may be explained ... synovial tissue (p < 0.015) Expression of BMP-4 in RA synovial tissue was also lower than in tissues from patients with OA (p < 0.02) For BMP-4, there was no overlap between the ranges of RA and...

Ngày tải lên: 09/08/2014, 07:20

... factor staining) Page of 10 (page number not for citation purposes) Figure Autocrine activation of cortisol and the regulation of fibroblast function of fibroblast function Bone marrow, dermal ... Hardy et al Figure Expression of 11β-HSD1 in synovial tissue Co-localization of 11β-HSD1 with markers of endothelial cells (vWF), fibroblasts (ASO2/CD90), T-cells tissue (CD3), dendritic cells ... using Microsoft Excel Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol No Hardy et al Figure Tissue- specific fibroblasts cortisol levels inexpression of 11β-HSD1...

Ngày tải lên: 09/08/2014, 08:22

... to number of molecules and the values for each sample calculated as the ratio of the number of molecules of the target gene/number of molecules of GAPDH Phenotypic characterization of human subchondral ... activation of Syp phosphatase to IRS-1 Discussion As an increasing amount of literature is demonstrating the involvement of bone tissue in the initiation/progression of OA, a better understanding of ... increased remodeling in OA bone could possibly account for the observation of hypomineralization of the subchondral bone tissues in established OA [9-11] Not only the bone matrix is altered in...

Ngày tải lên: 09/08/2014, 08:23

... true estimation of the effect of anti-TNFa treatment on bone In this study, an early and transient effect on markers of bone turnover (increased bone formation and decreased bone resorption) ... observed only in bone resorption markers (urinary excretion of N-telopeptide of type I collagen and deoxypyridinoline) [18] No effect on serum bone alkaline phosphatase, a marker of bone formation, ... analysis of covariance models for bone mineral density (BMD) variations (final values minus initial values) to analyze the effect of cofactors (continuous variables and discrete variables) on that of...

Ngày tải lên: 09/08/2014, 10:20

... levels of bone remodelling seen in OA bone and perhaps a net gain of under-mineralized bone rather than the net loss of bone volume seen in OP Interestingly, and in contrast to the large number of ... perturbation of these processes and a role for altered bone remodelling in OA pathogenesis The trabecular bone sampled in this study included all of the cellular elements of bone, including the bone ... regulator of bone formation and mineralization Targeted disruption of MEPE has been found to result in increased bone formation and bone mass [58] MEPE was found to be downregulated in OA bone, which...

Ngày tải lên: 09/08/2014, 10:21

... cancer, increased expression of several components of the IGF axis is seen in liver, normal mammary tissue and mammary tumors of these mice along with increased levels of IGF-1 in serum [13] Currently, ... and lower) An enlarged view of a cell indicating the contact surfaces of the source and the drain is shown to the right of the wafer Gate voltage is applied at the back of the wafer Also indicated ... month of age when both p53 alleles are intact but is increased significantly (37-80%) by p53 haploinsufficiency [10,11] The presence of the floxed Brca1 alleles, of wild-type Brca1 alleles, and of...

Ngày tải lên: 11/08/2014, 00:23

Ngày tải lên: 13/08/2014, 01:20

... reporting induction of apoptosis by ectopic expression of a dominantnegative form of Stat5 in MT-2 cells [25] Our data of a weaker effect of AG490 on the growth of normal PBMCs than that of ATL cells ... or βcasein probe AG490 inhibits the cell growth of HTLV-1-infected T-cell lines and primary ATL cells Next we examined the effect of AG490 on the growth of HTLV-1-infected T-cell lines and primary ... expression of anti-apoptotic proEffects of AG490 on the expression of anti-apoptotic proteins (A) HTLV-1-infected T-cell lines were treated with increasing concentrations of AG490 for 24 h Amounts of...

Ngày tải lên: 13/08/2014, 09:21

... development of modulators of MMP/TIMP activity could be used as a new class of drugs for the treatment of severe sepsis, as suggested by the beneficial effect of targeting MMPs with the administration of ... higher levels of TIMP-1, reduced Figure and SOFA score as predictors of mortality Receiver operation characteristic analysis using TIMP-1, lactic acid, and SOFA score as predictors of mortality ... TIMP = tissue inhibitor of matrix metalloproteinase Page of (page number not for citation purposes) Critical Care Vol 13 No Lorente et al higher levels of MMP-9 were observed in the group of patients...

Ngày tải lên: 13/08/2014, 19:20

... index of body growth for lingcod Ophiodon elongatus using plasma insulin-like growth factor (IGF1) with the ultimate goal of measuring spatial differences in relative growth rates Insulin-like growth ... measure growth One of the principal hormones regulating growth is insulin-like growth factor (IGF1) In the laboratory, positive relationships between the concentration of plasma IGF1 and growth ... rates of return of adults (Beckman et al 1999) Beckman (2010) concluded, based on a review of the current literature on IGF1 and growth in fish, that IGF1 could provide a valid index of growth...

Ngày tải lên: 04/09/2015, 17:15

... Tissue- engineered bone grafts 39 2.2.3.1 Types of polymers used for tissue- engineered bone grafts 40 2.2.3.2 Types of n-HA/Collagen-based composites used for tissue- engineered bone ... scaffolding, leading to the lack of bone remodeling A myriad of research has focused on developing tissue- engineered bone grafts with the aim to replace the use of autologous bone grafts and improving ... 56 2.3 Types of cells used in bone tissue engineering for osteogenic differentiation 59 2.3.1 Potential of mesenchymal stem cells (MSCs) for bone healing 60 2.3.2 Potential of bone marrow...

Ngày tải lên: 11/09/2015, 09:57