1 epidermal growth factor receptors egfr her2 neu

... components Taking into account that growth factor receptors, including EGFr, and integrin receptors are functionally associated [27,28], we explored the behaviour of EGFr to lower Triton X-100 concentrations ... regulation of growth factor receptors Nat Cell Biol 4, E75–E76 Wang, X.Q., Sun, P & Paller, A.S (2002) Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor ... epidermal growth factor receptor (EGFr) membrane distribution after EGF stimulation Wild-type CHO-K1 cells (CHO-K1 wt, GM3+) and cells from clone (GD3+), transiently expressing human EGFr, were...

Ngày tải lên: 16/03/2014, 16:20

... an amplified epidermal growth factor receptor (EGFR) gene in human glioblastoma xenograft J Neuropathol Exp Neurol 1999, 58:697-701 Messa C, Russo F, Caruso MG, Di Leo A: EGFR, TGF-alpha, and EGF-R ... activation of epidermal growth factor receptors in meningiomas J Neurosurg 1997, 87(2):315-323 Diedrich U, Lucius J, Baron E, Behnke J, Pabst B, Zoll B: Distribution of epidermal growth factor receptor ... chemotherapy in Her2- positive breast cancer N Engl J Med 2005, 353(16):1659-1672 Sanfilippo JS, Rao CV, Guarnascelli JJ: Detection of epidermal growth factor and transforming growth factor alpha...

Ngày tải lên: 09/08/2014, 09:20

... association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments ... transforming growth factor α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck Cancer 1996, 78:1284-1292 Baumann M, Krause M: Targeting the epidermal growth ... of EGFR and VEGF, looks very promising for the future Abbreviations SCCHN: squamous-cell carcinoma of the head and neck 10 RT: radiation therapy EGF: epidermal growth factor EGFR: epidermal growth...

Ngày tải lên: 09/08/2014, 10:20

... B6.129 F1 B6.129 F1 + + + Wnt3avt/vt + + Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Egfrwa2/wa2 Total activitya Daytime ... transforming growth factor- alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters Brain Research 2005, 1038:171-182 Wakefield LM, Yang Y, Dukhanina O: Transforming growth factor- beta ... phenotypes associated with Egfr [1,12] However, use of the B6EiC3Ha/A-Egfrwa2 Wnt3avt stock to study effects of the Egfrwa2 allele is immediately problematic since Egfrwa2 homozygotes are also...

Ngày tải lên: 10/08/2014, 09:20

... (1993) A 40-kDa epidermal growth factor/ transforming growth factor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor J Biol Chem ... epidermal growth factor by affinity labeling Mol Cell Biol 8, 1831–1834 16 Wu, D., Wang, L., Sato, G.H., West, K.A., Harris, W.R., Crabb, J.W & Sato, J.D (1989) Human epidermal growth factor (EGF) ... Staros, J.V (1996) Identification of residues of the epidermal growth factor receptor proximal to residue 45 of bound epidermal growth factor J Biol Chem 271, 19656–19659 20 Kohda, D., Odaka, M.,...

Ngày tải lên: 24/03/2014, 03:21

... kinase domain of epidermal growth factor receptor Cell 125, 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations, function ... according to the extent of deletion, and termed EGFR vI, EGFR vII and EGFR vIII) have been reported in the extracellular domain of the EGFR gene [6] In the EGFR vI mutation, the extracellular domain ... to bind to the ERBB family of receptors [3] These can be classified into three groups (a) ligands that specifically bind to EGFR (including EGF, transforming growth factor- a, amphi- A B Signal transduction...

Ngày tải lên: 16/02/2014, 09:20

... class of agents for targeting growth factor receptors frequently expressed in epithelial cancers [9] Two such inhibitors of the tyrosine kinase activity of EGFR (EGFR- TKIs), gefitinib and erlotinib, ... ATP-binding cleft of the EGFR [32] Some irreversible EGFR- TKIs have been shown to inhibit EGFR phosphorylation, as well as the growth of NSCLC cell lines harboring the EGFR- targeted anticancer ... sensitivity to inhibition by EGFR- TKIs compared with that of the wild-type receptor (Fig 2) [11,25] These factors combine to render EGFR mutation-positive NSCLC more sensitive to EGFR- TKIs Molecular mechanisms...

Ngày tải lên: 16/02/2014, 09:20

... Bundred NJ (2001) ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFRpositive cancer cell lines with or without erbB2 ... (2002) Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor J Biol Chem 277, 27643–27650 10 Janmaat ML, Kruyt ... Bianco R, Simpson JF & Arteaga CL (2001) Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2 ⁄ neu (erbB2)-overexpressing breast cancer cells in vitro...

Ngày tải lên: 18/02/2014, 13:20

... studies indicate that growth factors such as nerve growth factor, insulin-like growth factor, fibroblast growth factor, epidermal growth factor (EGF), and hepatocyte growth factor can suppress apoptosis ... it from exerting its proapoptotic effect on mitochondria Nerve growth factor, insulin-like growth factor, and fibroblast growth factor have been reported to transmit survival signals through the ... transcription factor, thereby inhibiting them, the PtdIns3K ⁄ Akt signaling pathway has emerged as the major mechanism by which growth factors promote cell survival [26] The transcription factor activator...

Ngày tải lên: 19/02/2014, 06:20

... PKC also phosphorylates EGFR Internalized EGFR (iEGFR), although still capable of signalling to Ras, is normally degraded over time [57] PKC-mediated phosphorylation of iEGFR causes it to recycle ... Cooper, J.A & Hunter, T (1984) C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor- stimulated tyrosine protein kinase activity J Biol Chem 259, ... kinase C and epidermal growth factor receptor kinase Biochem J 348, 381–387 49 Lahaye, D.H., Camps, M.G., Erp, P.E., Peters, P.H & Zoelen, E.J (1998) Epidermal growth factor (EGF) receptor density...

Ngày tải lên: 19/02/2014, 16:20

... growth factor (EGF1) of Jagged-1 was found in a group of patients with deafness, congenital heart defects and posterior embryotoxon [12], and a G274D mutation in the second epidermal growth factor ... Gly –> Ser change causes defective folding in vitro of calcium-binding epidermal growth factor- like domains from factor IX and fibrillin-1 J Biol Chem 273, 7807–7813 20 Whiteman P, Smallridge RS, ... and G106 in factor IX (Fig 8) The G274D mutation, however, appears to affect folding in a more drastic way (Fig 2) than the G1127S mutation in fibrillin-1 and the G106S mutation in factor IX [19,20]...

Ngày tải lên: 16/03/2014, 00:20

... epidermal growth factor Cell Biol Int 19, 413–430 51 Ray, P., Mey, F.J., Montelione, G.T., Liu, J.F., Narang, S.A., Scheraga, H.A & Wu, R (1988) Structure–function studies of murine epidermal growth factor: ... site-directed mutagenesis of epidermal growth factor gene Biochemistry 27, 7289–7295 52 Engler, D.A., Montelione, G.T & Niyogi, S.K (1990) Human epidermal growth factor Distinct role of tyrosine 37 ... epidermal growth factor- like domain: implication for the Marfan syndrome and other genetic disorders Cell 85, 597–605 77 Taylor, J.M., Mitchell, W.M & Cohen, S (1972) Epidermal growth factor: physical...

Ngày tải lên: 16/03/2014, 16:20

... homeostatic processes [8] SCN expression of EGFR [9-11] and transforming growth factor alpha (TGF-alpha; an EGFR ligand) [9,10,12,13] have been reported EGFR signaling has been implicated in the ... of transforming growth factor- alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters Brain Res 2005, 1038:171-182 Hao H, Schwaber J: Epidermal growth factor receptor ... Epidermal growth factor- mediated activation of the ETS domain transcription factor elk-1 requires nuclear calcium J Biol Chem 2002, 277:27517-27527 Gong Q, Pitas RE: Synergistic effects of growth factors...

Ngày tải lên: 14/08/2014, 16:21

... of epidermal growth factor family in the regulation of postnatal somatic growth Endocr Rev 28, 284–296 Henson ES & Gibson SB (2006) Surviving cell death through epidermal growth factor (EGF) ... Henson ES, Haney N, Villanueva J & Gibson SB (2002) Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor- related apoptosis-inducing ligand-induced apoptosis by ... N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas J Neurooncol 88, 11–17 Astsaturov I, Cohen RB & Harari P (2007) EGFRtargeting monoclonal antibodies in head and...

Ngày tải lên: 16/02/2014, 09:20

... of the epidermal growth factor and nerve growth factor receptors J Biol Chem 271, 30505–30509 Browaeys-Poly E, Cailliau K & Vilain JP (1998) Fibroblast and epidermal growth factor receptor expression ... epidermal growth factor in epithelial LLC-PK1 cells Am J Physiol 265, C966–C975 29 Elliget KA, Phelps PC & Smith MW (1996) Transforming growth factor b modulation of the epidermal growth factor ... receptor (EGFR) This tyrosine kinase receptor belongs to the ErbB family, which comprises four members: EGFR ⁄ ErbB1 ⁄ HER1, ErbB2 ⁄ Neu ⁄ HER2, ErbB3 ⁄ HER3 and ErbB4 ⁄ HER4 These receptors...

Ngày tải lên: 06/03/2014, 09:22

... epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer Res 65, 226–235 Prenzel N, Fischer OM, Streit S, Hart S & Ullrich A (2001) The epidermal growth ... R, Schneider PM, Park J, Salonga D, Holscher AH & Danenberg PV ¨ (2001) Epidermal growth factor receptor and HER 2neu mRNA expression in non-small cell lung cancer is correlated with survival Clin ... Ono M & Kuwano M (2006) Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR- targeting drugs Clin Cancer Res 12, 7242–7251 18 Ioriol...

Ngày tải lên: 07/03/2014, 00:20

... 1616.851 1739.018 1814.944 2004.994 2045.011 2082.033 2151.085 To determine whether epidermal growth factor (EGF) can activate Src and influences the association between MVP and Src, we treated ... MVP in a time-dependent manner, which is abrogated by specific Src kinase inhibitor Epidermal growth factor- dependent coimmunoprecipitation of Src and MVP prompted us to test if they colocalize ... reduced its affinity for Src These results prompted us to speculate that a signal (like epidermal growth factor receptor activation), which brings Src and MVP in close proximity to each other, results...

Ngày tải lên: 07/03/2014, 12:20

... Estrada, C (2002) Antiproliferative effect of nitric oxide on epidermal growth factor- responsive human neuroblastoma cells J Neurochem 83, 119–131 13 Takagi, K., Isobe, Y., Yasukawa, K., Okouchi, ... Brown, C., Mendelsohn, J & Darnell, J.E Jr (1998) Epidermal growth factor- induced growth inhibition requires Stat1 activation Cell Growth Differ 9, 505–512 34 Laemmli, U.K (1970) Cleavage of structural ... dephosphorylation of EGFR and NOIPP-58, and whether similar dephosphorylation pathways act on other activated receptors of the ErbB family and/or other unrelated tyrosine kinase receptors Acknowledgements...

Ngày tải lên: 17/03/2014, 03:20

... REFERENCES Schlessinger, J & Ullrich, A (1992) Growth factor signaling by receptor tyrosine kinases Neuron 9, 383–391 Komada, M & Kitamura, N (1995) Growth factor- induced tyrosine phosphorylation of ... to activated growth factor receptors Science 250, 979–982 Rahimi, N., Hung, W., Tremblay, E., Saulnier, R & Elliott, B (1998) c-Src kinase activity is required for hepatocyte growth factor- induced ... endosomes J Biol Chem 272, 20538–20544 27 Ebner, R & Derynck, R (1991) Epidermal growth factor and transforming growth factor- alpha: differential intracellular routing and processing of ligand-receptor...

Ngày tải lên: 17/03/2014, 11:20

... unique epidermal growth factor repeats J Biol Chem 266, 2818– 2823 Swindle, C.S., Tran, K.T., Johnson, T.D., Banerjee, P., Mayes, A.M., Griffith, L & Wells, A (2001) Epidermal growth factor (EGF)-like ... Bork, P (1993) Epidermal growth factor- like modules Curr Opin Struct Biol 3, 385–392 11 Hommel, U., Harvey, T.S., Driscoll, P.C & Campbell, I.D (1992) Human epidermal growth factor: high resolution ... in the structure and activity of epidermal growth factor Protein Sci 7, 1738–1749 17 Valcarce, C., Bjork, I & Stenflo, J (1999) The epidermal growth factor precursor: a calcium-binding, beta-hydroxyasparagine...

Ngày tải lên: 23/03/2014, 13:20